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Horticultural Plant Journal 2024年第1期10卷 273-287页

作者： Wei huang Danni Ma Fawad Zaman Xulei Hao Li Xia E Zhang Pu Wang Mingle Wang Fei Guo Yu Wang Dejiang Ni hua Zhao National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhanHubei 430070China

In plants,the lysine and histidine transporter(LHT)family represent a class of proteins that mediate the uptake,translocation,and utilization of amino *** tea plant(Camellia sinensis)is a perennial evergreen with a relatively high level of amino ***,systematic identification and molecular characterization of the LHT gene family has rarely been reported in tea *** this study,22 CsLHTs were identified from the‘Shuchazao’genome and classified into two *** modeled three-dimensional structure and the conserved domains presented a high similarity among the LHTs ***,it was predicted that a few genes were conserved through the analysis of the physiochemical characters,structures and cis-elements in *** expression patterns in tea plants revealed that CsLHT7 was mainly expressed in the roots,and CsLHT4 and CsLHT11 exhibited relatively high expression in both the roots and ***,the expression of all three genes could be induced by organic ***,heterogeneous expression of CsLHT4,CsLHT7 and CsLHT11 in Arabidopsis thaliana decreased the aerial parts biomass compared with that in WT plants while significantly increased the rosette biomass only for CsLHT11transgenic plants versus WT ***,our results provide fundamental information about CsLHTs and potential genes in N utilization for further analysis in tea plants.

关键词： Camellia sinensis Nitrogen Lysine and histidine transporter(LHT)family

New insights into mechanisms and interventions of locoregional therapies for hepatocellular carcinoma

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Chinese Journal of Cancer Research 2024年第2期36卷 167-194页

作者： Hanyuan Liu Chunmei Wang Ruiqiang Wang Hengsong Cao Yongfang Cao Tian huang Zhengqing Lu hua Xiao Mengcheng Hu Hanjin Wang Jun Zhao Department of General surgery Nanjing First HospitalNanjing Medical UniversityNanjing 210019China Department of Oncology Sir Run Run HospitalNanjing Medical UniversityNanjing 211166China School of Public Health China Medical UniversityShenyang 110122China Hepatobiliary/Liver Transplantation Center the First Affiliated Hospital of Nanjing Medical UniversityKey Laboratory of Living Donor TransplantationChinese Academy of Medical SciencesNanjing 210024China Department of Gastroenterology the Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjing 211103China Department of Nuclear Medicine the Affiliated Changzhou Second People's Hospital of Nanjing Medical UniversityChangzhou 213001China

Hepatocellular carcinoma(HCC) is responsible for a significant number of cancer-related deaths worldwide and its incidence is increasing. Locoregional treatments, which are precision procedures guided by imaging to specifically target liver tumors, play a critical role in the management of a substantial portion of HCC cases. These therapies have become an essential element of the HCC treatment landscape, with transarterial chemoembolization(TACE)being the treatment of choice for patients with intermediate to advanced stages of the disease. Other locoregional therapies, like radiofrequency ablation, are highly effective for small, early-stage HCC. Nevertheless, the advent of targeted immunotherapy has challenged these established treatments. Tyrosine kinase inhibitors(TKIs) and immune checkpoint inhibitors(ICIs) have shown remarkable efficacy in clinical settings. However, their specific uses and the development of resistance in subsequent treatments have led clinicians to reevaluate the future direction of HCC therapy. This review concentrates on the distinct features of both systemic and novel locoregional therapies. We investigate their effects on the tumor microenvironment at the molecular level and discuss how targeted immunotherapy can be effectively integrated with locoregional therapies. We also examine research findings from retrospective studies and randomized controlled trials on various combined treatment regimens, assessing their validity to determine the future evolution of locoregional therapies within the framework of personalized, comprehensive treatment.

关键词： Locoregional therapies transarterial chemoembolization hepatocellular carcinoma immunotherapy tumor microenvironment

Des-Arg(9)bradykinin as a causal metabolite for autism spectrum disorder

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World Journal of Psychiatry 2024年第1期14卷 88-101页

作者： Zhong-Yu huang Zi-Pan Lyu Hong-Gui Li hua-Zhi You Xiang-Na Yang Cai-Hui Cha Center for Medical Research on Innovation and Translation Institute of Clinical MedicineGuangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510000Guangdong ProvinceChina School of Biological Sciences Nanyang Technological UniversityNanyang Ave 639798Singapore Department of Pediatrics First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Nutrition First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Pediatric Traditional Chinese Medicine Clinic Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina Department of Psychology Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Early diagnosis and therapeutic interventions can greatly enhance the developmental trajectory of children with autism spectrum disorder(ASD).However,the etiology of ASD is not completely *** presence of confounding factors from environment and genetics has increased the difficulty of the identification of diagnostic biomarkers for *** To estimate and interpret the causal relationship between ASD and metabolite profile,taking into consideration both genetic and environmental *** A two-sample Mendelian randomization(MR)analysis was conducted using summarized data from large-scale genome-wide association studies(GWAS)including a metabolite GWAS dataset covering 453 metabolites from 7824 European and an ASD GWAS dataset comprising 18381 ASD cases and 27969 healthy *** in plasma were set as exposures with ASD as the main *** causal relationships were estimated using the inverse variant weight(IVW)*** also performed leave-one-out sensitivity tests to validate the robustness of the *** on the drafted metabolites,enrichment analysis was conducted to interpret the association via constructing a protein-protein interaction network with multi-scale evidence from databases including Infinome,SwissTargetPrediction,STRING,and *** Des-Arg(9)-bradykinin was identified as a causal metabolite that increases the risk of ASD(β=0.262,SE=0.064,P_(IVW)=4.64×10^(-5)).The association was robust,with no significant heterogeneity among instrument variables(P_(MR Egger)=0.663,P_(IVW)=0.906)and no evidence of pleiotropy(P=0.949).Neuroinflammation and the response to stimulus were suggested as potential biological processes mediating the association between Des-Arg(9)bradykinin and *** Through the application of MR,this study provides practical insights into the potential causal association between plasma metabolites and *** findings offer perspectives for the discovery of diagnos

关键词： Des-Arg(9)bradykinin Autism spectrum disorder Mendelian randomization Metabolite Enrichment analysis

Risk stratification in gastric cancer lung metastasis: Utilizing an overall survival nomogram and comparing it with previous staging

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 357-381页

作者： Zhi-Ren Chen Mei-Fang Yang Zhi-Yuan Xie Pei-An Wang Liang Zhang Ze-hua huang Yao Luo Department of Science and Education Xuzhou Medical UniversityXuzhou Clinical CollegeXuzhou 221000Jiangsu ProvinceChina Department of Neurology Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Neurology Clinical LaboratoryGastrointestinal SurgeryCentral Hospital of XuzhouCentral Hospital of XuzhouXuzhou 221000Jiangsu ProvinceChina Department of Public Health Xuzhou Central HospitalXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology Xuzhou Centre HospitalXuzhou 221000Jiangsu ProvinceChina Department of Public Health Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is prevalent and aggressive,especially when patients have distant lung metastases,which often places patients into advanced *** identifying prognostic variables for lung metastasis in GC patients,it may be po-ssible to construct a good prediction model for both overall survival(OS)and the cumulative incidence prediction(CIP)plot of the *** To investigate the predictors of GC with lung metastasis(GCLM)to produce nomograms for OS and generate CIP by using cancer-specific survival(CSS)*** Data from January 2000 to December 2020 involving 1652 patients with GCLM were obtained from the Surveillance,epidemiology,and end results program *** major observational endpoint was OS;hence,patients were se-parated into training and validation *** analysis determined va-rious *** and multivariate Cox analyses validated the independent predictive *** distinction and calibration were performed with the time-dependent area under the curve(AUC)and calibration *** evaluate the accuracy and clinical usefulness of the nomograms,decision curve analysis(DCA)was *** clinical utility of the novel prognostic model was compared to that of the 7th edition of the American Joint Committee on Cancer(AJCC)staging system by utilizing Net Reclassification Improvement(NRI)and Integrated Discrimination Improvement(IDI).Finally,the OS prognostic model and Cox-AJCC risk stratification model modified for the AJCC system were *** For the purpose of creating the OS nomogram,a CIP plot based on CSS was *** multivariate regression analysis identified eleven significant prognostic factors(P0),time-de-pendent ROC curve(training/v

关键词： Gastric cancer Lung metastasis Nomograms Surveillance Epidemiology Surveillance epidemiology and end results program database Overall survival Prognosis

Gut microbiota induced abnormal amino acids and their correlation with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 883-895页

作者： Sheng-Qun Jiang Su-Na Ye Yin-hua huang Yi-Wen Ou Ke-Yang Chen Jian-Su Chen Shi-Bo Tang Aier Eye Hospital Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Aier Eye Institute and Changsha Aier Hospital Changsha 410000Hunan ProvinceChina The First Affiliated Hospital of Bengbu Medical University Bengbu 233000Anhui ProvinceChina School of Public Health Anhui Medical UniversityHefei 230000Anhui ProvinceChina

AIM:To explore the correlation of gut microbiota and the metabolites with the progression of diabetic retinopathy(DR)and provide a novel strategy to elucidate the pathological mechanism of ***:The fecal samples from 32 type 2 diabetes patients with proliferative retinopathy(PDR),23 with nonproliferative retinopathy(NPDR),27 without retinopathy(DM),and 29 from the sex-,age-and BMI-matched healthy controls(29 HC)were analyzed by 16S rDNA gene *** fecal samples from PDR,DM,and HC groups were assayed by untargeted *** metabolites were measured using liquid chromatographymass spectrometry(LC-MS)*** between gut microbiota and fecal metabolites were ***:A cluster of 2 microbiome and 12 metabolites accompanied with the severity of DR,and the close correlation of the disease progression with PDR-related microbiome and metabolites were *** be specific,the structure of gut microbiota differed in four *** and richness of gut microbiota were significantly lower in PDR and NPDR groups,than those in DM and HC groups.A cluster of microbiome enriched in PDR group,including Pseudomonas,Ruminococcaceae-UCG-002,Ruminococcaceae-UCG-005,Christensenellaceae-R-7,was *** analysis showed that the glucose and nicotinate degradations were significantly higher in PDR group than those in HC ***,serine,ornithine,and arachidonic acid were significantly enriched in PDR group,while proline was enriched in HC *** analysis illustrated that arginine biosynthesis,lysine degradation,histidine catabolism,central carbon catabolism in cancer,D-arginine and D-ornithine catabolism were elevated in PDR *** analysis revealed that Ruminococcaceae-UCG-002 and Christensenellaceae-R-7 were positively associated with L-arginine,ornithine levels in fecal ***:This study elaborates the different microbiota structure in the gut from four *** relative abundance of

关键词： proliferative retinopathy gut microbiota Ruminococcaceae amino acid metabolism arginine

论生成式人工智能侵权的责任主体——以集体主义为视角

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南昌大学学报（人文社会科学版） 2024年第1期55卷 119-131页

作者：陆小华陆赛赛天津大学新媒体与传播学院天津300072 天津大学法学院天津300072

生成式人工智能的快速发展与模糊的责任主体之间形成了巨大的责任鸿沟。生成式人工智能的多方参与者加剧了责任主体的不确定性,故有必要审视现有法律规范框架。侵权法所贯彻个人主义思想的侵权责任规范仍有适用空间,但适用范围有限。生... 详细信息

生成式人工智能的快速发展与模糊的责任主体之间形成了巨大的责任鸿沟。生成式人工智能的多方参与者加剧了责任主体的不确定性,故有必要审视现有法律规范框架。侵权法所贯彻个人主义思想的侵权责任规范仍有适用空间,但适用范围有限。生成式人工智能侵权的救济思维应当转向集体主义视角。尊重技术逻辑构建机器/人-机联合体,并依托侵权场景的类型化搭建多元责任主体的识别路径,进而在联合体内部将责任与经济利益相绑定,以此实现责任分配。

关键词：生成式人工智能人机交互联合体类型集体主义

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Layered niobium carbide enabling excellent kinetics and cycling stability of Li-Mg-B-H hydrogen storage material Layered niobium carbide enabling excellent kinetics

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Rare Metals 2024年第3期43卷 1153-1166页

作者： Li-Wen Lu Hui Luo Guang-Xu Li Yun Li Xin-hua Wang Cun-Ke huang Zhi-QiangLan Wen-Zheng Zhou Jin Guo Mohammad Ismail Hai-Zhen Liu Guangxi Novel Battery Materials Research Center of Engineering Technology Guangxi Colleges and Universities Key Laboratory of Blue Energy and Systems IntegrationSchool of Physical Science and TechnologyGuangxi UniversityNanning530004China State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Nanning530004China School of Mechanical and Electrical Engineering Quzhou College of TechnologyQuzhou324000China Department of Materials Science and Engineering Zhejiang UniversityHangzhou310027China Faculty of Ocean Engineering Technology and Informatics Universiti Malaysia Terengganu21030Kuala NerusTerengganuMalaysia Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin300071China

The Li-Mg-B-H composite(2LiBH_(4)+MgH_(2))has a high capacity of 11.4 wt%as a hydrogen storage ***,the slow kinetics and poor cycling stability severely restrict its practical *** this work,a layered Nb_(2)C MXene was first synthesized and then introduced to tailor the kinetics and cycling stability of the Li-Mg-B-H *** milled 2LiH+MgB_(2)composites were initially hydrogenated to obtain the 2LiBH_(4)+MgH_(2)*** 2LiBH_(4)+MgH_(2)+5wt%Nb_(2)C can release 9.0 wt%H_(2)in 30 min at 400℃,while it is only 2.7 wt%for the undoped 2LiBH_(4)+MgH_(2).The dehydrogenation activation energies of MgH_(2)and LiBH_(4)are 123 and 154 kJ·mol^(-1)respectively for the 5 wt%Nb_(2)C-doped composite,lower than the undoped composite(164 and 165 kJ·mol^(-1)).The 2LiBH_(4)+MgH_(2)+5 wt%Nb_(2)C possesses excellent cycling stability,with the reversible capacity only slightly reduced from 9.4 wt%for the 1st cycle to 9.3 wt%for the 20th ***_(2)C keeps stable in the composite and acts as an efficient catalyst for the Li-Mg-B-H *** is believed that both the layered structure and the active Nb element contribu te to the enhanced hydrogen storage performances of the Li-Mg-B-H *** work confirms that the Nb_(2)C MXene with layered stru cture has a significant enhancing impact on the Li-Mg-B-H hydrogen storage materials,which is different from the bulk NbC.

关键词： Hydrogen storage Lithium borohydride Magnesium hydride Nb_(2)C MXene

Highly Hydrolysis-Resistant Polyimide Fibers Prepared by Thermal Crosslinking with Inherent Carboxyl Groups

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Chinese Journal of Polymer Science 2024年第2期42卷 247-255,I0010页

作者： Can-Can Zhang Jun-Long Yang Ya-Jiang huang Guang-Xian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu610065China

Easy hydrolysis in alkaline environments limits the use of polyimide fibers in environmental protection. The hydrolysis resistance levels of polyimide fibers can be improved by crosslinking of the macromolecular chains. In this work, crosslinked polyimide fibers(CPI fibers) were produced by intrinsic carboxyl decarboxylation for the first time. The thermal stability of the polyimide fibers containing the intrinsic carboxyl groups(PIC fibers) was studied, and the temperature of the decarboxylation-crosslinking reaction was determined to be 450 ℃. The PIC fibers were hotdrawn to initiate thermal crosslinking of the carboxyl groups and molecular chain orientation at high temperature. The CPI fibers had high tensile strengths(0.72-1.46 GPa) and compressive strengths(401-604 MPa). The oriented macromolecules and chemically crosslinked structure improved the tightness of the molecular chains and endowed the CPI fibers with excellent hydrolytic resistance. The CPI-50 fiber did not dissolve in a 0.5 wt% NaOH solution during heating at 90 ℃ for 10 h, and the tensile strength retention reached 87% when treated in 0.5 wt% NaOH solutions at 90 ℃ for 1 h, providing a guarantee for its application in alkaline corrosive environments.

关键词： Polyimide Carboxyl group Crosslinking Hydrolysis-resistance

Catalytic asymmetric dearomative azo-Diels–Alder reaction of 2-vinlyindoles

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Chinese Chemical Letters 2024年第4期35卷 357-362页

作者： Yu-Hang Miao Zheng-Xu Zhang Xu-Yi huang Yuan-Zhao hua Shi-Kun Jia Xiao Xiao Min-Can Wang Li-Ping Xu Guang-Jian Mei Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450052China School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000China Institute of Pharmaceutical Science and Technology Zhejiang University of TechnologyHangzhou 310014China

Due to the high electrophilic nature of azo-dienophiles, azo-Diels–Alder proceeds rapidly even without the need of a catalyst and is therefore regarded as the “click reaction”. This spontaneity causes strong background reaction and poses a daunting challenge to chemists for developing the catalytic asymmetric version. Reported herein is the first catalytic asymmetric dearomative azo-Diels–Alder reaction between2-vinylindoles and triazoledione. This protocol makes use of the high energy barrier of dearomatization to avert the strong background reaction of azo-Diels–Alder reaction, allowing the implementation of the projected reaction at ambient temperature. Density functional theory calculations have been performed to gain insights into the reaction mechanism and the origins of the enantioselectivity. By using this method,a variety of tetracyclic indole derivatives have been readily prepared in good to excellent yields and with excellent diastereo-and enantio–selectivities(33 examples, up to 97% yield and >99% ee, >20:1 dr).

关键词： Catalytic asymmetric dearomatization Azo-Diels–Alder reaction 2-Vinylindoles Chiral phosphoric acid Tetracyclic indole derivatives

Progress and prospects of graphene-based materials in lithium batteries

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Rare Metals 2024年第5期43卷 1886-1905页

作者： Shen Lai Tao huang Pei Liu Hong-Bin Wang Shi-Chun Yang Xin-hua Liu Kai Yang Qian-Ling Zhang Jian-Hong Liu Jiang-Tao Hu Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen518060China School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Department of Electrical and Electronic Engineering Advanced Technology InstituteUniversity of SurreyGuildfordSurrey GU27XHUK

Reasonable design and applications of graphene-based materials are supposed to be promising ways to tackle many fundamental problems emerging in lithium batteries,including suppression of electrode/electrolyte side reactions,stabilization of electrode architecture,and improvement of conductive ***,extensive fundamental research on this aspect has been performed so ***,when it comes to large-scale industrial applications,the utilization of graphene-based materials progresses at a very slow ***,there presents a severe technological decoupling between academic research and industrial application,and there is an urgent need to link ***,in order to address current issues of graphene-based materials used in lithium batteries,we present their latest advancements with stateof-the-art *** applications of graphenebased materials in practical lithium batteries are highlighted and predicted to bridge the gap between the academic progress and industrial manufacture,thereby paving the way for accelerating the development of graphenebased material as well as lithium battery industry.

关键词： Lithium batteries Graphene-based materials Academic research Industrial application Development direction