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Significance of incidental focal fluorine-18 fluorodeoxyglucose uptake in colon/rectum,thyroid,and prostate:With a brief literature review

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World Journal of Clinical Cases 2022年第34期10卷 12532-12542页

作者： Haejun Lee Kyung-Hoon hwang Department of Nuclear Medicine Gachon University College of MedicineGil Medical CenterIncheon 21565South Korea

BACKGROUND Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography(F-18 FDG PET/CT),a functional imaging method,is usually performed on the entire torso,and regions of unexpected suspicious focal hypermetabolism are not infrequently *** the regions,colon,thyroid,and prostate were found to be the common organs in a recent umbrella *** studies reported that a high rate of malignancy was shown in incidentally identified focal hypermetabolic regions and suggested that further examinations should not be *** To investigate the malignancy rate of incidental focal FDG uptake,useful PET parameters and their cutoffs in discrimination between malignant and benign *** Retrospectively,the final reports of 16510 F-18 FDG PET/CT scans performed at our hospital between January 2016 and March 2022 were reviewed to identify incidentally observed FDG uptake in the colon/rectum,thyroid,and *** scans of patients with current or prior malignancies at each corresponding location,without the final reports of histopathology or colonoscopy(for colon and rectum)for the corresponding hypermetabolic regions,or with diffuse(not focal)hypermetabolism were ***,88 regions of focal colorectal hypermetabolism in 85 patients(48 men and 37 women with mean age 67.0±13.4 years and 63.4±15.8 years,respectively),48 focal thyroid uptakes in 48 patients(12 men and 36 women with mean age 62.2±13.1 years and 60.8±12.4 years,respectively),and 39 focal prostate uptakes in 39 patients(mean age 71.8±7.5 years)were eligible for this *** those unexpected focal hypermetabolic regions,rates of malignancy were calculated,PET parameters,such as standardized uptake value(SUV),capable of distinguishing between malignant and benign lesions were investigated,and the cutoffs of those PET parameters were determined by plotting receiver operating characteristic *** In the colon and rectum,29.5%(26/88)were malignant and 33.0%(2

关键词： Incidental Focal Uptake Fluorine-18 fluorodeoxyglucose Positron emission tomography/computed tomography Standardized uptake value

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Liquid-Liquid Phase Transition as a New Means of Protein Targeting in Chloroplasts

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Molecular Plant 2020年第5期13卷 679-681页

作者： Dong Wook Lee Inhwan hwang Department of Integrative Food Bioscience and BiotechnologyChonnam National UniversityGwangju 61186Korea Department of Bioenergy Science and Technology Chonnam National UniversityGwangju 61186Korea Division of Integrative Biosciences and Biotechnology Pohang University of Science and TechnologyPohang 37673Korea Department of Life Sciences Pohang University of Science and TechnologyPohang 37673t Korea

The chloroplast is a unique organelle in that it possesses an intra-organellar membrane-enclosed structure called thylakoid,which is central to ***,the timely expression and correct localization of thylakoid proteins are of utmost importance to plant growth and development(Lee et al.,2017;New et al.,2018).Biogenesis of thylakoid proteins is highly complex;they are encoded by two different genomes,nuclear and chloroplast genomes,and translated in the cytosol and chloroplasts,***-encoded thylakoid proteins are first imported into the stroma of chloroplasts before they are targeted to *** the stroma,multiple sorting mechanisms exist to ensure import or insertion of thylakoid luminal or membrane proteins,respectively(Lee et al.,2017).Approximately 50%of thylakoid luminal proteins are imported through the cpTAT(chloroplast twin-arginine translocation)pathway,which is also present in bacteria and plant mitochondria(Cline,2015;Schafer et al.f 2020).

关键词： al. Transition insertion

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Endoscopic resection of gastric and esophageal cancer

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Gastroenterology Report 2015年第4期3卷 330-338,I0002页

作者： Bryan Balmadrid Joo Ha hwang Division of Gastroenterology University of WashingtonSeattleWAUSA

Endoscopic submucosal dissection(ESD)and endoscopic mucosal resection(EMR)techniques have reduced the need for surgery in early esophageal and gastric cancers and thus has lessened morbidity and mortality in these *** is a relatively new technique in western countries and requires rigorous training to reproduce the proficiency of Asian countries,such as Korea and Japan,which have very high complete(en bloc)resection rates and low complication *** plays a valuable role in early esophageal *** has shown better en bloc resection rates but it is easier to master and maintain proficiency in EMR;it also requires less procedural *** early esophageal adenocarcinoma arising from Barrett’s,ESD and EMR techniques are usually combined with other ablative modalities,the most common being radiofrequency ablation because it has the largest dataset to prove its *** EMR techniques have been used with some success in early gastric cancers but ESD is currently preferred for most of these *** has the added advantage of resecting into the submucosa and thus allowing for endoscopic resection of more aggressive(deeper)early gastric cancer.

关键词： endoscopic submucosal dissection endoscopic mucosal resection endoscopic ablation early gastric cancer early esophageal cancer

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Quasiparticle interference and impurity resonances on WTe2

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Nano Research 2020年第9期13卷 2534-2540页

作者： Hyeokshin Kwon Taehwan Jeong Samudrala Appalakondaiah Youngtek Oh Insu Jeon Hongki Min Seongjun Park Young Jae Song Euyheon hwang Sungwoo hwang Samsung Advanced Institute of Technology Samsung Electronics Co.Suwon 16678Republic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Nano Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Physics and Astronomy Seoul National UniversitySeoul 08826Republic of Korea Department of Physics Sungkyunkwan UniversitySuwon 16419Republic of Korea Center for Integrated Nanostructure Physics(CINAP) Institute for Basic Science(IBS)Sungkyunkwan UniversitySuwon 16419Republic of Korea

Using scanning tunneling microscopy/spectroscopy(STM/STS),we examine quasiparticle scattering and interference properties at the surface of ***2,layered transition metal dichalcogenide,is predicted to be a type-ll Weyl *** Weyl fermion states in WTe2 emerge as topologically protected touching points of electron and hole pockets,and Fermi arcs connecting them can be visible in the spectral function on the *** probe the properties of surface states,we have conducted low-temperature STM/STS(at 2.7 K)on the surfaces of WTe2 single *** visualize the surface states of WTe2 with atomic scale *** surface states emerging from the bulk electron pocket have been identified and their connection with the bulk electronic states shows good agreement with *** show the interesting double resonance peaks in the local density of states appearing at localized *** low-energy resonant peak occurs near the Weyl point above the Fermi energy and it may be mixed with the surface state of Weyl points,which makes it difficult to observe the topological nature of the Weyl semimetal WTe2.

关键词： WTe2 Weyl semimetal quasi-particle interference scanning tunneling microscopy/spectroscopy

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Development of novel 5-FU modified siRNA against BCL-2 with enhanced efficacy and vehicle-free cellular uptake

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Genes & Diseases 2024年第1期11卷 23-25页

作者： Andrew Fesler Ga-Ram hwang Jingfang Ju Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA The Northport Veteran's Administration Medical Center NorthportNY 11768USA Curamir Therapeutics Inc. WoburnMA 01801USA

One of the major obstacles for nucleic acid-based medicine is cellular uptake due to the concern of efficiencyand potential toxicity of the *** this work,we developed a novel approach to eliminate the need for a vehicle to allow for the cellular uptake of siRNA-based therapy with a unique modification strategy that also further enhances therapeutic *** discovery may be of great importance for the development of siRNA-based therapeutics as cellular uptake remains a critical *** this study,we have tested the potential of this modification strategy for siRNA using a siRNA that targets B-cell lymphoma-2(BCL-2).

关键词： eliminate uptake modified

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Implementation of unambiguous comparison for unknown pure quantum states with cavity-assisted interaction

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Chinese Physics B 2013年第5期22卷 136-140页

作者：程留永王洪福张寿 Yeon Kyu-hwang Center for the Condensed-Matter Science and Technology Department of PhysicsHarbin Institute of Technology Department of Physics College of ScienceYanbian University BK21 Program Physics & Department of Physics College of Natural ScienceChungbuk National University

We propose two effective schemes for local and remote unknown atomic state comparisons with a cavity-assisted single photon input--output process without any initial entanglement or auxiliary resource. The unambiguous state discrim- ination is considered using the state comparison process as the basic module. All the implementation schemes here just involve common quantum logic gates and the single qubit measurement. The analysis shows that our schemes are feasible under the current experimental conditions.

关键词： unambiguous state comparison atomic qubit cavity-assisted interaction

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An Enhanced Privacy Preserving, Secure and Efficient Authentication Protocol for VANET

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Computers, Materials & Continua 2022年第5期71卷 3703-3719页

作者： Safiullah Khan Ali Raza Seong Oun hwang Department of IT Convergence Engineering Gachon UniversitySeongnam13320Korea ENSAIT GEMTEX-Laboratoire de Genie et Materiaux TextilesUniversity of LilleLilleF59000France School of Computing&Institute of Cyber Security(ICSS) University of KentUnited Kingdom Department of Computer Engineering Gachon UniversitySeongnam13320Korea

Vehicular ad hoc networks (VANETs) have attracted growing interest in both academia and industry because they can provide a viable solutionthat improves road safety and comfort for travelers on roads. However, wireless communications over open-access environments face many security andprivacy issues that may affect deployment of large-scale VANETs. Researchershave proposed different protocols to address security and privacy issues in aVANET, and in this study we cryptanalyze some of the privacy preservingprotocols to show that all existing protocols are vulnerable to the Sybilattack. The Sybil attack can be used by malicious actors to create fakeidentities that impair existing protocols, which allows them to imitate trafficcongestion or at worse cause an accident that may result in the loss of humanlife. This vulnerability exists because those protocols store vehicle identitiesin an encrypted form, and it is not possible to search over the encryptedidentities to find fake vehicles. This attack is serious in nature and veryprevalent for privacy-preserving protocols. To cope with this kind of attack,we propose a novel and practical protocol that uses Public key encryptionwith an equality test (PKEET) to search over the encrypted identities withoutleaking any information, and eventually eliminate the Sybil attack. Theproposed approach improves security and at the same time maintains privacyin VANET. Our performance analysis indicates that the proposed protocoloutperforms state-of-the-art protocols: The proposed beacon generation timeis constant compared to a linear increase in existing protocols, with beaconverification shown to be faster by 7.908%. Our communicational analysisshows that the proposed protocol with a beacon size of 322 bytes has the leastcommunicational overhead compared to other state-of-the-art protocols.

关键词： VANET authentication protocol cryptanalysis privacy preserving intelligent systems

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Framework for Measuring the Resilience of Utility Poles of an Electric Power Distribution Network

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International Journal of Disaster Risk Science 2019年第2期10卷 270-281页

作者： MdMorshedul Alam Berna Eren Tokgoz Seokyon hwang Department of Industrial Engineering Lamar UniversityBeaumontTX77710USA Construction Management Program Lamar UniversityBeaumontTX77710USA

The utility poles of an electric power distribution system are frequently damaged by wind-related *** study notes that the wooden poles are particularly vulnerable to such disasters and the failures of the poles can cause a network-level failure leading to short-or longterm power outages. To mitigate the problem, this study proposes a framework for measuring the resilience of the wooden utility poles based on the angular deflection of a pole due to the wind force. Given the existing inclination angle of a pole, the angular deflection is measured by finite element analysis using ANSYS~? Workbench^1 to determine the resilience area under various wind speeds. For this, the conditions of load and support for a pole, which are called boundary conditions in ANSYS~?, are generated. The proposed framework also includes an approach to cost–benefit analysis that compares different strategies for corrective action. The results of the case study in which the framework was applied show that the proposed framework can be effectively utilized by electric power distribution companies to increase the resilience of their systems.

关键词： Angular deflection Cost–benefit analysis Finite element analysis Pole damage Utility system resilience Wind-related disaster

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Fabrication and Properties of SiB6-B4C with Phenolic Resin as a Carbon Source

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Journal of Materials Science & Technology 2008年第1期24卷 102-104页

作者： G. C.hwang J.Matsushita United Graduate School of Science and Engineering Tokai University 1117 Kitakaname Hiratsuka 259-12921 Japan

Si-B-C ceramic composites were synthesized using SiB-6,B-4C,and phenolic resin as a carbon source by pressureless sintering in an Ar ***,the Si-B-C ceramic composites were fabricated to determine their potential for applications as high hardness and high temperature *** X-ray diffraction patterns of sintered bodies of SiB-6-B-4C with carbonized phenolic resin can be seen that SiB-6 and C changed to B-4C and *** this study,it is obtained that carbonized phenolic resin is good addition material as a reaction material comparing to carbon powder at 1683 K for 1 h by pressureless sintering in an Ar atmosphere.

关键词： Silicon boride Boron carbide Phenolic resin

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Antioxidant and anti-inflammatory activities of Orostachys japonicus

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Asian Pacific Journal of Tropical Biomedicine 2020年第11期10卷 516-522页

作者： Eun-Sun hwang Nhuan Do Thi School of Wellness Industry Convergence Food&NutritionHankyong National University327 Chungang-roAnseong-siGyeonggi-do 17579Korea

Objective: To determine the bioactive compounds of Orostachys japonicus(O. japonicus)(Maxim.) A. Berger extraction by different solvents(70% ethanol or water) and to evaluate the in vitro antioxidant and anti-inflammatory activities. Methods: Total polyphenol, flavonoid, and anthocyanin contents in O. japonicus extract were measured. Antioxidant activities were determined by DPPH, ABTS, and superoxide radical-scavenging ability assays. Anti-inflammatory activities were evaluated by nitric oxide production, tumor necrosis factor-α, and interleukin-6 expression techniques. Results: Extraction with 70% ethanol yielded the highest total polyphenol(60.03 mg/g dry weight) and flavonoid(55.50 mg/g dry weight) contents. The total anthocyanin contents in 70% ethanol and water extracts were 57.25 and 91.71 mg/g dry weight, respectively. The 70% ethanol extract also showed stronger antioxidant activity than the water extract. Antioxidant activity and reducing power increased with the increasing concentration of O. japonicus extract. O. japonicus extract at 0-400 μg/m L did not affect the growth of RAW 264.7 cells, whereas dose-dependent inhibition of nitric oxide, tumor necrosis factor-α, and interleukin-6 production was ***: O. japonicus inhibits oxidative and inflammatory reactions with potentially positive health-related effects.

关键词： Antioxidant inflammatory oxidative

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