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Role of solute in stress development of nanocrystalline films during heating:An in situ synchrotron X-ray diffraction study

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Journal of Materials Science & Technology 2023年第13期144卷 188-197页

作者： Jing Wang Xiaohu Li Emad Maawad Lu Han yuan huang Yongchang Liu Zumin Wang State Key Lab of Hydraulic Engineering Simulation and Safety School of Materials Science and EngineeringTianjin UniversityTianjin 300350China German Engineering Materials Centre at MIZ Helmholtz-Zentrum GeesthachtGarching D-85747Germany Helmholtz-Zentrum Geesthacht Institute of Materials PhysicsMax-Planck-Str.1Geesthacht D-21502Germany

The effect of the solute(Mo)on the stress development of nanocrystalline Ni and Ni-Mo films upon heat-ing has been investigated in real time using in situ synchrotron X-ray *** complex and distinct relationship between the film stress and grain boundaries(GBs)has been examined by the evolution of real-time intrinsic stress in combination with the in situ grain growth and thermal *** different intrinsic stress evolutions in the Ni and Ni-Mo films during the heating process result from the modification of GBs by Mo alloying,including GB amorphization,GB relaxation,and GB *** has been found that GBs play a vital role in the stress development of nanocrystalline *** addition of a solute can not only inhibit grain growth but also influence the stress evolution in the film by changing the atomic diffusivity at the *** work provides valuable and unique insights into the effect of solutes on stress development in nanocrystalline films during annealing,permitting control of the film stress through solute addition and heat treatment,which is critical for improving the design,processing,and lifetime of advanced nanocrystalline film devices at high temperatures.

关键词： Synchrotron X-ray diffraction Nanocrystalline film Solute Stress development Grain boundary

Stimuli-responsive nano vehicle enhances cancer immunotherapy by coordinating mitochondria-targeted immunogenic cell death and PD-L1 blockade

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2533-2549页

作者： Qiuyi Li Cheng Chen Jinxia Kong Lian Li Junlin Li yuan huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Induction of immunogenic cell death promotes antitumor immunity against cancer. However, majority of clinically-approved drugs are unable to elicit sufficient ICD. Here, our study revealed that mitochondria-targeted delivery of doxorubicin(DOX) massively amplified ICD via substantial generation of reactive oxygen species(ROS) after mitochondrial damage. The underlying mechanism behind increased ICD was further demonstrated to be ascribed to two pathways:(1) ROS elevated endoplasmic reticulum(ER) stress, leading to surface exposure of calreticulin;(2) ROS promoted release of various mitochondriaassociated damage molecules including mitochondrial transcription factor A. Nevertheless, adaptive upregulation of PD-L1 was found after such ICD-inducing treatment. To overcome such immunosuppressive feedback,we developed a tumor stimuli-responsive nano vehicle to simultaneously exert mitochondrial targeted ICD induction and PD-L1 blockade. The nano vehicle was self-assembled from ICD-inducing copolymer and PD-L1 blocking copolymer, and possessed long-circulating property which contributed to better tumor accumulation and mitochondrial targeting. As a result, the nano vehicle remarkably activated antitumor immune responses and exhibited robust antitumor efficacy in both immunogenic and non-immunogenic tumor mouse models.

关键词： Immunogenic cell death Mitochondrial targeting PD-L1 blockade Endoplasmic reticulum stress Mitochondria-associated damage molecules Stimuli-responsive Antitumor immune responses Antitumor efficacy

Oil droplet movement and micro-flow characteristics during interaction process between gas bubble and oil droplet in flotation

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Chinese Journal of Chemical Engineering 2022年第5期35卷 229-237页

作者： Shenglin Yan Yan Zhang Chong Peng Xiaoyong Yang yuan huang Zhishan Bai Xiao Xu State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process School of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237China Sinopec Dalian Research Institute of Petroleum and Petrochemicals Dalian 116041China Institute of Environmental Pollution and Health School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China

Flotation is an efficient pre-treatment technology for oily *** this work,the interaction process between the moving oil droplet and the gas bubble was studied by high-speed camera and Bassset-Boussinesq-Oseen(BBO)theoretical model,and the experimental and simulation results of the oil droplet trajectory were ***,the micro-particle image velocimetry system was utilized to observe the flow inside and outside of the moving oil *** results show that the BBO model with the mobile bubble’s surface can reflect the velocity change trend of the oil droplet during the interaction process between the moving oil droplet and the gas bubble,but there are some significant differences between the experimental and simulation *** the oil droplet is moving on the bubble’s surface,the velocity of the area near the contact point of oil droplet–gas bubble is less than that of the other areas inside the oil ***,the flow of water above the oil drop is more biased towards the gas bubble.

关键词： Flotation Oil droplet-gas bubble interaction Approach process Hydrodynamics

可生物降解的纳米CaCO_(3)/BF/PHA/PE复合材料的制备及性能

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塑料科技 2024年第7期52卷 121-124页

作者：吴静黄嘉园蓝峻峰陈燕萌叶有明韦周巧广西科技师范学院食品与生化工程学院无机绿色材料重点实验室广西来宾546100

研究以聚乙烯(PE)为原料,聚羟基脂肪酸酯(PHA)、改性后的纳米CaCO_(3)和甘蔗渣纤维(BF)为复合填料,通过熔融挤压和注塑成型制备纳米CaCO_(3)/BF/PHA/PE复合材料。通过力学性能测试、傅里叶变换红外光谱(FTIR)分析、热重(TG)分析、扫描... 详细信息

研究以聚乙烯(PE)为原料,聚羟基脂肪酸酯(PHA)、改性后的纳米CaCO_(3)和甘蔗渣纤维(BF)为复合填料,通过熔融挤压和注塑成型制备纳米CaCO_(3)/BF/PHA/PE复合材料。通过力学性能测试、傅里叶变换红外光谱(FTIR)分析、热重(TG)分析、扫描电子显微镜(SEM)等表征方法,考察PHA含量、改性纳米CaCO_(3)及BF的最佳配比及其含量对复合材料内部结构和性能的影响。结果表明:5%PHA、5%BF以及5%纳米CaCO_(3)时,复合材料的力学性能最佳,达到12.9 MPa;在此配比下,纳米CaCO_(3)/BF/PHA/PE复合材料的最大热分解温度达到463℃,高于改性前复合材料热分解温度(453℃)。研究为可降解高分子材料的绿色发展提供了思路。

关键词：复合材料聚羟基脂肪酸酯纳米碳酸钙甘蔗渣纤维

以认知神经科学为导向的课堂教学环境构建机理与实践分析

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军事高等教育研究 2024年第1期47卷 103-108页

作者：刘涛黄媛蒋燕妮李轲高贵海军工程大学电子工程学院湖北武汉430033 西南交通大学地球科学与环境工程学院四川成都611756

针对雷达系统课程内容多、难度大等问题,从认知神经科学理论出发,阐述了神经递质与深度学习之间的关系,揭示了课堂教学本质并给出了神经学解释,提出了以诱导神经递质分泌为牵引、以人脑协同认知为目标的课堂教学环境构建方案,体现了“... 详细信息

针对雷达系统课程内容多、难度大等问题,从认知神经科学理论出发,阐述了神经递质与深度学习之间的关系,揭示了课堂教学本质并给出了神经学解释,提出了以诱导神经递质分泌为牵引、以人脑协同认知为目标的课堂教学环境构建方案,体现了“学为中心”的教育理念。教学环境由日常舒适环境、教室舒适环境、内容舒适环境、好奇挑战环境和自主舒适环境五部分构成。课堂教学环境的构建使得课程从舒适区边缘展开突破,符合脑科学机理,培养了学员以“新旧知识关系建立”为核心的自主学习能力。

关键词：认知神经神经递质多巴胺雷达系统自学能力环境

放射性心脏损伤相关信号通路及药物干预的研究进展

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天津医药 2024年第8期52卷 888-892页

作者：黄愿王刚李燕玲谢萍甘肃中医药大学第一临床医学院 730000 兰州大学第一临床医学院甘肃省人民医院心内一科

放射性心脏损伤(RIHD)是继发于胸部肿瘤放疗后的心脏毒性事件,已成为除癌细胞毒性外,影响癌症患者机体健康的又一不利因素。信号传导在细胞信息交流中发挥重要作用,RIHD可诱导信号通路失调,阻碍通路功能的正常发挥,从而引起心肌组织发... 详细信息

放射性心脏损伤(RIHD)是继发于胸部肿瘤放疗后的心脏毒性事件,已成为除癌细胞毒性外,影响癌症患者机体健康的又一不利因素。信号传导在细胞信息交流中发挥重要作用,RIHD可诱导信号通路失调,阻碍通路功能的正常发挥,从而引起心肌组织发生凋亡、氧化应激及纤维化等病变。现综述RIHD发生发展中失调的相关通路,以及药物干预对通路的调控作用,为防治RIHD提供参考依据。

关键词：化放疗肿瘤放射性心脏损伤信号通路药物干预

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罗沙司他治疗肾性贫血不良反应的研究进展

蛇志 2024年第2期36卷 235-241页

作者：黄爱芳潘玲周红卫黄媛韦潇潇霍冬梅广西医科大学第一附属医院肾内科广西南宁530021

罗沙司他是治疗肾性贫血的一种新型口服药物,主要通过作用于缺氧诱导因子(HIF)通路,促进内源性促红细胞生成素(EPO)的产生及其受体的表达,优化铁的利用等机制,起到升高血红蛋白的作用。然而,罗沙司他在纠正肾性贫血的同时,可能导致深静... 详细信息

罗沙司他是治疗肾性贫血的一种新型口服药物,主要通过作用于缺氧诱导因子(HIF)通路,促进内源性促红细胞生成素(EPO)的产生及其受体的表达,优化铁的利用等机制,起到升高血红蛋白的作用。然而,罗沙司他在纠正肾性贫血的同时,可能导致深静脉血栓形成、动静脉内瘘血栓形成、高血压、高钾血症等不良反应风险的增加。因此,临床应用罗沙司他时,应加强对患者血管通路、血压、电解质等的监测,及时发现和处理相关不良反应,确保患者的用药安全。

关键词：罗沙司他肾性贫血不良反应

不同家庭收入水平对老年人成功老龄化的影响研究

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中国全科医学 2024年第8期27卷 930-935页

作者：张亚访闻萱杨中婷杜兴梅邓春燕叶卿云邓睿黄源昆明医科大学公共卫生学院云南省昆明市650500

背景成功老龄化有助于缓解衰老进程,但可能会受到家庭收入的影响。目的探讨不同家庭收入水平对老年人成功老龄化的影响,为改善中国老年人健康公平提供基础数据。方法选取2018年中国健康与养老追踪调查(CHARLS)60岁及以上的老年人数据,... 详细信息

背景成功老龄化有助于缓解衰老进程,但可能会受到家庭收入的影响。目的探讨不同家庭收入水平对老年人成功老龄化的影响,为改善中国老年人健康公平提供基础数据。方法选取2018年中国健康与养老追踪调查(CHARLS)60岁及以上的老年人数据,基于各省的家庭年收入水平将老年人群分为高收入老年人(≤33.33%)、中等收入老年人(33.34%~66.66%)和低收入老年人(≥66.67%);根据ROWE和KAHN模型,测量老年人的成功老龄化水平,运用多因素Logistic回归模型分析不同家庭收入水平对成功老龄化的影响。结果最终纳入研究对象7741人,低收入、中等收入、高收入老年人分别为2192人(28.32%)、2680人(34.62%)、2869人(37.06%)。2018年中国老年人成功老龄化水平为15.55%(1204/7741),低收入老年人成功老龄化水平为10.77%(236/2192),低于中等收入(13.62%,365/2680)和高收入老年人(21.02%,603/2869)(P0.05)。多因素Logistic回归分析结果显示,控制社会人口学特征(年龄、性别、民族、学历、居住地区)后,中等和高收入老年人成功老龄化水平分别是低收入老年人的1.226倍(OR=1.226,95%CI=1.028~1.463)和1.721倍(OR=1.721,95%CI=1.300~1.882);继续控制健康状况与行为因素(夜间睡眠时长、意外跌倒情况、近1年住院情况、听力、咀嚼功能)后,高收入老年人成功老龄化水平是低收入老年人的1.559倍(OR=1.559,95%CI=1.028~1.463);同时控制家庭生活环境(洗澡设施、家庭卫生)后,高收入老年人成功老龄化水平是低收入老年人的1.461倍(OR=1.461,95%CI=1.207~1.770)(P<0.05)。结论中国老年人的成功老龄化水平较低,家庭收入水平是老年人成功老龄化的独立影响因素。关注低收入家庭老年人的身心健康和功能改善,提高老年人社会参与是推进健康中国建设和积极应对人口老龄化的重要举措。

关键词：成功老龄化健康老龄化收入老年人中国影响因素分析

Toxic metals and metalloids:Uptake,transport,detoxification,phytoremediation,and crop improvement for safer food

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Molecular Plant 2022年第1期15卷 27-44页

作者： Fang-Jie Zhao Zhong Tang Jia-Jun Song Xin-yuan huang Peng Wang State Key Laboratory of Crop Genetics and Germplasm Enhancement College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjingJiangsu 210095China

Agricultural soils are under threat of toxic metal/metalloid contamination from anthropogenic activities,leading to excessive accumulation of arsenic(As),cadmium(Cd),lead(Pb),and mercury(Hg)in food crops that poses significant risks to human *** how these toxic metals and their methylated species are taken up,translocated,and detoxified is prerequisite to developing strategies to limit their accumulation for safer *** metals are taken up and transported across different cellular compart-ments and plant tissues via various transporters for essential or beneficial nutrients,*** by phosphate and silicon transporters,and Cd by manganese(Mn),zinc(Zn),and iron(Fe)*** transport processes are subjected to interactions with nutrients and the regulation at the transcriptional and post-translational *** with thiol-rich compounds,such as phytochelatins,and sequestration in the vacuoles are the common mechanisms for detoxification and for limiting their translocation.A num-ber of genes involved in toxic metal uptake,transport,and detoxification have been identified,offering tar-gets for genetic manipulation via gene editing or transgenic *** variations in toxic metal accumulation exist within crop germplasm,and some of the quantitative trait loci underlying these variations have been cloned,paving the way for marker-assisted breeding of low metal accumulation *** plants to extract and remove toxic metals from soil is also possible,but this phytoremediation approach requires metal hyperaccumulation for *** gaps and future research needs are also discussed.

关键词： toxic metals/metalloids heavy metals transporters detoxification phytoremediation food safety