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Activity Enhancement of MgCl2-supported Ziegler-Natta Catalysts by Lewis-acid pre-treatment for Ethylene polymerization

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Chinese Journal of polymer Science 2019年第10期37卷 1031-1038,I0006页

作者： Matthieu humbert Sébastien Norsic Jean Raynaud Vincent Monteil UMR 5265 Laboratoire de Chimie Catalyse polymères et procédés (C2p2) Université de Lyon

Ziegler-Natta precatalysts were synthetized from Lewis-base-modified-MgCl2 supports and treated by various Lewis acids,prior to activation by triethylaluminum, in order to increase their activity in ethylene polymerization. BCl3 provided the highest increase in activity. Interestingly, polymerization results showed no substantial modification of polymer properties, which is consistent with that Lewis acid only promotes the creation of new active sites, after activation by TEA, possessing very similar features to the original ones achievable with conventional precatalysts(i.e. without Lewis-acid treatment).

关键词： Ziegler-Natta catalysis Ethylene polymerization Heterogeneous catalysis Lewis acids

Iterative Reconstruction for Transmission Tomography on GpU Using Nvidia CUDA

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Tsinghua Science and Technology 2010年第1期15卷 11-16页

作者： Damien Vintache Bernard humbert David Brasse Institut pluridisciplinaire Hubert Curien CNRS/IN2P323 rue du Loess BP28 67037 StrasbourgFrance

The iterative reconstruction algorithms for X-ray CT image reconstruction suffer from their high computational cost. Recently Nvidia releases common unified device architecture （CUDA）, allowing developers to access to the processing power of Nvidia graphical processing units （GpUs）, in order to perform general purpose computations. The use of the GpU, as an alternative computation platform, allows decreasing processing times, for parallel algorithms. This paper aims to demonstrate the feasibility of such an implementation for the iterative image reconstruction. The ordered subsets convex （OSC） algorithm, an iterative reconstruction algorithm for transmission tomography, has been developed with CUDA. The performances have been evaluated and compared with another implementation using a single CpU node. The result shows that speed-ups of two orders of magnitude, with a negligible impact on image accuracy, have been observed.

关键词： tomography image reconstruction parallel processing

Targeted Sub-Attomole Cancer Biomarker Detection Based on phase Singularity 2D Nanomaterial-Enhanced plasmonic Biosensor

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Nano-Micro Letters 2021年第6期13卷 284-294页

作者： Yuye Wang Shuwen Zeng Aurelian Crunteanu Zhenming Xie Georges humbert Libo Ma Yuanyuan Wei Aude Brunel Barbara Bessette Jean-Christophe Orlianges Fabrice Lalloué Oliver GSchmidt Nanfang Yu Ho-pui Ho Department of Biomedical Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongPeople’s Republic of China CNRS XLIM Research InstituteUMR 7252University of Limoges123Avenue Albert ThomasLimogesFrance Department of Applied physics and Applied Mathematics Columbia UniversityNew York CityNYUSA Institute for Integrative Nanosciences IFW DresdenHelmholtzstr.20DresdenGermany Faculty of Medicine University of LimogesEA3842-CAPTuRGEIST2 rue du Dr MarclandLimogesFrance

Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer,monitoring treatment and detecting ***,a highly enhanced plasmonic biosensor that can overcome this challenge is developed using atomically thin two-dimensional phase change *** precisely engineering the configuration with atomically thin materials,the phase singularity has been successfully achieved with a significantly enhanced lateral position shift *** on our knowledge,it is the first experimental demonstration of a lateral position signal change>340μm at a sensing interface from all optical *** this enhanced plasmonic effect,the detection limit has been experimentally demonstrated to be 10^(-15) mol L^(−1) for TNF-α cancer marker,which has been found in various human diseases including inflammatory diseases and different kinds of *** as-reported novel integration of atomically thin Ge_(2)Sb_(2)Te_(5) with plasmonic substrate, which results in a phase singularity and thus a giant lateral position shift, enables the detection of cancer markers with low molecular weight at femtomolar level. These results will definitely hold promising potential in biomedical application and clinical diagnostics.

关键词： 2D nanomaterials Cancer marker detection phase singularity Surface plasmon

Everolimus halts hepatic cystogenesis in a rodent model of polycystic-liver-disease

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World Journal of Gastroenterology 2017年第30期23卷 5499-5507页

作者： Frederik Temmerman Feng Chen Louis Libbrecht Ingrid Vander Elst petra Windmolders Yuanbo Feng Yicheng Ni humbert De Smedt Frederik Nevens Jos van pelt Laboratory of Hepatology Department of Clinical and Experimental Medicine Faculty of Medicine University of Leuven Department of Gastroenterology and Hepatology University Hospitals KU Leuven Department of Radiology The first Affiliated Hospital School of Medicine Zhejiang University Department of pathology Ghent University Hospital Department of Imaging and pathology Faculty of Medicine Laboratory of Molecular and Cellular Signalling Unit of Clinical Digestive Oncology Department of Oncology KU Leuven and Leuven Cancer Institute (LKI)

AIM To develop a MRI-based method for accurate determination of liver volume(LV) and to explore the effect of long-term everolimus(EVR) treatment on LV in pCK rats with hepatomegaly. METHODS Thirty-one female pCK rats(model for polycystic-liverdisease: pCLD) were randomized into 3 groups and treatment was started at 16 wk, at the moment of extensive hepatomegaly(comparable to what is done in the human disease). Animals received: controls(n = 14), lanreotide(LAN: 3 mg/kg per 2 wk)(n = 10) or everolimus(EVR: 1 mg/kg per day)(n = 7). LV was measured at week 16, 24, 28. At week 28, all rats were sacrificed and liver tissue was harvested. Fibrosis was evaluated using quantitative image analysis. In addition, gene(quantitative RT-pCR) and protein expression(by Western blot) of the pI3K/Ak T/m TOR signaling pathway was investigated. RESULTS LV determination by MRI correlated excellent with the ex vivo measurements(r = 0.99, p progression compared with controls(respectively, p = 0.01 and p = 0.04). Furthermore, EVR significantly reduced the amount of liver fibrosis(p = 0.004) thus might also prevent the development of portal hypertension. There was no difference in phosphorylation of Akt(Threonine 308) between LAN-treated pCK rats control pCK rats, whereas S6 was significantly more phosphorylated in the LAN group. phosphorylation of Akt was not different between controls and EVR treated rats, however, for S6 there was significantly less phosphorylation in the EVR treated rats. Thus, both drugs interact with the pI3K/Ak T/m TOR signaling cascade but acting at different molecular *** Everolimus halts cyst growth comparable to lanreotide and reduces the development of fibrosis. m TORinhibition should be further explored in pCLD patients especially those that need immunosuppression.

关键词： Fibrocystic liver disease mTOR inhibitor somatostatin analogue liver volume measurement Magnetic resonance imaging

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四环素类药在皮肤病中的应用

国外医学（皮肤性病学分册） 1992年第6期18卷 354-356页

作者： humbert p 李惠民李玲芳

四环素是应用最多、最广泛的抗生素之一。本文经体外免疫试验及生物活性酶的研究,进一步介绍了其抗炎作用和免疫抑制作用的机理。为其在炎性和免疫性皮肤病中的应用提供了一些依据,并拓宽了此药在皮肤病中应用的前景。

关键词：四环素类皮肤病治疗应用

Efficacy of Oral Micronutrient Supplementation on Linear Nail Growth in Healthy Individuals

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Journal of Cosmetics, Dermatological Sciences and Applications 2020年第4期10卷 191-203页

作者： Ferial Fanian Adeline Jeudy Ahmed Elkhyat Thomas Lihoreau philippe humbert Center for Studies and Research on the Integument (CERT) Department of Dermatology University Hospital of Besan&#231 on Besan&#231 on France Clinical Investigation Center (INSERM CIC 1431) Besan&#231 on University Hospital Besan&#231 on France INSERM UMR1098 FED4234 IBCT University of Franche-Comté Besan&#231 on France

Introduction: Several studies demonstrate the effects of the oral supplementations on the skin while there are limited data for their effects on the nail quality in healthy individuals. Only placebo controlled double blind studies could provide the reliable data considering the physiologic nail growth. Objective: The objective of this study was to evaluate the efficacy of consumption of a micronutrient supplementation on linear nail growth and thickness. Subjects and Method: 60 healthy female volunteers aged 35 to 65 years old were enrolled, randomized blindly in treatment and placebo groups, taking one tablet per day for 3 months. The evaluation was performed on D0 and D90 ± 3 days by measuring the linear nail growth, nail thickness by high frequency ultrasound imaging and also subjects’ self-assessment. Results: All 60 subjects finished the study without any serious adverse event. At D90 both groups revealed a significant linear nail growth (5.20 ± 0.35 for treatment group (p = 0.001) and 5.15 ± 0.30 for placebo group (p = 0.001)). However, the difference between the treatment and placebo group was statistically significant (p = 0.01) demonstrating the efficacy of oral supplementation on linear nail growth. No significant difference was observed at D90 for nail thickness measured with HFUS between 2 groups. The self-assessment score regarding ?brittle nails? and ?split nails? was diminished non-significantly in both groups. Conclusion: The results observed in this trial revealed that the oral micronutrient supplementation can provide beneficial effect on nail growth. This result may be due to the whole formula as the single vitamin treatment like biotin was shown to be non-effective. A longer study would be needed to confirm the efficacy on nail thickness.

关键词： Linear Growth Nail Growth Oral Supplementation

Efficacy and Safety of a Botanical Topical Serum on Male and Female Androgenetic Alopecia

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Journal of Cosmetics, Dermatological Sciences and Applications 2022年第1期12卷 51-66页

作者： Ferial Fanian pauline Meunier Diana Bumbea Karima Dahel philippe humbert FILLMED Laboratories Paris France Laboratoires JF Lazartigue Paris France Sallanches France LyRec and Dermatech Lyon France Double Board Certified in Dermatology and Internal Medicine University of Bourgogne-Franche Comté Besan&#231 on France

Androgenetic alopecia (AGA) is a common form of hair loss in both men and women, it affects up to 80% of men and 50% of women during their life. The current treatments approved for AGA are limited, inconstantly effective and might be associated with adverse events. The aim of this study was to evaluate the efficacy and safety of a botanical topical serum (SERUM THICKER) applied for 6 months in 14 males and 10 females with mild to moderate androgenetic alopecia. The hair parameters were assessed using trichoscopy images obtained with high resolution camera FotoFinder Leviacamp>®p> and analyzed with optimized software from TrichoLABp>TMp> and Vitual tattoop>TMp> technology. Hair loss was assessed using a wash-test procedure, and self-assessments were collected via questionnaires. Both at 28 days and 168 days, a significant increase of the hair density was observed, respectively +4.8% (p = 0.038);+11.7% (p pplication per day and +5.2% (p = 0.032);+9% (p pplications/week. Reported to the whole scalp, this represents an estimation of hair gain of 7000 hair in 6 months for subjects applying SERUM THICKER once a day and 5000 hair for subjects applying SERUM THICKER twice then once a week. Although, the analysis of hair shedding during washing did not permit to show a time effect or any effect of the application frequency, the analysis showed a marginal time effect in the group treated once a day (p = 0.0674). Regarding efficacy on hair loss and regrowth, although no statistical analysis were performed, it seems that for all questions and for both groups the positive answers were higher after 6 months of treatment than after 1 month. SERUM THICKER represents an interesting, effective, well-tolerated and safe multitarget treatment to address mild to moderate AGA in male and female. Efficacy was observed from one application per week and seems greater once applied once daily.

关键词： Hair Regrowth Androgenic Alopecia Botanical

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活体皮肤表面纹理无创性研究进展

国外医学（皮肤性病学分册） 2004年第5期30卷 291-293页

作者：李利 Mac-Mary S humbert p 四川大学华西医院皮肤性病科成都610041 Laboratory of Engineering and Cutaneous Biology CHU St Jacques

皮肤表面纹理客观定量评价在皮肤病学和医学美容学中受到极大关注 ,是研究皮肤光老化机制和疗效评价的重要手段。

关键词：皮肤表面纹理无创性皮肤轮廓测量技术皮肤衰老整容术激光皮肤轮廓测量技术

黄芪甲苷对人皮肤成纤维细胞增殖和凋亡的影响

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中华医学美学美容杂志 2006年第2期12卷 93-97页

作者：王曦石钰 *** 李利 p.humbert 四川大学华西医院皮肤性病科 Laboratoired Ingenierieet de Biologie Cutanees UFR Medecine Pharmacie25030 BesanconFrance

目的探讨黄芪甲苷对体外培养的有皱纹、无皱纹中老年人皮肤成纤维细胞生物学特性的影响。为黄芪甲苷用于延缓皮肤衰老和皱纹形成提供细胞水平的客观依据,为进一步探讨皮肤衰老机制和开发抗衰老护肤品提供新思路。方法体外培养中年人眼... 详细信息

目的探讨黄芪甲苷对体外培养的有皱纹、无皱纹中老年人皮肤成纤维细胞生物学特性的影响。为黄芪甲苷用于延缓皮肤衰老和皱纹形成提供细胞水平的客观依据,为进一步探讨皮肤衰老机制和开发抗衰老护肤品提供新思路。方法体外培养中年人眼角皱纹与眼角无皱纹皮肤深处成纤维细胞;老年人面颊皮肤成纤维细胞。加入不同浓度的黄芪甲苷,干预24、72、120h后,检测黄芪甲苷对这3例皮肤成纤维细胞系增殖活性、Ⅰ型胶原蛋白、Ⅲ型胶原蛋白、弹性蛋白合成和凋亡率的影响。结果黄芪甲苷在较低浓度(5～20μg/ml)时可促进皱纹和无皱纹皮肤成纤维细胞增殖,促进皱纹、无皱纹和老年皮肤成纤维细胞Ⅰ型胶原蛋白合成,降低皱纹和无皱纹皮肤成纤维细胞凋亡率(p<0.01)。结论黄芪甲苷在较低浓度时具有改善皱纹和非皱纹皮肤成纤维细胞生物学特性的作用。

关键词：黄芪甲苷成纤维细胞细胞培养增殖凋亡