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Triclosan-conjugated,Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms

Chinese Journal of Polymer Science 2024年第6期42卷 718-728页

作者： Yan-Qiang huang Yuan-feng Li Yong Liu Lin-Qi Shi Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise533000China Translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325035China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of Educationand Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China

Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative *** this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery *** micelles were created using an amphiphilic block polymer synthesized via ring-opening polymerization ofε-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial *** important advantage of our micelles lies in their interaction with local bacterial lipases within *** lipases triggered rapid micelle degradation,releasing triclosan in a controlled *** liberated triclosan effectively eliminated bacteria embedded in the ***,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and *** finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial *** triclosan-conjugated,lipase-responsive polymeric micelles exhibit promising characteristics for addressing drug resistance in bacterial *** harnessing biofilm properties and implementing a responsive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.

关键词： Self-assembly Polymer prodrug Ring-opening polymerization Biofilm eradication Cytotoxicity

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Experimental and numerical study of combustion characteristics of ammonia-hydrogen-air swirling flame with/without secondary air injection

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Chinese Journal of Aeronautics 2024年第4期37卷 243-255页

作者： Chunyu LIU Chenhu GAO Yue huang Hua JIN dan ZHAO Wenjiang XU Yancheng YOU School of Aerospace Engineering Xiamen UniversityXiamen 361005China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Mechanical Engineering University of CanterburyChristchurch 8041New Zealand

Ammonia (NH_(3)) is currently considered to be a potential carbon-free alternative fuel,and its large-scale use as such would certainly decrease greenhouse gas emissions and meet increasingly stringent emission *** the low flame propagation speed and high NO production of NH_(3) hinder its direct application as a renewable fuel,co-combustion of NH_(3)–H_(2)is an effective way to overcome these *** this study,the combustion characteristics of NH_(3)–H_(2)swirling flames under different equivalence ratios and H_2blending ratios conditions are both numerically and experimentally ***,the One-Dimensional (1D) laminar flame computation presents a comparison base and the Three-Dimensional (3D) numerical simulation yields detailed flame property ***,the high-speed camera takes instantaneous swirl flame images and the gas analyzer measures the NO emission at the exit plane of the flame *** and quantitative analysis is performed on the flame structure and NO emission for a series of NH_(3)–H_(2)swirl *** variation trends of the NO emission calculated using different techniques agree very *** quantitative results show that the NO emissions are much higher at lean equivalence ratios than those at rich equivalence ratios,and such difference is closely related to the combustion flame ***,it is shown that the utilization of secondary air injection can achieve a significant reduction in NO emissions at the exit of the combustion chamber at equivalence ratios less than or equal to 0.9.

关键词： Ammonia combustion Swirling flow NO emission characteristics Secondary combustion Chemical reaction mechanism

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Directly targeting BAX for drug discovery:Therapeutic opportunities and challenges

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2378-2401页

作者： Zhenwei Zhang Linghui Hou dan Liu Shenglin Luan Min huang Linxiang Zhao Key Laboratory of Structure-Based Drugs Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China China Resources Sanjiu Medical&Pharmaceutical Co. Ltd.Shenzhen 518000China

For over two decades,the development of B-cell lymphoma-2(Bcl-2)family therapeutics has primarily focused on anti-apoptotic proteins,resulting in the first-in-class drugs called BH3 mimetics,especially for Bcl-2 inhibitor *** pro-apoptotic protein Bcl-2-associated X protein(BAX)plays a crucial role as the executioner protein of the mitochondrial regulated cell death,contributing to organismal development,tissue homeostasis,and *** dysregulation of BAX is closely associated with the onset and progression of diseases characterized by pathologic cell survival or death,such as cancer,neurodegeneration,and heart *** addition to conducting thorough investigations into the physiological modulation of BAX,research on the regulatory mechanisms of small molecules identified through biochemical screening approaches has prompted the identification of functional and potentially druggable binding sites on BAX,as well as diverse all-molecule BAX *** review presents recent advancements in elucidating the physiological and pharmacological modulation of BAX and in identifying potentially druggable binding sites on ***,it highlights the structural and mechanistic insights into small-molecule modulators targeting diverse binding surfaces or conformations of BAX,offering a promising avenue for developing next-generation apoptosis modulators to treat a wide range of diseases associated with dysregulated cell death by directly targeting BAX.

关键词： Apoptosis Pro-apoptotic protein BAX Dynamic conformational activation Small-molecule apoptosis modulators

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Upcycling electroplating sludge into bioengineering-enabled highly stable dual-site Fe-Ni_(2)P@C electrocatalysts for efficient oxygen evolution

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Nano Research 2024年第8期17卷 6984-6992页

作者： Jiawen Liu Zunpeng Zuo feng Gao Kai Yi Jiahui Lin Mengye Wang Zhang Lin feng huang State Key Laboratory of Optoelectronic Materials and Technologies School of MaterialsSun Yat-Sen UniversityGuangzhou 510275China Department of Chemistry City University of Hong KongHong Kong 999077China School of Metallurgy and Environment Central South UniversityChangsha 410083China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China

The advancement of bimetallic catalysts holds significant promise for the innovation of oxygen evolution reaction(OER)*** from adsorbate evolution mechanism(AEM)and lattice oxygen oxidation mechanism(LOM),the incorporation of dual active sites has the potential to foster novel OER pathways,such as the coupled oxygen evolution mechanism(COM),which can surpass the limitations of OER and elevate catalytic *** this study,uniformly distributed Fe/Ni dual-site Fe-Ni_(2)P@C electrocatalysts are crafted by upcycling metals in electroplating sludge via an eco-friendly and sustainable microbial engineering *** findings indicate that a substantial number of defects emerge at the Ni2P crystal during the OER process,laying the groundwork for lattice oxygen ***,the displacement of Ni/Fe in the crystal lattice intensifies the asymmetry of the electronic structure at the metal active sites,facilitating the deprotonation *** research introduces an innovative paradigm for the synthesis of effective and robust transition metal-based OER catalysts,with implications for sustainable energy generation technologies.

关键词： oxygen evolution reaction dual active sites adsorbate evolution mechanism lattice oxygen mechanism bioengineering

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The role of vitamin E in polyunsaturated fatty acid synthesis and alleviating endoplasmic reticulum stress in sub-adult grass carp(Ctenopharyngodon idella)

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Animal Nutrition 2024年第1期16卷 275-287页

作者： Ke Yao Lin feng Wei-dan Jiang Yang Liu Lu Zhang Hai-feng Mi Xiao-Qiu Zhou Pei Wu Animal Nutrition Institute Sichuan Agricultural University Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural University Key Laboratory of Animal Disease-Resistance Nutrition Ministry of Education Ministry of Agriculture and Rural Affairs Key Laboratory of Sichuan Province Tongwei Co. Ltd. Healthy Aquaculture Key Laboratory of Sichuan Province

Vitamin E(VE) is an essential lipid-soluble vitamin that improves the fish flesh quality. However, the underlying molecular mechanisms remain unclear. This study aimed to investigate the effects of VE on growth performance and flesh quality in sub-adult grass carp(Ctenopharyngodon idella). A total of 450fish(713.53 ± 1.50 g) were randomly divided into six treatment groups(three replicates per treatment)and fed for nine weeks with different experimental diets(dietary lipid 47.8 g/kg) that contained different levels of VE(5.44, 52.07, 96.85, 141.71, 185.66, and 230.12 mg/kg diet, supplemented as dl-a-tocopherol acetate). Notably, the treatment groups that were fed with dietary VE ranging from 52.07 to230.12 mg/kg diet showed improvement in the percent weight gain, special growth rate, and feed efficiency of grass carp. Moreover, the treatment groups supplemented with dietary VE level of 141.71,185.66, and 230.12 mg/kg diet showed enhancement in crude protein, lipid, and a-tocopherol contents in the muscle, and the dietary levels of VE ranging from 52.07 to 141.71 mg/kg diet improved muscle pH24h and shear force but reduced muscle cooking loss in grass carp. Furthermore, appropriate levels of VE(52.07 to 96.85 mg/kg diet) increased the muscle polyunsaturated fatty acid content in grass carp. Dietary VE also increased the mRNA levels of fatty acid synthesis-related genes, including fas, scd-1, fad,elovl, srebp1, pparγ, and lxra, and up-regulated the expression of SREBP-1 protein. However, dietary VE decreased the expression of fatty acid decomposition-related genes, including hsl, cpt1, acox1, and ppara,and endoplasmic reticulum stress-related genes, including perk, ire1, atf6, eif2a, atf4, xbp1, chop, and grp78, and down-regulated the expression of p-PERK, p-IRE1, ATF6, and GRP78 proteins. In conclusion,dietary VE increased muscle fatty acid synthesis, which may be partly associated with the alleviation of endoplasmic reticulum stress, and ultimately improves fish fles

关键词： Vitamin E Flesh quality Muscle polyunsaturated fatty acid level Endoplasmic reticulum stress Growth performance Grass carp

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Dynamic simulation analysis of molten salt reactor-coupled air-steam combined cycle power generation system

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Nuclear Science and Techniques 2024年第2期35卷 222-233页

作者： Jing-Lei huang Guo-Bin Jia Li-feng Han Wen-Qian Liu Li huang Zheng-Han Yang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the molten salt reactor and power *** model considers the impact of thermal properties of fluid variation on accuracy and has been validated with *** study reveals the capability of the control system to compensate for anomalous situations and maintain shaft stability in the event of perturbations occurring in high-temperature molten salt tank outlet ***,the control system’s impact on the system’s dynamic characteristics under molten salt disturbance is also *** results reveal that after the disturbance occurs,the controlled system benefits from the action of the control,and the overshoot and disturbance amplitude are positively correlated,while the system power and frequency eventually return to the initial *** simulation model provides a basis for utilizing molten salt reactors for power generation and maintaining grid stability.

关键词： Molten salt reactor Combined cycle Dynamic characteristic Control

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Permanent Magnet Temperature Estimation for PMSMs Using Virtual Position-offset Injection

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 51-60页

作者： Beichen Ding Yuting Lu Kaide huang Guodong feng Chunyan Lai IEEE the School of Intelligent Systems Engineering Sun Yat-sen UniversityShenzhen 518107China the Fosan University Foshan 528225China the Department of Electrical and Computer Engineering Concordia UniversityQCCanada

This paper proposes a virtual position-offset injection based permanent magnet temperature estimation approach for permanent magnet synchronous machines(PMSMs). The concept of virtual position-offset injection is mathematically transforming the machine model to a virtual frame with a position-offset. The virtual frame temperature estimation model is derived to calculate the permanent magnet temperature(PMT) directly from the measurements with computation efficiency. The estimation model involves a combined inductance term, which can simplify the establishment of saturation compensation model with less measurements. Moreover, resistance and inverter distorted terms are cancelled in the estimation model, which can improve the robustness to the winding temperature rise and inverter distortion. The proposed approach can achieve simplified computation in temperature estimation and reduced memory usage in saturation compensation. While existing model-based approaches could be affected by either the need of resistance and inverter information or complex saturation compensation. Experiments are conducted on the test machine to verify the proposed approach under various operating conditions.

关键词： PMSM Magnet temperature estimation Virtual position offset injection Inverter nonlinearity

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Tailoring crystallization zinc hydroxide sulfates growth towards stable zinc deposition chemistry

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Nano Research 2024年第6期17卷 5243-5250页

作者： Kaixin huang Xianguang Zeng dan Zhang Yujie Wang Mu Lan Chengyan Wen Yi Guo College of Materials Science and Engineering Sichuan University of Science and EngineeringZigong 643000China Department of Chemistry College of Resource and EnvironmentBaoshan UniversityBaoshan 678000China College of Optoelectronic Engineering Chengdu University of Information TechnologyChengdu 610225China

The unstable zinc anode/electrolyte interface induced by corrosion,interfacial water splitting reaction,and dendrite growth seriously degrades the performances of metal Zn anode in aqueous ***,the nucleation and growth of zinc hydroxide sulfate(ZHS),an interfacial by-product,has been tailored by Tween 80 in the electrolyte,which thereby assists in in-situ forming a dense solid electrolyte interphase(SEI)with small-sized ZHS and evenly distributed Tween *** SEI has high corrosion resistance and uniform distribution of zinc ions,which not only contributes to blocking the interfacial side reactions but also induces stable and calm zinc plating/***,the modified electrolyte can confer the assembled Zn||Zn symmetric cell with a stable operation life over 1500 h at 1 mA·cm^(−2)and 1 mAh·cm^(−2)as well as the practical Zn||NH4V4O10 full battery with a high-rate capacity of 120 mAh·g^(−1)at the current density of 5 A·g^(−1).This work provides a way for regulating and reusing interfacial by-products,and a new sight on stabilization electrodes/electrolyte interfaces.

关键词： zinc hydroxide sulfides tailoring crystallization in-situ solid electrolyte interphase electrolyte engineering strategy aqueous zinc-ion battery

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Enhanced and asymmetric signatures of hybridization at climatic margins: Evidence from closely related dioecious fig species

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Plant Diversity 2024年第2期46卷 181-193页

作者： Jian-feng huang Clive T.Darwell Yan-Qiong Peng CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China National Center for Genetic Engineering and Biotechnology(BIOTEC) 113 Thailand Science ParkPhahonyothin RoadKhlong NuengKhlong LuangPathum Thani 12120Thailand

Hybridization plays a significant role in biological evolution. However, it is not clear whether ecological contingency differentially influences likelihood of hybridization, particularly at ecological margins where parental species may exhibit reduced fitnesses. Moreover, it is unknown whether future ecosystem change will increase the prevalence of hybridization. Ficus heterostyla and F. squamosa are closely related species co-distributed from southern Thailand to southwest China where hybridization, yielding viable seeds, has been documented. As a robust test of ecological factors driving hybridization, we investigated spatial hybridization signatures based on nuclear microsatellites from extensive population sampling across a widespread contact range. Both species showed high population differentiation and strong patterns of isolation by distance. Admixture estimates exposed asymmetric interspecific gene *** of hybridization increase significantly towards higher latitude zones, peaking at the northern climatic margins. Geographic variation in reproductive phenology combined with ecologically challenging marginal habitats may promote this phenomenon. Our work is a first systematic evaluation of such patterns in a comprehensive, latitudinally-based clinal context, and indicates that tendency to hybridize appears strongly influenced by environmental conditions. Moreover, that future climate change scenarios will likely alter and possibly augment cases of hybridization at ecosystem scales.

关键词： Hybridization Heterospecific visitation Fig Pollinator wasp Asymmetric gene flow

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An artificial intelligence diabetes management architecture based on 5G

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Digital Communications and Networks 2024年第1期10卷 75-82页

作者： Ruochen huang Wei feng Shan Lu Tao shan Changwei Zhang Yun Liu Department of Geriatrics The First Affiliated Hospital of Nanjing Medical UniversityNanjing210096China Department of Information The First Afliated Hospital of Nanjing Medical UniversityNanjing210096China Department of Medical Informatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing211166China Department of Outpatient The First Affiliated Hospital of Nanjing Medical UniversityNanjing210096China Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing210003China

Along with the development of 5G network and Internet of Things technologies,there has been an explosion in personalized healthcare *** the 5G and Artificial Intelligence(Al)is introduced into diabetes management architecture,it can increase the efficiency of existing systems and complications of diabetes can be handled more effectively by taking advantage of *** this article,we propose a 5G-based Artificial Intelligence Diabetes Management architecture(AIDM),which can help physicians and patients to manage both acute complications and chronic *** AIDM contains five layers:the sensing layer,the transmission layer,the storage layer,the computing layer,and the application *** build a test bed for the transmission and application ***,we apply a delay-aware RA optimization based on a double-queue model to improve access efficiency in smart hospital wards in the transmission *** application layer,we build a prediction model using a deep forest *** on real-world data show that our AIDM can enhance the efficiency of diabetes management and improve the screening rate of diabetes as well.

关键词： Diabetes 5G Artificial intelligence Deep forest Smart hospital ward

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