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清肝润肺止咳露高效液相色谱特征图谱、含量测定及化学模式识别的研究

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中药新药与临床药理 2024年第4期35卷 580-586页

作者：黄樱华熊颖骆月姬梁振生广州中医药大学第一附属医院广东广州510405 广州市药品检验所广东广州510160

目的建立清肝润肺止咳露高效液相色谱(HPLC)特征图谱,测定其中吗啡、可待因、罂粟碱、那可丁的含量,并结合化学模式识别方法,综合评价该制剂的质量。方法采用HPLC法,以甲醇-5μmoL·L^(-1)庚烷硫酸钠溶液(用磷酸调节pH至2.6)为流动相进... 详细信息

目的建立清肝润肺止咳露高效液相色谱(HPLC)特征图谱,测定其中吗啡、可待因、罂粟碱、那可丁的含量,并结合化学模式识别方法,综合评价该制剂的质量。方法采用HPLC法,以甲醇-5μmoL·L^(-1)庚烷硫酸钠溶液(用磷酸调节pH至2.6)为流动相进行梯度洗脱,流速:1.0 mL·min^(-1),柱温:20℃,检测波长:220 nm,进样量:10μL。利用指纹图谱相似度评价软件,结合聚类分析(CA)、主成分分析(PCA)和偏最小二乘法判别分析(PLS-DA)对10批清肝润肺止咳露的特征图谱进行评价。结果10批清肝润肺止咳露特征图谱共确定16个共有峰,指认了5个共有峰,分别为吗啡、可待因、蒂巴因、罂粟碱、那可丁。其中4个成分在线性范围内(吗啡0.70~8.70μg、可待因0.68~8.50μg、罂粟碱0.60~7.55μg、那可丁0.38~4.80μg)均有良好的线性关系(r≥0.9997);精密度、稳定性、重复性试验的RSD均小于3.0%;平均加样回收率在97.93%~99.43%之间(RSD<3.1%);含量测定结果:吗啡43.58~76.47μg·mL^(-1),可待因16.64~78.92μg·mL^(-1),罂粟碱29.93~41.22μg·mL^(-1),那可丁14.44~33.22μg·mL^(-1)。通过CA、PCA和PLS-DA分析,可将10批清肝润肺止咳露分为2类(S3、S4、S8、S10聚为一类,其余聚为一类),并筛选出峰2、峰4、峰13、峰11(吗啡)、峰1、峰10、峰8、峰12、峰16(那可丁)9个差异性成分。结论该研究建立的HPLC特征图谱及含量测定方法简单、准确,结合化学模式识别法,可用于清肝润肺止咳露的质量控制。

关键词：清肝润肺止咳露罂粟壳特征图谱含量测定化学模式识别法

基于矿柱失稳风险分析的采空区关键矿柱重定义与辨识

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岩石力学与工程学报 2024年第1期43卷 216-225页

作者：蔡鑫黄涯帅周子龙袁纪锋臧海智陈璐黄英华付俊王运敏中南大学资源与安全工程学院湖南长沙410083 中钢集团马鞍山矿山研究总院股份有限公司金属矿山安全与健康国家重点实验室安徽马鞍山243000 长沙矿山研究院有限责任公司金属矿山安全技术国家重点实验室湖南长沙410012 中国有色金属工业昆明勘察设计研究院有限公司云南昆明650051

采空区大规模坍塌是地下矿山典型灾害之一,采空区内关键矿柱失稳是其发生的重要诱因。为精准辨识采空区内的关键矿柱,基于采空区矿柱群连锁失稳机制与风险理论,完善采空区关键矿柱基本概念,并创新提出一种基于矿柱失稳风险分析的关键矿... 详细信息

采空区大规模坍塌是地下矿山典型灾害之一,采空区内关键矿柱失稳是其发生的重要诱因。为精准辨识采空区内的关键矿柱,基于采空区矿柱群连锁失稳机制与风险理论,完善采空区关键矿柱基本概念,并创新提出一种基于矿柱失稳风险分析的关键矿柱识别方法,主要包含以下步骤:(1)通过现场调研或经验估计,获得采空区矿柱强度分布特征,进而构建采空区矿柱强度概率密度函数;(2)引入应力扩散最大距离公式,计算各矿柱承载应力,从而获得各矿柱的失稳概率;(3)假定任意矿柱率先失稳,通过矿柱应力动态更新迭代方法,计算单矿柱失稳诱发柱间应力传递与矿柱群系统失稳特征;(4)利用采空区矿柱群承载面积损失率指标定量表征单矿柱失稳致灾性(单矿柱失稳诱发采空区坍塌灾害的严重程度);(5)联合矿柱失稳概率及其致灾性,确定各矿柱失稳风险值,取失稳风险值最高矿柱为采空区关键矿柱。将提出方法应用于Fetr6矿区进行验证,结果表明,该方法所需参数较易获取,计算过程简单,物理意义明确,较传统安全系数法结果更科学、合理,有望在实际工程中取得广泛应用。

关键词：采矿工程采空区地下矿柱群连锁坍塌关键矿柱失稳概率失稳致灾性风险评估

城市竣工测绘典型要素语义分割PointNet++深度学习模型适用性分析

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测绘通报 2024年第2期 85-89页

作者：黄应华董振川李昊陈壮刘长睿张献州西南交通大学地球科学与环境工程学院四川成都611756 成都市勘察测绘研究院四川成都610081 中国铁路设计集团有限公司天津300000

处理三维激光扫描仪获取的城市竣工测绘点云场景数据的传统方法存在较多局限性,无法适应信息化社会对产品高效处理的需求。基于此,本文分析了城市竣工测绘点云场景分类需求,研究了利用深度学习网络模型对点云场景进行自动化处理的方法... 详细信息

处理三维激光扫描仪获取的城市竣工测绘点云场景数据的传统方法存在较多局限性,无法适应信息化社会对产品高效处理的需求。基于此,本文分析了城市竣工测绘点云场景分类需求,研究了利用深度学习网络模型对点云场景进行自动化处理的方法。首先,对输入的城市竣工测绘数据进行预处理,以实现点云降采样、去噪、地面点与非地面点分割;然后,人工标注5个区域场景数据毫米级标签,进行数据增强;最后,测试PointNet++网络在城市竣工测绘点云场景下的语义分割性能和效果。测试结果表明,在少量样本下,PointNet++网络可以较好地实现城市竣工测绘点云场景的激光点云语义分割,总体mIoU达73.06%,能够满足城市竣工测绘点云语义自动化分割需求,为城市竣工测绘点云数据处理提供了新思路。

关键词：城市竣工测绘点云场景语义分割深度学习模型适用性

Chao Yuanfang and his Treatise on the Causes and Manifestations of Diseases

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 1-2页

作者： Yongxuan Liang yinghua huang Beijing University of Chinese Medicine Beijing 100029China

Chao Yuanfang was a famous physician of the Sui *** is no record about his biography and life in official *** is said that he served as an imperial court physician and the minister of the Imperial Health Administration from 605 to *** the imperial order,he took charge of compilation of Treatise on the Causes and Manifestations of Diseases(Zhu Bing Yuan Hou Lun),the first book about disease causes and symptoms in *** to the Emperor Yang Digging the Grand Canal(Yang Di Kai He Ji),a novel of the Song Dynasty,Emperor Yang appointed Ma Shumou as the head of the *** when he arrived in Ningling County(now Ningling County,Henan Province)Ma fell ill with swollen limbs and chills,and couldn't sit *** the moment,Chao was immediately sent by the emperor to help *** examinations Chao believed that it was caused by invasion of the striated layer by *** suggested him to take steamed tender mutter with some medicinal *** soon the patient was *** above we know that Chao was proficient in medicine.

关键词： Grand invasion Dynasty

Wang Shuhe and his Pulse Classic

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Journal of Traditional Chinese Medical Sciences 2022年第4期9卷 349-350页

作者： Yongxuan Liang yinghua huang Beijing University of Chinese Medicine Beijing102488China

Wang Shuhe(c.210‒285),also known as Wang Xi or Wang Gaoping,was from Gaoping,present Shanxi Province,or Zoucheng City,Shandong *** was one of the celebrated medical scientists of the Wei and Jin dynasties(220-420)and he once served as the minister of imperial *** is the author of The Pulse Classic(Mai Jing),the extant first monograph on pulse in *** was born into a family of *** placid temper he was eager to learn since *** a young boy he had extensive knowledge and studied the various schools of thoughts and their *** to avoid chaos of war his family moved to Jingzhou City,Hubei Province,where he met Wei Xun,a disciple of Zhang Zhongjing(150e219).

关键词： Pulse temper chaos

Jianzhen's eastward sea-voyage

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Journal of Traditional Chinese Medical Sciences 2023年第2期10卷 125-126页

作者： Yongxuan Liang yinghua huang Beijing University of Chinese Medicine Beijing100029China

Chunyu Jianzhen(688-763)was from the Jiangyang County,Guangling(now Yangzhou,Jiangsu Province).He was an eminent Buddhist monk and learned medical scientist of the Tang Dynasty(618-907).He is the author of Jianshen's Secret Recipes(Jian Shang Ren Mi Fang).At the invitation of Japan,he went there and intro-duced Buddhism,medical and other technical knowledge to Japan,so he was honored by the Japanese people with the“Founder of Japanese Kampo Medicine”and“Master from Overseas”.

关键词： Japanese Japan Jiangsu

Buddhist monk Lin Daoren,specialist of traumatology and orthopedics

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Journal of Traditional Chinese Medical Sciences 2023年第3期10卷 245-246页

作者： Yongxuan Liang yinghua huang Beijing University of Chinese Medicine Beijing100029China

Buddhist monk Lin Daoren(790-850,from Xi'an,Shaanxi Province)was a specialist of traumatology and orthopedics of the Tang *** of Treating Wounds and Rejoining Fractures(Li Shang Xu Duan Fang)written by him is the first extant monography on traumatology and orthopedics in *** to the preface of the book,he had profound medical knowledge especially about the theory,diagnosis and treatment for wounds and fractures.

关键词： Buddhist monk Lin Daoren specialist of traumatology and orthopedics

Chunyu Yi and his pioneer case records

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Journal of Traditional Chinese Medical Sciences 2022年第3期9卷 207-208页

作者： Yongxuan Liang yinghua huang Tingyu Fang Beijing University of Chinese Medicine Beijing100029China 不详

Chunyu Yi(215 _(BC)-150 _(BC))once served as an official of granary in the Qi *** he had a nickname of granary *** ancestral home was Linzi(present Linzi,Shandong Province).He was a celebrated practitioner of the West... 详细信息

关键词： listed records Chun

Bian Que,the founder of diagnostics of traditional Chinese medicine

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Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 93-94页

作者： Yongxuan Liang yinghua huang Tingyu Fang Beijing University of Chinese Medicine Beijing100029China 不详

Bian Que or Qin Yueren(ca 5th century B.C.)was a medical scientist with profound influence in the Warring States Period(475 BC-221 BC).There is argument about his native place,but it is generally acknowledged he came from Bohai Sea Mo County(present Renqiu County,Hebei Province).It is said that he was the author of Bian Que's Internal Classic(Bian Que Nei Jing)and Bian Que's External Classic(Bian Que Wai Jing).It is a pity they are all lost.

关键词： Bohai Bia Internal