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Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan kim Hyemi Eo Sang ryong kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Application of flavonoids for the protection of nigral dopaminergic neurons from oxidative stress

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Neural Regeneration Research 2021年第7期16卷 1409-1410页

作者： Sang ryong kim School of Life Sciences BK21 plus KNU Creative BioResearch Group/Institute of Life Science&Biotechnology/Brain Science and Engineering InstituteKyungpook National UniversityDaeguKorea

Oxidative stress in Parkinson's disease(PD): Oxidative stress is the imbalance between oxidants, which generate reactive oxygen species(ROS;free radicals), and antioxidants, which remove free *** healthy conditions, the levels of oxidants and antioxidants are ***, excessive production of ROS and a deficiency of antioxidants leads to oxidative stress, which may be the cause of accelerating the development of neurodegenerative diseases(Hwang, 2013), suggesting that the prevention of ROS production and reduction of oxidative stress is critical for both the prevention and treatment of neurodegenerative diseases, including PD.

关键词： prevention remove oxidative

Beneficial effects of AAV1-Rheb(S16H) administration in the adult hippocampus

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Neural Regeneration Research 2020年第8期15卷 1479-1480页

作者： Sang ryong kim School of Life Sciences BK21 plus KNU Creative BioResearch Group Institute of Life Science & Biotechnology Brain Science and Engineering Institute Kyungpook National University

Neurotrophic factors against neurodegenerative diseases such as Alzheimer’s disease(AD)and Parkinson’s disease(PD):A clear understanding of the etiology of neurodegenerative diseases,such as AD and PD remains *** there is still no therapy to prevent or block neurodegeneration,in vivo and in vitro experimental results have shown that the direct administration of neurotrophic factors,such as brain-derived neurotrophic factor(BDNF)and ciliary neurotrophic factor(CNTF),and the induction of these neurotrophic factors via specific gene delivery may protect neurons against neurotoxicity in neurodegenerative disease models(kim et al.,2012;Jeong et al.,2013,2015).

关键词： al. diseases Alzheimer

Inhibition of microglial activation and induction of neurotrophic factors by flavonoids:a potential therapeutic strategy against Parkinson's disease

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Neural Regeneration Research 2015年第3期10卷 363-364页

作者： Sang ryong kim School of Life Sciences BK21 plus KNU Creative Bio Research GroupBrain Science and Engineering InstituteKyungpook National University

Parkinson＇s disease （PD） is characterized by the progressive degeneration of dopaminergic （DA） neurons and a decrease in striatal dopamine, which is associated with clinical movement disorders including a tremor at rest, rigidity of the limbs, bra- dykinesia （slowness and paucity of voluntary movement） and postural instability （a tendency to fall even in the absence of weakness or cerebellar balance disturbance）（kim et al., 2012）. Although the lack of fully understanding of the etiology of PD, accumulating evidence suggests that microglial activation （kim et al., 2010） and insufficient support of neurotrophic factors （kim et al., 2012; Nam et al., 2014） may be crucial for the ini- tiation and progression of PD. Thus the control of microglial activation and the support of neurotrophic factors may be useful to prevent the degeneration of the nigrostriatal DA pro- jections in the adult brain.

关键词： PD BDNF GDNF MPTP

Mammalian target of rapamycin complex 1 as an inducer of neurotrophic factors in dopaminergic neurons

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Neural Regeneration Research 2014年第23期9卷 2036-2037页

作者： Sang ryong kim School of Life Sciences BK21 plus KNU Creative Bio Research Group Institute of Life Science & Biotechnology Kyungpook National University Brain Science and Engineering Institute Kyungpook National University

The defining neuropathological feature of Parkinson＇s disease （PD） is the loss of nigrostriatal dopaminergic （DA） projections. This results in striatal dopamine levels and a biochemical reduction of movement disorders, such as a tremor at rest, rigidity of the limbs, bradykinesia, and postural instability （kim et al., 2011; kim et al., 2012; Burke and O＇Malley, 2013; Leem et al., 2014; Namet al., 2014）.

关键词： Rheb Mammalian target of rapamycin complex 1 as an inducer of neurotrophic factors in dopaminergic neurons GDNF BDNF

Effect of a seasonal diffuse pollution migration on natural organic matter behavior in a stratified dam reservoir

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Journal of Environmental Sciences 2010年第6期22卷 908-914页

作者： Soon Ju Yu Jae Yil Lee Sung ryong ha National Institute of Environmental Research Department of Urban Engineering Chungbuk National University

This article aims to describe the influence of diffuse pollution on the temporal and spatial characteristics of natural organic matter （NOM） in a stratified dam reservoir, the Daecheong Dam, on the basis of intensive observation results and the dynamic water quality simulation using CE-QUAL-W2. Turbidity is regarded as a comprehensive representation of allochothonous organic matter from diffuse sources in storm season because the turbidity concentration showed reasonable significance in a statistical correlation with the UV absorbance at 254 nm and total phosphorus. CE-QUAL-W2 simulation results showed good consistency with the observed data in terms of dissolved organic matter （DOM） including refractory dissolved organic carbon （RDOC） and labile DOC and also well explained the internal movement of constituents and stratification phenomenon in the reservoir. Instead turbidity and NOM were related well in the upper region of the reservoir according to flow distance, gradually as changing to dissolved form of organic matter, RDOM affected organic matter concentration of reservoir water quality compared to turbidity. To control the increase of soluble organic matters in the dam reservoir, appropriate dam water discharge gate operation provided effective measurement. Because of the gate operation let avoid the accumulation of organic matter within a dam reservoir by shorten of turbid regime retention time.

关键词： CE-QUQL-W2 natural organic matter stratified dam reservoir turbidity flow

Oxidative stress:culprit or consequence in Alzheimer's amyloidopathy

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Neural Regeneration Research 2023年第9期18卷 1948-1949页

作者： Chanchal Sharma Sang ryong kim School of Life Sciences Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National UniversityDaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

Oxidative stress in Alzheimer’s disease:Oxidative stress refers to an imbalance between the prooxidative and anti-oxidative states that are part of normal cell metabolism that results in the elevated production of reactive oxygen species(ROS) and free *** products oxidize lipids,proteins,and DNA,significantly threatening the integrity of neurons(Pratico,2008;Padurariu et al.,2013).

关键词： metabolism Alzheimer elevated

Naringin as a beneficial natural product against degeneration of the nigrostriatal dopaminergic projection in the adult brain

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Neural Regeneration Research 2017年第8期12卷 1375-1376页

作者： Sang ryong kim School of Life Sciences BK21 plus KNU Creative BioResearch Group Brain Science and Engineering Institute Kyungpook NationalUniversity Daegu Korea

The progressive degeneration of nigral dopaminergic（DA）neurons and the biochemical reduction of striatal dopamine levels are associated with major clinical symptoms,including tremor at rest,rigidity of the limbs,slo... 详细信息

关键词： Naringin as a beneficial natural product against degeneration of the nigrostriatal dopaminergic projection in the adult brain DA TOR PD

Prothrombin kringle-2, a mediator of microglial activation: new insight in Alzheimer’s disease pathogenesis

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Neural Regeneration Research 2022年第12期17卷 2675-2676页

作者： Jae Man Lee Sang ryong kim Department of Biochemistry and Cell Biology Cell and Matrix Research InstituteSchool of MedicineKyungpook National UniversityDaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea School of Life Sciences BK21 FOUR KNU Creative BioResearch GroupInstitute of Life Science and BiotechnologyKyungpook National UniversityDaeguKorea

Microglial activation in Alzheimer’s disease(AD):In 1907,*** Alzheimer,a Bavarian-born German psychiatrist and neuropathologist,published an article describing the clinical and neuropathological features of an unclassified psychiatric *** disorder was later named AD and is currently the most common brain disorder(Takata et al.,2021).AD involves the accumulation of amyloid-β(Aβ)and hyperphosphorylated tau proteins in the brain,which are associated with senile plaques and neurofibrillary tangles,respectively(Vergara et al.,2019;Takata et al.,2021).AD is characterized by cognitive impairment and memory loss with hippocampal neurodegeneration(kim et al.,2021).

关键词： Alzheimer Aβ tau