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The local density of H3K9me3 dictates the stability of HP1α condensates-mediated genomic interactions

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Journal of Genetics and Genomics 2023年第10期50卷 776-785页

作者： Ying Feng Li Guo Chen Yang hui zheng Xiao Xiao Hanhui Ma School of Biotechnology East China University of Science and TechnologyShanghai 200237China Gene Editing Center School of Life Science and TechnologyShanghaiTech UniversityShanghai 201210China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

The human genome can be demarcated into domains based on distinct epigenetic *** trimethylation of histone H3 lysine 9(H3K9me3)is essential for the formation of constitutive heterochromatin ***,the extent to which genomic regions require specific densities or degrees of H3K9me3 for stable interactions remains ***,we utilize CRISPR-based DNA imaging to investigate the role of endogenous or ectopic H3K9me3 in chromatin dynamics and genomic *** select three loci(IDR3,TCF3,and PR1)with distinct levels of H3K9me3 to examine the genomic interactions and association with endogenous Heterochromatin Protein 1(HP1α)*** results demonstrate a positive correlation between the levels of H3K9me3 at the loci and their association with HP1α*** dual-color labeling and long-term tracking of IDR3 and PR1 loci,we find a periodical association between the two ranging from one to three *** perturbation-induced Genome organization(EpiGo)-KRAB introduces∼20 kilobases of H3K9me3 at the TCF3 locus,which is sufficient to establish a stable association between TCF3 and HP1α*** addition,EpiGo-mediated H3K9me3 also leads to stable genomic interaction between IDR3 and ***,these data suggest that the density of H3K9me3 could dictate the stability of interactions between genomic loci and HP1αcondensates.

关键词： H3K9me3 HP1α Chromatin dynamics Genomic interaction Epigenetic perturbation

Probing intermolecular interactions of ZnO-nanoparticle-reinforced molten energetic material

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Rare Metals 2022年第9期41卷 3180-3185页

作者： Qing Ma Shu-Ming Wang Mao-Ping Wen Bao-hui zheng Heng-Jian Huang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang621900China Analysis and Testing Center Southwest University of Science and TechnologyMianyang621900China

In this work,metal oxide nanoparticle ZnO was employed for the reinforcement of *** electronic microscopy(SEM)was used to study the microstructure on the fractured surface of TNT/nano-ZnO,and ultraviolet-visible(UV-Vis)spectroscopy was utilized for structure ***,to understand the reinforcing mechanism between ZnO and TNT,quantum chemistry and molecular dynamics simulation were undertaken to investigate the intermolecular interaction and mechanical *** is concluded that with 2.85 wt%ZnO nanoparticle addition,the amount of voids and defects decreases with the increase in bulk and shear *** modified TNT/ZnO composite has high heat of formation,negative oxygen balance,and good detonation properties,which is expected to be a candidate for high-energy blended explosives.

关键词： 2 4 6-Trinitrotoluene Zinc oxide Intermolecular interaction Molecular dynamics simulation

Multiple-Stage Mineralization in the Huayangchuan U-REE-Mo-Cu-Fe Ore Belt of the Qinling Orogen,Central China:Geological and Re-Os Geochronological Constraints

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Journal of Earth Science 2022年第1期33卷 193-204页

作者： Hongjun Jiang Chunsi Yang Dequan Wang hui zheng Jie Li Huayong Chen Key Laboratory of Mineralogy and Metallogeny Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China CAS Center for Excellence in Deep Earth Science Guangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Guangdong Provincial Key Laboratory of Mineral Physics and Materials Guangzhou 510640China State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Geological Party No.214 Sino Shaanxi Nuclear Industry GroupXi'an 710100China Sino Shaanxi Nuclear Industry Group Xi'an 710100China

The Huayangchuan ore belt is located in the western segment of Xiaoqinling Orogen in the southern margin of the North China Craton(NCC),and hosts voluminous magmatism and significant U-REE-Mo-Cu-Fe polymetallic ***,geochronological framework of the various mineralization phases in this region is poorly ***,we present new Re-Os isochron ages on magnetite from the Caotan Fe deposit(2 675 ± 410 Ma,MSWD = 0.55),and on pyrite from the Jialu REE deposit(2 127 ± 280 Ma,MSWD = 1.9) and Yuejiawa Cu deposit(418 ± 23 Ma,MSWD =11.5),and Re-Os weighted average model age on pyrite from the Taoyuan Mo-U deposit(235 ± 14 Ma,MSWD = 0.17).These ages,combined with regional geology and mineralization ages from other deposits,suggest that mineralization in the Huayangchuan ore belt lasted from the Neoarchean to the Late *** mineralization corresponds to regional tectono-magmatic events,including the Neoarchean alkali magmatism(REE mineralization),Paleoproterozoic plagioclase-amphibolite emplacement(Fe mineralization),Paleoproterozoic pegmatite magmatism(U mineralization),Paleozoic Shangdan oceanic slab subduction-related arc magmatism(Cu mineralization),Early Mesozoic Paleo-Tethys Ocean subduction-related arc magmatism(Mo-U mineralization),and Late Mesozoic Paleo-Pacific oceanic plate subduction direction change-related Mo(-Pb) *** proposed that the Huayangchuan ore belt has undergone prolonged metallogenic evolution,and the magmatism and associated mineralization were controlled by regional geodynamic events.

关键词： Re-Os dating U-REE-Mo-Cu-Fe mineralization Huayangchuan ore belt extra-long metallogenic history Qinling Orogen geochemistry

Evaluation of the Community Microwave Emission Model Coupled with the Community Land Model over East Asia

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Atmospheric and Oceanic Science Letters 2011年第4期4卷 209-215页

作者： JIA Bing-Hao XIE zheng-hui State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

The Community Microwave Emission Model (CMEM) developed by the European Centre for Me-dium-Range Weather Forecasts (ECMWF) can provide a link between surface states and satellite observations and simulate the passive microwave brightness temperature of the surface at low frequencies (from 1 GHz to 20 GHz).This study evaluated the performance of the CMEM cou-pled with the Community Land Model (CLM) (CMEM-CLM) using C-band (6.9 GHz) microwave brightness temperatures from the Advanced Microwave Scanning Radiometer on Earth Observing System (AMSR-E) over East *** results support the argument that the simulated brightness temperatures of CMEM-CLM from July 2005 to June 2010 are comparable to AMSR-E observational ***-CLM performed better for vertical polarization,for which the root mean square error was approximately 15 K,compared to over 30 K for horizontal *** evaluation performed over seven sub-regions in China indicated that CMEM-CLM was able to capture the temporal evolution of C-band brightness temperatures well,and the best correlation with AMSR-E appeared over western Northwest China (over 0.9 for vertical polarization).However,larger biases were found over southern North China and the middle and lower reaches of the Yangtze River.

关键词： Community Microwave Emission Model Community Land Model microwave brightness temperature AMSR-E

Synthesis and biological evaluation of novel triazole derivatives as antifungal agents

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Chinese Chemical Letters 2013年第3期24卷 219-222页

作者： hui Tang Can-hui zheng Xiao-hui Ren Jia Liu Na Liu Jia-Guo Lv Ju Zhu You-Jun Zhou Pharmacy Provincial Hospital Affiliated to Shandong University School of Pharmacy Second Military Medical University

A series of 1-（benzylamino）-2-（2,4-difiuorophenyl）-3-（lH-1,2,4-triazol-l-yl）propan-2-ols compounds were synthesized and evaluated for their antifungal activities in vitro. The results showed that compounds 6A and 6B exhibited good antifungal activity. Compound 6tt8 showed the strongest antifungal activity, which was significantly higher than that of the lead compounds and positive-control drugs Fluconazole and Itraconazole. In particular, the antifungal activity of compound 6/18 against Candida albicans and Candida krusei （MIC80 both at 0.00097 p.g/mL） was 515 and 64 times that of Fluconazole, respectively. The structure-activity relationships of the synthesized compounds were discussed, and the docking model of the target compounds with fungal lanosterol 14a-demethylase （CYP51） was analyzed.

关键词： TriazoleAntifungalStructure-activity relationshipCYP51

Decomposition reaction of phosphate rock under the action of microwave plasma

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Chinese Physics B 2021年第4期30卷 361-368页

作者： hui zheng Meng Yang Cheng-Fa Jiang Dai-Jun Liu Department of Chemical Engineering Sichuan UniversityChengdu 610065China

The decomposition reaction of phosphate rock under the action of microwave plasma was *** rock and its decomposition products were characterized by x-ray diffraction(XRD),energy disperse spectroscopy(EDS),and chemical *** measurements of electron temperature(T_(e)) and electron density(N_(e)) of plasma plume under atmospheric pressure were carried out using optical emission spectroscopy(OES).The electron temperature(T_(e)) was determined based on the calculation of the relative intensity of the O Ⅱ(301.91 nm) and O Ⅱ(347.49 nm) spectral ***,electron densities were obtained using the Saha ionization equation which was based on the C Ⅰ(247.86 nm) line and the C Ⅱ(296.62 nm) line under the assumption of local thermodynamic equilibrium(LTE).The relationship between the relative intensity of the active components and the gas output was studied by the *** the reaction mechanism of the decomposition of the phosphate rock under the action of the atmospheric pressure microwave plasma was *** results showed that with the increase of CO flow and microwave power,the electron temperature and electron density in the plasma show a decreasing and increasing *** CO is dissociated into gaseous carbon ions under the action of microwave plasma,and the presence of gaseous carbon ions promotes the decomposition of the phosphate rock.

关键词： microwave plasma phosphorus decomposition optical emission spectroscopy reaction mechanism

Effect of early stepwise cardiopulmonary rehabilitation on function and quality of life in sepsis patients

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World Journal of Clinical Cases 2024年第4期12卷 729-736页

作者： Ming-hui zheng Wen-Jun Liu Juan Yang Division of Cardiovascular First Ward Departments of Internal Medicine Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077Hubei ProvinceChina Department of Respiratory Medicine PuRen Hospital Affiliated to Wuhan University of Science and Technology/Respiratory MedicineWuhan 430000Hubei ProvinceChina Department of Cardiology Huanggang Central HospitalHuanggang 438000Hubei ProvinceChina

BACKGROUND Sepsis,as a non-limiting host infection disease,can be accompanied by serious complications such as organ failure,which seriously threatens patient quality of *** To investigate the effect of early stepwise cardiopulmonary rehabilitation on cardiopulmonary function and quality of life in patients evacuated from mechanical ventilation with *** A total of 80 patients with sepsis who were hospitalized in our hospital from January 2021 to January 2022 were selected and divided into the observation group(n=40)and the control group(n=40)according to the random number table *** observation group was treated with early stepwise cardiopulmonary rehabilitation,and the control group was treated with a conventional treatment *** function indexes(central venous pressure,cardiac troponin I,B-type brain natriuretic peptide),lung function indicators(diaphragmatic mobility,changes in central venous oxygen saturation,oxygenation index),and quality of life(Quality of Life Evaluation Scale)were compared between the two groups after *** After treatment,the central venous pressure,diaphragm mobility,central venous oxygen saturation,oxygenation index,and Quality of Life Evaluation Scale scores in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The observation group was less than that of the control group for other parameters,and the differences were statistically significant(P<0.05).CONCLUSION Early stepwise cardiopulmonary rehabilitation can effectively enhance cardiac and pulmonary function and improve the quality of life in patients evacuated from mechanical ventilation with sepsis.

关键词： Stepwise cardiopulmonary rehabilitation Sepsis Evacuation of mechanical ventilation Cardiopulmonary function Quality of life

Assimilating the LAI Data to the VEGAS Model Using the Local Ensemble Transform Kalman Filter: An Observing System Simulation Experiment

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Atmospheric and Oceanic Science Letters 2014年第4期7卷 314-319页

作者： JIA Bing-Hao Ning ZENG XIE zheng-hui State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG) Institute of Atmospheric Physics Chinese Academy of Sciences Department of Atmospheric and Oceanic Science & Earth System Science Interdisciplinary Center University of Maryland College Park

Information on the spatial and temporal patterns of surface carbon flux is crucial to understanding of source/sink mechanisms and projection of future atmospheric CO2 concentrations and climate. This study presents the construction and implementation of a terrestrial carbon cycle data assimilation system based on a dynamic vegetation and terrestrial carbon model Vegetation-Global-Atmosphere-Soil(VEGAS) with an advanced assimilation algorithm, the local ensemble transform Kalman filter(LETKF, hereafter LETKF-VEGAS). An observing system simulation experiment(OSSE) framework was designed to evaluate the reliability of this system, and numerical experiments conducted by the OSSE using leaf area index(LAI) observations suggest that the LETKF-VEGAS can improve the estimations of leaf carbon pool and LAI significantly, with reduced root mean square errors and increased correlation coefficients with true values, as compared to a control run without assimilation. Furthermore, the LETKF-VEGAS has the potential to provide more accurate estimations of the net primary productivity(NPP) and carbon flux to atmosphere(CFta).

关键词： carbon cycle data assimilation VEGAS,land-atmosphere CO2 flux LETKF OSSE

Excellent Hydrophilic and Anti-bacterial Fouling PVDF Membrane Based on Ag Nanoparticle Self-assembled PCBMA Polymer Brush

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Chinese Journal of Polymer Science 2017年第7期35卷 809-822页

作者：李建华 De-bin Zhang Xing-xing Ni hui zheng 张其清 Institute of Biomedical and Pharmaceutical Technology Fuzhou University Fuzhou 350001 China

A silver nanoparticles-poly（carboxybetaine methacrylate）（AgNPs-PCBMA） nanocomposite was prepared on poly（vinylidene fluoride）（PVDF） membrane surface to improve its hydrophilicity and antifouling properties. Firstly, the PVDF membranes were grafted by PCBMA via physisorbed free radical grafting technique. Then Ag＋ coordinated to the carbonyl group on PCBMA and subsequently was reduced to silver nanoparticles. The hydrophilicity of the PVDF-g- PCBMA/Ag membrane was enhanced with the increasing fixed degree （FD） of AgNPs, and the original water contact angle of membrane was reduced to 33.97°. Additionally, water flux recovery ratio （FRR） and bovine serum albumin （BSA） rejection ratio of PVDF-g-PCBMA/AgNPs membrane were improved from 52% to 93.32% and 28.12% to 91.12%, respectively. Further, the PVDF-g-PCBMA/AgNPs membranes exhibited the more pronounced inhibition zone. The study demonstrated that compared with pure AgNPs or the PCBMA polymer brush, the synergistic effect of PCBMA and AgNPs made PVDF membranes have better hydrophilicity and anti-bacterial performances.

关键词： PVDF membrane Zwitterionic monomer CBMA Silver nanoparticle Antifouling performance Antibacterialability