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All types of base conversions allowed by base editors

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Science China(Life Sciences) 2024年第2期67卷 431-433页

作者： Shun-qing liang Wen Xue RNA Therapeutics Institute UMass Chan Medical SchoolWorcester 01655USA Department of Molecular Cell and Cancer BiologyUMass Chan Medical SchoolWorcester 01655USA Department of Molecular Medicine UMass Chan Medical SchoolWorcester 01655USA Li Weibo Institute for Rare Diseases Research UMass Chan Medical SchoolWorcester 01655USA

Base editors(BEs) hold great promise as tools for introducing single-base-pair changes in both basic research and therapeutic applications(Rees and Liu,2018).Base editors are composed of a Cas9 nickase fused to a DNA-modifying enzyme,which chemically modifies nucleobases within a specific targeting window near the Cas9-binding site.

关键词： base bases allowed

Rotor Angle Stability Prediction Using Temporal and Topological Embedding Deep Neural Network Based on Grid-informed Adjacency Matrix

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 695-706页

作者： Peiyuan Sun Long huo Xin Chen Siyuan liang the School of Electrical Engineering Xi'an Jiaotong University the School of Electrical Engineering and the Center of Nanomaterials for Renewable Energy State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong University the Department of Computer Science and Engineering The Chinese University of Hong Kong

Rotor angle stability(RAS) prediction is critically essential for maintaining normal operation of the interconnected synchronous machines in power systems. The wide deployment of phasor measurement units(PMUs) promotes the development of data-driven methods for RAS prediction. This paper proposes a temporal and topological embedding deep neural network(TTEDNN) model to accurately and efficiently predict RAS by extracting the temporal and topological features from the PMU data. The grid-informed adjacency matrix incorporates the structural and electrical parameter information of the power grid. Both the small-signal RAS with disturbance under initial operating conditions and the transient RAS with short circuits on transmission lines are considered. Case studies of the IEEE 39-bus and IEEE 300-bus power systems are used to test the performance, scalability, and robustness against measurement uncertainties of the TTEDNN model. Results show that the TTEDNN model performs best among existing deep learning models. Furthermore, the superior transfer learning ability from small-signal RAS conditions to transient RAS conditions has been proved.

关键词： Power system stability Phasor measurement units Rotors Transient analysis Stability criteria Deep learning Circuit stability

Integral precession calibration method of PIGA on linear vibration table

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Chinese Journal of Aeronautics 2024年第3期37卷 219-236页

作者： Chuang SUN Shun-qing REN Jun-wei CAO Ru huo Department of Automation Tsinghua UniversityBeijing 100084China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China Faculty of Information technology Beijing University of TechnologyBeijing 100124China

Linear vibration table can provide harmonic accelerations to excite the nonlinear error terms of Pendulous Integrating Gyro Accelerometer(PIGA).Integral precession calibration method is proposed to calibrate PIGA on a linear vibration table in this paper.Based on the precise expressions of PIGA’s inputs,the error calibration model of PIGA is established.Precession angular velocity errors of PIGA are suppressed by integer periodic precession and the errors caused by non-integer periods vibrating are compensated.The complete calibration process,including planning,preparation,PIGA testing,and coefficient identification,is designed to optimize the test operations and evaluate the calibration results.The effect of the main errors on calibration uncertainty is analyzed and the relative sensitivity function is proposed to further optimize the test positions.Experimental and simulation results verify that the proposed 10-position calibration method can improve calibration uncertainties after compensating for the related errors.The order of calibration uncertainties of the second-and third-order coefficients are decreased to 10^(-8)(rad.s^(-1))/g^(2)and 10^(-8)(rad.s^(-1))/g3,respectively.Compared with the other two classical calibration methods,the calibration uncertainties of PIGA’s nonlinear error coefficients can be effectively reduced and the proportional residual errors are decreased less than 3×10-6(rad.s^(-1))/g by using the proposed calibration method.

关键词： PIGA Linear vibration table Vibration measurement Calibration Error analysis Uncertainty analysis

High performance photodegradation resistant PVA@TiO_(2)/carboxyl-PES self-healing reactive ultrafiltration membrane

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Chinese Journal of Chemical Engineering 2024年第2期66卷 31-39页

作者： Yu liang Yuanfang Fan Zhongmin Su Mingxin huo Xia Yang Hongliang huo Chi Wang Zhi Geng College of Environment Engineering Research Center of Low-Carbon Treatment and Green Development of Polluted Water in Northeast ChinaMinistry of EducationNortheast Normal UniversityChangchun 130117China School of Science Hainan UniversityHaikou 570225China

The occurrence of ultrafiltration(UF)membrane fouling frequently hampers the sustainable advancement of UF technology.Reactive self-cleaning UF membranes can effectively alleviate the problem of membrane fouling.Nevertheless,the self-cleaning process may accelerate membrane aging.Addressing these concerns,we present an innovative design concept for composite self-healing materials based on self-cleaning UF membranes.To begin,TiO_(2)nanoparticles were incorporated into the polymer molecular structure via molecular design,resulting in the synthesis of TiO_(2)/carboxyl-polyether sulfone(PES)hybrid materials.Subsequently,the nonsolvent-induced phase inversion technique was employed to prepare a novel of UF membrane.Lastly,a polyvinyl alcohol(PVA)hydrogel coating was applied to the hybrid UF membrane surface to create PVA@TiO_(2)/carboxyl-PES self-healing reactive UF membranes.By establishing a covalent bond,the TiO_(2)nanoparticles were effectively and uniformly dispersed within the UF membrane,leading to exceptional self-cleaning properties.Furthermore,the water-absorbing and swelling properties of PVA hydrogel,along with its capacity to form hydrogen bonds with water molecules,resulted in UF membranes with improved hydrophilicity and active self-healing abilities.The results demonstrated that the water contact angle of PVA@5%TiO_(2)/carboxyl-PES UF membrane was 43.1°.Following a 1-h exposure to simulated solar exposure,the water flux recovery ratio increased from 48.16%to 81.03%.Moreover,even after undergoing five cycles of 12-h simulated sunlight exposure,the UF membranes exhibited a consistent retention rate of over 97%,thus fully demonstrating their exceptional self-cleaning,antifouling,and selfhealing capabilities.We anticipate that the self-healing reactive UF membrane system will serve as a pioneering and comprehensive solution for the self-cleaning antifouling challenges encountered in UF membranes while also effectively mitigating the aging effects of reactive UF membranes.

关键词： Ultrafiltration membrane Self-cleaning Self-healing Poly(aryl ether sulfone)

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Investigation of Quantum Dot Color Filter Micro-LED Display

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Photonic Sensors 2024年第1期14卷 40-47页

作者： Xuhui PENG Yang ZENG Sitao huo Zhenyuan YANG Xiaoping HUANG qing ZHAO School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China Shanghai Tianma Microelectronics Shanghai 201201China

In this work,we present the investigation of the quantum dot color filter(QDCF)micro-light emitting diode(micro-LED)display.Green and red quantum dot photoresist(QDPR)materials are patterned into a pixelated array and precisely bonded with an all-blue micro-light emitting diode(micro-LED)substrate,forming a red,green,and blue(RGB)full color display through color conversion.A few factors that influence the achievable color gamut are further investigated.The resulting 1.1-inch 228-pixels per inch(ppi)display demo shows the good performance.The findings in this paper pave a way to the future industrialization of the micro-LED display.

关键词： Quantum dot color filter(QDCF) color conversion micro-light emitting diode(micro-LED) color gamut

Tailoring electron vortex beams with customizable intensity patterns by electron diffraction holography

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Opto-Electronic Advances 2024年第2期7卷 14-21页

作者： Pengcheng huo Ruixuan Yu Mingze Liu Hui Zhang Yan-qing Lu Ting Xu National Laboratory of Solid-State Microstructures and Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China College of Engineering and Applied Sciences Key Laboratory of Intelligent Optical Sensing and Manipulation and Jiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjing 210093China

An electron vortex beam(EVB) carrying orbital angular momentum(OAM) plays a key role in a series of fundamental scientific researches, such as chiral energy-loss spectroscopy and magnetic dichroism spectroscopy. So far, almost all the experimentally created EVBs manifest isotropic doughnut intensity patterns. Here, based on the correlation between local divergence angle of electron beam and phase gradient along azimuthal direction, we show that free electrons can be tailored to EVBs with customizable intensity patterns independent of the carried OAM. As proof-of-concept, by using computer generated hologram and designing phase masks to shape the incident free electrons in the transmission electron microscope, three structured EVBs carrying identical OAM are tailored to exhibit completely different intensity patterns. Furthermore, through the modal decomposition, we quantitatively investigate their OAM spectral distributions and reveal that structured EVBs present a superposition of a series of different eigenstates induced by the locally varied geometries. These results not only generalize the concept of EVB, but also demonstrate an extra highly controllable degree of freedom for electron beam manipulation in addition to OAM.

关键词： electron vortex beam orbital angular momentum diffraction holography

Studying the co-evolution of information diffusion,vaccination behavior and disease transmission in multilayer networks with local and global effects

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Chinese Physics B 2024年第3期33卷 677-689页

作者：霍良安武兵杰 Business School University of Shanghai for Science and TechnologyShanghai 200093China School of Intelligent Emergency Management University of Shanghai for Science and TechnologyShanghai 200093China

Today,with the rapid development of the internet,a large amount of information often accompanies the rapid transmission of disease outbreaks,and increasing numbers of scholars are studying the relationship between information and the disease transmission process using complex networks.In fact,the disease transmission process is very complex.Besides this information,there will often be individual behavioral measures and other factors to consider.Most of the previous research has aimed to establish a two-layer network model to consider the impact of information on the transmission process of disease,rarely divided into information and behavior,respectively.To carry out a more in-depth analysis of the disease transmission process and the intrinsic influencing mechanism,this paper divides information and behavior into two layers and proposes the establishment of a complex network to study the dynamic co-evolution of information diffusion,vaccination behavior,and disease transmission.This is achieved by considering four influential relationships between adjacent layers in multilayer networks.In the information layer,the diffusion process of negative information is described,and the feedback effects of local and global vaccination are considered.In the behavioral layer,an individual's vaccination behavior is described,and the probability of an individual receiving a vaccination is influenced by two factors:the influence of negative information,and the influence of local and global disease severity.In the disease layer,individual susceptibility is considered to be influenced by vaccination behavior.The state transition equations are derived using the micro Markov chain approach(MMCA),and disease prevalence thresholds are obtained.It is demonstrated through simulation experiments that the negative information diffusion is less influenced by local vaccination behavior,and is mainly influenced by global vaccination behavior;vaccination behavior is mainly influenced by local disease conditions,and is less influenced by glob

关键词： information diffusion vaccination behavior disease transmission multilayer networks local and global effect

Day-ahead P2P Energy Sharing Strategy Among Energy Hubs Considering Flexibility of Energy Storage and Loads

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1105-1118页

作者： Penghua Li Wanxing Sheng qing Duan Jun liang Cunhao Zhu China Electric Power Research Institute Beijing 100192China School of Engineering Cardiff UniversityUK IEEE

Multi-energy systems are one of the key technologies to tackle energy crisis and environmental pollution.An energy hub(EH)is a minimum multi-energy system.Interconnection of multiple EHs through energy routers(ERs)can realize mutual energy assistance.This paper proposes a peer-to-peer(P2P)energy sharing strategy between EHs including ERs in an interconnected system,which is divided into two levels.In the lower level,a method of determining the charging/discharging constraints of energy storage devices is proposed.Based on the Lyapunov optimization method,virtual queues are used to model the energy storage devices and flexible loads in the system.The objective is to minimize the overall operating cost of the interconnected system.In the upper level,a non-cooperative game model is introduced to minimize the cost of purchasing power from other EHs for each EH.A best response-based method is adapted to find the Nash equilibrium.The simulation outcomes demonstrate that application of the proposed strategy can reduce operating costs of an interconnected system and each EH.On basis of a real-world dataset of interconnected EHs,both analytical and numerical results show the effectiveness of the proposed strategy.

关键词： Energy hub energy router Lyapunov optimization non-cooperative game peer to peer virtual queue

Isogeometric Analysis for the Arbitrary AFG Microbeam with Two-Phase Nonlocal Stress-Driven Model

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Acta Mechanica Solida Sinica 2024年第2期37卷 341-360页

作者： Pei-liang Bian Zhaowei Liu Hai qing Tiantang Yu Department of Engineering Mechanics Hohai UniversityNanjing211100China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China

Scale effects play critical roles in the mechanical responses of microstructures.An isogeometric analysis was developed here to investigate the mechanical responses of an axially functionally graded microbeam.The Euler–Bernoulli beam model was utilized,and size effects in the structure were modeled with a stress-driven two-phase local/nonlocal integral constitution.The governing equation of microstructures was given in an equivalent differential form with two additional constitutive boundary conditions.The framework was verified and utilized to analyze the microbeam’s static and dynamic mechanical responses.The present work showed great potential for modeling various types of functionally graded microstructures.

关键词： Isogeometric analysis Size effect Functionally graded material Nonlocal theory Euler-Bernoulli beam