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A highly efficient humidity sensor based on lead(Ⅱ) coordination polymer via in-situ decarboxylation and hydrolysis synthesis

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Rare Metals 2022年第5期41卷 1652-1660页

作者： ha. Dong le-Xi Zha.g Heng Xu Yan-Yan Yin Yi-fei Liu Li-Jian Bie School of Materials Science and Engineering Tianjin Key Laboratory for Photoelectric Materials and DevicesKey Laboratory of Display Materials and Photoelectric Devices(Ministry of Education)National Demonstration Center for Experimental Function Materials EducationTianjin University of TechnologyTianjin 300384China Department of Environmental Science and Engineering Nankai University Binhai CollegeTianjin 300270China

Function-oriented design of coordination polymers is emerging as an attracting topic to explore their practical applications, e.g., gas/humidity sensing. However,the successful synthesis of new coordination polymers showing splendid sensing property is an urgent need in fields of materials and sensors, yet still at the initial *** this contribution, a new one-dimensional(1D) coordination polymer with formula of [Pb(TAA)(BA)(H_(2)O)]_(n)(namedasPbL,HTAA = 3-thiopheneaceticacid,HBA = benzoic acid) ha. been successfully synthesized by a hydrothermal method, which involves in-situ synthesis of both decarboxylation and hydrolysis. As an impedimetric humidity sensing material, this coordination polymer exhibits excellent humidity sensing performance including high response, fast response, small hysteresis, and good repeatability. In the total relative humidity range(11%–97%) at room temperature, it is worth noting tha. the sensitivity of the humidity sensor is as high as 1.18×10^(4),the response time is only 2 s, and the max humidity hysteresis is as small as 1.8%. At last, we discussed the sensing mecha.ism using the alternating current(AC) impedance technique at various relative humidity.

关键词： lead Coordination polymer In-situ synthesis Humidity sensor

Application of Metabolomics in the Study of Natural Products

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Natural Products and Bioprospecting 2018年第4期8卷 321-334页

作者： Qi Zha. Jia-le Zha.g fei Li State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Lanzhou University of Technology Lanzhou 730050People’s Republic of China

LC-MS-based metabolomics could ha.e a major impact in the study of natural products,especially in its metabolism,toxicity and *** review highlights recent applications of metabolomics approach in the study of metabolites and toxicity of natural products,and the understanding of their effects on various *** ha. been employed to study the in vitro and in vivo metabolism of natural compounds,such as osthole,dehydrodiisoeugenol,and *** pha.macological effects of natural compounds and extracts were determined using metabolomics technology combined with diseases models in animal,including osthole and nutmeg *** ha. been demonstrated tha. metabolomics is a powerful technology for the investigation of xenobiotics-induced *** metabolism of triptolide and its hepatotoxicity were ***-MS-based metabolomics ha. a great potential in the druggability of natural *** application of metabolomics should be broadened in the field of natural products in the future.

关键词： Metabolomics Natural products Metabolism Bioactivity Toxicity

Research progress of protein ha.e in white wines

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Food Science and Human Wellness 2023年第5期12卷 1427-1438页

作者： Zha.long Liu le Xu Jun Wang Cha.gqing Duan Yanfeng Sun Qingsen Kong fei He Center for Viticulture and Enology College of Food Science&Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Key Laboratory of Viticulture and Enology Ministry of Agriculture and Rural AffairsBeijing 100083China College of Agriculture Liaocheng UniversityLiaocheng 252000China Ji’an Ginseng Featuer Industry Development Center Ji’an 134200China Ji’an Yajiang Valley Winery Co. Ltd.Ji’an 134202China

Protein ha.e was one of the main causes of the instability of white wines. Proteins tha. caused ha.e or precipitation in white wines mainly came from grape fruits, and their compositions and contents were affected by many factors such as fruit diseases, ha.vesting methods and water stress. Unstable wine proteins were usually pathogenesis-related(PR)proteins of grapes, mainly chitinases and tha.matin-like proteins(TLPs), which ha. lower isoelectric point(pI)and smaller molecular weight, and were highly resistant to the low pH values of wines and the protease hydrolysis during fermentation. At present, the technology of protein stabilization and clarification in white wines mainly included bentonite fining, heat treatment, enzymatic hydrolysis, polysaccha.ide treatment and ultrafiltration methods. Among them, the most commonly used method was bentonite treatment. In this paper, the research progresses of the origin, mecha.ism and influencing factors of the unstable proteins in white wines were summarized, and the applications, advantages and disadvantages of various clarification techniques were also concluded, in order to provide some support for the theoretical and technological research of the protein stability in white wines in the future.

关键词： White wine Protein ha.e Bentonite Stabilization

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基于CFL的去中心工控系统签名认证方案

计算机系统应用 2024年第7期33卷 84-93页

作者：谢云飞赵东东石乐义中国石油大学(华东)计算机科学与技术学院青岛266580 歌尔科技有限公司青岛266104

近来,工业控制系统的身份认证和数字签名等安全问题受到越来越多的关注.本文将去中心化的CFL认证体制引入到工控系统身份认证中,提出了基于CFL的工控系统签名认证方案,建立了基于CFL认证体制的工控系统认证模型CFL-SYS,引入UKey作为证... 详细信息

近来,工业控制系统的身份认证和数字签名等安全问题受到越来越多的关注.本文将去中心化的CFL认证体制引入到工控系统身份认证中,提出了基于CFL的工控系统签名认证方案,建立了基于CFL认证体制的工控系统认证模型CFL-SYS,引入UKey作为证书载体,实现了签名验证过程去中心化;通过计算用户ID的哈希值生成随机私钥和标志私钥实现一人一密,满足了用户对私钥的私有权并且保护了用户的隐私.理论分析和实验结果表明,本文方案在吞吐量、系统验证响应时间等性能上能够满足毫秒级应用需求,能为大规模工业控制系统提供一种自主、可靠、高效的签名认证方案.

关键词：工业控制系统数字身份认证 CFL认证体制去中心化

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抗Ku及其他高频抗原抗体的鉴定思路

中国实验血液学杂志 2024年第3期32卷 875-882页

作者：张飞飞李婧薇沈伟何屹袁红田力叶志君四川省医学科学院·四川省人民医院输血科四川成都610072 上海市血液中心上海200051 中国医学科学院输血研究所四川成都610052 四川省医学科学院·四川省人民医院营养科四川成都610072

目的:通过对一例女性高频抗原抗体(抗-Ku)病例进行血清学鉴定及血型基因测序分析,为高频抗原抗体的鉴定提供一定思路。方法:运用血型鉴定、患者红细胞抗原鉴定、抗体筛选、抗体鉴定等方式检测该患者的血型及抗体。以巯基试剂处理后的血... 详细信息

目的:通过对一例女性高频抗原抗体(抗-Ku)病例进行血清学鉴定及血型基因测序分析,为高频抗原抗体的鉴定提供一定思路。方法:运用血型鉴定、患者红细胞抗原鉴定、抗体筛选、抗体鉴定等方式检测该患者的血型及抗体。以巯基试剂处理后的血清与筛选细胞反应、患者血清与酶或巯基试剂处理的筛选细胞反应的方式来判断该抗体的类型及特点,采用基因测序的方法确定患者血型的基因型。结果:该患者血型为O型RhD^(+),其血清与抗体筛选细胞及抗体鉴定细胞在间接抗人球及盐水介质中的反应呈强反应性,且强度一致,自身阴性,直接抗人球蛋白弱阳性;其他血型为CcEe、Jk(a+b-)、P1-、le(a-b-)、Lu(a-b+)、K-、k-、Kp(a-b-)。血清经2-ME处理后,在间接抗人球介质中仍与3组筛选细胞反应;血清与经木瓜酶、菠萝酶修饰后的筛选细胞反应强度不变,与巯基试剂DTT、2-ME处理后的筛选细胞反应为阴性。基因测序显示该患者KEL基因型为KEL*02N.24,为罕见的K0表型。结论:血清学试验和分子生物学实验鉴定出该患者为罕见的Kell-null血型(又称K0),该患者体内产生了IgG及IgM性质的高频抗原抗体抗-Ku。血清学方法及分子生物学方法在此类稀有血型及高频抗原抗体的鉴定中具有重要意义。

关键词：高频抗原抗体 K0 抗-Ku 血清学实验基因测序

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植物根系吸水模型研究进展

科学技术与工程 2024年第4期24卷 1326-1337页

作者：杨乐龙兰艾施荣施俊林王龙飞李紫怡江西农业大学计算机与信息工程学院南昌330045

根系是植物获取水分的主要器官,它直接影响整个植株的输水量以及生命活动。在水资源短缺的状况下,了解根系生长过程中的需水特性并提高农业中水资源的利用率,一直是节水灌溉技术中研究创新的热点。因此,在研究过程中需要对植物根系的吸... 详细信息

根系是植物获取水分的主要器官,它直接影响整个植株的输水量以及生命活动。在水资源短缺的状况下,了解根系生长过程中的需水特性并提高农业中水资源的利用率,一直是节水灌溉技术中研究创新的热点。因此,在研究过程中需要对植物根系的吸水量进行精确估算,建立根系吸水模型是定量化研究植物根系吸水特性的重要方法。概述根系吸水的原理及其主要影响因素,对不同研究方法下的根系吸水模型进行分类研究,并阐述其适用范围及优缺点,同时介绍了水盐共同胁迫下的根系吸水模型。最后对目前的根系吸水模型进行分析,提出了今后的研究方向。研究成果为构建水稻根系三维动态吸水模型提供了基础。

关键词：植物根系吸水模型宏观模型微观模型土壤植物大气连续体(SPAC)体系

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煤矿取用水智慧水务管理系统建设实践

水电能源科学 2024年第5期42卷 76-79页

作者：贾一飞张翔宇李恩宽李强坤白乐黄河水利科学研究院河南郑州450003

为提高煤矿的取用水效率,建立了煤矿取用水智慧水务管理系统,该系统采用MLP神经网络模型,通过深度学习不同煤矿各用水环节的用水指标,并与相关用水定额进行综合对比,确定适合于系统应用煤矿各环节的合理用水区间,通过实时计算分析用水数... 详细信息

为提高煤矿的取用水效率,建立了煤矿取用水智慧水务管理系统,该系统采用MLP神经网络模型,通过深度学习不同煤矿各用水环节的用水指标,并与相关用水定额进行综合对比,确定适合于系统应用煤矿各环节的合理用水区间,通过实时计算分析用水数据,及时预报预警不合理的用水环节,并将该系统应用于内蒙古鄂尔多斯市某煤矿中。结果表明,系统应用后该煤矿年取水量由117.75×10~4m~3降至86.87×10~4m~3,节水率达到26.23%,节水效果明显。可为后续煤矿类智慧水务管理系统的建设提供参考。

关键词：煤矿智慧水务信息化水资源管理系统设计

Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1αsignaling pathway

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Chinese Journal of Natural Medicines 2021年第2期19卷 143-152页

作者： SUN lei-Tao Zha.G le-Yin Sha. fei-Yu SHEN Min-He RUAN Sha.-Ming Department of Medical Oncology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006China The First Clinical Medical College of Zhejiang Chinese Medical University Hangzhou 310053China Department of Traditional Chinese Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China

Drug resistance is a major obstacle in the development of effective colorectal cancer(CRC)*** study aimed to explore the reversal abilities of Jiedu Sangen decoction(JSD)on the 5-fluorouracil(5-FU)resistance and its underlying molecular *** cha.ges in HIF-1 of CRC tissues were firstly revealed by bioinformatics ***,cell viabilities of JSD and 5-FU treatments on 5-FU resistant human colon cancer cells(HCT-8/5-FU)were *** of phosphoinositide 3-kinase(PI3K),protein kinase B(AKT)/p-AKT,hypoxia-inducible factor 1(HIF-1α),as well as glycolysis related proteins such as L-lactate dehydrogenase A(LDha.,Glucose transporter type 1(Glut1),Hexokinase 2(HKII),and cysteinyl aspartate specific proteinase(Caspase)family members in HCT-8/5-FU cells,HIF-1αsilenced HCT-8/5-FU cells and tumor tissues were detected by western ***-1αwas found over expressed in CRC tissues according to public available datasets in *** inhibition rates of HCT-8/5-FU cells were increased along with the increase of JSD *** caused down-regulated HIF-1α,PI3K,AKT/p-AKT,HKII and Glut1,as well as up-regulated Caspase3 and Caspase9 in HCT-8/5-FU cells and tumor *** HIF-1αsilenced HCT-8/5-FU cells,synergistic group showed significantly reduced expression levels of PI3K,AKT,***,up-regulated expressions of Caspase6 and Caspase7 were *** combined with 5-FU also exhibited obvious inhibitory efficiency on tumor growth in *** may reverse 5-FU resistance by suppressing glycolysis via PI3K/AKT/HIF-1αsignaling pathway,thereby inhibiting glycolysis and induce apoptosis to enha.ce anti-tumor activity.

关键词： Jiedu Sangen decoction 5-Fluorouracil resistance Glycolysis Apoptosis Colorectal cancer

基于抗扰增强型广义预测控制的永磁同步电机伺服系统

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控制与决策 2024年第6期39卷 1967-1976页

作者：魏亚飞冒建亮张传林杨俊上海电力大学自动化工程学院上海200090 拉夫堡大学航空与汽车工程系拉夫堡LE113TU

为了提高永磁同步电机(permanent magnet synchronous motor,PMSM)伺服系统的响应速度及控制精度,提出一种连续时间域下基于抗扰增强型广义预测控制方法.首先,通过构造高阶扩张状态观测器(high-order extended state observer,HOESO)对... 详细信息

为了提高永磁同步电机(permanent magnet synchronous motor,PMSM)伺服系统的响应速度及控制精度,提出一种连续时间域下基于抗扰增强型广义预测控制方法.首先,通过构造高阶扩张状态观测器(high-order extended state observer,HOESO)对模型参数摄动及外部不确定性负载扰动进行估计,同时将干扰以及转子角速度的估计信息引入至位置轨迹输出预测序列中,实现对预测模型偏差的修正.进一步,通过求解位置跟随误差性能指标的优化问题,得到最优控制序列的显示解析解,并从理论上给出控制参数的选择规则.最终,利用Lyapunov理论对闭环系统进行严格的稳定性分析,并在快速控制原型(rapid control prototype,RCP)对拖实验平台上进行所提控制算法的性能验证.实验结果表明,与串级PI控制和传统广义预测控制相比,所提方法提高了伺服系统的位置跟踪精度和抗干扰性能.

关键词：永磁同步电机伺服系统高阶扩张状态观测器广义预测控制扰动估计不确定受扰系统