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Substance graphs are optimal simple-graph representations of metabolism

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Chinese Science Bulletin 2010年第27期55卷 3161-3168页

作者： HOLME Petter huss mikael Department of Physics Ume University Department of Energy Science Sungkyunkwan University Science for Life Laboratory Stockholm Box 1031 171 21 SolnaSweden Computational and Systems Biology Genome Institute of Singapore

One approach to study the system-wide organization of biochemistry is to use statistical graph *** such heavily simplified methods,which disregard most of the dynamic aspects of biochemistry,one is faced with fundamental *** such question is how the chemical reaction systems should be reduced to a graph retaining as much functional information as possible from the original reaction *** these graph representations,should the edges go between substrates and products,or substrates and substrates,or both?Should vertices represent substances or reactions?Different representations encode different information about the reaction system and affect network measures in different *** paper investigates which representation reflects the functional organization of the metabolic system in the best way,according to the defined *** different graph representations of metabolism(three where the vertices are metabolites,one where the vertices are reactions)are evaluated using data from different organisms and *** graph representations are evaluated by comparing the overlap between clusters(network modules)and annotated functions,and also by comparing the set of identified currency metabolites with those that other authors have identified using qualitative biological *** is found that a"substance network",where all metabolites participating in a reaction are connected,is better than others,evaluated with respect to both the functional overlap between modules and functions and to the number and identity of the identified currency metabolites.

关键词：图形表示代谢物物质生物数据库反应体系化学反应系统顶点表示代谢产物

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踌躇的西行:中国大陆科幻的命运变迁

踌躇的西行:中国大陆科幻的命运变迁

Lipid bound extended release buprenorphine(high and low doses)and sustained release buprenorphine effectively attenuate post-operative hypersensitivity in an incisional pain model in mice(Mus musculus)

作者：辛禄高郑军 mikael huss

＜正＞科幻很可能是由鲁迅最先引介到中国的,他在1902年或1903年翻译了凡尔纳的《月界旅行》和《地心游记》。同时,鲁迅还写了《〈月界旅行〉弁言》,试图对科幻文学的原理进行界定。1917—1918年,另一名著名作家茅盾,和他弟弟沈德济合...

＜正＞科幻很可能是由鲁迅最先引介到中国的,他在1902年或1903年翻译了凡尔纳的《月界旅行》和《地心游记》。同时,鲁迅还写了《〈月界旅行〉弁言》,试图对科幻文学的原理进行界定。1917—1918年,另一名著名作家茅盾,和他弟弟沈德济合译了法国、英国、美国的科幻小说,凡尔纳和威尔斯依然排在榜首。鲁迅在译介《月界旅行》时,赞扬了他称之为"科学小说"（当时尚无"科幻"的说法）的可能性:"导中国人群以进行,必自科学小说始。"他希望通过"给科学小说

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来源： cnki会议评论

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Animal Models and Experimental Medicine 2021年第2期4卷 129-137页

作者： Kaela Navarro Katechan Jampachaisri Monika huss Cholawat Pacharinsak Department of Comparative Medicine Stanford UniversityStanfordCAUSA Department of Mathematics Naresuan UniversityPhitsanulokThailand

Background:Extended-release buprenorphine(XR)is indicated for pain management in rodents,but little is known about its use in *** study aimed to investigate whether high dose XR effectively attenuates post-operative hypersensitivity better than low dose XR in a mouse model of incisional ***:Mice(n 44)were randomly assigned to 1 of 4 treatment groups:(a)saline(1 ml/kg SC,once);(b)sustained release buprenorphine(Bup-SR,1 mg/kg SC,once);(c)low dose extended-release buprenorphine(XR-lo,3.25 mg/kg SC,once);(d)high dose extended-release buprenorphine(XR-hi,6.5 mg/kg SC,once).On days􀆴1,0(4 hours),1,2,and 3,mechanical and thermal hypersensitivities were evaluated,and plasma buprenorphine concentrations were ***:Mechanical(days 0-2)and thermal(days 0-1)hypersensitivities were ob-served in the saline ***-SR,XR-lo,and XR-hi attenuated mechanical hyper-sensitivity on days 0,1,and *** of the treatment groups,except XR-Lo on day 0,attenuated thermal hypersensitivity on days 0 or *** buprenorphine concen-tration peaked at 4 hours(day 0)in all treatment groups and remained greater than 1 ng/mL on days *** abnormal clinical observations or gross pathologic findings were seen in any ***:The results indicate XR-hi did not effectively attenuate post-operative hypersensitivity better than *** both 3.25 and 6.5 mg/kg XR are recom-mended for attenuating post-operative hypersensitivity for at least up to 48 hours in mice.

关键词： analgesia analgesics buprenorphine mouse pain management

Bone marrow-derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion

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International Journal of Oral Science 2014年第3期6卷 154-161页

作者： Silke Schwarz Ralf huss Michaela Schulz-Siegmund Breda Vogel Sven Brandau Stephan Lang Nicole Rotter Department of Otorhinolaryngology Ulm University Medical Center Apceth Munich Germany Institute of Pharmaceutical Technology University of Leipzig Department of Otorhinolaryngology University of Duisburg–Essen

Xerostomia is a severe side effect of radiation therapy in head and neck cancer patients. To date, no satisfactory treatment option has been established. Because mesenchymal stem cells（MSCs） have been identified as a potential treatment modality, we aimed to evaluate stem cell distribution following intravenous and intraglandular injections using a surgical model of salivary gland damage and to analyse the effects of MSC injections on the recruitment of immune cells. The submandibular gland ducts of rats were surgically ligated. Syngeneic adult MSCs were isolated, immortalised by simian virus 40（SV40） large T antigen and characterized by flow cytometry. MSCs were injected intravenously and intraglandularly. After 1, 3 and 7 days, the organs of interest were analysed for stem cell recruitment. Inflammation was analysed by immunohistochemical staining. We were able to demonstrate that, after intravenous injection, MSCs were recruited to normal and damaged submandibular glands on days 1, 3 and 7. Unexpectedly, stem cells were recruited to ligated and non-ligated glands in a comparable manner. After intraglandular injection of MSCs into ligated glands, the presence of MSCs, leucocytes and macrophages was enhanced, compared to intravenous injection of stem cells. Our data suggest that injected MSCs were retained within the inflamed glands, could become activated and subsequently recruited leucocytes to the sites of tissue damage.

关键词： duct ligation mesenchymal stem cells submandibular gland injury xerostomia