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Design of RFSoC-based Digital Phased Array Feed(PAF)and Hybrid Architecture Beamforming System

Research in Astronomy and Astrophysics 2022年第4期22卷 169-184页

作者： Xin Pei Na Wang Dan Werthimer Xue-Feng Duan Jian Li Toktonur Ergesh Qi Liu Ming-hui cai Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Xinjiang Key Laboratory of Microwave Technology Urumqi 830011China Department of Astronomy University of CaliforniaBerkeleyCA 94720USA

As the number of array elements and bandwidth increase,the design challenges of the Phased Array Feed(PAF)front-end and its signal processing system *** at the ng-PAF of the 110 m radio telescope,this article introduces the concept of fully digital receivers and attempts to use Radio Frequency System-on-Chip(RFSo C)technology to digitize close to the feed array,reduce the complexity and analog components of the front-end,and improve the fidelity of the *** article discusses the digital beamforming topology and designs a PAF signal processing experimental system based on RFSo C+GPU hybrid *** system adopts a ZCU111board to design RF-direct digitization and preprocessing front-end,which can sample eight signals up to 2.048GSPS,12 bit,channelize the signals into 1024 chunks,then reorder into four data streams and select one of the 256MHz frequency bands to output through four 10 Gb links.A GPU server is equipped with four RTX 3090 GPUs running four HRBF_HASHPIPE instances,each receiving a 64 MHz bandwidth signal for high-throughput realtime *** experimental system uses a signal generator to emulate Sa-like signals and propagates through rod antennas,which verifies the effectiveness of the beamforming *** tests show that after algorithm optimization,the average processing time for a given 4 ms data is less than 3 ms in the four-GPU parallel processing *** RFSo C integrated design shows significant advantages in power consumption and electromagnetic radiation compared with discrete circuits according to the measurement results.

关键词： instrumentation:miscellaneous techniques:miscellaneous telescopes

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Hyperactive reactive oxygen species impair function of porcine Sertoli cells via suppression of surface protein ITGB1 and connexin-43

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Zoological Research 2020年第2期41卷 203-207页

作者： Dan-Chen Zhang Rong Chen Yi-hui cai Jing-Jing Wang Chang Yin Kang Zou Germline Stem Cells and Microenvironment Lab College of Animal Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu 210095China

DEAR EDITOR,Gap junctions regulate intercellular communication between Sertoli cells and germ cells in male testes and play vital functions in *** factors in animal breeding and husbandry can induce oxidative stress,which can impair the testis microenvironment and male animal ***,the underlying mechanisms are largely ***,we identified that androgen signals promote the expression of connexin-43(Cx43),a key component of gap junctions,to regulate ***,we asked whether hyperactive reactive oxygen species(ROS)can impair gap junctions by interfering with Cx43 in porcine *** a porcine Sertoli cell in vitro system,we found that hyperactive ROS caused extensive apoptosis in Sertoli cells,remarkable decrease in Cx43 expression,and failed maintenance of co-cultured spermatogonial stem cells(SSCs),indicating that ROS impaired the function of Sertoli cells and promoted loss of *** observation provides a possible mechanism for the impact of ROS on fertility of male animals.

关键词： impaired function husbandry

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Influence and Correction of Wavefront Primary Aberrations for Radio Telescopes using Aberration Theory

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Research in Astronomy and Astrophysics 2023年第2期23卷 187-196页

作者： Bin-bin Xiang Wei Wang You Ban Shang-min Lin Zhi-gang Wen Da-lin He Ming-hui cai School of Mechanical Engineering Xinjiang UniversityUrumqi 830017China School of Mechano-Electronic Engineering Xidian UniversityXi'an 710071China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi'an 710119China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

Dual-reflector antennas are widely used in astronomical observations and satellite *** deformations of the reflectors for radio telescopes are inevitable in outside working conditions due to exterior environment loads,which will cause distortion in the surface of the primary reflector and displacement of the subreflector,then lead to gain degradation and *** this paper,the influence and correction of misalignment in a dual-reflector antenna have been *** the perspective of wavefront aberration,a method is proposed to correct the wavefront primary aberration by adjusting the subreflector *** characteristics of wavefront errors caused by structural deformation of the reflector have been analyzed,and relationships between the position motions of the subreflector and the Seidel wavefront aberrations are *** adjustment quantities of the subreflector are also *** results show the appropriate positional change of the subreflector in the lateral and axial directions can effectively correct the effects of the tilt and defocus in the primary aberrations caused by antenna structural deformations.

关键词： telescopes-methods analytical-instrumentation miscellaneous

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Cell apoptosis in perihematomal brain regions and expression of Caspase-3 protein in patients with hypertensive intracerebral hemorrhage

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Neural Regeneration Research 2006年第5期1卷 420-423页

作者： Xinqing Zhang Xiaoliang Yin Kun Zhang Zhimin Zhang hui cai Honglan Xu Department of Neurosurgery Beijing Chuiyangliu Hospital Beijing 100022 China Department of Pathology Beijing Chuiyangliu Hospital Beijing 100022 China

BACKGROUND： In patients with intracerebral hemorrhage （ICH）, besides the space-occupying effect of hematoma, hematomal component also causes the pathological changes of perihematomal region, including the death of neurons and glial cells, vasogenic brain edema, the destruction of blood brain barrier and so on, which are the important factors to influence the prognosis of patients. Therefore, it is necessary to perform further investigation and study on the pathological characteristics of injury and death of brain nerve cells. OBJECTIVE： To observe the pathological changes of apoptosis and Caspase-3 expression in perihematomal brain regions in patients with hypertensive ICH （HICH） in different stages of onset, and analyze their relationship. DESIGN ： Case-control observation. SETTING： Departments of Neurosurgery and Pathology of Beijing Chuiyangliu Hospital.PARTICIPANTS： Totally 19 patients with HICH, including 12 male, 7 female, aged （58.3±12.8） ranging from 49 to 78 years, whose mean volume of hemorrhage was （48.6±16.4） mL, were involved . All the cases conformed to the diagnostic criteria of intracerebral hemorrhage formulated in the 4^th National Cerebrovascular Diseases Conference and were confirmed by skull CT scanning. Informed consents of operation and specimens were obtained from the patients and relatives. METHODS： ①Patients with HICH who had undergone surgical evacuation of an intracerebral hematoma by traverse temporal lobe approach in the Department of Neurosurgery, Beijing Chuiyangliu Hospital from January 2004 to July 2005 were involved. Nineteen specimens of brain tissue from perihematomal region of HICH patients in different phases served as patient group. Five specimens were obtained from distant regions of patients in the super-early phase as the control group. According to the time from onset to operation, the 19 cases were divided into 3 groups： 6 cases in super-early phase（onset 〈 8 hours）, 8 cases in early phase （onset about 8 to 24 h

关键词： intracerebral hemorrhage cell apoptosis correlation analysis pathological characteristics immunohistochemical staining visual field signal transduction diagnostic criteria blood brain barrier protein expression measurement data temporal lobe nerve cells CT scanning brain edema

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Design of HIV-1 vaccines using synthetic N-linked glycopeptide

Design of HIV-1 vaccines using synthetic N-linked glycopepti...

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2020年糖科学青年科技论坛

作者： hui cai School of Pharmaceutical Sciences (Shenzhen) Sun Yat-sen University

Eliciting protective antibody responses against HIV-1 is a major goal for a successful prophylactic HIV-1 *** discovery of broadly neutralizing antibodies(bNAbs) provide ideal templates for HIV-1 vaccine *** elicit similar antibody responses,the first critical step is to identify the neutralizing epitopes of these *** we used chemo-enzymatic method to synthesize HIV-1 related N-linked glycopeptides derived from the V3 domain of *** performed glycopeptide epitope mapping to determine the minimal glycopeptide sequence as the epitope of V3-glycan-specific bNAbs,including PGT128,10-1074 and *** found the33-mer V3 glycopeptide carrying a high-mannose glycan at the N332 site could mimic the epitope of PGT128 and *** mimic the Env trimer presented on the virus surface,we also synthesized trimeric glycopeptide and found the trimeric glycopeptide carrying a high-mannose glycan at the N332 site exhibited enhanced affinity to 10-1074 antibody,suggesting a better mimic by this trimeric *** further constructed self-adjuvant three-component immunogens that consists of a lipopeptide(Pam

关键词： HIV vaccine glycopeptide N-glycan

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Dietary Salts Modulate NCC through Aldosterone-Mediated WNK4-ERK1/2 Signaling Pathway

Dietary Salts Modulate NCC through Aldosterone-Mediated WNK4...

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中国生理学会肾脏生理专业委员会第二届学术年会

作者： hui cai Renal Division Emory University School of Medicine

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Association of a single nucleotide polymorphism at 6q25.1, rs2046210, with endometrial cancer risk among Chinese women

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Chinese Journal of Cancer 2011年第2期30卷 138-143页

作者： Guoliang Li Yong-Bing Xiang Regina Courtney Jia-Rong Cheng Bo Huang Ji-Rong Long hui cai Wei Zheng Xiao-Ou Shu Qiuyin cai Division of Epidemiology and Vanderbilt Epidemiology Center Department of Medicine Vanderbilt University School of Medicine and Vanderbilt-lngram Cancer Center Nashville Tennessee 37232 USA Department of Epidemiology Shanghai Cancer Institute Shanghai 200032 P. R. China.

A recent genome-wide association study identified a new susceptibility locus for breast cancer, rs2046210, which is a single nucleotide polymorphism (SNP) located upstream of the estrogen receptor α (ESR1) gene on chromosome 6q25.1. Given that endometrial cancer shares many risk factors with breast cancer and both are related to estrogen exposure and that rs2046210 is in close proximity to the ESR1 gene, we evaluated the association of SNP rs2046210 with endometrial cancer risk among 953 cases and 947 controls in a population-based, case-control study conducted in Shanghai, China. Logistic regression models were used to derive odds ratios (ORs) and 95% confidence intervals (95% CIs) after adjusting for potential confounders. We found that the A allele of rs2046210, linked to an increased risk of breast cancer, was associated with increased but not statistically significant risk of endometrial cancer (OR = 1.16, 95% CI = 0.96-1.41 for the GA and AA genotypes compared with the GG genotype); the association was stronger among post-menopausal women (OR = 1.28, 95% CI = 1.00-1.65). The association tended to be stronger among women with higher or longer estrogen exposure than among women with relatively lower or shorter exposure to estrogen. Our study suggests that rs2046210 may play a role in the etiology of endometrial cancer. Additional studies are needed to confirm our findings.

关键词：单核苷酸多态性子宫内膜癌风险因素协会妇女 Logistic回归模型中国雌激素受体

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High Performance of Paper Strength and Energy Savings in OCC Pulp Papermaking via MFC Addition

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Paper And Biomaterials 2023年第2期8卷 66-77页

作者： hui cai Jiulong Sha Changsheng Lu Wenlun Qiu Junjie Liu Yang Liu China National Pulp and Paper Research Institute Co. Ltd.Beijing100102China Pulp and Paper Centre University of British ColumbiaBritish ColumbiaV6T 1Z4Canada School of Environment Tsinghua UniversityBeijing100084China College of Light Industry and Food Engineering Guangxi UniversityNanningGuangxi Zhuang Autonomous Region530004China China Energy Engineering Group Financial Leasing Co. Ltd.Beijing100020China

Fiber screen fractionation of recycled old corrugated container(OCC)pulp and subsequent targeted processing of each fraction can lead to higher fiber quality,more uniform pulp,and increased handsheet strength and surface *** pilot-scale study evaluates the benefits of fiber fractionation using a pressure screen prior to low consistency(LC)refining.A 0.81-mm smooth holed screen cylinder is utilized,and two refiner plate patterns are adopted(wide 0.99 km/rev BEL and interim 2.01 km/rev BEL).Here,LC-refined reject fractions are mixed with the created microfibrillated cellulose(MFC),and the mixed pulp and paper qualities are compared with no-MFC OCC *** results indicate that the highest tensile strength of the handsheet is obtained by the addition of MFC to the fractionated refined OCC pulp compared to the unfractionated refined OCC and primary OCC pulps at a given specific ***,the experimental approach adopted in this study can be used to optimize recycled OCC pulping ***,the results indicate that fractionated LC refining plus MFC addition provides higher pulp and paper qualities and the potential for saving energy to reach the desired tensile strength of the OCC pulp.

关键词： OCC pulp fractionation LC refining MFC fiber properties

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Relationship between the GH-IGFs axis and the proliferation of bile duct cancer cell line QBC939 in vitro

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Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 76-81页

作者： cai, hui-Hua Sun, Yue-Ming Bai, Jian-Feng Shi, Yi Zhao, Han-Lin Miao, Yi Nanjing Med Univ Affiliated Hosp 1 Dept Minimally Invas Surg Nanjing 210029 Peoples R China

BACKGROUND: In recent years, recombined human growth hormone (rhGH) has been increasingly used in patients to help them recover from operation. But GH, as a mitogen, can promote cell renewal and increase malignant transformation. In the current study, we assessed the proliferation of a bile duct cancer cell line (QBC939) in vitro with GH and explored the possible relationship with the axis of GH-IGFs (insulin-like growth factors). METHODS: QBC939 cells in the exponential growth stage were harvested and divided into an experimental group (GH group) and a control group (NS group). The GH group was divided into four sub-groups according to the dose of GH and culture time (50 mu g/L for 2 hours, 50 mu g/L for 24 hours, 100 mu g/L for 2 hours, 100 mu g/L for 24 hours). The NS group was divided into two sub-groups (NS for 2 hours and NS for 24 hours). After 2 or 24 hours, IGF-1 and IGF-2 were detected using the enzyme-linked immunosorbent assay. The QBC939 cells cultured for 24 hours with two GH concentrations were made into single cell suspensions and samples underwent subsequent cell cycle evaluation. Messenger RNA of IGF-1 and IGF-2 receptor (IGF-1RmRNA and IGF-2RmRNA) were tested with the method of in situ hybridization. RESULTS: There was no statistically significant difference between the GH and NS groups after 2 hours of culture (P>0.05). But after 24 hours of culture, GH stimulated cell growth in vitro and also elevated the percentage in S phase and the proliferation index (P<0.05). IGF-1RmRNA and IGF-2RmRNA were expressed in QBC939 in contrast to the blank group. The expression of IGF-1RmRNA increased with the dose of GH, but IGF-2RmRNA did not. CONCLUSION: GH can stimulate QBC939 cell growth and proliferation in vitro and the mechanism is most likely by the GH-IGF-1-IGF-1R axis.

关键词： growth hormone bile duct cancer cell cycle

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Imaging of mixed epithelial and stromal tumor of the kidney: A case report and review of the literature

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World Journal of Clinical Cases 2019年第17期7卷 2580-2586页

作者： Jing Ye Qing Xu Jing Zheng Shou-An Wang Ya-Wei Wu Jun-hui cai Hu Yuan Department of Medical Imaging Clinic Medical SchoolYangzhou UniversityNorthern Jiangsu Province HospitalYangzhou 225000Jiangsu ProvinceChina Dalian Medical University Dalian 116000Liaoning ProvinceChina

BACKGROUND Mixed epithelial and stromal tumors of the kidney (MESTKs) are a rare entity (about a hundred cases reported).They occur almost exclusively in postmenopausal women,with only seven cases reported in *** this entity is very rare,little is known on its imaging features,especially magnetic resonance imaging (MRI) *** women,at MRI,the cystic component shows T1 hypointensity and T2 hyperintensity,while the solid component shows T1 hyperintensity and T2 *** SUMMARY We report the computed tomography (CT) and MRI findings of MESTK in a 19- year-old male *** our knowledge,this case report is the first report of MRI findings of MESTK in male *** patient was admitted to Subei People's Hospital (Jiangsu Province,China) in July 2017 after a renal mass on the left side was detected by ultrasound during a clinical *** tests were all ***-enhanced CT showed a round,well-circumscribed complex mass,approximately 45 mm × 40 mm in *** revealed a clear wellcircumscribed mass with a mixed arrangement of solid and cystic *** T2 weighted images,some hypointensities were found in the solid *** contrast enhancement,moderate or mild enhancement was found in the solid component,which increased with time.A radical left nephrectomy was *** pathology analysis revealed a mixed epithelial and stromal *** patient had no imaging findings of recurrence or metastasis at 12 months following *** The possibility of MESTK should be considered in male *** can provide useful information for the preoperative diagnosis.

关键词： Mixed epithelial and stromal tumor of the kidney Adolescent Magnetic resonance imaging Preoperative diagnosis Case report

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