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Molecular characteristics and stages of chronic hepatitis B virus infection

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World Journal of Gastroenterology 2009年第25期15卷 3099-3105页

作者： ying-hui Shi Chang-He Shi Department of Microbiology Centers for Disease Control and Prevention of Qingdao Qingdao 266034 Shandong Province China Department of Hepatitis Qingdao Infectious Disease Hospital Qingdao 266033 Shandong Province China

Hepatitis B virus (HBV) is a common viral pathogen that causes a substantial health burden worldwide. Remarkable progress has been made in our understanding of the natural stages of chronic HBV infection. A dynamic balance between viral replication and host immune response is pivotal to the pathogenesis of liver disease. Knowledge of the HBV genome organization and replication cycle can unravel HBV genotypes and molecular variants, which contribute to the heterogeneity in outcome of chronic HBV infection. Most HBV infections are spontaneously resolved in immunocompetent adults, whereas they become chronic in most neonates and infants at a great risk of developing complications such as cirrhosis and hepatocellular carcinoma (HCC). Those with chronic HBV infection may present in one of the four phases of infection: immune tolerance, immune clearance [hepatitis B eantigen (HBeAg)-positive chronic hepatitis B (CHB)], inactive carrier state, and reactivation (HBeAg-negative CHB). Understanding the dynamic nature of chronic HBV infection is crucial in the management of HBV carriers. Long-term monitoring and optimal timing of antiviral therapy for chronic HBV infection help to prevent progression of HBV-related liver disease to its later stage, particularly in patients with higher risk markers of HCC, such as serum DNA concentration, HBeAg status, serum aminotransferase, HBV genotypes, and pre-core or core mutants.

关键词： Hepatitis B virus Pathology Immune tolerance Immune clearance Inactive hepatitis B surface antigen carriers Reactivation T-cell response Cytokines

Distribution and changes in hepatitis C virus genotype in China from 2010 to 2020

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World Journal of Clinical Cases 2022年第14期10卷 4480-4493页

作者： Jia Yang hui-Xin Liu ying-ying Su Zhi-Sheng Liang hui-ying Rao Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesPeking University People’s HospitalBeijing 100044China Department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijing 100044China National Institute of Diagnostics and Vaccine Development in Infectious Diseases School of Public HealthXiamen UniversityXiamen 361000Fujian ProvinceChina Department of Global Health School of Public HealthPeking UniversityBeijing 100044China

BACKGROUND Hepatitis C virus(HCV)causes a large number of infections *** infections seem to be increasing according to a report of the World Health Organization in *** direct-acting antivirals are quite effective for most genotypes of the HCV,some genotypes fail to ***,the trend of genotype distribution is vital to better control the development of this *** To analyze the distribution and trends of the HCV genotype before and after the emergence of direct-acting antivirals in *** We searched all literature published in five electronic databases-China National Knowledge Infrastructure,Wan Fang Data,VIP Chinese Journal Database,Chinese Biomedical Literature Service System,and PubMed-from January 1,2010 to December 31,*** search strategy combined medical subject headings and free-text terms,including“hepatitis C virus”or“HCV”and“genotype”or“subtype”and“China”or“Chinese”.Additional relevant articles were searched by manual *** were extracted to build a *** of the data were totaled according to regions,periods,routes of transmission,and *** percentages in various stratifications were *** There were 76110 samples from 30 provinces included in the *** 1(G1)accounted for 58.2%of cases nationwide,followed by G2,G6,G3b,G3a,unclassified and mixed infections(17.5%,7.8%,6.4%,4.9%,1.8%,and 1.2%,respectively).The constitution of genotype varied among different regions,with G6 and G3b being more common in the south and southwest,respectively(28.1%,15.4%).The past ten years have witnessed a decrease in G1 and G2 and an increase in G3 and G6 in almost all *** drug-use population had the most abundant genotypes,with G6 ranking first(33.3%),followed by G1 and G3b(23.4%,18.5%).CONCLUSION G3 and G6 pose a new challenge for HCV *** study revealed the distribution of HCV genotypes in China over the past 10 years,providing information for HCV management strategie

关键词： Hepacivirus Genotype China Drug users Direct-acting antiviral Hepatitis C virus

The Lie Group and Integrability of the Fisher Type Travelling Wave Equation

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Acta Mathematicae Applicatae Sinica 2009年第2期25卷 305-320页

作者： Ming-hui Liu Ke-ying Guan Department of Mathematics Beijing Jiaotong University Beijing 100044 China

For the Fisher-type wave equation, which has two stable states and one unstable state, it is proved that only in two particular cases, the corresponding travelling wave equation admits a double parameter Lie group, and based on a method different to the traditional one, its two independent first integrals are given. It is proved further that in the two integrable cases, the different bounded and non-trivial travelling wave solutions, which are corresponding the invariant manifolds of the corresponding equation under the Lie transformation, can be expressed with elementary functions although they cannot be obtained directly from the two independent first integrals.

关键词： Fisher type wave equation travelling wave Lie group first integral invariant manifold

The Recursive Solution for Geom/G/1(E,SV) Queue with Feedback and Single Server Vacation

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Acta Mathematicae Applicatae Sinica 2011年第1期27卷 155-166页

作者： Chuan-yi Lu ying-hui Tang School of Economic Mathematics Southwestern University of Finance and Economics Chengdu 610074 China School of Mathematics and Software Science Sichuan Normal University Chengdu 610066 China

Using recursive method, this paper studies the queue size properties at any epoch n＋ in Geom/G/ I（E, SV） queueing model with feedback under LASDA （late arrival system with delayed access） setup. Some new results about the recursive expressions of queue size distribution at different epoch （n＋, n, n-） are obtained. Furthermore the important relations between stationary queue size distribution at different epochs are discovered. The results are different from the relations given in M/G/1 queueing system. The model discussed in this paper can be widely applied in many kinds of communications and computer network.

关键词： Discrete time queue feedback single server vacation recursive expression

Degradation of 2,4-dichlorophenoxyacetic acid in water by ozonehydrogen peroxide process

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Journal of Environmental Sciences 2006年第6期18卷 1043-1049页

作者： YU ying-hui MA Jun HOU Yan-jun School of Municipal and Environmental Engineering Harbin Institute of Technology P.O. Box 2627 Harbin 150090 China

This study reports an investigation into the degradation of 2,4-dichlorophenoxyacetic acid in bubble contactor column by O2/H2O2 process, which is widely used as a principal advanced oxidation process. The degradation of 2,4-dichlorophenoxyacetic acid was studied under different H202/O3 molar ratio and pH value. Meanwhile, TOC removal was investigated both in distilled water and tap water. The influences of ozone transfer and consumed hydrogen peroxide were also discussed. The degradation products and oxidation intermediates were identified by GC-MS and LC-MS. A possible reaction mechanism was thus proposed.

关键词： 2,4-dichlorophenoxyacetic acid ozone hydrogen peroxide advanced oxidation process

MgN_(4)掺杂石墨烯CO氧化催化活性的密度泛函研究

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原子与分子物理学报 2025年第2期42卷 57-62页

作者：袁利郑灵丹周慧颖徐先燕广州医科大学公共卫生学院广州511436 韶关学院化学与土木工程学院韶关512005

鉴于镁卟啉所呈现的催化活性,采用密度泛函理论考察了MgN_(4)结构掺杂石墨烯的CO氧化催化活性.研究发现MgN_(4)掺杂石墨烯具有良好的结构稳定性,O_(2)优先吸附在金属活性位点且不易解离.其CO氧化以Eley-Rideal(ER)机理实现,决速步能垒仅... 详细信息

鉴于镁卟啉所呈现的催化活性,采用密度泛函理论考察了MgN_(4)结构掺杂石墨烯的CO氧化催化活性.研究发现MgN_(4)掺杂石墨烯具有良好的结构稳定性,O_(2)优先吸附在金属活性位点且不易解离.其CO氧化以Eley-Rideal(ER)机理实现,决速步能垒仅为0.67 eV,与FeC_(3)、AlN_(4)掺杂石墨烯具有相当的催化活性.MgN_(4)掺杂石墨烯有望是一种具有潜在CO氧化催化活性的催化剂.

关键词： MgN_(4)掺杂石墨烯 CO氧化密度泛函理论

Bifurcations and Chaos in a Nonlinear Discrete Time Cournot Duopoly Game

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Acta Mathematicae Applicatae Sinica 2014年第4期30卷 951-964页

作者： ying-hui GAO Bing LIU Wei FENG School of Mathematics and System Sciences Beihang UniversityLMIB of the Ministry of Education Department of Mathematics Anshan Normal University

A nonlinear discrete time Cournot duopoly game is investigated in this paper. The conditions of existence for saddle-node bifurcation, transcritical bifurcation and flip bifurcation are derived using the center manifold theorem and the bifurcation theory. We prove that there exists chaotic behavior in the sense of Marotto＇s definition of chaos. The numerical simulations not only show the consistence with our theoretical analysis, but also exhibit the complex but interesting dynamical behaviors of the model. The computation of maximum Lyapunov exponents confirms the theoretical analysis of the dynamical behaviors of the system.

关键词： discrete Cournot duopoly game bifurcation Marotto chaos

Optimal investment based on relative performance and weighted utility

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 328-342页

作者： WANG Lei DONG ying-hui HUA Chun-rong Department of Mathematics Suzhou University of Science and TechnologySuzhou 215009China Changshu Institute of Technology Changshu 215500China

This paper studies the optimal portfolio allocation of a fund manager when he bases decisions on both the absolute level of terminal relative performance and the change value of terminal relative performance comparison to a predefined reference point. We find the optimal investment strategy by maximizing a weighted average utility of a concave utility and an Sshaped utility via a concavification technique and the martingale method. Numerical results are carried out to show the impact of the extent to which the manager pays attention to the change of relative performance related to the reference point on the optimal terminal relative performance.

关键词： relative performance weighted utility S-shaped utility concavification

Accelerating the solving of mechanical equilibrium caused by lattice misfit through deep learning method

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Advances in Manufacturing 2024年第3期12卷 512-521页

作者： Chen-Xi Guo hui-ying Yang Rui-Jie Zhang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083People’s Republic of China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing100083People’s Republic of China

Precipitation is a common phenomenon that occurs during heat *** is internal stress around the precipitate owing to the lattice misfit between the precipitate and *** internal stress has a significant influence not only on the precipitation kinetics but also on the material *** misfit stress can be obtained by numerically solving the mechanical equilibrium ***,this process is complex and *** developed a new approach based on deep learning to accelerate the solution *** training data were first generated by a phase-field model coupled with elastic mechanical equilibrium equations,which were solved using the finite difference *** obtained precipitate morphologies and corresponding stress distributions were input data for training the physics-informed(PI)UNet *** well-trained PI-UNet model can then be applied to predicting stress distributions with the precipitate morphology as the *** accuracy and efficiency are discussed in this *** results showed that the PI-UNet model was an appropriate approach for quickly predicting the misfit stress between the precipitate and matrix.

关键词： Precipitate Mechanical equilibrium Heat treatment Deep learning