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Petrography of alluvial sands as a past and present environmental indicator:Case of the Loire River(France)

International Journal of Sediment Research 2013年第3期28卷 285-303页

作者： jean-Jacques MACAIRE Isabelle GAY-OVEJERO michel BACCHI Constantin COCIRTA Luc PATRYL Stéphane RODRIGUES University Franqois-Rabelais of Tours University Francois-Rabelais of Tours SARL RIVE 4. Commissariat a l'Energie Atomique-CEA DAMDIF

Four sample sets of the Upper and Middle Loire river sands were analyzed in order to study the impact of natural and anthropogenic factors on their petrographic composition in space(on an 800 km stretch) and *** was determined by modal analysis of three sand-size fractions using a polarizing optical microscope and calculated for each sample("standard sand" = Sst).The watershed is composed mainly of endogenic(Massif Central) and sedimentary(southern Parisian Basin) rocks.B-set sands collected in channels for different water flows in 1996 show that Sst compositions vary by only 5%.Present-day sands in the Upper Loire and Middle Loire have very high petrographic immaturity comparing to others worldwide fluvial sands,although bio-climatic conditions favor sand maturation by source-rock weathering in the *** shows the strong impact of the Massif Central on sediment yield due to relief rejuvenation as a consequence of the formation of the Alps during the *** sands stored during the Weichselian and the Holocene in the Middle Loire floodplain,although partly weathered since their deposition,show higher inputs from the endogenic rocks of the Massif Central than present-day *** can be explained by Weichselian periglacial conditions and the development of crop farming since the Neolithic,which favored mechanical erosion,particularly in the Massif Central which is characterized by a cold,humid climate and steep *** upstream-downstream change in the composition of presently deposited sand is low in the diked *** shows however that basalt and some heavy mineral grains are vulnerable to abrasion during transport and indicates a marked sediment yield from ancient sediment stored in the *** is in line with the high incision of the river bed over the last 150 years partly due to dam construction and aggregate mining.

关键词： Fluvial sand Sand petrography Sediment source Tectonics impact Human impact Loire river

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Conducting polymer tattoo electrodes in clinical electro-and magneto-encephalography

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npj Flexible Electronics 2020年第1期4卷 36-44页

作者： Laura M.Ferrari Usein Ismailov jean-michel Badier Francesco Greco Esma Ismailova Center for MicroBiorobotics Istituto Italiano di Tecnologia56025 PontederaItaly The BioRobotics Institute Scuola Superiore Sant’Anna56025 PontederaItaly Department of Bioelectronics Ecole Nationale Supérieure des Mines de Saint EtienneCMP-EMSEMOC1354 GardanneFrance Aix Marseille Univ INSERMINSInst Neurosci SystMarseilleFrance Institute of Solid State Physics NAWI GrazGraz University of Technology8010 GrazAustria Department of Life Science and Medical Bioscience Waseda University169-8480 TokyoJapan

Temporary tattoo electrodes are the most recent development in the field of cutaneous *** have successfully demonstrated their performances in the monitoring of various electrophysiological signals on the *** epidermal electronic devices offer a conformal and imperceptible contact with the wearer while enabling good quality recordings over *** of brain activity in clinical practice face multiple limitations,where such electrodes can provide realistic technological solutions and increase diagnostics *** we present the performance of inkjet-printed conducting polymer tattoo electrodes in clinical electroencephalography and their compatibility with *** working mechanism of these dry sensors is investigated through the modeling of the skin/electrode impedance for better understanding of the biosignals transduction at this ***,a custom-made skin phantom platform demonstrates the feasibility of high-density recordings,which are essential in localizing neuropathological *** evaluations provide valuable input for the successful application of these ultrathin electronic tattoos sensors in multimodal brain monitoring and diagnosis.

关键词： polymer recording conformal

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Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor

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Nano-Micro Letters 2021年第6期13卷 284-294页

作者： Yuye Wang Shuwen Zeng Aurelian Crunteanu Zhenming Xie Georges humbert Libo Ma Yuanyuan Wei Aude Brunel Barbara Bessette jean-Christophe Orlianges Fabrice Lalloué Oliver GSchmidt Nanfang Yu Ho-Pui Ho Department of Biomedical Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongPeople’s Republic of China CNRS XLIM Research InstituteUMR 7252University of Limoges123Avenue Albert ThomasLimogesFrance Department of Applied Physics and Applied Mathematics Columbia UniversityNew York CityNYUSA Institute for Integrative Nanosciences IFW DresdenHelmholtzstr.20DresdenGermany Faculty of Medicine University of LimogesEA3842-CAPTuRGEIST2 rue du Dr MarclandLimogesFrance

Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer,monitoring treatment and detecting ***,a highly enhanced plasmonic biosensor that can overcome this challenge is developed using atomically thin two-dimensional phase change *** precisely engineering the configuration with atomically thin materials,the phase singularity has been successfully achieved with a significantly enhanced lateral position shift *** on our knowledge,it is the first experimental demonstration of a lateral position signal change>340μm at a sensing interface from all optical *** this enhanced plasmonic effect,the detection limit has been experimentally demonstrated to be 10^(-15) mol L^(−1) for TNF-α cancer marker,which has been found in various human diseases including inflammatory diseases and different kinds of *** as-reported novel integration of atomically thin Ge_(2)Sb_(2)Te_(5) with plasmonic substrate, which results in a phase singularity and thus a giant lateral position shift, enables the detection of cancer markers with low molecular weight at femtomolar level. These results will definitely hold promising potential in biomedical application and clinical diagnostics.

关键词： 2D nanomaterials Cancer marker detection Phase singularity Surface plasmon

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Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI

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World Journal of Gastroenterology 2009年第30期15卷 3748-3756页

作者： Hervé Trillaud jean-michel Bruel Pierre-jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis Department of radiology University of Victor Segalen Bordeaux 2CHU Bordeaux Hospital Saint André1 rue Jean Burguet33075 BordeauxFrance Department of radiology CHU of Montpellier HospitalSaint Eloi34295 MontpellierCedex 5France Department of radiology CHU Lyon University69437 Lyon Cedex 03France Department of radiology Hospital Beaujon92110 ClichyFrance Department of radiology Hospital CaenCaen14033 Caen CedexFrance Department of radiology University Hospitals LeuvenGasthuisbergHerestrat 493000 LeuvenBelgium Department of radiology Zaklad Diagnostyki ObrazowejWojewodzki Zespol Publicznych ZakladowOpieki Zdrowotnejul Kendrtatowicza 803-242 WarszawaPoland Department of Radiology General University HospitalU Nemocnice 212000 Praha 2Czech Republic Department of Radiology University Hospital Brno BohuniceJihlavka 2063900 BrnoCzech Republic Ultrasound Medical Department Bracco Imaging Deutschland GmbHMax-Stromeyer-Strasse 11678467 KonstanzGermany

AIM： To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVue-enhancement; and to compare this method with computed tomography （CT） and magnetic resonance imaging （MRI）. METHODS： One hundred and thirty four patients withone focal liver lesion detected in baseline ultrasound （US） were examined with conventional US, contrastenhanced US （n = 134）, contrast-enhanced CT （n = 115） and/or dynamic contrast-enhanced MRI （n = 70）. The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The final diagnosis based on the combined information of all imaging examinations, clinical information and histology （n = 32） was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions.RESULTS： In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization （malignant/benign） of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVue -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available （n = 30）, sensitivity was 95.5% （CEUS）, 72.2% （CT） and 81.8% （MRI）, and specificity was 75.0% （CEUS）, 37.5% （CT） and 42.9% （MRI）. The sensitivity and specificity of CEUS for the identification of focal nodular hyperplasia （FNH） and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%.CONCLUSION： SonoVue-enhanced sonography emerges as the most sensitive, ost specific and thus most accurate imaging modality for the characterization of focal liver lesions.

关键词： Contrast-enhanced sonography Contrastmedia Dynamic sonography Liver lesion Liverdisease Liver Oncologic imaging Sonography

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Slow Pyrolysis of Sugarcane Bagasse for the Production of Char and the Potential of Its By-Product for Wood Protection

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Journal of Renewable Materials 2021年第1期9卷 97-117页

作者： Febrina Dellarose Boer Jérémy Valette jean-michel Commandré Mériem Fournier Marie-France Thévenon CIRAD UR BioWooEBTA B-114/1673 Rue Jean-François BretonF-34398 MontpellierCedex 5France BioWooEB Universitéde MontpellierCIRADMontpellierFrance AgroParisTech Centre de Nancy Nancy54000France Universitéde Lorraine AgroParisTechINRAUMR SilvaNancyF-54000France

Sugarcane bagasse was pyrolyzed using a laboratory fixed bed reactor to produce char and its by-product(pyrolysis liquid).The pyrolysis experiments were carried out using different temperatures(400℃ and 500℃),heating rate(1℃/min and 10℃/min),and holding time(30 min and 60 min).Char was characterized according to its thermal properties,while the pyrolysis liquid was tested for its anti-fungal and anti-termite *** temperature and heating rate had a significant influence on the char properties and the yield of char and pyrolysis liquid,where a high-quality char and high yield of pyrolysis liquid can be obtained at a temperature of 500℃ and a heating rate of 10℃/*** yield of char and pyrolysis liquid was 28.97%and 55.46%,*** principal compounds of pyrolysis liquid were water,acetic acid,glycolaldehyde,1-hydroxy-2-propanone,methanol,formic acid,levoglucosan,furfural,followed by some phenol compounds and guaiacol *** liquid at a concentration of 0.20%and 0.25%(v/v)caused a 100%inhibition of Coniophora puteana and Trametes versicolor,respectively,when performing inhibition growth tests in Petri *** paper treated with 10%of pyrolysis liquid caused 100%of termite mortality,while only 5.65%–7.03%of the treated filter papers consumed by termites at such *** liquid is potentially effective to be used in the formulation of wood protection against fungi and termites.

关键词： Anti-fungal anti-termite biomass char pyrolysis liquid slow pyrolysis sugarcane bagasse valorization

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Modeling and Optimization of Relocation of Some Heavy Metals and Micro-nutrients in the Argan Trees

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Journal of Chemistry and Chemical Engineering 2011年第7期5卷 663-669页

作者： Faez Abdullah Esmail Mohammed Rahma Bchitou jean michel Roger Ahmed Bouhaouss bernard Palagos Laboratory General of Physical Chemistry Materials Nanoma-terials and Environment Faculty of Science UniversityMohammed V-Agdal Rabat Morocco Unite Mixed Research Cemagref-ENSAM-CIRAD Montpellier France

This work constitutes a contribution to the study of the physical-chemical performance of some heavy metals and micro-nutrients in the Argan trees. The samples are harvested from small Argan trees, three samples （soil, wood, leaves） per tree. The content of various heavy metals and micro-nutrient in aerial parts （leaves, wood and soil） were analyzed in the Argan tree by the method of ICP-ES. The results of analysis of data for the chemical variables were measured for several trees at different measurement times, do not affect the dispersion of the data. The use of chemometrics has allowed us to interpret the results obtained especially those related to the characterization of heavy metals and micro-nutrient after calibration by variable regression of these results in order to get an overall estimate of the optimal content, and to follow changes in the methods of treatment. The results of the characteristics of Argan trees have been treated using the statistical method of Principal Component Analysis （MFA）, The MFA was used to analyze the three groups simultaneously. These groups are fairly similar.

关键词： Heavy metals micro-nutrients argan trees principal component analysis MFA ICP-AES.

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Low-Loss Dielectric Material Characterization and High-Q Resonator Design from Microwave to Millimetre Waves Frequencies

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Journal of Physical Science and Application 2011年第1期1卷 15-28页

作者： jean-michel Le Floch Michael E. Tobar Georges humbert David Mouneyrac Denis Ferachou Romain Bara michel Aubourg John G. Hartnett Dominique Cros jean-Marc Blondy Jerzy Krupka School of Physics University of Western Australia 35 Stirling Hwy 6009 Crawley Western Australia XLIM UMR CNRS No 6172 123 av. A. Thomas 87060 Limoges Cedex France Institute of Microelectronics and Optoelectronics Warsaw University of Technology Kosykowa 75 Warsaw Poland

Dielectric resonators are key components in many microwave and millimetre wave circuits and applications, including high-Q filters and frequency-determining elements for precision frequency synthesis. Multilayered and bulk low-loss single crystal and polycrystalline dielectric structures have become very important for designing these devices. Proper design requires careful electromagnetic characterisation of low-loss material properties. This includes exact simulation with precision numerical software and precise measurements of resonant modes. For example, we have developed the Whispering Gallery mode technique, which has now become the standard for characterizing low-loss structures. This paper will review some of the common characterisation techniques used in the microwave to millimetre wave frequency regime.

关键词： Dielectric resonator Bragg mode whispering gaUery mode bulk and thin film characterization.

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Multivariate Approach to Characterizing Soil Quality of Gabonese’s Ferralitic Soils

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Open Journal of Soil Science（土壤科学期刊） 2024年第4期 237页

作者： Neil-Yohan Musadji Rolf Gaël Mabicka Obame michel Mbina Mounguengui jean Aubin Ondo Lydie-Stella Koutika Eric Ravire Claude Geffroy

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Effects of Institut Georges Lopez-1 and Celsior preservation solutions on liver graft injury

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World Journal of Gastroenterology 2015年第14期21卷 4159-4168页

作者： Donia Tabka Mohamed Bejaoui James Javellaud Joan Roselló-Catafau jean-michel Achard Hassen Ben Abdennebi Unité de recherche "Biologie et anthropologie moléculaire appliquées au développe- mentetàla santé" (UR12ES11) University of MonastirFaculty of Pharmacy Experimental Hepatic Ischemia--Reperfusion Unit Institut d’Investigacions Biomèdiques de Barcelona--Consejo Superior de Investigaciones Cientificas INSERM Unité Mixte de Recherche S-8508000 LimogesFrance

AIM: To compare Institut Georges Lopez(IGL-1) and Celsior preservation solutions for hepatic endothelium relaxation and liver cold ischemia reperfusion injury(IRI).METHODS: Two experimental models were *** the first one, acetylcholine-induced endotheliumdependent relaxation(EDR) was measured in isolated ring preparations of rat hepatic arteries preserved or not in IGL-1 or Celsior solutions(24 h at 4 ℃).To determine nitric oxide(NO) and cyclooxygenase EDR, hepatic arteries were incubated with L-NG-nitroarginine methyl ester(L-NAME), an inhibitor of endothelium nitric oxide synthase(e NOS), or with L-NAME plus indomethacin, an inhibitor of *** the second experiment, rat livers were cold-stored in IGL-1 or Celsior solutions for 24 h at 4 ℃ and then perfused "ex vivo " for 2 h at 37 ℃.Liver injury was assessed by transaminase measurements, liver function by bile production and bromosulfophthalein clearance, oxidative stress by malondialdehyde levels and catalase activity and alterations in cell signaling pathways by pA kt, pA MPK, eN OS and MAPKs proteins ***: After cold storage for 24 h with either Celsior or IGL-1, EDR was only slightly *** isolated arteries, EDR was exclusively mediated by ***, cold-stored arteries showed NOand COX-dependent *** decrease in NO-dependent relaxation after cold storage was significantly more marked with *** second study indicated that IGL-1 solution obtained better liver preservation and protection against IRI than *** injury was reduced, function was improved and there was less oxidative ***-1 solution activated Akt and AMPK, which was concomitant with increased eN OS expression and nitrite/nitrate ***, MAPKs kinases were regulated in livers preserved with IGL-1 solution since reductions in p-p38, p-ERK and p-JNK protein levels were ***: IGL-1 solution preserved NO-dependent relaxation better than Celsior storage solutio

关键词： Organ preservation solutions Institut Georges Lope

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Hepatitis C virus: Virology, diagnosis and management ofantiviral therapy

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World Journal of Gastroenterology 2007年第17期13卷 2461-2466页

作者： Stéphane Chevaliez jean-michel Pawlotsky French National Reference Center for Viral Hepatitis B C and deltaDepartment of Virology & INSERM U841 Henri Mondor Hospital University of Paris XII Créteil France

Hepatitis C virus (HCV) infects approximately 170 million individuals worldwide. Prevention of HCV infection complications is based on antiviral therapy with the combination of pegylated interferon alfa and ribavirin. The use of serological and virological tests has become essential in the management of HCV infection in order to diagnose infection, guide treatment decisions and assess the virological response to antiviral therapy. Anti- HCV antibody testing and HCV RNA testing are used to diagnose acute and chronic hepatitis C. The HCV genotype should be systematically determined before treatment, as it determines the indication, the duration of treatment, the dose of ribavirin and the virological monitoring procedure. HCV RNA monitoring during therapy is used to tailor treatment duration in HCV genotype 1 infection, and molecular assays are used to assess the end-of-treatment and, most importantly the sustained virological response, i.e. the endpoint of therapy.

关键词： Hepatitis C virus serological tests HepatitisC virus genotype HCV RNA quantification Interferon alpha Ri-bavirin-

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