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Recognition for avian influenza virus proteins based on support vector machine and linear discriminant analysis

Science China Chemistry 2008年第2期51卷 166-170页

作者： LIANG GuiZhao CHEN ZeCong YANG ShanBin MEI Hu ZHOU Yuan YANG Li ZHOU Peng YANG ShengXi SHU Mao LIAO ChunYang WU ShiRong LI GenRong HE Liu GAO JianKun Gan MengYu LI DeJing CHEN GuoPing WANG GuiXue LONG Sha JING JuHua ZHENG XiaoLin ZENG Hui ZHANG QiaoXia ZHANG MengJun YANG Qi TIAN FeiFei TONG JianBo WANG JiaoNa LIU YongHong LI Bo QIU LiangJia CAI ShaoXi ZHAO Na YANG Yan SU XiaLi SONG Jian CHEN MeiXia ZHANG XueJiao SUN JiaYing LI JingWei CHEN GuoHua CHEN Gang DENG Jie PENG ChuanYou ZHU WanPing XU LuoNan WU YuQuan LIAO LiMin LI Zhi LI Jun LU DaJun SU QinLiang huang zhenghu ZHOU Ping LI ZhiLiang College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 400044China Key Laboratory for Biomechanics and Tissue Engineering under Ministry of Education at Chongqing University Chongqing 400044China College of Bioengineering Chongqing UniversityChongqing 400044China Technology Centre for Life Sciences and Biotechnology Singapore PolytechnicSingapore 139651Singapore

Total 200 properties related to structural characteristics were employed to represent structures of 400 HA coded proteins of influenza virus as training samples. Some recognition models for HA proteins of avian influenza virus (AIV) were developed using support vector machine (SVM) and linear discriminant analysis (LDA). The results obtained from LDA are as follows: the identification accuracy (Ria) for training samples is 99.8% and Ria by leave one out cross validation is 99.5%. Both Ria of 99.8% for training samples and Ria of 99.3% by leave one out cross validation are obtained using SVM model, respectively. External 200 HA proteins of influenza virus were used to validate the external predictive power of the resulting model. The external Ria for them is 95.5% by LDA and 96.5% by SVM, respectively, which shows that HA proteins of AIVs are preferably recognized by SVM and LDA, and the performances by SVM are superior to those by LDA.

关键词： avian influenza virus (AIV) HA protein support vector machine (SVM) linear discriminant analysis (LDA)

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高龄颅内主要供血动脉急性闭塞患者抽吸联合支架取栓后早期神经功能恶化相关因素

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脑与神经疾病杂志 2024年第3期32卷 133-137页

作者：黄淮徐正虎国树超河北中石油中心医院神经内科廊坊065000

目的分析高龄颅内主要供血动脉急性闭塞抽吸联合支架取栓后早期神经功能恶化(END)相关因素及预测模型构建。方法选择2020年11月至2022年11月河北中石油中心医院神经内科收治的110例高龄(81.60±3.04)岁,颅内主要供血动脉急性闭塞患者... 详细信息

目的分析高龄颅内主要供血动脉急性闭塞抽吸联合支架取栓后早期神经功能恶化(END)相关因素及预测模型构建。方法选择2020年11月至2022年11月河北中石油中心医院神经内科收治的110例高龄(81.60±3.04)岁,颅内主要供血动脉急性闭塞患者,所有患者均采取抽吸联合支架取栓术治疗。根据术后END发生情况分组,将发生END患者纳入END组,将未发生END组患者纳入无END组。比较两组基线资料,采用Logistic回归分析各因素与高龄颅内主要供血动脉急性闭塞患者抽吸联合支架取栓后END发生的危险因素;绘制ROC曲线分析各因素联合预测高龄颅内主要供血动脉急性闭塞患者抽吸联合支架取栓后END发生的价值。结果 END组H型高血压、糖尿病患者占比高于无END组[35.71%(10/28)、32.14%(9/28) vs 15.85%(13/82)、13.42 (11/82)],WBC、CRP、脂蛋白相关磷脂酶A2 (lipoprotein-associated phospholipaseA2,Lp-PLA2)高于无END组[(11.19±1.27)×10^(9)个·L^(-1)、(16.36±1.25)mg·L^(-1)、(181.22±35.48)μg·L^(-1)vs(10.05±1.04)×10^(9)个·L^(-1)、(12.57±2.11) mg·L^(-1)、(107.52±28.31)μg·L^(-1)](P 1,P <0.05);绘制ROC曲线发现,各因素联合预测高龄颅内主要供血动脉急性闭塞患者抽吸联合支架取栓后END发生的AUC:0.923、95%CI:0.860~0.987、P<0.05、特异度:0.854、灵敏度:0.929、约登指数:0.783,有一定预测价值。结论H型高血压、糖尿病与WBC、CRP、Lp-PLA2高表达是高龄颅内主要供血动脉急性闭塞患者抽吸联合支架取栓后END发生的危险因素,基于多因素构建的预测模型可有效预测END发生。

关键词：颅内主要供血动脉急性闭塞早期神经功能恶化抽吸支架

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S-Trifluoroethyl Benzenesulfonothioate:A Bench-Stable Reagent for Electrophilic Trifluoroethylthiolation

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Chinese Journal of Chemistry 2020年第12期38卷 1625-1628页

作者： Shuai huang Ziheng Xi Kui Lu Haifeng Lu Chen-Ho Tung zhenghu Xu Key Lab for Colloid and Interface Chemistry of Education Ministry Shandong UniversityJlinanShandong 250100China Stote Key Laborctory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghai 200032China Land Surveying and Mapping Institute of Shandong Province JinanShandong 250013China

of main observation and conclusion We report herein a practical approach for synthesis of an electrophilic trifluoroethylthiolation reagent PhSO2SCH2CF3(1)from easily available *** reaction proceeded through a protonation and nucleophilic substitution cascade of the in situ formed *** bench-stable reagent could easily be applied to introduce trifluoroethylthio group into small organic molecules.

关键词： materials. reagent substitution

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Copper(I)-Catalyzed Interrupted Click/Sulfenylation Cascade:One-Pot Synthesis of Sulfur Cycle Fused 1,2,3-Triazoles

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Chinese Journal of Chemistry 2020年第5期38卷 445-448页

作者： Weiguo Wang Shuai huang Shikun Yan Xuejun Sun Chen-Ho Tung zhenghu Xu School of Chemistry and Chemical Engineering Qufu Normal UniversityQufuShandong 273165China Key Lab for Colloid and Interface Chemistry of Education Ministry Shandong UniversityJinanShandong 250100China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Herein,we report a practical protocol for the synthesis of sulfur cycle fused 1,2,3-triazoles through a copper(I)-catalyzed tandem click/intramolecular sulfenylation *** reaction proceeded via a copper-catalyzed alkyne azide cycloaddition,followed by interception of the in situ formed cuprate-triazole intermediate with *** reaction shows broad substrate scope,complete regioselectivity,and excellent functional group tolerance under mild reaction conditions.

关键词： reaction. catalyzed copper

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Self-synchronized temporal-spectral characterization system for revealing ultrafast fiber laser dynamics

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Photonics Research 2023年第2期11卷 173-180页

作者： YULONG CAO zhenghu CHANG QIANG WU JINGSHENG huang LAIYANG DANG AI LIU YIYANG LUO LIGANG huang WEI huang LEI GAO TAO ZHU Key Laboratory of Optoelectronic Technology&Systems(Ministry of Education) Chongqing UniversityChongqing 400044China Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina

Due to the electronic bottleneck limited real-time measurement speed of common temporal-spectral detection and the particle-like nature of optical soliton enabled nonrepeatable transient behaviors, capturing the ultrafast laser pulses with unknown times of arrival and synchronously characterizing their temporal-spectral dynamic evolution is still a challenge. Here, using the Raman soliton frequency shift based temporal magnifier and dispersive Fourier transform based spectral analyzer, we demonstrate a self-synchronized, ultrafast temporal-spectral characterization system with a resolution of 160 fs and 0.05 nm, and a recording length above milliseconds. The synchronized nonlinear process makes it possible to image full-filled temporal sub-picosecond pulse trains regardless of their arrival times and without extra pump lasers and photoelectric conversion devices. To demonstrate the significance of this improvement, a buildup dynamic process of a soliton laser with a complex breakup and collisions of multisolitons is visually displayed in the spectral and temporal domains. The soliton dynamic evolution processes observed by our characterization system are in one-to-one correspondence with the numerical simulation results. We believe this work provides a new multidimensional technique to break the electronic bottleneck to gain additional insight into the dynamics of ultrafast lasers and nonlinear science.

关键词： fiber pump soliton

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Single-shot measurement of wavelength-resolved state of polarization dynamics in ultrafast lasers using dispersed division-of-amplitude

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Photonics Research 2023年第1期11卷 35-43页

作者： QIANG WU LEI GAO YULONG CAO STEFAN WABNITZ zhenghu CHANG AI LIU JINGSHENG huang LIGANG huang TAO ZHU Key Laboratory of Optoelectronic Technology&Systems(Ministry of Education) Chongqing UniversityChongqing 400044China Dipartimento di Ingegneria dell'Informazione Elettronica e TelecomunicazioniSapienza Universitadi Roma00184 RomaItaly CNR-INO Istituto Nazionale di Ottica80078 Pozzuoli(NA)Italy

Characterization of the state of polarization(SOP)of ultrafast laser emission is relevant in several application fields such as field manipulation,pulse shaping,testing of sample characteristics,and biomedical ***,since high-speed detection and wavelength-resolved measurements cannot be simultaneously achieved by commercial polarization analyzers,single-shot measurements of the wavelength-resolved SOP of ultrafast laser pulses have rarely been ***,we propose a method for single-shot,wavelength-resolved SOP measurements that exploits the method of division-of-amplitude under far-field transformation.A large accumulated chromatic dispersion is utilized to time-stretch the laser pulses via dispersive Fourier transform,so that spectral information is mapped into a temporal *** calibrating our test matrix with different wavelengths,wavelength-resolved SOP measurements are achieved,based on the division-of-amplitude approach,combined with high-speed opto-electronic *** a proof-of-concept demonstration,we reveal the complex wavelength-dependent SOP dynamics in the build-up of dissipative *** experimental results show that the dissipative soliton exhibits far more complex wavelength-related polarization dynamics,which are not shown in single-shot spectrum *** method paves the way for single-shot measurement and intelligent control of ultrafast lasers with wavelength-resolved SOP structures,which could promote further investigations of polarization-related optical signal processing techniques,such as pulse shaping and hyperspectral polarization imaging.

关键词： polarization resolved dynamics

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基于P2P的大尺寸内容发布算法研究

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华中科技大学学报（自然科学版） 2005年第Z1期33卷 73-75页

作者：陈海涛黄遵国龚正虎国防科学技术大学计算机学院湖南长沙410073

针对并发下载问题建模,给出了可能的优化方向.提出一种基于分组的下载调度算法(GBS),通过内容和节点分组为下载调度提供压缩的内容分布信息,在内容互补节点之间建立连接,提高邻居节点之间的内容交叉度和平均连接持续时间;区分节点的下... 详细信息

针对并发下载问题建模,给出了可能的优化方向.提出一种基于分组的下载调度算法(GBS),通过内容和节点分组为下载调度提供压缩的内容分布信息,在内容互补节点之间建立连接,提高邻居节点之间的内容交叉度和平均连接持续时间;区分节点的下载过程,根据节点不同下载状态采取不同的连接管理和下载策略.模拟测试表明,GBS算法在系统吞吐量、用户平均下载时间、节点带宽利用率等方面优于BitTorrent采用的随机下载调度算法.

关键词：内容发布并发下载连接管理激励相容

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一种基于学习的P2P搜索算法

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计算机研究与发展 2005年第9期42卷 1600-1604页

作者：陈海涛龚正虎黄遵国国防科学技术大学计算机学院长沙410073

对于规模对等网络,搜索是一个必备的基本功能,但同时是一个困难而又富于挑战性的问题.提出一种基于学习的搜索方法———***采取分布式的被动学习方式,从历史搜索结果中学习节点之间的兴趣相似度,将节点按照兴趣分类,在具有相似兴趣节... 详细信息

对于规模对等网络,搜索是一个必备的基本功能,但同时是一个困难而又富于挑战性的问题.提出一种基于学习的搜索方法———***采取分布式的被动学习方式,从历史搜索结果中学习节点之间的兴趣相似度,将节点按照兴趣分类,在具有相似兴趣节点之间建立朋友关系.搜索请求首先转发到朋友节点,当其失效后利用广播进行搜索.模拟测试表明,SmartSearch稳定高效,相比传统算法在低开销情况下性能有数量级的提高.

关键词：搜索对等网络分类分布式学习

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CFTR is a negative regulator ofγδT cell IFN-γproduction and antitumor immunity

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Cellular & Molecular Immunology 2021年第8期18卷 1934-1944页

作者： Yuanyuan Duan Guangqiang Li Miaomiao Xu Xiaofei Qi Mingxia Deng Xuejia Lin Zhiwei Lei Yi Hu zhenghu Jia Quanli Yang Guangchao Cao Zonghua Liu Qiong Wen Zhenhua Li Jie Tang Wei Kevin Zhang Pingbo huang Limin Zheng Richard A.Flavell Jianlei Hao Zhinan Yin Zhuhai Precision Medical Center Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Jinan UniversityZhuhai519000GuangdongChina The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhou510632GuangdongChina Department of Physiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515GuangdongChina The First Affiliated Hospital Jinan UniversityGuangzhou510632China School of Pharmaceutical Sciences South-Central University for NationalitiesWuhan430074HubeiChina Division of Life Science Hong Kong University of Science and Technology(HKUST)Hong KongChina State Key Laboratory of Oncology in Southern China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou510060China Department of Immunobiology School of MedicineYale UniversityNew HavenCT06520USA

CFTR,a chloride channel and ion channel regulator studied mostly in epithelial cells,has been reported to participate in immune regulation and likely affect the risk of cancer ***,little is known about the effects of CFTR on the differentiation and function ofγδT *** this study,we observed that CFTR was functionally expressed on the cell surface ofγδT *** deletion and pharmacological inhibition of CFTR both increased IFN-γrelease by peripheralγδT cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in ***,the molecular mechanisms underlying the regulation ofγδT cell IFN-γproduction by CFTR were either TCR dependent or related to Ca^(2+)*** was recruited to TCR immunological synapses and attenuated Lck-P38 MAPK-c-Jun *** addition,CFTR was found to modulate TCR-induced Ca^(2+)influx and membrane potential(Vm)-induced Ca^(2+)influx and subsequently regulate the calcineurin-NFATc1 signaling pathway inγδT ***,CFTR serves as a negative regulator of IFN-γproduction inγδT cells and the function of these cells in antitumor *** investigation suggests that modification of the CFTR activity ofγδT cells may be a potential immunotherapeutic strategy for cancer.

关键词： CFTR γδT cells TCR Membrane potential Antitumor immunity

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无铅手工焊接工艺分析和试验研究

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热加工工艺 2012年第15期41卷 200-202页

作者：黄丽娟朱正虎南京信息职业技术学院江苏南京210046 中国航天科工八五一一研究所江苏南京210007

结合现有的有铅焊接技术,对无铅手工焊接进行了工艺分析和试验研究。从焊接接头的物理化学性能和力学性能方面进行了试验对比分析,得出手工无铅焊接的最优工艺参数为:无铅焊料选用Sn-0.7Cu,印制板焊盘进行ENIG处理,使用METCAL智能烙铁... 详细信息

结合现有的有铅焊接技术,对无铅手工焊接进行了工艺分析和试验研究。从焊接接头的物理化学性能和力学性能方面进行了试验对比分析,得出手工无铅焊接的最优工艺参数为:无铅焊料选用Sn-0.7Cu,印制板焊盘进行ENIG处理,使用METCAL智能烙铁进行手工焊接时,在(370±10)℃焊接温度下,焊接时间为3～5 s。

关键词：无铅焊料印制板工艺参数性能测试

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