检索结果-南通市图书馆

International Journal of Ophthalmology(English edition) 2024年第9期17卷 1723-1730页

作者： Hai-Yan huang Jing Wang bo Qin yao Tan Clinical Medical College of Guizhou Medical University Guiyang 550004Guizhou ProvinceChina Postdoctoral Station of Clinical Medicine The Third Xiangya HospitalCentral South UniversityChangsha 410000Hunan ProvinceChina The Third Xiangya Hospital Central South UniversityChangsha 410000Hunan ProvinceChina

AIM:To assess the causal link between 211 gut microbiota(GM)taxa and dry age-related macular degeneration(dAMD)***:Mendelian randomization using instrumental factors taken from a genome-wide association study(GWAS)were *** variance weighted(IVW)analysis and sensitivity analysis were performed on the FinnGen project,which included 5095 cases and 222590 ***:The IVW analysis showed substantial genusand family-level relationships between GM taxa and dAMD ***,the family Peptococcaceae(P=0.03),genus Bilophila(P=3.91×10^(-3)),genus Faecalibacterium(P=6.55×10^(-3)),and genus Roseburia(P=0.04)were linked to a higher risk of developing dAMD,while the genus Candidatus Soleaferrea(P=7.75×10^(-4)),genus Desulfovibrio(P=0.04)and genus Eubacterium ventriosum group(P=0.04)exhibited a protective effect against *** significant causal relationships were observed at higher taxonomic ***,in the reverse IVW analysis,no meaningful causal effects of the 7 GM ***:These findings give support for the gutretina axis participation in dAMD and shed light on putative underlying *** on the connection between GM and dAMD have not yet revealed the underlying mechanism.

关键词： dry age-related macular degeneration gut microbiota mendelian randomization gut-retina axis genome-wide association study

Lesson Learned from COVID-19 Retrospective Study: An Entropy-Based Clinical-Interpretable Scorecard for Mortality Risk Control at ICU Admission

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2024年第1期29卷 34-45页

作者： Chong yao Chonghui huangqi Anpeng huang Laboratory of Network Information Security Beihang UniversityBeijing 100191China Andrew and Erna Viterbi School of Engineering University of Southern CaliforniaLos AnglesCA 90089USA Beijing Goodwill Information and Technology Co. Ltd.and Mobile Health LaboratoryPeking UniversityBeijing 100871China

With severe acute respiratory syndrome coronavirus 2 spreading globally and causing 2019 coronavirus disease(COVID-19),a challenge that we unprepared for was about how to optimally plan and distribute limited top-medical resources for patients in need of urgent *** address this challenge,physicians desperately needed a scientific tool to methodically differentiate between cases with varying *** this study,the unique data of COVID-19 intensive care unit(ICU)patients provided by the national medical team in Wuhan were classified into discrete and continuous variable *** continuous data were discretized using an entropy-based method and transformed into serial information margins,in which each information margin is related to a specific symptom or clinical ***,all these native and processed discrete data were used to configure a readable scorecard through logistic regression,which is the desired scientific tool aforementioned.A total of 322 ICU patients(age:[median:64,interquartile range:54-75],males:178[55.28%],and death:72[22.36%])were included in the *** of mortality in COVID-19 patients can be evaluated using a scorecard model(calibration slope:1.343,Brier:0.048,Dxy=0.972,and population stability index=0.071),with desired model performances(accuracy=0.948,area under curve=0.99,sensitivity=1,and specificity=0.939).This new model can interpret clinical meanings from complex data,and compare it with existing machine learning methods through a black-box *** new data-information model answers a critical question of how a computing algorithm produces clinically meaningful results that will help physicians logically allocate medical resources for COVID-19 ***,this tool has limitations,giving that this research is a retrospective ***,this tool will be tested further and optimized for adaptation to similar clinical cases in the future.

关键词： COVID-19 scorecard clinical-interpretable machine learning ICU admission control

Access to High-Molecular-Weight Polyethylenes through High Temperature Ethylene Polymerization Catalysed by Ethylene-Bridged ansa-(3-R-Cyclopentadienyl)(Fluorenyl) Zirconocene Complexes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第1期42卷 42-51,I0007页

作者： bo Li Haiyan Ma Jiling huang Shanghai Key Laboratory of Functional Materials Chemistry and Laboratory of Organometallic Chemistry School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

A series of C1-symmetric ethylene-bridged ansa-(3-R-cyclopentadienyl)(fluorenyl) metallocene complexes(Zr: 1-5;Hf: 6) have been synthesized, characterized and investigated as catalyst precursors for the high temperature ethylene polymerization. Using methylaluminoxane(MAO) as the cocatalyst, zirconium complexes 1-5 bearing a bulky substituent on the 3-position of the cyclopendienyl ring showed high catalytic activities up to 1.48×10^(7) g PE·mol_(Zr)^(-1)·h^(-1) toward the polymerization of ethylene and afforded polyethylenes with high molecular weights(1.49×10^(5)-6.31×10^(5) g/mol), meanwhile exhibting great thermal stability at high temperatures up to 120 ℃ together with a long catalytic life time up to 2 h. By adopting low Al/Zr ratios, such as 125, polyethylenes with ultra high molecular weights up to 2.86×106 g/mol were obtained. It is worthy of noting that zirconium complexes 1-4 bearing a substituent with an aryl pendant showed temperature-dependent activities, which increased rapidly with the increase of polymerization temperature, thus weak interaction of the pendent aryl group with the cationic active center is proposed to account for the very low activities displayed at low temperatures. In contrast to zirconocene complexes 1-5, hafnocene complex 6 only displayed very low catalytic activities toward the polymerization of ethylene and afforded polyethylenes with molecular weights ten times smaller than those obtained by zirconocene complexes 1-5. Zirconocene complexes 1-5 were also able to catalyse the polymerization of propylene at high temperatures, but only afforded waxes with low molecular weights.

关键词： ansa-Metallocene Ethylene Propylene Polymerization High temperature

Synthesis and applications of carbon nanospheres:A review

在线全文

学校读者我要写书评

暂无评论

Particuology 2024年第4期87卷 325-338页

作者： Yaqi yao Jinming Xu Yanqiang huang Tao Zhang State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

The synthesis of carbon nanospheres(CNS)has developed rapidly in recent years,and they are widely used owing to the tunability of their porous structures and surface properties and the unique hydrodynamic advantages conferred by their spherical *** review summarizes the methods used to synthesize CNS and their applications in various *** review first describes the four main methods of CNS synthesis,*** template,spray-drying,hydrothermal carbonization,Stöber and chemical vapor depo-sition ***,applications in the fields of energy storage,adsorption,biological medicine,and catalysis are ***,some insights on the development and design of CNS are presented.

关键词： Carbon nanosphere Synthesis Application

A Selective‑Response Hypersensitive Bio‑Inspired Strain Sensor Enabled by Hysteresis Effect and Parallel Through‑Slits Structures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第2期16卷 139-153页

作者： Qun Wang Zhongwen yao Changchao Zhang Honglie Song Hanliang Ding bo Li Shichao Niu Xinguan huang Chuanhai Chen Zhiwu Han Luquan Ren Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China Liaoning Academy of Materials LiaoningShenyang 110167People’s Republic of China Key Laboratory of CNC Equipment Reliability(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China

Flexible strain sensors are promising in sensing minuscule mechanical signals,and thereby widely used in various advanced ***,the effective integration of hypersensitivity and highly selective response into one flexible strain sensor remains a huge ***,inspired by the hysteresis strategy of the scorpion slit receptor,a bio-inspired flexible strain sensor(BFSS)with parallel through-slit arrays is designed and ***,BFSS consists of conductive monolayer graphene and viscoelastic styrene–isoprene–styrene block *** the synergistic effect of the bio-inspired slit structures and flexible viscoelastic materials,BFSS can achieve both hypersensitivity and highly selective frequency ***,the BFSS exhibits a high gage factor of 657.36,and a precise identification of vibration frequencies at a resolution of 0.2 Hz through undergoing different morphological changes to high-frequency vibration and low-frequency ***,the BFSS possesses a wide frequency detection range(103 Hz)and stable durability(1000 cycles).It can sense and recognize vibration signals with different characteristics,including the frequency,amplitude,and *** work,which turns the hysteresis effect into a"treasure,"can provide new design ideas for sensors for potential applications including human–computer interaction and health monitoring of mechanical equipment.

关键词： Bio-inspired strain sensors Hysteresis effect Hypersensitivity Selective frequency response Health monitoring applications

Effect of Texture on the Grain-Size-Dependent Functional Properties of NiTi Shape Memory Alloys and Texture Gradient Design:A Phase Field Study

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2024年第1期37卷 10-32页

作者： bo Xu Beihai huang Chong Wang Qingyuan Wang Failure Mechanics and Engineering Disaster Prevention Key Laboratory of Sichuan ProvinceSichuan UniversityChengdu 610065China Department of Mechanical Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Key Laboratory of Deep Underground Science and Engineering Ministry of EducationSichuan UniversityChengdu 610065China

Texture is inevitably introduced during the manufacturing of most NiTi shape memory alloys(SMAs),and the textured nanocrystalline NiTi has been extensively employed in ***,the effect of texture,and the joint effect of grain size(GS)and texture on the functional properties of NiTi SMAs and the corresponding microscopic mechanisms have not been clearly understood *** this work,based on the phase field method,the effect of texture on the GS-dependent functional properties of NiTi SMAs,including super-elasticity(SE),one-way shape memory effect(OWSME),and stress-assisted two-way shape memory effect(SATWSME),is investigated,and the corresponding microscopic mechanisms are ***,the samples with discrete geometrical gradients and/or texture gradients are designed to achieve graded functional *** simulation results indicate that the dependence of functional properties on texture is due to the effect of crystallographic orientation on martensite transformation and reorientation,which can lead to different inelastic *** the designed samples with texture gradients,the stress–strain responses of sheets with various textures are different,allowing for the coordination of overall deformation of the sample by combining such sheets,with varying inelastic deformation ***,the overall response of the sample differs from that without texture gradient,leading to the achievement of graded functional *** simulation results and new findings in this work contribute to a deeper understanding of the effects of texture,GS,and their interaction on the functional properties of SMAs,and provide valuable reference for the design and development of SMA-based devices with desired functional properties.

关键词： Phase field NiTi shape memory alloy Texture Grain size Functional property Texture gradient

Enhancing Low-Frequency Microwave Absorption Through Structural Polarization Modulation of MXenes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第10期16卷 435-452页

作者： bo Shan Yang Wang Xinyi Ji Yi huang College of Light Industry Science and Engineering State Key Laboratory of Biobased Fiber Manufacturing TechnologyTianjin University of Science and TechnologyTianjin 300457People's Republic of China National Institute for Advanced Materials Tianjin Key Laboratory of Metal and Molecule Based Material ChemistryKey Laboratory of Functional Polymer MaterialsCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)School of Materials Science and EngineeringNankai UniversityTianjin 300350People's Republic of China

Two-dimensional carbon-based materials have shown promising electromagnetic wave absorption capabilities in mid-and high-frequency ranges,but face challenges in low-frequency absorption due to limited control over polarization response mecha-nisms and ambiguous resonance *** this study,we pro-pose a novel approach to enhance absorption efficiency in aligned three-dimensional(3D)MXene/CNF(cellulose nanofibers)cavities by modifying polarization properties and manipulating resonance response in the 3D MXene *** controlled polarization mechanism results in a significant shift of the main absorption region from the X-band to the S-band,leading to a remarkable reflection loss value of-47.9 dB in the low-frequency ***,our findings revealed the importance of the oriented electromagnetic coupling in influencing electromagnetic response and microwave absorption *** present study inspired us to develop a generic strategy for low-frequency tuned absorption in the absence of magnetic element participation,while orientation-induced polarization and the derived magnetic resonance coupling are the key controlling factors of the method.

关键词： Hierarchical structure MXene Microwave absorption Low-frequency

In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan yao Tang Tianwen huang Lining Ke En huang Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

Enhancing sheepgrass through genomic exploration and targeted editing

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第3期67卷 629-630页

作者： Miao Sun Sanwen huang yao Zhou Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Tropical Crop Breeding Shenzhen BranchGuangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China State Key Laboratory of Tropical Crop Breeding Chinese Academy of Tropical Agricultural SciencesHaikou 571101China

The growth of grass industry is essential for meeting human needs for proteins and sustaining grassland ecosystems(Bengtsson et al., 2019). Leymus chinensis, also known as sheepgrass, is a perennial Triticeae forage r... 详细信息

关键词： grassland sheep ecosystems

A Distributed Self-Tallying Electronic Voting System Using the Smart Contract

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第4期33卷 1063-1076页

作者： Jingyu yao bo YANG Tao WANG Wenzheng ZHANG School of Computer Science Shaanxi Normal University State Key Laboratory of Integrated Services Networks Xidian University Science and Technology on Communication Security Laboratory

For electronic voting(e-voting) with a trusted authority, the ballots may be discarded or tampered, so it is attractive to eliminate the dependence on the trusted party. An e-voting protocol, where the final voting result can be calculated by any entity, is known as self-tallying e-voting protocol. To the best of our knowledge, addressing both abortive issue and adaptive issue simultaneously is still an open problem in self-tallying e-voting *** Ethereum blockchain with cryptographic technologies, we present a decentralized self-tallying e-voting protocol. We solve the above problem efficiently by utilizing optimized Group Encryption Scheme and standard Exponential El Gamal Cryptosystem. We use zero-knowledge proof and homomorphic encryption to protect votes' secrecy and achieve self-tallying. All ballots can be verified by anyone and the final voting result can be calculated by any entity. In addition, using the paradigm of score voting and “1-out-of-k” proof, our e-voting system is suitable for a wide range of application scenarios. Experiments show that our protocol is more competitive and more suitable for large-scale voting.

关键词： Electronic voting systems Smart contracts Blockchains Cryptocurrency Electronic voting Homomorphic encryption Standards