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基于张量化微结构表征的筏化镍基单晶高温合金疲劳寿命评估

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力学学报 2024年第7期56卷 2029-2050页

作者：罗诚袁荒清华大学航天航空学院北京100084 清华大学航空发动机研究院北京100084

镍基单晶高温合金的微观组织在长时高温服役下会发生粗化和筏化等微结构演化,导致力学性能衰减,影响航空发动机的服役寿命.文章研究了粗化和筏化镍基单晶DD6合金的低周疲劳行为,通过高温热暴露和预蠕变处理分别制备了粗化和筏化合金,针... 详细信息

镍基单晶高温合金的微观组织在长时高温服役下会发生粗化和筏化等微结构演化,导致力学性能衰减,影响航空发动机的服役寿命.文章研究了粗化和筏化镍基单晶DD6合金的低周疲劳行为,通过高温热暴露和预蠕变处理分别制备了粗化和筏化合金,针对具有不同微结构状态的合金开展了980℃下的等温低周疲劳试验,发现粗化和筏化合金的疲劳寿命相比初态合金显著下降.基于电子扫描显微镜和光学显微镜对试件断口表面进行了微观表征,揭示了筏化组织对低周疲劳损伤机理的影响.裂纹扩展路径受微结构状态影响,相比初态合金,粗化和筏化合金中I型微裂纹会更早发生偏折,沿晶体学面扩展而导致更早的疲劳失效.基于组构张量及其张量分解方案对合金的微结构进行了量化表征,提取了微结构的特征参数,进一步提出了一种新的微结构敏感的等温疲劳寿命预测模型.通过分别关联γ-基体相和γ′-强化相组构张量的独立分量,解耦了粗化和筏化对寿命的影响.在新模型中,γ/γ′微结构形态对低周疲劳的影响得到了较好描述,预测结果的准确性和保守性得到了显著提高.研究结果可为工程中镍基单晶涡轮叶片的强度设计和寿命评估提供理论指导.

关键词：单晶合金张量化表征筏化疲劳寿命评估

Identification of Mulberry Bacterial Blight Caused by Klebsiella oxytoca in Bazhong,Sichuan,China

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 1995-2008页

作者： yuan huang Jia Wei Peigang Liu Yan Zhu Tianbao Lin Zhiqiang Lv Yijun Li Mei Zong Yun Zhou Junshan Gao Zilong Xu School of Life Science Anhui Agricultural UniversityHefei230036China Institute of Sericulture and Tea Zhejiang Academy of Agricultural SciencesHangzhou310021China School of Life Science Anqing Normal UniversityAnqing246133China

To provide a scientific basis for controlling mulberry bacterial blight in Bazhong,Sichuan,China(BSC),this study aimed to isolate and purify pathogenic bacteria from diseased branches of mulberry trees in the region and to clarify their taxonomic status using morphological observation,physiological and biochemical detection,molecular-level identification,and the construction of a phylogenetic tree.A total of 218 bacterial strains were isolated from samples of diseased mulberry *** these,7 strains were identified as pathogenic bacteria based on pathogenicity tests conducted in accordance with Koch’s *** findings from the analysis of the 16S rRNA sequence indicated that the 7 pathogenic bacteria are members of Klebsiella *** observation revealed that the pathogenic bacteria were oval-shaped and had capsules but no *** could secrete pectinase,cellulase,and protease and were able to utilize D-glucose,D-mannose,D-maltose,and *** 7 strains of pathogenic bacteria exhibited the highest homology with Klebsiella *** study identifies Klebsiella oxytoca as the causative agent of mulberry bacterial blight in BSC,laying the foundation for the prevention and control of this pathogen and further investigation into its pathogenic mechanism.

关键词： Mulberry bacterial blight pathogenic identiﬁcation Klebsiella spp. Klebsiella oxytoca

Effects of acetylcysteine on micro-inflammation and pulmonary ventilation in chronic obstructive pulmonary disease exacerbation

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World Journal of Clinical Cases 2024年第18期12卷 3482-3490页

作者： Li-yuan huang Bin huang Zheng Lv Xiao-Dan Lu Department of Integration of Traditional Chinese and Western Medicine School of Clinical MedicineChangchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Department of Infectious Diseases Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Zoology School of Life SciencesChangchun Normal UniversityChangchun 130032Jilin ProvinceChina Precision Medical Center Jilin Province General HospitalChangchun 130021Jilin ProvinceChina

BACKGROUND Acute exacerbation of chronic obstructive pulmonary disease(AECOPD)is a serious complication of chronic obstructive pulmonary disease,often characterized by increased morbidity and *** traditional Chinese medicine,AECOPD is linked to phlegm-heat and blood-stasis,presenting symptoms like thick sputum,fever,and chest *** has been shown that acetylcysteine inhalation in conjunction with conventional therapy significantly reduced inflammatory markers and improved lung function parameters in patients with AECOPD,suggesting that acetylcysteine may be an important adjunctive therapy for patients with phlegm-heat-blood stasis type *** To investigate the effect of acetylcysteine on microinflammation and lung ventilation in patients with phlegm-heat and blood-stasis-type *** One hundred patients with phlegm-heat and blood-stasis-type AECOPD were randomly assigned to two *** treatment group received acetylcysteine inhalation(10%solution,5 mL,twice daily)along with conventional therapy,whereas the control group received only conventional *** treatment duration was 14 *** markers(C-reactive protein,interleukin-6,and tumor necrosis factor-alpha)in the serum and sputum as well as lung function parameters(forced expiratory volume in one second,forced vital capacity,and peak expiratory flow)were assessed pre-and *** inhalation led to significant reductions in inflammatory markers and improvements in lung function parameters compared to those in the control group(P<0.05).This suggests that acetylcysteine could serve as an effective adjunct therapy for patients with phlegm-heat and blood-stasis-type *** Acetylcysteine inhalation significantly reduced inflammatory markers in the serum and sputum and improved lung ventilation function parameters in patients with phlegm-heat and blood-stasis type AECOPD compared with the control *** differences were statistically significant(P

关键词： Acute exacerbation Chronic obstructive pulmonary disease Traditional Chinese medicine Acetylcysteine Phlegm-heat and blood-stasis Lung ventilation function

女之为医:夏葛医学院与近代中国女医职业的在地化

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妇女研究论丛 2024年第4期 87-104页

作者：黄永远中山大学国际翻译学院东亚研究中心广东珠海529000

夏葛医学院作为持续时间最长、培养毕业生最多、具有广泛影响力的女子医学校,对于构建近代中国医疗体系的两性平等具有重要的象征和典范意义。夏葛医学院虽是一所教会学校,但它立足岭南地域文化和业医环境,顺应女子教育现实,实行实用性... 详细信息

夏葛医学院作为持续时间最长、培养毕业生最多、具有广泛影响力的女子医学校,对于构建近代中国医疗体系的两性平等具有重要的象征和典范意义。夏葛医学院虽是一所教会学校,但它立足岭南地域文化和业医环境,顺应女子教育现实,实行实用性、大众化教育。夏葛医学院培养的更多是擅长妇产科与分娩接生的临床女医,而非医学精英。但正是该校毕业生在地方社会开展的诸如临床实践、助产教育与社会参与等行动,切实推动了西方医学知识和分娩卫生在近代中国的落地以及女医职业社会地位与形象的构建。近代女医职业难以摆脱国族主义和父权制笼罩的社会文化与性别秩序的左右,但夏葛女医所呈现的自我调适与能动性昭示了女之为医的希望与力量所在。

关键词：夏葛医学院女医医学教育性别

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农村简约治理变迁:背景、问题与出路

华南农业大学学报（社会科学版） 2024年第5期23卷 129-140页

作者：刘锐黄源源四川大学公共管理学院四川成都610065 四川大学社会发展与社会控制研究中心四川成都610065 中山大学政治与公共事务管理学院广东广州510006

城乡融合发展带来基层治理事务属性变迁,对乡政村治分级治理模式提出挑战。信息技术嵌入带来简约治理模式转型,但脱离实体治理需要的技术约化制度,忽视超辖区交叠事务协同治理机制,使基层治理呈现形式清晰但实质模糊矛盾,出现“上动但... 详细信息

城乡融合发展带来基层治理事务属性变迁,对乡政村治分级治理模式提出挑战。信息技术嵌入带来简约治理模式转型,但脱离实体治理需要的技术约化制度,忽视超辖区交叠事务协同治理机制,使基层治理呈现形式清晰但实质模糊矛盾,出现“上动但下不动”及“有限主体互动”的困局。京郊B镇的技术赋能经验说明,加强治理过程主体关系协调,适配增加治理要素、构建扁平管理机制,能填补基层治理能力结构堕距,推动简约治理传统现代调适,实现合作治理的简约高效。技术型简约治理模式的有效运转,有赖要素衔接与补位治理机制,夯实主辅协同分级治理机制。

关键词：简约治理事务变迁治理转型技术嵌入合作治理

超高性能混凝土牛腿受剪性能试验与承载力模型研究

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建筑结构学报 2024年第8期45卷 108-117页

作者：黄远夏文琳洪志诚湖南大学工程结构损伤诊断湖南省重点试验室湖南长沙410082 湖南大学土木工程学院湖南长沙410082

通过对12个超高性能混凝土(UHPC)牛腿的静力加载试验,研究了剪跨比、钢纤维体积率以及箍筋配筋率等主要变化参数对牛腿受剪性能的影响。结果表明:相比于高性能混凝土中未加入钢纤维的牛腿,UHPC牛腿的开裂荷载显著提高,同时破坏模式也从... 详细信息

通过对12个超高性能混凝土(UHPC)牛腿的静力加载试验,研究了剪跨比、钢纤维体积率以及箍筋配筋率等主要变化参数对牛腿受剪性能的影响。结果表明:相比于高性能混凝土中未加入钢纤维的牛腿,UHPC牛腿的开裂荷载显著提高,同时破坏模式也从剪切破坏转变为弯曲破坏;通过减小剪跨比和增加箍筋配筋率可以提高牛腿受剪承载力。收集了UHPC牛腿试验数据,对GB 50010—2010《混凝土结构设计规范》和JGJ/T 465—2019《钢纤维混凝土结构设计标准》和理论模型中牛腿受剪承载力计算公式的适用性进行评估,发现已有的计算模型偏于保守,导致对UHPC牛腿的承载力的预测结果偏低。在此基础上,提出了一种适用于UHPC牛腿受剪承载力的改进拉压杆模型,该模型计算结果与收集的试验结果比值的平均值为1.15,变异系数为0.07。改进模型的准确性和离散性优于已有的计算模型,可供UHPC牛腿设计参考。

关键词：超高性能混凝土牛腿静载试验拉压杆模型受剪性能

圆形钢管混凝土柱轴压承载力及承载力组成研究

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建筑钢结构进展 2024年第6期26卷 94-104页

作者：陈立康黄远湖南大学土木工程学院长沙410082 湖南大学工程结构损伤诊断湖南省重点实验室长沙410082

为了研究相互作用下圆形钢管混凝土(circular concrete-filled steel tube,CCFST)柱中钢管和混凝土各自的承载力贡献,通过ABAQUS软件中的VUMAT子程序导入一种新的混凝土材料本构,建立了能够反映CCFST柱中钢管和混凝土相互作用的三维有... 详细信息

为了研究相互作用下圆形钢管混凝土(circular concrete-filled steel tube,CCFST)柱中钢管和混凝土各自的承载力贡献,通过ABAQUS软件中的VUMAT子程序导入一种新的混凝土材料本构,建立了能够反映CCFST柱中钢管和混凝土相互作用的三维有限元模型,并通过试验数据验证了模型的荷载-位移曲线、钢管和混凝土的荷载-变形曲线以及侧向变形曲线。在此基础上分析了混凝土强度、钢管屈服强度、径厚比以及套箍系数对CCFST柱承载力及其组成的影响。然后结合有限元模型推导了CCFST柱在轴压荷载下峰值承载力的数学模型,模型中提出的钢管环向应力比例系数和混凝土承载力贡献系数可以评估钢管和混凝土的受力状态。将计算模型与现行规范及现有研究进行对比,发现提出的计算公式具有良好的计算精度,且可以评估钢管和混凝土各自的承载力贡献。

关键词：圆形钢管混凝土柱相互作用约束作用有限元法轴压承载力

Downregulation of the circadian clock gene period 2 aggravates prognosis in breast cancer patients with obesity

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Oncology and Translational Medicine 2024年第2期10卷 73-78页

作者： Ru-Xing Wu Dan Hu Han-Wang Zhang Xiao-yuan huang Liang Zhuang Reproductive Medicine Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Cancer Biology Research Centre Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Cancer Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Background:Obese individuals diagnosed with breast cancer often experience a less favorable prognosis;however,the underlying mechanisms linking obesity to breast cancer outcomes remain *** study aimed to identify and validate novel prognostic markers associated with breast cancer in patients with ***:We conducted a reanalysis of gene expression profiles from normal-weight,overweight,and obese breast cancer patients to identify candidate ***,we validated the protein levels of these candidates using ***,we investigated the association between candidate genes and breast cancer prognosis at Tongji Hospital,utilizing data from an 8-year follow-up through the Kaplan-Meier method and univariate and multivariate Cox regression ***:The fold change of the circadian clock gene period 2(PER2),which exhibited a declining trend with increasing body mass index,was 0.76 in obese patients compared with normal-weight *** expression rates of PER2 protein were 44.7%,51.5%,and 61.3%in normal-weight,overweight,and obese patients,*** 8-year recurrence-free survival rates were 75.9%,69.6%,and 64.1%,whereas the 8-year overall survival rates were 86.8%,83.0%,and 76.1%in normal-weight,overweight,and obese patients,respectively(P<0.05).Furthermore,the 8-year recurrence-free survival rates were 66.2%and 76.4%,and the 8-year overall survival rates were 79.9%and 86.3%in the low and high PER2 expression groups,respectively(P<0.05).The unadjusted hazard ratio for PER2 was 1.550(95%confidence interval,1.029–2.335),and the adjusted hazard ratio was 3.003(95%confidence interval,1.838–4.907).Conclusions:Our findings indicate that low PER2 expression serves as an independent risk factor for breast cancer prognosis and may contribute to the unfavorable outcomes observed in obese patients.

关键词： Breast cancer Obesity PER2 Prognosis

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基于字合成运算的标签组群组共存证明协议

计算机应用与软件 2024年第1期41卷 315-321,327页

作者：黄源彭迪重庆航天职业技术学院计算机系重庆400021 西南政法大学国家刑事侦查学院重庆401120

针对现有的大多数证明协议无法同时证明多标签同时存在缺陷,提出一种具有可扩展性的电子标签组证明协议。协议采用按位运算设计实现的字合成运算对信息加密,字合成运算可使得协议达到超轻量级计算;同时字合成运算实现中巧妙运用参数自... 详细信息

针对现有的大多数证明协议无法同时证明多标签同时存在缺陷,提出一种具有可扩展性的电子标签组证明协议。协议采用按位运算设计实现的字合成运算对信息加密,字合成运算可使得协议达到超轻量级计算;同时字合成运算实现中巧妙运用参数自身具备的汉明重量,可减少参量引入;协议基于先验证再响应机制,可抵抗假冒攻击等。对协议进行不同角度分析,表明协议能够提供较高的安全性能,同时能够适用于现有低成本被动式电子标签系统中。

关键词：物联网射频识别系统标签组群组证明协议可扩展性字合成运算