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Polygonatum kingianum rhizome extract alleviates collagen antibody-induced arthritis by modulating proinflammatory cytokine production in mice

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Asian Pacific Journal of Tropical Biomedicine 2020年第11期10卷 490-495页

作者： Huyen Do Thi Thanh Phuong Ngo Thi Hien Nguyen Thi Thu Nga Nguyen Thi Hung le Ngoc Thao DoThi ha le minh Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Institute of Natural Products Chemistry Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam hanoi Open University101 Nguyen Hien str Hai Ba Trung Dist.HanoiVietnam Laboratory of Bioassay Institute of BiotechnologyVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Chemistry Lab Project Center for Research and Technology transferVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam

Objective: To evaluate the anti-arthritic effects of Polygonatum kingianum rhizome extract using both in vitro and in vivo ***: Lipopolysaccharide-induced RAW 264.7 macrophages were treated with an ethanol extract of Polygonatum kingianum rhizomes at different concentrations to determine nitric oxide and prostaglandin E2(PGE2) production. For in vivo study, Polygonatum kingianum ethanol extract was further investigated for its antiinflammatory effect in a mouse model with collagen antibodyinduced arthritis. Phytochemical study of Polygonatum kingianum ethanol extract was also ***: Saponins(142 mg/g total yield) was the main component in the Polygonatum kingianum ethanol extract. 5α,8α-ergosterol peroxide,(E,E)-9-oxooctadeca-10,12-dienoic acid and 3-(2?-hydroxy-4?-methoxy-benzyl)-5,7-dihydroxy-8-methyl-chroman-4-one were isolated from the extract. Polygonatum kingianum ethanol extract exhibited potential anti-inflammatory effects by inhibiting nitric oxide and PGE2 production in RAW 264.7 cells in a dosedependent manner. The level of arthritis in mice with collagen antibody-induced arthritis was significantly reduced(Phanol extract, particularly at a dose of 1 000 mg/kg body weight. Besides, the extract demonstrated the regulatory effects on serum tumor necrosis factoralpha, interleukin-6, and interleukin-10 in treated ***: Polygonatum kingianum ethanol extract has beneficial effects on inflammatory cytokine regulation and PGE2 inhibition in an experimental mouse model with collagen antibody-induced arthritis. The phytochemical screening reveals that the saponin, as the main component, and sterols(daucosterol and 5α,8α-ergosterol peroxide) from Polygonatum kingianum ethanol extract may contribute to its promising in vitro and in vivo anti-inflammatory activities.

关键词： inflammatory cytokine PGE2

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

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Effects of low energy (160 keV) X-ray on microbial inactivation,sprouting inhibition and genetic variation in potato

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Food Bioscience 2022年第3期47卷 262-270页

作者： Nguyen An Son Nguyen Thi Nguyet ha Nguyen Thi minh Sang le Doan Dinh Duc le Ngoc Trieu Faculty of Physic and Nuclear Engineering Da Lat UniversityViet Nam Dalat Vocational Training College Viet Nam Faculty of Biology Da Lat UniversityViet Nam

The effects of low energy X-ray irradiation on microbial inactivation,sprouting inhibition and genetic variation were *** was an inverse correlation between the exposure dose in range of 0 Gy–5000 Gy and the survival rate of *** dose of 1000 Gy seemed to be suitable for inactivation of microorganisms because the respective survival rate is relatively low (0.59%).Dose rate of 13.87 Gy/min was the most appropriate to inactivate the microorganisms,with the survival rate of 0.37%.Applying the irradiation dose of 1000 Gy and dose rate of 13.87 Gy/min,there was a significant sprouting inhibition of irradiated potatoes compared to the control for six months *** effect of irradiation dose (100–1200 Gy) and dose rate (8.63–19.62 Gy/min) on genetic variation of the irradiated samples was assessed by DNA fingerprints induced from using three molecular techniques including Random Amplified Polymorphic DNA (RAPD),Start Codon Targeted Polymorphism (SCoT) and CAAT box – derived polymorphism (CBDP).At the irradiation dose of 1000 Gy and dose rate of 13.87 Gy/min,the level of genetic variation was relatively low (4.85%).Thus,this treatment is a suitable condition of irradiation for potato treatment with the purpose of preservation.

关键词： Dose Dose rate Low energy X-ray Microbial inactivation Potato

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Negative Index Materials and Their Applications:Recent Mathematics Progress(Dedicated to ham Brezis for his 70th birthday with esteem)

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Chinese Annals of Mathematics,Series B 2017年第2期38卷 601-628页

作者： Hoai-minh NGUYEN EPFL SB MAThaA CAMA Station 8CH-1015 LausanneSwitzerland

Negative index materials are artificial structures whose refractive index has negative value over some frequency range. These materials were first investigated theoretically by Veselago in 1946 and were confirmed experimentally by Shelby, Smith, and Schultz in2001. Mathematically, the study of negative index materials faces two difficulties. Firstly,the equations describing the phenomenon have sign changing coefficients, hence the ellipticity and the compactness are lost in general. Secondly, the localized resonance, i.e.,the field explodes in some regions and remains bounded in some others as the loss goes to 0, might appear. In this survey, the author discusses recent mathematics progress in understanding properties of negative index materials and their applications. The topics are reflecting complementary media, superlensing and cloaking by using complementary media, cloaking a source via anomalous localized resonance, the limiting absorption principle and the well-posedness of the Helmholtz equation with sign changing coefficients.

关键词： Negative index materials, Localized resonance, Cloaking, Superlensing

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Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells

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Journal of Rare Earths 2019年第11期37卷 1183-1187页

作者： ha Thi Phuong Tran Thu Huong le Thi Vinh Hoang Thi Khuyen Do Thi Thao Nguyen Thanh Huong Pham Thi Lien le Quoc minh Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoiViet Nam Graduate University of Science and Technology-Vietnam Academy of Science and Technology 18 Hoang Quoc VietCau GiayHanoiViet Nam Department of Chemistry Hanoi Medical University1-Ton That TungDong DaHanoiViet Nam Department of Chemistry Hanoi University of Mining and Geology18-Pho LienBac Tu LiemHanoiViet Nam Institute of Biotechnology Vietnam Academy of Science and Technology18-Hoang Quoc VietCau GiayHanoiViet Nam Duy Tan University K7/25 Quang TrungDa NangViet Nam

Upconversion nanophosphors are new promising nanomaterials to be used as biolabels for detection and imaging of cancer *** nanophosphors absorb long-wavelength excitation radiation in the infrared or near infrared region and emit shorter wavelength,higher energy radiation from ultraviolet to *** this paper,we studied the hydrothermal method and optical properties of the functionalized NaYF4:Yb^3+,Er^3+for biomedical *** synthesis,these NaYF4:Yb^3+,Er^3+nanophosphors were functionalized with aminosilanes and folic *** acid binds to the folate receptor on the surface of MCF-7 breast cancer cells and this binding promotes internalization of the nanophosphors via *** sizes of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA(folic acid)nanophosphors can be controlled with length of the rod about 300-800 nm and diameter of the rod about 100-200 *** structure of NaYF4:Yb^3+,Er^3+is in hexagonal crystal *** photo luminescence(PL)spectra of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA nanophosphors were *** nanophosphors emit in red color with the strongest band at 650 nm under 980 nm *** result can provide NaYF4:Er^3+,Yb^3+@silica-N=FA complex for developing fluorescence label and image tool in cancer biology and medicine.

关键词： Upconversion luminescence NaYF4:Yb^3+,Er^3+ Nanophosphors Bioimaging Cancer cell Rare earths

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Upconversion luminescence of Gd2O3:Er3+and Gd2O3:Er3+/silica nanophosphors fabricated by EDTA combustion method

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Journal of Rare Earths 2019年第11期37卷 1126-1131页

作者： le Quoc minh Tran Kim Anh Nguyen Duy Hung Pham Thi minh Chau Nguyen Thi Quy hai Ho Van Tuyen Vu Thi Thai ha Vu Duc Tu Wieslaw Strek Institute of Theoretical and Applied Research Duy Tan UniversityDa Nang 55000Viet Nam Advanced Institute for Science and Technology Hanoi University of Science and Technology1 Dai Co VietHai Ba TrungHanoiViet Nam Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadCau Giay DistrictHanoiViet Nam Institute of Low Temperature and Structure Research Polish Academy of Science 2 OkolnaWroclawPoland

Gd2O3:Er^3+nanophosphors were fabricated by the combustion method in presence of Na2 ethylene diamine tetra acetic acid(EDTA-Na2)as fuel at not high temperature(≤350℃)within a very short time of 5 *** added concentration of Er^3+ions in Gd2O3 matrix was changed from 0.5 mol%to 5.0 mol%.The X-ray diffraction pattern of samples indicates the monoclinic structure of Gd2O3:Er^3+.The morphology and chemical composition analysis of the Gd2O3:Er^3+samples are characterized by a field emission scanning electron microscope(FESEM)and a Fourier-transform infrared spectrometer(FTIR).The photoluminescence(PL),photo luminescence excitation(Ple)and upconversion(UC)at room temperature of the prepared materials with different concentrations of Er^3+were *** PL of Gd2O3:Er^3+nanomaterials are shown in visible at 545,594,623,648,688 nm under excitation at 275 *** emission bands from transitions of Er^3+from 2P3/2 to 4F9/2 are observed,UC luminescent spectra of the Gd2O3:Er^3+/silica nanocomposites under 976 nm excitation show the bands at 548 and 670 *** influence of excitation power at 980 nm for transitions were measured and *** results indicate that the upconversion process of Gd2O3:Er^3+/silica is two photons absorption *** low temperature dependence of UC luminescent intensities of the main bands of Gd2O3:Er^3+was investigated towards development of a nanotemperature sensor in the range of 10-300 K.

关键词： Upconversion luminescence Gd2O3:Er3+ Gd2O3:Er3+/silica Nanophosphors EDTA combustion Rare earths

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Detection of decline in estimated glomerular filtration rate in patients with type 2 diabetes by cystatin C-based equations

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World Journal of Nephrology 2024年第4期13卷 103-116页

作者： Tam Thai Thanh Tran Tien Kim ha Nhut minh Phan minh Van le Tin Hoang Nguyen Department of Physiology Faculty of MedicineCan Tho University of Medicine and PharmacyCan Tho 900000Viet Nam Department of Functional Exploration Can Tho University of Medicine and Pharmacy HospitalCan Tho 900000Viet Nam School of Medicine and Pharmacy The University of Da NangDa Nang 550000Viet Nam Faculty of Medicine Can Tho University of Medicine and PharmacyCan Tho 900000Viet Nam

BACKGROUND Aging population is a significant issue in Viet Nam and across the *** individuals are at higher risk of chronic kidney disease(CKD),especially those with *** studies found that the estimated glomerular filtration rate(eGFR)determined using creatinine-based equations was not as accurate as that determined using cystatin C-based *** C-based equations may be beneficial in elderly patients with an age-associated decline in kidney *** determination of eGFR decline and associated factors would aid in appropriate interventions to improve kidney function in elderly patients with *** To determine the utility of cystatin C-based equations in early detection of eGFR decline and to explore factors associated with eGFR decline in elderly patients with *** This cross-sectional study included 93 participants aged≥60 years evaluated in Can Tho University of Medicine and Pharmacy Hospital between October 2022 and July 2023,including 47 and 46 participants with and without diabetes respectively,according to the American Diabetes Association criteria for *** kappa coefficient,Student’s t,Mann-Whitney,χ2,Pearson’s correlation,multivariate logistic regression,and multiple linear regression analyses were *** The eGFRs were lower with the cystatin C-based equations than with the creatinine-based *** agreement was found between the Modification of Diet in Renal Disease(MDRD)and CKD Epidemiology Collaboration(CKD-EPI)2021 creatinine-cystatin C equations(kappa=0.66).In the diabetes group,30%of the participants had low *** plasma glucose and glycated hemoglobin were associated with an increased risk of eGFR decline(Plesterol,and exercise were independently associated with low *** multiple linear regression,higher plasma glucose levels were correlated with lower eGFR(P=0.026,

关键词： Cystatin C Estimated glomerular filtration rate Elderly Diabetes Nephrology Kidney function

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An Automatically Filtering Blacklist Model of Social Network Based on Semantic Web

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Journal of harbin Institute of Technology(New Series) 2014年第6期21卷 67-73页

作者： le ha Guo-Zi Sun College of Computer Nanjing University of Posts & Telecommunications Jiangsu High Technology Research Key Laboratory for Wireless Sensor Networks

According to the features of the semantic web technology,it is very suitable to solve the security issue of the current social network ***,in this paper,it extends the existing ontology model of the social network with some relevant classes,and introduces a brand new ontology which is used to represent the malicious *** introducing these models,a method of identifying the malicious message is ***,the experiments and simulations analyze the feasibility of the whole *** results validate that the malicious users can be automatically filtered,and some worthy digital evidence can be effectively provided to forensic investigators.

关键词： social network semantic web ontology OWL digital evidence

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Investigation of Punch Resistance of the Allomyrira dichtoloma Beetle Forewing

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Journal of Bionic Engineering 2018年第1期15卷 57-68页

作者： Ngoc San ha Vinh Tung le Nam Seo Goo Smart Microsystem Research Laboratory Department of Advanced Technology Fusion Division of Interdisciplinary Studies Konkuk University Seou105029 Republic of Korea Faculty of Science Engineering and Technology Swinburne University of Technology Hawthorn VIC 3122 Australia

In this study, the punch resistance of the beetle forewing was investigated to address the ability of the forewing against the external force. The punch resistance of the forewing was measured for different sizes and sexes of beetles using a conventional testing method in conjunction with the Digital Image Correlation （DIC） technique. The results showed that the maximum fracture load was measured around 23 N for the female beetle and around 20.2 N for the male beetle in the front-side punch test. Moreover, the fracture load in the front-side punch test was higher than that in the back-side punch test for both male and female beetles. This means that the beetle forewing plays a protection role against external loads. Furthermore, the puncture energy in the front-side punch test for the female beetle （6.91 m J） was a little higher than that for the male beetle （5.27 mJ）. In addition, the DIC results revealed that the first crack occurred along the trachea line and the second crack then appeared in the direction that was perpendicular to the direction of the first crack. This study provides a com- prehensive understanding of the mechanical protection properties of the beetle forewing and offers a good lesson for studying lightweight bio-inspired composite material.

关键词： beetle forewing punch test punch energy digital image correlation

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Fuzzy Feedback Control for Electro-Hydraulic Actuators

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Intelligent Automation & Soft Computing 2023年第5期36卷 2441-2456页

作者： Tan Nguyen Van Huy Q.Tran Vinh Xuan ha Cheolkeun ha Phu Huynh minh School of Engineering-Technology Thu Dau Mot UniversityThu Dau Mot City590000Vietnam Faculty of Engineering-Technology Nguyen Tat Thanh UniversityHo Chi Minh City754000Vietnam Hue Industrial College Hue City530000Vietnam Robotics and Mechatronics Lab University of UlsanUlsan City44610Korea

Electro-hydraulic actuators(Eha)have recently played a signiﬁcant role in modern industrial applications,especially in systems requiring extremely high *** can be explained by Eha’s ability to precisely control the position and force through advanced sensors and innovative control *** of the promising approaches to improve control accuracy for Eha systems is applying classical to modern control algorithms,in which the proportional–inte-gral–derivative(PID)algorithm,fuzzy logic controller,and a hybrid of these methods are popular *** this paper,we developed a novel version of the fuzzy control algorithm and linear feedback control method,namely fuzzy lin-ear feedback control,to improve the control *** achieve the highest performance,weﬁrst designed a mathematical Eha model based on the Matlab/Simulink software packages thanks to the selected parameters,which are similar to a real Eha ***,we respectively applied PID,fuzzy PID(FPID),and fuzzy linear feedback control(FLFC)before comparing them to have a full view of the outstanding advantages of the proposed *** simulation results showed that the proposed FLFC algorithm is approximately 99%and 77%super-ior in performance to the PID and feedback control algorithms,respectively.

关键词： Electro-hydraulic actuator fuzzy PID feedback control

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