检索结果-南通市图书馆

Nuclear Science and Techniques 2001年第4期12卷 250-255页

作者： huya－er XIAZong－Qin 等 ResearchLaboratoryofCellRegulation ShanghaiSecondMedicalUniversityShanghai200025

The aim of this study was to establish a model by single injection of Aβ1-40+IA into rat brain basal ganglion and examine the effect of ZDY101, an active component of a Yin tonic from Chinese traditional medicinal herb. The results showed that the amnestic effect of co-injection of Aβ and IA lasted for at least 2 months. At same time, the total M-receptor density in model brain was significantly lower than blank control, indicating the change is profound enough for long term pathological studies or drug screening. It can be clearly seen that the decreased brain M-receptor density caused by Aβ was significantly increased by ZDY101. Such an elevation effect was significantly correlated with dose of ZDY101 when the dose was examined in a certain reasonable range. It can also he clearly seen that such an elevation of M-cholinergic receptor density was significantly correlated with the improvement of memory which indicated that the increase of M-cholinergic receptor density was an important factor in improving the memory of such animal model.

关键词：放射医学 Alzeimer病动物模型

Metal-organic frameworks (MOFs) in aqueous batteries (ABs):unlocking potential through innovative materials design

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Bo Han erhai Hu Bei-er Jia Ziyang Liu Shuen Tso Afriyanti Sumboja Ivandini T.Anggraningrum Anne Zulfia Syahrial Qingyu Yan SCARCE Laboratory Energy Research Institute NTU (ERIN) Nanyang Technological University School of Materials Science and Engineering Nanyang Technological University Material Science and Engineering Research Group Faculty of Mechanical and Aerospace Engineering Institut Teknologi Bandung Department of Chemistry University of Indonesia Metallurgical & Materials Engineering Department Fakultas Teknik Universitas Indonesia

Metal-organic frameworks (MOFs) represent a revolutionary class of materials in the field of energy storage,particularly for aqueous batteries (ABs).Distinguished by their large surface area,tuneable porosity,and adaptable chemical activity,MOFs offer significant advantages over conventional materials in battery *** article provides a thorough analysis of the crucial role that MOFs play in improving the efficiency of *** includes a concise review of the current research progress,emphasizing the fundamental processes by which MOFs enhance electrochemical ***,the review examines the synthesis and design strategies for the structure of MOFs to maximize ion transport,improve conductivity,and enhance *** structural advantages,chemical versatility,stability,durability and functionalization potential of MOFs are comprehensively ***,we explore the distinct advantages of MOFs in overcoming common challenges encountered in ABs,such as declining capacity,inadequate cycling stability,and limited energy *** paper also highlights the future research directions needed to fully harness their *** goal is to develop a fundamental understanding and stimulate further progress in the use of MOFs for advanced energy storage solutions.

关键词：

一种基于柱面镜聚焦系统的高灵敏度全谱光谱仪

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

光谱学与光谱分析 2025年第1期45卷 222-230页

作者：陈吉文陈作儿赵迎北方工业大学电气与控制工程学院北京100144

很多元素的最灵敏谱线主要分布在紫外波段。一些常被作为检测对象的重要元素,例如C、P和S,其谱线甚至位于200 nm以下的真空紫外波段。然而真空紫外波段内的辐射极易受空气吸收而无法在空气中传输。因此为了适用于紫外波段各谱线的检测,... 详细信息

很多元素的最灵敏谱线主要分布在紫外波段。一些常被作为检测对象的重要元素,例如C、P和S,其谱线甚至位于200 nm以下的真空紫外波段。然而真空紫外波段内的辐射极易受空气吸收而无法在空气中传输。因此为了适用于紫外波段各谱线的检测,常使用光程短、系统精简的罗兰圆光学系统作为光谱仪的色散系统,并且在进行检测分析时,还需对设备腔体内部建立相对真空的环境进行实验,进而减小实验环境对真空紫外波段内各谱线强度的削弱作用。然而即使在该条件下,P和S这两种元素在真空紫外波段的谱线灵敏度仍然较弱。为此为了实现真空紫外波段范围内的高灵敏度,本研究在距离像面前30 mm处位置设计了一个柱面镜聚焦系统。其采用了材料为CaF_(2)、中心厚度为5 mm以及弧矢面曲率半径为22.06 mm的柱面镜作为核心部件。并利用仿真软件Zemax对设计的光学系统进行仿真与优化,以及从非序列模式下的辐射照度仿真结果可知,柱面镜聚焦系统在几乎不影响分辨率的情况下对各波长成像灵敏度有较大的提升。最后以中低合金钢为检测样品,使用电火花激发光源对样品中各元素在紫外波段内的各谱线进行激发,进而验证光谱仪的各项性能:通过一次拟合、参比拟合以及二次拟合,建立每个元素谱峰强度和实际含量之间的数学模型,并算得各元素的拟合优度R^(2)均在0.99以上;柱面镜聚焦系统显著提高了设备在真空紫外波段的灵敏度,响应提高了1倍以上。实验结果表明,柱面镜聚焦系统的设计方法对于提升罗兰圆色散系统的灵敏度具有一定的参考价值。

关键词：紫外光谱罗兰圆光学系统柱面镜灵敏度拟合优度

siRNA therapeutics:a clinical reality

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2020年第4期63卷 485-500页

作者： Phei er Saw er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Zhongshan School of Medicine Breast SurgeryGuangzhou 510080China

Since the revolutionary discovery of RNA interference(RNAi),a remarkable progress has been achieved in understanding and harnessing gene silencing mechanism;especially in small interfering RNA(siRNA)*** its tremendous potential benefits,major challenges in most siRNA therapeutics remains unchanged-safe,efficient and target oriented delivery of *** years after the discovery of RNAi,siRNA therapeutics finally charts its way into *** we journey through the decades,we reminisce the history of siRNA discovery and its application in a myriad of disease ***,we highlight the breakthroughs in si RNA therapeutics,with special feature on the first FDA approved RNAi therapeutics Onpattro(Patisiran)and the consideration of effective siRNA delivery system focusing on current siRNA nanocarrier in clinical ***,we present some challenges and multiple barriers that are yet to be fully overcome in siRNA therapeutics.

关键词： siRNA therapeutic disease treatment systemic siRNA delivery clinical application

Phage display screening of therapeutic peptide for cancer targeting and therapy

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2019年第11期10卷 787-807页

作者： Phei er Saw er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Recently,phage display technology has been announced as the recipient of Nobel Prize in Chemistry *** display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched through the biopanning process;proving to be a powerful technique in the screening of peptide with high affinity and *** this review,we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands by in situ,in vitro,in vivo,and ex vivo screening *** will then discuss prominent examples of solid tumor targeting-peptides;namely peptide targeting tumor vasculature,tumor microenvironment(TME)and overexpressed receptors on cancer cells identified through phage display *** will also discuss the current challenges and future outlook for targeting peptidebased therapeutics in the clinics.

关键词： phage display tumor targeting peptide,tumor vasculature tumor microenvironment tumor stromal cells over-expressed receptor

Simple Traits among Diaspore Weight/Number,Plant Height and Ability of Vegetative Propagation

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2008年第12期50卷 1563-1569页

作者： Bozena erá Institute of Systems Biology and Ecology Academy of Sciences of the Czech Republiceské Budějovice 37005

Several expected correlations among followed internal plant traits were confirmed using the dataset of 492 herbaceous species from the temporal zone of Central Europe. Average diaspore weight （seed mass）, reproductive capacity of population （number of produced diaspores）, species height, and ability of lateral spread were the plant traits considered. The evident correlations were confirmed among all investigated traits：（i） The reproductive capacity of population negatively correlated with diaspore weight, plant height, and vegetative propagation. The diaspore weight and their number are closely correlated and co-adapted. （ii） Bigger plant species produce bigger diaspores. These trends are obvious at the inter- and intra-family levels. （iii） Larger plant species showed higher ability to vegetative propagation.

关键词： comparison lateral spread reproduction seed production seed weight strategy trade-off.

New Physicochemical Treatment Method of Poppy Seeds for Agriculture and Food Industries

在线全文

学校读者我要写书评

暂无评论

Plasma Science and Technology 2013年第9期15卷 935-938页

作者： Bozena er Iveta GAJDOV Michal er'Y Petr PATENKA Institute of Nanobiology and Structural Biology GCRC Academy of Sciences of the Czech RepublicDepartment of NanobiotechnologyNa Sadkach 7Ceske Budejovicecz-37005Czech Republic Department of Biology Faculty of EducationUniversity of South Bohemia in Ceske BudejoviceJeronymova 10Ceske Budejovicecz-37115Czech Republic Department of Applied Physics and Technics Faculty of EducationUniversity of South Bohemia in Ceske BudejoviceJeronymova 10Ceske Budejovicecz-37115Czech Republic

Poppy seeds （Papaver somniferum L.） are often attacked by various fungal dis- eases, and their field germination rate is low. The aim of this experiment was to increase the germination rate and growth of seedlings by modifying the poppy seeds using cold plasma dis- charge. The seeds were treated in a Plasonic AR-550-M under power of 500 W with argon gas flow of 50 mL/min, oxygen gas flow of 50 mL/min for different time durations in seconds （0, 180, 300, 600, 1800, 3000, 4200, and 5400）. The seed germination rate and growth of the seedlings were recorded. Cold plasma positively affected the seed germination rate for time exposure between 180～3000 s. Seedling acceleration on the sixth day of the experiment showed the highest values at exposure 180～600 s. Cold plasma seems to be a good physicochemical way to modify seeds without chemical agronomical application.

关键词： biotechnology early growth low-pressure discharge Papaver somniferum,seed modification seed germination

Gravitational lensing properties of an isothermal universal halo profile

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2013年第5期13卷 517-525页

作者： Xin-Zhong er National Astronomical Observatories Chinese Academy of Sciences

N-body simulations predict that dark matter halos with different mass scales are described by a universal model, the Navarro-Frenk-White （NFW） den- sity profiles. As a consequence of baryonic cooling effects, these halos will become more concentrated, and similar to an isothermal sphere over a large range in radii （～ 300 h-1 kpc）. The singular isothermal sphere （SIS） model however has to be trun- cated artificially at large radii since it extends to infinity. We model a massive galaxy halo as a combination of an isothermal sphere and an NFW density profile. We give an approximation for the mass concentration at different baryon fractions and present exact expressions for the weak lensing shear and flexion for such a halo. We compare the lensing properties with the SIS and NFW profiles. We find that the combined pro- file can generate higher order lensing signals at small radii and is more efficient in generating strong lensing events. In order to distinguish such a halo profile from the SIS or NFW profiles, one needs to combine strong and weak lensing constraints for small and large radii.

关键词： gravitational lensing -- galaxies: halos -- cosmology: dark matter

Study of the Structural Evolution of the Babadag-Honaz and Pamukkale Fault Zones and the Related Earthquake Risk Potential of the Buldan Region in SW Anatolia, East of the Mediterranean

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2013年第3期24卷 397-409页

作者： Mete Han er Geological Engineering Department Pamukkale University

Denizli graben （DG） is bounded in the NE by the Pamukkale fault zone and in the SW by the Babadag-Honaz fault zone. The Babada and Honaz fault zones are generally made up as nearly E-W directed two segments. The Pamukkale fault also contains many overlapping segments in the Denizli area along the NE margin of the graben. The DG contains an NW-SE trending horst （Karakova） controlled by normal faults with oppositely dipping high angles and that truncate the Plio-Quaternary rock units. The faults that bound the DG are likely to have been initiated during the Early to Late Miocene and appear to be active today. The faults of the DG are active and the potential energy that accumulates in them is easily conducted to the other faults that they come in contact with. This signifies that a movement in one of the faults forming the grabens in the Denizli region affects the other structures as well. Earthquakes in the Buldan region usually occur 2-3 years after seismical movements occur in the Denizli Basin. The Buldan region is a ridge between DG and Ala ehir graben （ALG）. Based on the fact that DG in its south and ALG in its north move seismically, there is a probability that a break would appear in the Buldan region in the near future.

关键词： Denizli Turkey Anatolia Pamukkale graben fault.

Non-coding RNAs:the new central dogma of cancer biology

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2021年第1期64卷 22-50页

作者： Phei er Saw Xiaoding Xu Jianing Chen er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China

The central dogma of molecular biology states that the functions of RNA revolve around protein *** the last decade,most researches were geared towards characterization of RNAs as intermediaries in protein translation,namely,messenger RNAs(mRNAs)as temporary copies of genetic information,ribosomal RNAs(rRNAs)as a main component of ribosome,or translators of codon sequence(t RNAs).The statistical reality,however,is that these processes account for less than 2%of the genome,and insufficiently explain the functionality of 98%of transcribed *** discoveries have unveiled thousands of unique non-coding RNAs(ncRNAs)and shifted the perception of them from being"junk"transcriptional products to"yet to be elucidated"—and potentially monumentally important—*** ncRNAs are now known as key regulators in various networks in which they could lead to specific cellular responses and *** major cancers,ncRNAs have been identified as both oncogenic drivers and tumor suppressors,indicating a complex regulatory network among these ***,we provide a comprehensive review of the various ncRNAs and their functional roles in cancer,and the pre-clinical and clinical development of nc RNA-based therapeutics.A deeper understanding of ncRNAs could facilitate better design of personalized therapeutics.

关键词： non-coding RNAs anti-cancer therapeutics personalized intervention miRNA lncRNA circRNA