检索结果-南通市图书馆

Chinese Chemical Letters 1999年第1期10卷 55-58页

作者： Qin hua RU yi Ming WANg guo An LUO(Department of Chemistry. School of Life Science and Engineering,Tsinghua University. Beijing, 100084) Department of Chemistry Sch. of Life Science and Engineering Tsinghua University Beijing 100084 China

guillain-Barre syndrome (gBS) is considered to be an autoimmune disorder of peripheralnervous system. In this paper. capillary SDS gel electrophoresis was performed on neutral coatedfused-silica capillary to determine... 详细信息

关键词： Immunoglobulin g guillain-Barre syndrome Capillary SDS gel electrophoresis Molecular weight of protein

利用日光诱导叶绿素荧光数据分析2007年—2018年北半球植被物候特征空间格局及其变化趋势

在线全文

学校读者我要写书评

暂无评论

遥感学报 2023年第2期27卷 376-393页

作者：周浩然孙华史振伟彭飞林沂北京大学地球与空间科学学院北京100871 宝略科技(浙江)有限公司宁波315100

植被物候是指植被长期适应生活环境的周期性变化,形成与此相适应的生产发育节律。研究植被物候有助于更好地理解气候变化。目前利用植被遥感指数进行物候监测依然存在许多问题,而日光诱导叶绿素荧光(SIF)与总初级生产力(gPP)具有强耦合... 详细信息

植被物候是指植被长期适应生活环境的周期性变化,形成与此相适应的生产发育节律。研究植被物候有助于更好地理解气候变化。目前利用植被遥感指数进行物候监测依然存在许多问题,而日光诱导叶绿素荧光(SIF)与总初级生产力(gPP)具有强耦合关系,在植被物候研究中具有很大潜力。本文利用双逻辑斯蒂函数模型,基于3种SIF数据(gOME-2,gOSIF和CSIF)计算了北半球地区2007年—2018年的物候特征,并与两种gPP数据和5种植被指数(VIs)数据进行对比验证。接下来利用gOME-2 SIF数据分析了北半球地区的物候分布特征,并利用Sen斜率因子检测北半球地区的物候变化趋势,最后计算了3个主要的气候因子对植被物候变化的影响。结果表明:(1)基于SIF数据计算的SOS与EOS比基于VIs数据的计算结果要更加接近于基于gPP数据的计算结果。(2)基于gOME-2 SIF数据计算的北半球地区植被2007年—2018年平均生长季始期(SOS)主要(>90%)集中在100—170 d,平均生长季末期(EOS)则主要集中在220—270 d。高海拔地区和高纬度地区相对于其他地区,SOS较晚,而EOS则较早。(3)2007年—2018年间北半球地区的SOS主要呈显著提前趋势(平均Sen斜率因子为-0.173),而EOS则为非显著提前趋势(平均Sen斜率因子为-0.002)。(4)高纬度寒冷地区的物候主要受温度影响,而中低纬度干旱地区的物候主要受降水影响。总的来讲,相对于传统的VIs数据,SIF更加适合表达基于植被gPP的物候特征。相对于过去几十年,最近十年的物候变化速度减慢,尤其是EOS,保持在较为稳定的状态。

关键词：遥感日光诱导叶绿素荧光植被物候特征空间格局变化趋势气候因子

在线全文

学校读者我要写书评

暂无评论

烟草商业企业精益物流评价体系研究

中国烟草学报 2015年第4期21卷 85-93页

作者：刘毅曾华中国烟草总公司四川省公司物流管理处四川省成都市610041 四川省烟草公司成都市公司成都诚至诚商务物流有限责任公司四川省成都市610052

为科学评价烟草商业企业精益物流水平,本研究以平衡记分卡为基础,从物流成本、客户服务、运行管理和学习创新四个方面构建了精益物流评价指标体系。以前三项代表物流运营水平(L-Level),以最后一项代表精益改善能力(S-Skill),结合二维构... 详细信息

为科学评价烟草商业企业精益物流水平,本研究以平衡记分卡为基础,从物流成本、客户服务、运行管理和学习创新四个方面构建了精益物流评价指标体系。以前三项代表物流运营水平(L-Level),以最后一项代表精益改善能力(S-Skill),结合二维构面图理论,构建了L-S二维分类评价模型。依据评价结果在L-S平面上的投影分布,将商业企业精益状态进行分类,进而分析企业精益管理所处的阶段和潜在的问题,为企业管理决策提供依据。

关键词：精益物流评价体系二维分类模型烟草商业企业

Intrauterine Infections and Birth Defects

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2004年第4期17卷 476-491页

作者： XIAO-yiNg ZHENg TINg ZHANg yi-fei WANg CHEN XU gONg CHEN RuO-LEI XIN JIA-PENg CHEN XU-MEI HU QINg YANg XIN-MINg SONg LI-hua PANg yiNg JI HONg-MEI SUN LEI ZHANg JU-FEN LIU YAN-LINg gUO YAN ZHANg Institute of Population Research／WHO Collaborating Centeron Reproductive Health and Population Science Beijing 100871China Department of Infection and Immunity Capitallnstimte of PediatricsBeijing 100020China Medical School of Shanghai Jiatong University No.1954Huashan RoadShanghai 200030China Department of Embryology the Second Medical UniversityNo.280Chongqing NanluShanghai 200025China

Intrauterine infection is an important cause of some birth defects worldwide. The most common pathogens include rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. general information about these pathogens in epidemiology, consequence of birth defects, and the possible mechanisms in the progress of birth defects, and the interventions to prevent or treat these pathogens?infections are described. The infections caused by rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. are common, yet they are proved to be fatal during the pregnant period, especially during the first trimester. These infections may cause sterility, abortion, stillbirth, low birth weight, and affect multiple organs that may induce loss of hearing and vision, even fetal deformity and the long-term effects. These pathogens?infections may influence the microenvironment of placenta, including levels of enzymes and cytokines, and affect chondriosome that may induce the progress of birth defect. Early diagnosis of infections during pregnancy should be strengthened. There are still many things to be settled, such as the molecular mechanisms of birth defects, the effective vaccines to certain pathogens. Birth defect researches in terms of etiology and the development of applicable and sensitive pathogen detection technology and methods are imperative.

关键词： Intrauterine infections Birth defects Rubella virus Ureaplasma urealyticum Toxoplasma

Therapeutic effects of the extract of Sancao Formula, a Chinese herbal compound, on imiquimod-induced psoriasis via cysteine-rich protein 61

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2022年第4期20卷 376-384页

作者： Wan-jun guo yi Wang Yu Deng Lin-yan Cheng Xin Liu Ruo-fan Xi Sheng-jie Zhu Xin-yi Feng Liang hua Kan Ze Jian-yong Zhu Dong-jie guo Fu-lun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China School of Medicine Chengdu UniversityChengdu 610106Sichuan ProvinceChina Institute of Cancer Biology and Drug Discovery Chengdu UniversityChengdu 610106Sichuan ProvinceChina Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Objective: Psoriasis is a common chronic inflammatory skin disease that is prone to recurrence, and the proinflammatory factor, cysteine-rich protein 61(Cyr61), is important in its pathophysiology. Long-term clinical practice has shown that Sancao Formula(SC), a Chinese herbal compound, is effective in the treatment of psoriasis, but the precise mechanism remains unknown. In this study, we investigate the mechanism by which SC extract alleviates imiquimod(IMQ)-induced ***: The expression of Cyr61 in psoriatic lesions and normal healthy skin was detected using immunohistochemical analysis to investigate the biological role of Cyr61 in models of psoriatic inflammation. A psoriatic mouse model was established by topical application of IMQ, and the effect of topical application of SC extract was evaluated using the psoriasis area and severity index(PASI) score,hematoxylin-eosin staining, and histopathological features of the skin. Next, a HaCaT cell inflammation model was established using interferon-γ(IFN-γ), and the effect of SC extract on the mRNA and protein levels of Cyr61 and intercellular cell adhesion molecule-1(ICAM-1) was confirmed using Western blot and quantitative real-time polymerase chain reaction ***: Immunohistochemical staining showed that the expression of Cyr61 in psoriatic lesions was higher than that in normal skin samples(78.26% vs 41.18%, P gnificantly higher than in normal skin(18.66 ± 2.51 vs4.33 ± 1.52, P gnificantly improve the inflammatory phenotype, PASI score(10.875 ± 0.744 vs 3.875 ± 0.582, P gical features compared with those in IMQ model group;SC treatment was also associated with decreased levels of Cyr61 and ICAM-1. In the IFN-γ-induced inflammatory cell model, the mRNA and protein levels of Cyr61 and ICAM-1 were upregulated, w

关键词： Traditional Chinese medicine Sancao Formula Psoriasis Plant extracts Cysteine-rich protein 61 Intercellular cell adhesion molecule-1

在线全文

学校读者我要写书评

暂无评论

车辆-沥青路面耦合系统相互作用研究

振动与冲击 2013年第20期32卷 107-112页

作者：银花李懿内蒙古大学交通学院呼和浩特010070 北京交通大学土木建筑工程学院北京100044

在路面随机激励的时域仿真模型上选用双自由度的四分之一车辆振动模型建立了车辆-路面振动模型。同时基于分数阶导数沥青混合料粘弹性模型,建立了沥青路面结构二维有限元模型,并通过车辆与路面之间的几何和力学耦合关系,推导出车辆-路... 详细信息

在路面随机激励的时域仿真模型上选用双自由度的四分之一车辆振动模型建立了车辆-路面振动模型。同时基于分数阶导数沥青混合料粘弹性模型,建立了沥青路面结构二维有限元模型,并通过车辆与路面之间的几何和力学耦合关系,推导出车辆-路面耦合系统的分数阶动力学状态方程,求解其动态响应。在此基础上进行了车辆-沥青路面耦合系统相互作用的数值分析。分析表明,通过动态模量试验,采用分数阶导数三元件模型描述沥青混合料的动态粘弹性能进行路面数值模拟,更接近于路面结构实际的动态响应;路面平整度对随机动载荷的大小其决定作用,路面等级的降低会增加路面的动变形,进而会加速路面不平整度的发展及路面的破坏,应控制好路面平整度及施工质量,加强路面养护。

关键词：沥青混合料分数阶导数粘弹性路面不平整度车辆-路面相互作用

四川省16家大型禽类养殖场抗生素残留调查和细菌耐药性分析

在线全文

学校读者我要写书评

暂无评论

四川动物 2024年第1期43卷 1-9页

作者：吕华刘玲宋涛林家富褚以文刘蒙沙菁洲周雅靓程涛吴怡张力杨嵩马兴换成都大学抗生素研究与再评价四川省重点实验室成都610106 四川省固体废物与化学品管理中心成都610032 四川大学华西医院成都610041 四川省生态环境科学研究院成都610041 四川省农业生态资源保护中心成都610041 微山县第三人民医院山东微山277600

为评估禽类养殖场粪便中抗生素的残留及细菌耐药性情况,本研究以四川省16家大型规模化禽类养殖场为监测点,重点分析粪便中抗生素残留特征和肠杆菌耐药特征,并对粪便中抗生素的选择性耐药风险熵进行评估。16份粪便样品中共检出18种抗生素... 详细信息

为评估禽类养殖场粪便中抗生素的残留及细菌耐药性情况,本研究以四川省16家大型规模化禽类养殖场为监测点,重点分析粪便中抗生素残留特征和肠杆菌耐药特征,并对粪便中抗生素的选择性耐药风险熵进行评估。16份粪便样品中共检出18种抗生素,抗生素检出浓度0.54~2780.00μg·kg^(−1),其中,ZJZX中多西环素检出浓度最高,达到2780.00μg·kg^(−1);抗生素的选择性耐药风险熵为0.0040~10561.13,呈现出高选择性耐药风险;其次,从粪便中共筛选鉴定出14株肠杆菌科Enterobacteriaceae细菌,均表现出多重耐药性,且有33种耐药基因被不同程度检出。畜禽粪便中磺胺类、四环素类、氯霉素类和喹诺酮类抗生素残留较为严重,且养殖环境中肠杆菌科细菌表现出多重耐药性,建议有关部门加强畜禽养殖中多西环素、氟苯尼考和恩诺沙星等抗生素的管控,同时应加强对畜禽养殖企业中肠杆菌耐药性的监控。

关键词：禽类养殖场抗生素残留风险评估肠杆菌科

Optimized therapeutic strategy for patients with refractory or relapsed acutemyeloid leukemia:long-term clinical outcomes and health-related quality of life assessment

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2022年第12期42卷 1387-1402页

作者： Chen-hua Yan Yu Wang Yu-qian Sun yi-fei Cheng Xiao-dong Mo Feng-rong Wang Yu-hong Chen Yuan-yuan Zhang Ting-ting Han huan Chen Lan-ping Xu Xiao-hui Zhang Kai-yan Liu Xiao-jun hua.g Peking University Peoples Hospital Peking University Institute of HematologyBeijing 100044P.R.China National Clinical Research Center for Hematologic Disease Beijing 100044P.R.China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044P.R.China Peking-Tsinghua Center for Life Science Beijing 100044P.R.China

Background:Patients with refractory or relapsed acute myeloid leukemia(AML)have poor survival,necessitating the exploration of optimized therapeutic ***,we aimed to investigate clinical outcomes and health-related quality of life(HR-QoL)after total therapy,which included allogeneic hematopoietic stem cell transplantation(allo-HSCT),and prophylactic donor lymphocyte infusion(DLI)in the early phase after transplantation,followed bymultiplemeasurable residual disease(MRD)and graft-versus-host disease(gvHD)-guided ***:Consecutive patients who had refractory or relapsed AML and had received non-T-cell-depleted allo-HSCT at Peking University Institute of Hematology were included in the *** the patients achieved complete remission at 30 days after transplantation and had no evidence of relapse,severe infection,organ failure,and active gvHD at the time of planned DLI,prophylactic DLI was administered at 30 days after transplantation for human leukocyte antigen(HLA)-matched related HSCT or at 45-60 days after transplantation for haploidentical or unrelated ***,multiple DLIs were administered based on MRD results and whether they developed gvHD after ***:A total of 105 patients were ***-seven patients received prophylactic DLI(group B),while 18 did not receive prophylactic DLI(group A).Among 105 patients,the cumulative incidence of grade 2-4 acute gvHD and chronic gvHDwas 40.6%(95%confidence interval[CI]=30.6%-50.6%)and 73.3%(95%CI=67.4%-79.2%),*** cumulative incidence of relapse(CIR),transplant-related mortality(TRM),and leukemia-free survival(LFS)at 5 years after transplantation were 31.5%(95%CI=21.9%-41.1%),22.1%(95%CI=11.3%-32.9%),and 46.4%(95%CI=36.8%-56.0%),*** group B,the CIR,TRM,and LFS at 5 years after transplantation were 27.6%(95%CI=17.6%-37.6%),21.6%(95%CI=11.2%-32.0%),and 50.8%(95%CI=40.0%-61.6%),*** the end of follow-up,48 patients survived,and more than 90

关键词： acute myeloid leukemia allogeneic hematopoietic stem cell transplantation refractory relapsed total therapy

UHPLC-LTQ-Orbitrap-based metabolomics coupled with metabolomics pathway analysis method for exploring the protection mechanism of Kudiezi injection in a rat anti-ischemic cerebral reperfusion damage model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2017年第12期15卷 955-960页

作者： LIU Si-yi CAI Wei WANg fei LIU ying SHANg Zhan-Peng ZHANg Xiu-Ping WANg Zi-Jian LU Jian-Qiu ZHANg Jia-Yu Beijing Research Institution of Chinese Medicine Beijing University of Chinese Medicine Dong Pharmaceutical Research of Hunan Key Laboratory Hunan University of Medicine

Kudiezi injection has been used extensively in the treatment of cerebrovascular and cardiovascular diseases. However, its therapeutic effects and underlying mechanism of action are not fully understood. The aim of the present study was to clarify the protective mechanisms of Kudiezi injection on cerebral ischemic injury, using metabolomics methods. Middle cerebral artery occlusion(MCAO) was introduced in rats to build the cerebral ischemic damage. UHPLC-LTQ-Orbitrap-based analytical method was established for analysis of the metabolites. The raw mass data of all samples were normalized with Sieve 2.2 software and then introduced to orthogonal partial least squares discriminant analysis(OPLS-DA) model. Finally, 23 metabolites in plasma(15 were tentatively identified) were chosen as potential biomarkers, according to accurate mass measurements(gmentation patterns, and diagnostic product ions. Furthermore, on the basis of metabolic pathway analysis via metabolomics pathway analysis(Met PA), we first discovered that the protection mechanism in anti-ischemic cerebral reperfusion damage of Kudiezi injection was possibly related to the biosynthesis of phenylalanine, tyrosine, and tryptophan. The present study provided a useful approach for exploring the mechanism of ischemic stroke and evaluating the efficacy of Kudiezi injection or other traditional medicines.

关键词： Metabolomics Kudiezi injection Metabolomics pathway analysis(Met PA) Middle cerebral artery occlusion(MCAO) UHPLC-LTQ-Orbitrap

在线全文

学校读者我要写书评

暂无评论

玄武岩纤维在高温环境下的耐久性研究

合成纤维 2024年第9期53卷 32-35页

作者：裴芮吴亚飞曾小义马于杰樊平符东厅市共建玄武岩及复合材料四川省重点实验室四川达州635000 四川四众玄武岩纤维技术研发有限公司四川达州635000 四川文理学院四川达州635000

对国内生产的3种连续玄武岩纤维的耐高温性能进行了研究。玄武岩纤维单丝拉伸强度表明,随着温度的升高,玄武岩纤维的耐高温性能变差,并且高温处理后质量有所损失。通过对比几种连续玄武岩纤维的质量损失率发现在高温过程中纤维表面的浸... 详细信息

对国内生产的3种连续玄武岩纤维的耐高温性能进行了研究。玄武岩纤维单丝拉伸强度表明,随着温度的升高,玄武岩纤维的耐高温性能变差,并且高温处理后质量有所损失。通过对比几种连续玄武岩纤维的质量损失率发现在高温过程中纤维表面的浸润剂也随之分解。显微镜观察纤维形貌发现,700℃高温处理后,3种玄武岩纤维的直径均略有减小,纤维的颜色发生改变。

关键词：玄武岩纤维拉伸强度耐高温性能形貌