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Oncology Research 2022年第4期30卷 187-199页

作者： huaqing mo JINGYI SHEN YUXIAO ZHONG ZENAN CHEN TONG WU YANYU LV YANYAN XIE YANRONG HAO Cancer Center The People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanning530021China

Nasopharyngeal carcinoma(NPC)is the most prevalent human primary malignancy of the head and neck,and the presence of vasculogenic mimicry(VM)renders anti-angiogenic therapy ineffective and poorly ***,the underlying mechanisms are *** the present study,we used miR-940 silencing and overexpression for in vitro NPC cell EdU staining,wound healing assay and 3D cell culture assay,and in vivo xenograft mouse model and VM formation to assess miR-940 *** found that ectopic miR-940 expression reduced NPC cell proliferation,migration and VM,as well as tumorigenesis in *** bioinformatic analysis,circMAN1A2 was identified as a circRNA that binds to ***,we confirmed that circMAN1A2 acts as a sponge for miR-940,impairs the inhibitory effect of miR-940 on target ERBB2,and then activates the PI3K/AKT/mTOR signaling pathway using RNA-FISH,dual luciferase reporter gene and rescue analysis *** addition,upregulation of ERBB2 expression is associated with clinical staging and poor prognosis of *** together,the present findings suggest that circMAN1A2 promotes VM formation and progression of NPC through miR-940/ERBB2 axis and further activates the PI3K/AKT/mTOR ***,circMAN1A2 may become a biomarker and therapeutic target for anti-angiogenic therapy in patients with nasopharyngeal carcinoma.

关键词： MiR-940 circMAN1A2 ERBB2 Vasculogenic mimicry Nasopharyngeal carcinoma PI3K/AKT/mTOR signaling pathway

Physical Layer Encryption of OFDM-PON Based on Quantum Noise Stream Cipher with Polar Code

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China Communications 2024年第3期21卷 174-188页

作者： Xu Yinbo Gao Mingyi Zhu huaqing Chen Bowen Xiang Lian Shen Gangxiang Jiangsu Engineering Research Center of Novel Optical Fiber Technology and Communication Network Suzhou Key Laboratory of Advanced Optical Communication Network Technologythe School of Electronic and Information EngineeringSoochow UniversityNo.1 Shizi StreetSuzhou 215006China

Orthogonal frequency division multiplexing passive optical network(OFDM-PON) has superior anti-dispersion property to operate in the C-band of fiber for increased optical power budget. However,the downlink broadcast exposes the physical layer vulnerable to the threat of illegal eavesdropping. Quantum noise stream cipher(QNSC) is a classic physical layer encryption method and well compatible with the OFDM-PON. Meanwhile, it is indispensable to exploit forward error correction(FEC) to control errors in data transmission. However, when QNSC and FEC are jointly coded, the redundant information becomes heavier and thus the code rate of the transmitted signal will be largely reduced. In this work, we propose a physical layer encryption scheme based on polar-code-assisted QNSC. In order to improve the code rate and security of the transmitted signal, we exploit chaotic sequences to yield the redundant bits and utilize the redundant information of the polar code to generate the higher-order encrypted signal in the QNSC scheme with the operation of the *** experimentally demonstrate the encrypted 16/64-QAM, 16/256-QAM, 16/1024-QAM, 16/4096-QAM QNSC signals transmitted over 30-km standard single mode fiber. For the transmitted 16/4096-QAM QNSC signal, compared with the conventional QNSC method, the proposed method increases the code rate from 0.1 to 0.32 with enhanced security.

关键词： physical layer encryption polar code quantum noise stream cipher

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Flurbiprofen microneedle patches for the management of acute postoperative pain

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Nano Research 2024年第8期17卷 7493-7503页

作者： huaqing Chu Yanyan Zhang Yuan Yang Jiangtao Xue Cong Li Wei Zhang Zhou Li Hui Zheng National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases School of Integrated Chinese and Western MedicineHunan University of Chinese MedicineChangsha 410208China School of Life Science Institute of Engineering MedicineBeijing Institute of TechnologyBeijing 100081China Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China

Acute postoperative pain is commonly treated with flurbiprofen(FBP),but conventional delivery methods are *** study prepared a new non-burst release microneedles(MNs)using genipin cross-linked gelatin(cGel).By adding varying amounts of genipin to modulate the crosslinking degree of cGel,the drug release behavior of the drug-loaded MNs in the skin can be *** crosslinking parameters that meet therapeutic requirements are selected,thus providing rapid and longlasting analgesic *** solutions were successfully cross-linked,altering matrix material microstructure,confirmed by scanning electron microscope imaging and fourier transform infrared *** demonstrated increasing mechanical strength with higher *** release rates were rapid initially,then slowed,exhibiting a characteristic of decreased release rates with increasing degrees of *** vivo,FBP/cGel MNs significantly reduced allodynia and hyperalgesia post-surgery,with the greatest effect observed at 2–3 h post-surgery,and can maintain analgesia for up to 6 *** tests confirmed good ***/cGel MNs effectively penetrate the stratum corneum,safely delivering drugs with significant analgesic effects,excellent mechanical properties,and good biocompatibility,representing a promising strategy for managing acute postoperative pain.

关键词： microneedle postoperative pain flurbiprofen non-steroid anti-inflammatory drug cross-linked gelatin

A Scoping Review of Real-World Study in Vaccine Evaluation

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China CDC weekly 2024年第16期6卷 357-362页

作者： Lei Wang Hong Yang Lanfang Xia Quanwei Song Na Liu Guomin Zhang Fuzhen Wang huaqing Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Real-world study(RWS)gained prominence starting with a significant investigation on ramipril’s impact on hypertension in 1993(1).A key advancement for the Food and Drug Administration(FDA)occurred with the enactment of the 21st Century Cures Act in 2016,emphasizing RWS(2).The FDA’s Real-world Evidence Program establishes real-world data(RWD)as“data relating to patient health status and/or the delivery of health care routinely collected from a variety of sources”,while real-world evidence(RWE)is“clinical evidence about the usage and potential benefits or risks of a medical product derived from analysis of RWD”(3).The proliferation of big data,electronic medical records(EMR),electronic health records(EHR),and medical claims data offers vast information resources facilitating *** access to RWD allows for worldwide monitoring of the impacts of various public health initiatives like vaccination *** randomized clinical trials(RCTs)traditionally gauge vaccine efficacy and shortterm safety,RWS can assess vaccine performance and safety across larger,more diverse populations and are adept at identifying rare events not easily discernible in RCTs due to their infrequency.

关键词： routine gained traditionally

Floating periodic pontoons for broad bandgaps of water waves

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Applied Mathematics and Mechanics(English Edition) 2024年第11期45卷 1913-1928页

作者： huaqing JIN Haicheng ZHANG Ye LU Daolin XU College of Mechanical and Vehicle Engineering Hunan University Wuxi lntelligent Control Research Institute Hunan University China Ship Scientific Research Center

The narrow attenuation bands of traditional marine structures have long been a challenge in mitigating water waves. In this paper, a metastructure(MS) composed of floating periodic pontoons is proposed for broadband water wave attenuation. The interaction of surface gravity waves with the MS is investigated using linear wave *** potential solutions of water waves by the MS with a finite array are developed by using the eigenfunction expansion matching method(EEMM), and the band structure of the MS is calculated by the transfer matrix method(TMM), in which the evanescent modes of waves are considered. The solution is verified against the existing numerical result for a special case. Based on the present solution, the association between Bragg resonance reflection and Bloch bandgaps is examined, the effects of pontoon geometry are analyzed,and the comparison between floating MS and bottom-mounted periodic structures is conducted. A computational fluid dynamics(CFD) model is further developed to assess the structures in practical fluid environments, and the floating MS presents excellent wave attenuation performance. The study presented here may provide a promising solution for protecting the coast and offshore structures.

关键词：

Comparison of Statistical Signal Detection Methods in Adverse Events Following Immunization — China, 2011–2015

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China CDC weekly 2024年第16期6卷 350-356,I0001页

作者： Lanfang Xia Keli Li Yan Li Zhijie An Quanwei Song Lei Wang Zundong Yin huaqing Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Introduction:The current study aims to assess the performance of data mining techniques in detecting safety signals for adverse events following immunization(AEFI)using routinely obtained data in *** different methods for detecting vaccine safety signals were ***:The AEFI data from 2011 to 2015 was collected for our *** analyzed the data using four different methods to detect signals:the proportional reporting ratio(PRR),reporting odds ratio(ROR),Bayesian confidence propagation neural network(BCPNN),and multi-item gamma Poisson shrinker(MGPS).Each method was evaluated at 1–3 thresholds for *** assess the performance of these methods,we used the published signal rates as gold standards to determine the sensitivity and ***:The number of identified signals varied from 602 for PRR1(with a threshold of 1)to 127 for *** considering the common reactions as the reference standard,the sensitivity ranged from 0.9%for MGPS1/2 to 38.2%for PRR1/2,and the specificity ranged from 85.2%for PRR1 and ROR1 to 96.7%for *** considering the rare reactions as the reference standard,PRR1,PRR2,ROR1,ROR2,and BCPNN exhibited the highest sensitivity(73.3%),while MGPS1 exhibited the highest specificity(96.9%).Discussion:For common reactions,the sensitivities were modest and the specificities were *** rare reactions,both the sensitivities and specificities were *** study provides valuable insights into the selection of signal detection methods and thresholds for AEFI data in China.

关键词： specificity routine vaccine

OsPPG encodes a pseudouridine-5'-phosphate glycosidase and regulates rice spikelet development

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The Crop Journal 2024年第3期12卷 698-708页

作者： Rui Chen Dagang Tian Yarong Lin Jiaqing Huang Qinqin Yang Yupei Li huaqing Liu Shaohua Yang Jingyang Chen Shufen Zhou Feng Wang Shubiao Zhang Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of Education/Key Laboratory of Biological Breeding for Fujian and Taiwan CropsMinistry of Agriculture and Rural AffairsFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Key Laboratory of Genetic Engineering for Agriculture Biotechnology Research InstituteFujian Academy of Agricultural SciencesFuzhou 350003FujianChina Institute of Resources Environment and Soil FertilizerFujian Academy of Agricultural SciencesFuzhou 350013FujianChina

Florets are the basic structural units of spikelets,and their morphogenesis determines the yield and quality of rice ***,whether and how pseudouridine-5’-phosphate glycosidase participates in rice spikelet development remains an open *** this study,we identified a novel gene,OsPPG,which encodes a peroxisome-localized pseudouridine-5’-phosphate glycosidase and regulates the development of rice *** mutants exhibited abnormal sterile lemma,lemma,palea,lodicule,stamens,and pistils;male sterility;shorter panicles;and reduced plant *** was found to regulate several OsMADS genes,thereby affecting the morphogenesis of rice ***,metabolomics revealed that the OsPPG gene was involved in the decomposition of pseudouridine via the pyrimidine metabolism pathway and may affect the jasmonic acid signaling *** results suggest that OsPPG is a key regulator of rice spikelet development.

关键词： OsPPG Reproductive regulation Spikelet development Rice

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Impact of National Immunization Strategies on Vaccine- Preventable Diseases — China, 1950–2021

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China CDC weekly 2024年第16期6卷 339-343页

作者： Quanwei Song Yixing Li Lei Cao Lixin Hao Ning Wen Fuzhen Wang Chao Ma Guomin Zhang Hui Zheng Wenzhou Yu Zhijie An Zundong Yin huaqing Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The incidences of vaccine-preventable diseases(VPDs)included in the Expanded Program on Immunization in China have decreased significantly in recent *** is added by this report?This study summarizes the national incidences of nine VPDs and the seroprevalence of hepatitis B surface antigen(HBsAg)under different immunization strategies from 1950 through 2021 in *** sharpest decreases in VPD incidence and under-5-year HBsAg seroprevalence occurred during the latest stage of the National Immunization *** decreases in VPD incidence were most prominent among children under five years of *** are the implications for public health practice?These findings provide valuable insights for vaccine value assessment and emphasize the importance of implementing immunization strategies in targeted populations.

关键词： vaccine diseases Impact

Thirty Years of Experience of Acute Flaccid Paralysis Surveillance for Polio — China, 1993–2022

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China CDC weekly 2024年第16期6卷 344-349页

作者： Hong Yang Ning Wen Chunxiang Fan Fuzhen Wang Yong Zhang Lei Cao Shuangli Zhu Lixin Hao Dongmei Yan Lei Wang Quanwei Song Miao Wang Yifan Song Chao Ma Zhijie An Lance ERodewald huaqing Wang Zundong Yin National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Detecting poliovirus infections proves to be highly challenging due to their asymptomatic nature and infectious potential,highlighting the crucial importance of effective detection methods in the context of polio eradication *** many countries,including China,the primary approach for identifying polio outbreaks has been through acute flaccid paralysis(AFP)*** this study,we conducted an evaluation spanning three decades(1993–2022)to assess the effectiveness of AFP surveillance in ***:Data on all AFP cases identified since 1993 and national-level AFP surveillance system quality indicators aligned with the World Health Organization(WHO)standards were collected for *** quality indicators assess surveillance sensitivity,completeness,timeliness of detection notification,case investigation,and laboratory *** sensitivity is determined by the non-polio AFP(NPAFP)detection rate among children under 15 years of ***:Between 1993 and 2022,a total of 150,779 AFP cases were identified and *** this pool,surveillance identified 95 cases of wild poliovirus(WPV)and 24 cases due to vaccinederived *** 1995 onwards,the detection rate of NPAFP cases consistently adhered to the WHO and national standards of≥1 case per 100,000,falling between 1.38 and *** in 1997,all timeliness indicators consistently achieved the criteria of 80%,apart from the consistency in meeting standards set for the rate of positive specimens sent to the national ***:AFP surveillance has been instrumental in China’s accomplishment of maintaining a polio-free *** ongoing adherence to key performance indicators,ensuring sensitivity and prompt specimen collection,demonstrates that AFP surveillance is proficient in detecting poliovirus in *** we move into the post-eradication phase,AFP surveillance remains crucial for the sustained absence of polioviruses in the long term.

关键词： sustained prompt surveillance

基于多变量LSTM神经网络的地下水位预测方法研究

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干旱区资源与环境 2024年第9期38卷 138-146页

作者：田辽西覃华清甘肃省地质矿产勘查开发局兰州730000 中国科学院地质与地球物理研究所北京100029

地下水位的准确预测对于黑河流域水资源可持续开发及合理利用具有重要意义。针对物理模型、数值模型参数获取困难、建模过程复杂、建模数据时间跨度较短等问题,提出一种多变量LSTM算法来准确、快速预测地下水位。通过将黑河干流中游地区... 详细信息

地下水位的准确预测对于黑河流域水资源可持续开发及合理利用具有重要意义。针对物理模型、数值模型参数获取困难、建模过程复杂、建模数据时间跨度较短等问题,提出一种多变量LSTM算法来准确、快速预测地下水位。通过将黑河干流中游地区1986年至2018年月均地下水位观测数据作为数据集,构建了两层每层30个神经元的LSTM模型,并对单一动态类型、混合动态类型两种数据训练方式的预测结果进行比较。结果表明:1)构建的多变量LSTM神经网络模型准确预测了地下水位的月度变化,预测精度较高,RMSE均值为0.18,R^(2)均值为0.8以上。2)相同动态类型输入的预测正确率略高于混合动态类型输入,证明区分不同类型地下水并以相同动态类型的数据作为输入,有助于提高LSTM模型在时序数据预测中的准确性。该研究实现了地下水位的快速精确预测,确定了多变量LSTM模型在预测甘肃张掖盆地地下水位的可行性,进而为张掖盆地水资源初步判断、方案决策提供方法支撑。

关键词：张掖盆地水位预测地下水位动态分析深度学习长短时记忆网络

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