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Associative Tasks Computing Offloading Scheme in Internet of Medical Things with Deep Reinforcement Learning

China Communications 2024年第4期21卷 38-52页

作者： Jiang Fan Qin Junwei Liu Lei tian hui School of Communications and Information Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China

The Internet of Medical Things(Io MT) is regarded as a critical technology for intelligent healthcare in the foreseeable 6G era. Nevertheless, due to the limited computing power capability of edge devices and task-related coupling relationships, Io MT faces unprecedented challenges. Considering the associative connections among tasks, this paper proposes a computing offloading policy for multiple-user devices(UDs) considering device-to-device(D2D) communication and a multi-access edge computing(MEC)technique under the scenario of Io MT. Specifically,to minimize the total delay and energy consumption concerning the requirement of Io MT, we first analyze and model the detailed local execution, MEC execution, D2D execution, and associated tasks offloading exchange model. Consequently, the associated tasks’ offloading scheme of multi-UDs is formulated as a mixed-integer nonconvex optimization problem. Considering the advantages of deep reinforcement learning(DRL) in processing tasks related to coupling relationships, a Double DQN based associative tasks computing offloading(DDATO) algorithm is then proposed to obtain the optimal solution, which can make the best offloading decision under the condition that tasks of UDs are associative. Furthermore, to reduce the complexity of the DDATO algorithm, the cacheaided procedure is intentionally introduced before the data training process. This avoids redundant offloading and computing procedures concerning tasks that previously have already been cached by other UDs. In addition, we use a dynamic ε-greedy strategy in the action selection section of the algorithm, thus preventing the algorithm from falling into a locally optimal solution. Simulation results demonstrate that compared with other existing methods for associative task models concerning different structures in the Io MT network, the proposed algorithm can lower the total cost more effectively and efficiently while also providing a tradeoff between delay and energy co

关键词： associative tasks cache-aided procedure double deep Q-network Internet of Medical Things(IoMT) multi-access edge computing(MEC)

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TSPO deficiency exacerbates acute lung injury via NLRP3 inflammasome-mediated pyroptosis

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Chinese Medical Journal 2024年第13期137卷 1592-1602页

作者： Jingyi Han Xue Zhang Menghua Cai Feng tian Yi Xu hui Chen Wei He Jianmin Zhang hui tian Department of Thoracic Surgery Qilu Hospital of Shandong UniversityJinanShandong 250012China CAMS Key Laboratory of T Cell and Immunotherapy Department of ImmunologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeState Key Laboratory of Medical Molecular BiologyBeijing 100005China Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy ChangzhouJiangsu 213000China Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China

Background:Acute respiratory distress syndrome(ARDS)is a common cause of respiratory failure in many critically ill *** inflammasome activation plays an important role in the induction of acute lung injury(ALI)and ARDS,the regulatory mechanism of this process is still *** cells are stimulated by inflammation,the integrity and physiological function of mitochondria play a crucial part in ***,the underlying mechanisms and function of mitochondrial proteins in the process of pyroptosis are largely not yet ***,we identified the 18-kDa translocator protein(TSPO),a mitochondrial outer membrane protein,as an important mediator regulating nucleotide-binding domain,leucine-rich repeat,and pyrin domain-containing protein 3(NLRP3)inflammasome activation in macrophages during ***:TSPO gene knockout(KO)and lipopolysaccharide(LPS)-induced ALI/ARDS mouse models were employed to investigate the biological role of TSPO in the pathogenesis of *** macrophages were used to further characterize the effect of TSPO on the NLRP3 inflammasome *** of NLRP3 inflammasome was preformed through LPS+adenosine triphosphate(ATP)co-stimulation,followed by detection of mitochondrial membrane potential,reactive oxygen species(ROS)production,and cell death to evaluate the potential biological function of *** between two groups were performed with a two-sided unpaired ***:TSPO-KO mice exhibited more severe pulmonary inflammation in response to LPS-induced *** deficiency resulted in enhanced activation of the NLRP3 inflammasome pathway,promoting more proinflammatory cytokine production of macrophages in LPS-injured lung tissue,including interleukin(IL)-1β,IL-18,and macrophage inflammatory protein(MIP)-*** in TSPO-KO macrophages tended to depolarize in response to cellular *** increased production of mitochondrial damage-associated molecular pattern led to enhanced mitochondrial membr

关键词： Acute respiratory distress syndrome Acute lung injury 18-kDa translocator protein Macrophage NLRP3 inflammasome Inflammation

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Numerical and experimental research on axial injection end-burning hybrid rocket motors with polyethylene fuel

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Chinese Journal of Aeronautics 2024年第8期37卷 91-105页

作者： Xiangyu MENG hui tian Lingfei HE Jingfei GAO Xiaoting NIU Guobiao CAI School of Astronautics Beihang UniversityBeijing 100191China Key Laboratory of Spacecraft Design Optimization&Dynamic Simulation Technologies Ministry of EducationBeijing 100816China

This study investigates the end-burning hybrid rocket motors with polyethylene fuel by the numerical simulation and *** on computational fluid dynamics,a numerical model is *** model is validated by two firing tests in this hybrid rocket motor,which uses oxygen and polyethylene as *** results show that the numerical and experimental data are in good agreement,and the error of the chamber pressure is less than 2.63%.Based on the simulation mode,the blowoff limit of the end-burning hybrid rocket motors is *** the nozzle throat diameter and the inner diameter of grain are large,it is more difficult for the hybrid rocket motor to achieve end-burning mode,i.e.,the flame spreading is prevented in the narrow *** main reason is that when the nozzle throat and the grain port are large,chamber pressure and oxidizer flow velocity are ***,the friction velocity considering the pressure and flow velocity is *** critical friction velocity is about 4.054–4.890 m/s in the hybrid rocket *** the friction velocity exceeds the critical friction velocity,the combustion mode in hybrid rocket motors changes from the flame spreading mode to the end-burning ***,the regression rate formula is obtained by fitting,which shows that the regression rate has a good correlation with combustion chamber *** critical friction velocity and regression rate formula can provide an important reference for end-burning hybrid rocket motors.

关键词： Hybrid rocket motor End burning Blowoff limit Flame propagation Regression rate

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Regio-and Stereoselective Polymerization of Bio-based Ocimene by Rare-Earth Metal Catalysts

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Chinese Journal of Polymer Science 2024年第2期42卷 223-229,I0008页

作者： Qi-Yuan Wang Li-Peng Sang Zhen Zhang Yang Jiang hui tian Xia Zhao Xiang Guo Shi-hui Li State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechonologyXiangyang441003China Shanxi Coal Chemical Industry Technology Research Institute Xi’an710000China Hubei Institute of Aerospace Chemotechonology Xiangyang441003China

Coordination polymerization of renewable β-ocimene has been investigated using asymmetric diiminophosphinate lutetium complex1, β-diketiminate yttrium complex 2, bis(phosphino)carbazolide yttrium complex 3, half-sandwich benzyl fluorenyl scandium complex 4 and pyridyl-methylene-fluorenyl rare-metal complexes 5a–5c. Complexes 1, 4 and 5a–5c show trans-1,2-regioselectivities and high activities, of which 5c exhibits excellent isoselectivity(mmmm>99%). Conversely, complexes 2 and 3 promote β-ocimene polymerization to produce isotactic cis-1,4-polyocimenes(cis-1,4>99%, mm>95%). Diblock copolymers cis-1,4-PIP-block-cis-1,4-POc and cis-1,4-PBD-block-cis-1,4-POc are obtained in one-pot reactions of β-ocimene with isoprene and butadiene using complex 3. Epoxidation and hydroxylation of polyocimene afford functionalized polyolefins with enhanced T_(g)(from-20 ℃ to 79 ℃ and 74 ℃) and hydrophilicity.

关键词： Biobased monomer Terpenes Ocimene Rare-earths Polymerization Regio/stereoselectivity Elastomer

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Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling

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Journal of Integrative Medicine 2024年第1期22卷 83-92页

作者： Lu-lu Han Xin Zhang hui Zhang Ting Li Yi-chen Zhao Ming-hui tian Feng-lei Sun Bo Feng Department of Neurology Three The Fifth People’s Hospital of JinanJinan 250013Shandong ProvinceChina Department of Gastroenterology Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina The First Clinical Medical College Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of Geriatrics the First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital)Jinan 250014Shandong ProvinceChina Chinese Medicine Culture and Literature Research Institute Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of General Medicine Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of Traditional Chinese Medicine the Second People’s Hospital of Haibei PrefectureZangzu Autonomous Prefecture of Haibei810300Qinghai ProvinceChina

Objective Obesity is a global health concern with management strategies encompassing bariatric surgery and anti-obesity drugs;however,concerns regarding complexities and side effects persist,driving research for more effective,low-risk *** promotion of white adipose tissue(WAT)browning has emerged as a promising ***,alisol B 23-acetate(AB23A)has demonstrated efficacy in addressing metabolic disorders,suggesting its potential as a therapeutic agent in obesity ***,in this study,we aimed to investigate the therapeutic potential of AB23A for mitigating obesity by regulating metabolic phenotypes and lipid distribution in mice fed a high-fat diet(HFD).Methods An obesity mouse model was established by administration of an *** and insulin metabolism were assessed via glucose and insulin tolerance *** size was determined using hematoxylin and eosin *** expression of browning markers in WAT was evaluated using Western blotting and quantitative real-time polymerase chain *** cage monitoring involved the assessment of various parameters,including food and water intake,energy metabolism,respiratory exchange rates,and physical ***,oil red O staining was used to evaluate intracellular lipid accumulation.A bioinformatic analysis tool for identifying the molecular mechanisms of traditional Chinese medicine was used to examine AB23A targets and associated signaling *** AB23A administration significantly reduced the weight of obese mice,decreased the mass of inguinal WAT,epididymal WAT,and perirenal adipose tissue,improved glucose and insulin metabolism,and reduced adipocyte ***,treatment with AB23A promoted the expression of browning markers in WAT,enhanced overall energy metabolism in mice,and had no discernible effect on food intake,water consumption,or physical *** 3T3-L1 cells,AB23A inhibited lipid accumulation,and both AB23A and rapamycin inhibited t

关键词： Obesity Alisol B 23-acetate Adipose tissue mTOR-SREBP1 High-fat diet

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Pre-operative enhanced magnetic resonance imaging combined with clinical features predict early recurrence of hepatocellular carcinoma after radical resection

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1192-1203页

作者： Jian-Ping Chen Ri-hui Yang tian-hui Zhang Li-An Liao Yu-Ting Guan Hai-Yang Dai Department of Intervention Meizhou People’s HospitalMeizhou 514031Guangdong ProvinceChina Department of Medical Imaging Meizhou People’s HospitalMeizhou 514031Guangdong ProvinceChina Department of Medical Imaging Huizhou Municipal Central HospitalHuizhou 516001Guangdong ProvinceChina

BACKGROUND Indentifying predictive factors for postoperative recurrence of hepatocellular carcinoma(HCC)has great significance for patient *** To explore the value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)enhanced magnetic resonance imaging(MRI)combined with clinical features in predicting early recurrence of HCC after *** A total of 161 patients with pathologically confirmed HCC were *** patients were divided into early recurrence and non-early recurrence group based on the follow-up *** clinical,laboratory,pathological results and Gd-EOB-DTPA enhanced MRI imaging features were *** Of 161 patients,73 had early recurrence and 88 were had non-early *** analysis showed that patient age,gender,serum alpha-fetoprotein level,the Barcelona Clinic Liver Cancer stage,China liver cancer(CNLC)stage,microvascular invasion(MVI),pathological satellite focus,tumor size,tumor number,tumor boundary,tumor capsule,intratumoral necrosis,portal vein tumor thrombus,large vessel invasion,nonperipheral washout,peritumoral enhancement,hepatobiliary phase(HBP)/tumor signal intensity(SI)/peritumoral SI,HBP peritumoral low signal and peritumoral delay enhancement were significantly associated with early recurrence of HCC after *** logistic regression analysis showed that patient age,MVI,CNLC stage,tumor boundary and large vessel invasion were independent predictive *** data validation indicated that the area under the curve of the combined predictors was 0.861,suggesting that multivariate logistic regression was a reasonable predictive model for early recurrence of *** Gd-EOB-DTPA enhanced MRI combined with clinical features would help predicting the early recurrence of HCC after operation.

关键词： Hepatocellular carcinoma Enhanced magnetic resonance imaging Microvascular invasion Hepatobiliary phase Recurrence

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An Experimental Study on the Effect of a Nanofluid on Oil-Water Relative Permeability

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Fluid Dynamics & Materials Processing 2024年第6期20卷 1265-1277页

作者： hui tian Dandan Zhao Yannan Wu Xingyu Yi Jun Ma Xiang Zhou Baikouquan Oil Production Plant PetroChina Xinjiang Oilfield CompanyKaramay834000China Research Institute of Petroleum Exploration Development PetroChina Liaohe OilfieldPanjin124010China Petroleum Engineering School Southwest Petroleum UniversityChengdu610500China Oil and Gas Development Haosheng Xincheng Energy TechnologyLtd.of SicuanChengdu610213China

The low porosity and low permeability of tight oil reservoirs call for improvements in the current technologies for oil *** chemical solutions with large molecular size cannot effectively flow through the nanopores of the *** this study,the feasibility of Nanofluids has been investigated using a high pressure high temperature core-holder and nuclear magnetic resonance(NMR).The results of the experiments indicate that the specified Nanofluids can enhance the tight oil recovery *** water and oil relative permeability curve shifts to the high water saturation side after Nanofluid flooding,thereby demonstrating an increase in the water wettability of the *** the Nanofluid flooding process the oil recovery was enhanced by 15.1%,compared to waterflooding *** T2 spectra using the NMR show that after Nanofluid flooding,a 7.18%increment in oil recovery factor was gained in the small pores,a 4.9%increase in the middle pores,and a 0.29%increase in the large *** results confirm that the Nanofluids can improve the flow state in micro-sized pores inside the core and increase the ultimate oil recovery factor.

关键词： Tight oil reservoir nanofluid relative permeability nuclear magnetic resonance T2 spectrum

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Tuning the membrane rejection behavior by surface wettability engineering for an effective water-in-oil emulsion separation

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Chinese Chemical Letters 2024年第6期35卷 480-485页

作者： Yan Zou Yin-Shuang Hu Deng-hui tian Hong Wu Xiaoshu Lv Guangming Jiang Yu-Xi Huang Engineering Research Center for Waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Technology and Business UniversityChongqing 400067China School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology(Sun Yat-sen University) Guangzhou 510275China

Membrane-based separation is a promising technology to eliminate water impurities from the oil ***,it remains a great challenge to separate water from highly emulsified viscous oil owing to the high stability of the water droplets in *** we report a surface wettability engineering on an alumina ceramic membrane to achieve an efficient separation of a water-in-oil(W/O)*** with different carbon chain lengths and fluorinated status were introduced to endow the alumina membrane with different surface *** all the modified membranes exhibited excellent separation of the W/O without Span 80(surfactant),the one with amphiphobic wettability and lowest surface energy failed to separate the Span 80 stabilized W/*** presence of Span 80 reduced the interfacial tension of water droplets,making them easier to deform and penetrate the modified membrane with the lowest surface *** reveals that engineering proper surface wettability is the key to separating the oil and water ***,the modified membranes maintained decent separation performance and stability under long-term run separation of the emulsified W/O.

关键词： Water-in-oil emulsion Ceramic membrane Membrane separation Surface wettability

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Dual-curvilinear beam enabled tunable manipulation of high-and low-refractive-index particles

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Photonics Research 2024年第7期12卷 1427-1436页

作者： ZHENG YUAN CHENCHEN ZHANG YUAN GAO WENXIANG YAN XIAN LONG ZHI-CHENG REN XI-LIN WANG JIANPING DING hui-tian WANG National Laboratory of Solid State Microstructures and School of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Collaborative Innovation Center of Solid-State Lighting and Energy-Saving Electronics Nanjing 210093China

We present an innovative approach for the simultaneous agile manipulation of high-refractive-index(HRI) and low-refractive-index(LRI) particles. Our method involves introducing a dual-curvilinear optical vortex beam(DC-OVB) generated by superimposing a pair of curved beams: HRI and LRI particles are controlled by the bright curve and the dark channel between the two curves, respectively. The proposed DC-OVB provides customizable motion paths and velocities for both LRI and HRI particles. Each curve of the DC-OVB can support a distinct orbital flow density(OFD), enabling the application of torques to HRI and LRI particles, guiding them to orbit along specified trajectories and prompting them to execute various curvilinear motions simultaneously,including curvilinear movement, revolution, and rotation.

关键词： tunable refractive beam

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Iso-propagation vortices with OAM-independent size and divergence toward future faster optical communications

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Advanced Photonics 2024年第3期6卷 51-59页

作者： Wenxiang Yan Zhaozhong Chen Xian Long Yuan Gao Zheng Yuan Zhi-Cheng Ren Xi-Lin Wang Jianping Ding hui-tian Wang Nanjing University School of Physics National Laboratory of Solid State Microstructures Nanjing University Collaborative Innovation Center of Advanced Microstructures University of Glasgow James Watt School of Engineering Nanjing University Collaborative Innovation Center of Solid-State Lighting and Energy-Saving Electronics

Recognized in the 1990s, vortex beams' ability to carry orbital angular momentum(OAM) has significantly contributed to applications in optical manipulation and high-dimensional classical and quantum information communication. However, inherent diffraction in free space results in the inevitable expansion of beam size and divergence contingent upon the OAM, limiting vortex beams' applicability in areas such as spatial mode multiplexing communication, fiber-optic data transmission, and particle manipulation. These domains necessitate vortex beams with OAM-independent propagation *** introduce iso-propagation vortices(IPVs), vortex beams characterized by OAM-independent propagation behavior, achieved through precise radial index configuration of Laguerre–Gaussian beams. IPVs display notable transmission dynamics, including a reduced quality factor, resilience post-damage, and decreased and uniform modal scattering under atmospheric turbulence. Their distinctive attributes render IPVs valuable for potential applications in imaging, microscopy, optical communication, metrology, quantum information processing, and light–matter interactions. Notably, within optical communication, the case study suggests that the IPV basis, due to its OAM-independent propagation behavior, provides access to a more extensive spectrum of data channels compared with conventional spatial multiplexing techniques, consequently augmenting information capacity.

关键词： orbital angular momentum optical communication structured light optical vortices

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