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Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury

Virologica Sinica 2024年第2期39卷 309-318页

作者： Jian-Bo Cao Shu-Tong Zhu Xiao-Shan huang Xing-Yuan Wang Meng-Li Wu Xin Li Feng-Liang Liu Ling Chen Yong-Tang Zheng Jian-hua Wang Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China School of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230026China Key Laboratory of Bioactive Peptides of Yunnan Province Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of SciencesKIZCUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China University of Chinese Academy of Sciences Beijing 101408China

SARS-CoV-2 infection-induced hyper-inflammation is a key pathogenic factor of *** research,along with others',has demonstrated that mast cells(MCs)play a vital role in the initiation of hyper-inflammation caused by *** previous study,we observed that SARS-CoV-2 infection induced the accumulation of MCs in the peri-bronchus and bronchioalveolar-duct junction in humanized ***,we found that MC degranulation triggered by the spike protein resulted in inflammation in alveolar epithelial cells and capillary endothelial cells,leading to subsequent lung *** trachea and bronchus are the routes for SARS-CoV-2 transmission after virus inhalation,and inflammation in these regions could promote viral *** are widely distributed throughout the respiratory ***,in this study,we investigated the role of MCs and their degranulation in the development of inflammation in tracheal-bronchial *** analyses showed the accumulation and degranulation of MCs in the peri-trachea of humanized mice infected with *** degranulation caused lesions in trachea,and the formation of papillary hyperplasia was *** transcriptome analysis in bronchial epithelial cells,we found that MC degranulation significantly altered multiple cellular signaling,particularly,leading to upregulated immune responses and *** administration of ebastine or loratadine effectively suppressed the induction of inflammatory factors in bronchial epithelial cells and alleviated tracheal injury in *** together,our findings confirm the essential role of MC degranulation in SARS-CoV-2-induced hyper-inflammation and the subsequent tissue ***,our results support the use of ebastine or loratadine to inhibit SARS-CoV-2-triggered degranulation,thereby preventing tissue damage caused by hyper-inflammation.

关键词： SARS-CoV-2 Mast cell(MC) Bronchial epithelial cell Inflammation Tracheal injury

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3株霉菌对甲醛转化能力的研究

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中国环境科学 2008年第12期28卷 1111-1115页

作者：黄赛花陈能场毕鸿亮广东省生态环境与土壤研究所广东广州510650

利用含甲醛的选择性培养基分离并鉴定出3株甲醛转化霉菌Trichoderma viride H1,Penicillium javanicum H2,Aspergillus flavus H4,均能生长在以甲醛为唯一碳源的培养基上,并探讨了其最适生长pH值,研究了3株霉菌的甲醛转化能力.结果表明,... 详细信息

利用含甲醛的选择性培养基分离并鉴定出3株甲醛转化霉菌Trichoderma viride H1,Penicillium javanicum H2,Aspergillus flavus H4,均能生长在以甲醛为唯一碳源的培养基上,并探讨了其最适生长pH值,研究了3株霉菌的甲醛转化能力.结果表明,3株霉菌的最适pH值分别为4.5,5.0,5.5.30℃,160r/min揺床培养144h,H1、H2、H4可将甲醛浓度由1047,1059,1241mg/L转化至7.6,317,4.0mg/L,转化率分别为99.3%,70.1%,99.7%.

关键词：甲醛转化转化曲线转化率微生物霉菌

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Effects of plants-associated microbiota on cultivation and quality of Chinese herbal medicines

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Chinese Herbal Medicines 2024年第2期16卷 190-203页

作者： Yue Ouyang Qiqing Cheng Chunsong Cheng Ziyu Tang Yufeng huang Eyu Tan Shaofeng Ma Xinheng Lin Ying Xie hua Zhou Guangdong Provincial Hospital of Chinese Medicine Guangdong Provincial Academy of Chinese Medical SciencesState Key Laboratory of Dampness Syndrome of Chinese MedicineSecond Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease ResearchGuangzhou 510006China Faculty of Chinese Medicine Macao University of Science and TechnologyMacao 999078China School of Pharmacy Hubei University of Science and TechnologyXianning 437100China Key Laboratory of Plant Ex-situ Conservation and Research Center of Resource Plant Lushan Botanical GardenChinese Academy of SciencesJiujiang 332900China Jiangmen Wuyi Hospital of Traditional Chinese Medicine Jiangmen 529020China Joint Laboratory for Translational Cancer Research of Chinese Medicine Ministry of EducationGuangzhou University of Chinese MedicineGuangzhou 510006China

Microbial resource influences the life activities of medicinal plants from several ***,rhizosphere microorganisms,and other environmental microorganisms play essential roles in medicinal plant growth and development,plant yield,and clinical *** microbiota can influence the biosynthesis of active compounds in medicinal plants by stimulating specific metabolic *** induce host plants to improve their resistance to environmental stresses by accumulating secondary *** can interact with their host plants to produce long-term,targeted selection results and improve their ability to adapt to the *** to the interdependence and interaction between microorganisms and medicinal plants,Chinese herbal medicines(CHMs)quality is closely related to the associated *** review summarizes the relationship between medicinal plants and their associated microorganisms,including their species,distribution,life activities,and *** can aid in quality control,improve the efficacy of medicinal plants,and provide markers for identifying the origin and storage time of ***,a comprehensive understanding of the relationship between microorganisms and medicinal plants will help to control the quality of CHMs from different perspectives.

关键词： Chinese herbal medicines endophytes environmental microorganisms microbiota rhizosphere microorganisms

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Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan Sun Xiu-Na Yang Shuang-Shuang Yang Yi-Zhu Lyu Bing Zhang Kai-Wen Liu Na Li Jia-Chen Cui Guang-Xiang huang Cheng-Lin Liu Jie Xu Jian-Qing Mi Zhu Chen Xiao-Hu Fan sai-Juan Chen Shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China National Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular ***,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based *** co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple *** we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated *** analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in ***-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived *** results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

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Rapid progress of an iris metastasis from esophageal cancer:a case report and review of literature

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1557-1567页

作者： Meng Xie Xing-hua Wang Jun-Jie Yang Zi-Xuan Su Jia-Hui huang Peng-Cheng Li Fa-Gang Jiang Department of Ophthalmology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

This case report details a rare instance of rapid iris metastasis from esophageal cancer in a 59-year-old man.A literature review was conducted to explore recent advances in detecting,diagnosing,and treating intraocular metastatic *** emission tomographycomputed tomography played a crucial role in identifying primary sites and systemic *** treatment combined with systemic therapy effectively reduced tumor size,preserved useful vision,and improved the patient’s survival rate.A comparison was made of the characteristics of iris metastases from esophageal cancer and lung cancer,including age,gender,tumor characteristics,and *** challenges associated with diagnosis and treatment are discussed,highlighting the implications for clinical practice.

关键词： iris metastasis esophageal cancer positron emission tomography-computed tomography review

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Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-Li Zhang Xi Zhang Wang hua Zheng-De Xie Han-Min Liu Hai-Lin Zhang Bi-Quan Chen Yuan Chen Xin Sun Yi Xu sai-Nan Shu Shun-Ying Zhao Yun-Xiao Shang Ling Cao Yan-Hui Jia Luo-Na Lin Jiong Li Chuang-Li Hao Xiao-Yan Dong Dao-Jiong Lin Hong-Mei Xu De-Yu Zhao Mei Zeng Zhi-Min Chen Li-Su huang Department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina Department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina Department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina Department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina Department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory Department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina Department of Clinical Epidemiology Aarhus UniversityAarhusDenmark Department of Respirology Children's Hospital of Soochow UniversitySuzhouChina Department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina Department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina Department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina Department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

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交通流“流速密能”图谱模型与应用

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中国公路学报 2024年第4期37卷 84-97页

作者：黄健畅宋国华北京交通大学交通运输学院北京100044 北京交通大学综合交通运输大数据应用技术交通运输行业重点实验室北京100044

交通流的物理本质是能量驱动的物质位移。为挖掘交通流和能量的关系,基于交通流功率分布模型探索建立了流量、速度、密度和能量四要素图谱。其中,能量(kJ·km^(-1)·h^(-1))在数学上描述为能耗因子(kJ·km^(-1)·veh^(-1))和交通流量(ve... 详细信息

交通流的物理本质是能量驱动的物质位移。为挖掘交通流和能量的关系,基于交通流功率分布模型探索建立了流量、速度、密度和能量四要素图谱。其中,能量(kJ·km^(-1)·h^(-1))在数学上描述为能耗因子(kJ·km^(-1)·veh^(-1))和交通流量(veh·h^(-1))的乘积。首先,基于均衡态交通流不同空间平均速度下的功率分布,建立随平均速度变化的能耗因子曲线;其次,基于4个经典交通流基本图模型(Greenshields、Greenberg、Underwood和Van Aerde)建立速度与流量关系;最后,结合流量和能耗因子得到流量-速度-密度-能量图谱。当能量转换效率为100%时:在速度-能量方面,流量对能量的变化起到主导作用,因此,随着速度上升能量呈现先上升后下降趋势;在密度-能量方面,随着密度上升能量同样先上升后下降,但由于密度和速度呈负相关,其变化原理与速度-能量相反;在流量-能量方面,同一流量可对应低速/高速下的拥堵/非拥堵状态,能耗因子随着流量上升呈现2种状态,能耗因子上升或能耗因子下降,但下降速率低于流量上升速率。该研究是面向能量网络制定精细化政策和优化能源网络设施设计的先行工作。

关键词：交通工程流速密能图谱功率分布能量交能融合

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艾灸内关穴对乳腺癌化疗所致心肌损害的预防作用

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中国临床研究 2024年第3期37卷 375-378页

作者：耿洁李华贺赛西安交通大学第二附属医院心血管内科陕西西安710004 府谷县人民医院检验科陕西榆林719400 陕西省肿瘤医院乳腺病院陕西西安710061

目的研究艾灸内关穴在预防乳腺癌含蒽环类药物化疗所致心肌损害中的作用,探索艾灸内关穴减轻化疗心脏毒性的可行性。方法选取陕西省肿瘤医院乳腺科2020年5月至2021年5月收治的行EC-T(吡柔比星+环磷酰胺序贯多西他赛)方案术后辅助化疗的... 详细信息

目的研究艾灸内关穴在预防乳腺癌含蒽环类药物化疗所致心肌损害中的作用,探索艾灸内关穴减轻化疗心脏毒性的可行性。方法选取陕西省肿瘤医院乳腺科2020年5月至2021年5月收治的行EC-T(吡柔比星+环磷酰胺序贯多西他赛)方案术后辅助化疗的乳腺癌患者80例,依据随机数表法分为对照组40例和试验组40例。两组患者在前4周期化疗过程中,使用吡柔比星药物当天均同时使用右雷佐生;试验组患者于化疗前1天开始进行艾灸内关穴,每天2次,连续3 d。观察两组患者4周期化疗前后的心电图、心功能、血肌钙蛋白I(cTnI)和N末端脑钠肽前体(NT-proBNP)水平,以及Karnofsky功能状态评分(KPS)的变化。结果4周期化疗后,心律异常发生率[22.5%(9/40)vs 50.0%(20/40),χ^(2)=6.545,P=0.010]和QRS波群电压下降发生率试验组均低于对照组[27.5%(11/40)vs 55.0%(22/40),χ^(2)=6.241,P=0.012]。化疗后试验组心功能分级优于对照组(Z=2.388,P=0.017)。4周期化疗后,对照组左心室射血分数(LVEF)下降、左室舒张末期内径(LVEDD)增大,试验组LVEF、LVEDD变化不明显,两组cTnI和NT-proBNP水平及KPS评分均升高,且试验组LVEF、LVEDD、cTnI和NT-proBNP水平及KPS评分均优于对照组(P<0.05)。结论艾灸内关穴对于乳腺癌含蒽环类药物化疗所致心肌损害具有明显的保护作用,可以在右雷佐生作用的基础上进一步改善心肌功能。

关键词：艾灸内关穴乳腺癌化疗吡柔比星右雷佐生心肌损害肌钙蛋白脑钠肽心脏毒性

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T-CPS下考虑人驾车行为影响的混行车辆协同控制

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控制与决策 2024年第5期39卷 1424-1432页

作者：黄帅孙棣华赵敏重庆大学自动化学院重庆400030 重庆大学信息物理社会可信服务计算教育部重点实验室重庆400030 重庆邮电大学先进制造工程学院重庆400065

由于传统人驾车(traditional human-driven vehicles, HVs)驾驶行为会受到驾驶员的心理和生理活动的不确定性影响,可能使得车辆频繁地加减速,进而导致混合交通条件下网联自动车(connected and automated vehicles, CAVs)很难快速跟踪此... 详细信息

由于传统人驾车(traditional human-driven vehicles, HVs)驾驶行为会受到驾驶员的心理和生理活动的不确定性影响,可能使得车辆频繁地加减速,进而导致混合交通条件下网联自动车(connected and automated vehicles, CAVs)很难快速跟踪此行为.针对这一问题,首先提出一种提前预测传统人驾车行为的组合神经网络.在此基础上,考虑通信时延和车辆运动学特性,设计一种基于交通信息物理系统(transportation-cyber physical system, T-CPS)的混行车群内车辆协同控制策略,使其能够快速跟踪上传统人驾车行为,并对混行车群内网联自动车之间的串稳定性进行分析.最后,在混合交通条件下设置由1辆传统人驾车、1辆领头网联自动车和4辆跟随网联自动车形成的混行车群,利用下一代交通仿真(next generation simulation, NGSIM)车辆轨迹数据选出高质量传统人驾车状态,并通过仿真实验验证所提协同控制策略的有效性和可行性.由仿真实验结果可知,所提协同控制策略可以保证所有的网联自动车能够快速跟踪上传统人驾车行为,为解决新型混合交通带来的新问题提供一定的理论指导和借鉴.

关键词：混合交通交通信息物理系统人驾车行为协同控制组合神经网络 NGSIM

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Protaetia brevitarsis larvae extract ameliorated obesity in high fat diet-fed mice by modulating gut microbiota and lipid metabolism

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Food Science and Human Wellness 2024年

作者： Zong-Qi Zhang Si-Cong Chen Qing-Lei Wang Chun-Qin Liu Jin-hua Xiao Da-Wei huang College of Life Sciences Nankai University Hebei Key Laboratory of Soil Entomology Cangzhou Academy of Agricultural and Forestry Sciences

Due to the rapid development of obesity and related metabolic diseases in the world， it is particularly important to explore the ability of novel materials in regulating obesity. In this study， C57BL/6J obese mice were used as objects， and 16S rRNA gene sequencing and lipidomics techniques were used to explore the regulatory effect and mechanism of the P. brevitarsis ethanol extract (50%， v/v) against obesity. Our results showed that P. brevitarsis extract could significantly reduce the body weight， triglyceride (TG)， total cholesterol (TC)， low-density lipoprotein cholesterol (LDL-C)， and pro-inflammatory cytokines (TNF-α， IFN-γ， and IL-6) levels of HFD-fed mice. Moreover， the P. brevitarsis extract changed the composition and relative abundance of its gut microbiota， especially increasing Akkermansia muciniphila. Meanwhile， the content of short-chain fatty acids (SCFAs) was increased， especially acetic acid and butyric acid， which leads to a decrease in the synthesis and accumulation of lipids in the liver. Furthermore， the P. brevitarsis extract also induced the difference in lipid synthesis in the liver by down-regulating the mRNA levels of SREPB-1C， FAS， and ACC. Therefore， this research provided preliminary work and reference for the development of P. brevitarsis as a functional food for anti-obesity.

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