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Buxu Tongyu Granule Alleviates Myocardial Ischemia by Activating Vascular Smooth Muscle Cell Soluble Guanylate Cyclase to Inhibit Abnormal Vasomotion

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Engineering 2024年第7期38卷 133-143页

作者： Shuang Yang Yixiu Zhao xiaoling Cheng Tingting Zhan Jiaying Tian Xue Liu Chunyue Ma Zhiqi Wang Luying {2. Qian Liu Yanli Wang Jian huang {2.hui Wang Yan Zhang Baofeng Yang department of Pharmacology&Key Laboratory of Cardiovascular Medicine Research Ministry of Education of the People’s Republic of ChinaCollege of PharmacyHarbin Medical UniversityHarbin 150081China National Key Laboratory of Frigid Zone Cardiovascular Diseases(NKLFZCD) Harbin Medical UniversityHarbin 150081China department of Medicinal Chemistry and Natural Medicine Chemistry College of PharmacyHarbin Medical UniversityHarbin 150081China Research Unit of Noninfectious Chronic Diseases in Frigid Zones Chinese Academy of Medical SciencesHarbin 150081China

Myocardial ischemia is a serious threat to human health,and vascular dysfunction is its main *** Tongyu(BXTY)Granule is an effective traditional Chinese medicine(TCM)for treating myocardial ***,the underlying mechanism of BXTY is still *** this study,we demonstrate that BXTY ameliorates myocardial ischemia by activating the soluble guanylate cyclase(sGC)-30,50-cyclic guanosine monophosphate(cGMP)-protein kinase G(PKG)signaling pathway in vascular smooth muscle cells(VSMCs)to dilate the *** was given by gavage for ten consecutive days before establishing an animal model of acute myocardial ischemia in mice via the intraperitoneal injection of *** results showed that BXTY alleviated the symptoms of myocardial ischemia induced by pituitrin in mice,including electrocardiogram abnormalities and changes in plasma *** addition,BXTY dilated pre-constricted blood vessels and inhibited the vasoconstriction of the superior mesenteric artery in a dose-dependent but endothelial-independent *** effects were eliminated by preincubating vascular rings with the sGC inhibitors NS 2.2. or ODQ,or with the PKG inhibitor KT ***,BXTY increased the protein expression of sGC-b1 and the intracellular second messenger cGMP level in mouse aortic vascular smooth muscle cells(MOVAs).NS 2.2. or ODQ reversed these effects of *** expression level of the cGMP downstream effector protein PKG-1 increased after treating MOVAs with *** 2.2.,ODQ,or KT 582. also reversed this effect of *** conclusion,BXTY can improve the symptoms of acute myocardial ischemia in mice,and activating the sGC-cGMP-PKG pathway in VSMCs to induce vasodilation is its key pharmacodynamic mechanism.

关键词： Myocardial ischemia Vasomotion Soluble guanylate cyclase Buxu Tongyu Granule

Spectral observation of symmetry-protected selection rules for dynamical high-dimensional parity in alignment magnetic resonance

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Science china(Physics,mechanics & Astronomy) 2024年第10期67卷 1-11页

作者： Xu-Xing Geng Kai jin Lu Zhou Wang-Wang Tang Guoqing Yang Shangqing Liang Shao-Ping Wu Guang-Ming huang Gao-Xiang Li department of Physics Huazhong Normal UniversityWuhan 430079China College of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China

Multidimensional Floquet-driven alignment systems with dynamical symmetry present various exotic phenomena and ***,there are challenges in directly characterizing large-spin dynamical symmetry from ***,we first observe the symmetry-protected selection rules of dynamical high-dimensional parity in a large-spin(F=4)*** theoretically construct a Floquet-driven alignment system that can be used to reveal high-dimensional spatiotemporal *** the experiment,the system is implemented in Cs atomic gas subjected to two-dimensional Floquet-modulated magnetic resonance *** developing Floquet detection protocols of alignment double-sided spectra,we directly verify symmetry-protected selection rules of dynamical high-dimensional parity for large-spin *** work advances the exploration of dynamical symmetry to large spins,and unravels a universal Floquet scheme for the investigation of symmetry-protected selection rules.

关键词： dynamical high-dimensional symmetry symmetry-protected selection rules large-spin alignment magnetic resonance,Floquet two-mode detection

On Catastrophe and Cavitation for SphericalCavity

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Communications in Nonlinear Science and Numerical Simulation 1999年第4期4卷 249-254页

作者： Ming jin Kefu huang Jike WU({2. of {2. and Engineering Science, Peking University, Beijing 100871,china) department of mechanics and Engineering Science Peking University Beijing 100871 China

IntroductionInrecelltyears,theresearchesoncavitationandcatastropheofacavitysu***therwithbifllrcationtheory... 详细信息

IntroductionInrecelltyears,theresearchesoncavitationandcatastropheofacavitysu***therwithbifllrcationtheory...

关键词： nonlinearity bifurcation Hooke material

Analysis and Design of Cylindrical Magnetorheological Fluid Brake

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厦门大学学报（自然科学版） 2002年第S1期41卷 27-28页

作者： huang jin, ZHANG Jun-qian, YANG Yan ({2. of Engineering {2., Chongqing University, Chongqing 400044, china)

Magnetorheological (MR) fluids consist of stable suspensions of magnetic particles in a carrying fluid such as water or silicone oils. The magnetorheological response of MR fluids results from the polarization induced in suspended particles by application of an external magnetic field. The interaction between the induced dipoles causes the particles to form columnar structure, parallel to the applied field. These chain-like structures restrict the motion of fluids, thereby increasing the viscosity and yield stress of the MR fluids. These mechanical characteristics allow for the construction of magnetically controlled device such as the MR fluids rotary brakes. However, there has been little information published about the design of MR fluid brakes. In this paper the design of the cylindrical MR fluid brake is investigated theoretically. Bingham model is used to characterize the constitutive behaviors of the MR fluids subject to an external magnetic field. The operational principle of the cylindrical MR fluid brake is presented. The theoretical method is developed to analyze the transmission properties of the torque of the cylindrical MR fluid brake. An engineering expression for the torque is derived to provide the theoretical foundations in the design of the cylindrical MR fluid brake. Based on this equation the volume and thickness of the annular MR fluids within the brake is expressed as functions of the desired ratio of torques with saturated magnetic field and without external field, the controlled mechanical power and the MR fluid material properties. The parameters of the thickness and width of the fluid in the brake can be calculated from the obtained equations when the required mechanical power level, the desired torque ratio are specified.

关键词： MR fluids brake analysis method design method

双锚片螺旋锚倾斜拉拔承载特性与承载力计算方法研究

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岩土力学 2024年第6期45卷 1661-1674,1685页

作者：胡伟李砥柱林志冯世进黄勇祥湖南科技大学岩土工程稳定控制与健康监测湖南省重点实验室湖南湘潭411201 同济大学地下建筑与工程系上海200092 中国能源建设集团湖南省电力设计院有限公司湖南长沙410007

目前对多锚片螺旋锚倾斜拉拔承载特性机制的认识尚不全面,承载力计算方法也还不成熟。采用自制模型试验装置开展了双锚片螺旋锚的多角度倾斜拉拔模型试验,分析了荷载倾角、埋深比对荷载−位移曲线和抗拔承载力因子的影响规律。通过量化... 详细信息

目前对多锚片螺旋锚倾斜拉拔承载特性机制的认识尚不全面,承载力计算方法也还不成熟。采用自制模型试验装置开展了双锚片螺旋锚的多角度倾斜拉拔模型试验,分析了荷载倾角、埋深比对荷载−位移曲线和抗拔承载力因子的影响规律。通过量化水平向和竖向的控制程度分析了两个方向的耦合效应;基于数值模拟标定了锚片间距和荷载倾角对锚片上土压力的影响,提出了锚片上土压力影响系数计算方法,引入考虑位移影响的土压力近似计算方法和p-y曲线法,构建了双锚片螺旋锚倾斜拉拔力学模型,提出了双锚片螺旋锚倾斜拉拔承载力计算方法和相应步骤,并在3个试验案例的计算中取得了较好的效果。所提模型和计算方法的研究思路可推广至其他多锚片的情况,但螺旋锚需满足属于刚性短桩的前提条件。

关键词：螺旋锚倾斜拉拔模型试验锚片间距承载力

膈肌浅快呼吸指数联合肺部超声评分对ICU机械通气患者脱机不良结局的预测价值

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国际呼吸杂志 2024年第1期44卷 53-58页

作者：汪飞何瑾黄小勇梁敏朱晓玲自贡市第四人民医院重症医学科自贡643000 自贡市第四人民医院急诊科自贡643000 自贡市第四人民医院超声医学科自贡643000

目的探讨膈肌浅快呼吸指数(D-RSBI)联合肺部超声评分(LUS)用于重症监护病房(ICU)患者机械通气后脱机不良结局的预测价值。方法本研究为病例对照研究。采用非随机抽样的方法选取2.2.年10月至2.2.年10月自贡市第四人民医院ICU收治的100例... 详细信息

目的探讨膈肌浅快呼吸指数(D-RSBI)联合肺部超声评分(LUS)用于重症监护病房(ICU)患者机械通气后脱机不良结局的预测价值。方法本研究为病例对照研究。采用非随机抽样的方法选取2.2.年10月至2.2.年10月自贡市第四人民医院ICU收治的100例接受机械通气治疗的患者,根据脱机结果分为脱机成功组(63例)和脱机失败组(37例)。收集所有患者入院时性别、年龄、基础病(糖尿病、高血压、高脂血症、慢性阻塞性肺疾病)、心率、平均动脉压,以及机械通气时间、白细胞计数、乳酸和肌酐水平等临床资料,计算浅快呼吸指数(RSBI)和D-RSBI,并进行LUS。通过受试者操作特征曲线分析D-RSBI、RSBI、LUS预测脱机不良结局的价值,采用平行试验进行联合诊断,采用多因素logistic回归分析明确患者脱机不良结局的危险因素,并采用Spearman秩相关分析D-RSBI、LUS与RSBI的相关性。结果2.患者性别、年龄、心率、糖尿病、高血压、高脂血症、慢性阻塞性肺疾病、平均动脉压、机械通气时间、白细胞计数、肌酐和乳酸水平比较差异均无统计学意义(均P>0.05),脱机失败组RSBI、D-RSBI、LUS高于脱机成功组[(56.63±11.18)次·min^(-1)·L^(-1)比(43.58±9.2.)次·min^(-1)·L^(-1),(1.86±0.62.次·min^(-1)·mm^(-1)比(1.13±0.36)次·min^(-1)·mm^(-1),(38.63±7.51)分比(2..85±6.2.)分;t值分别为6.30、7.46、8.41,均P1,D-RSBI联合LUS预测脱机不良结局的曲线下面积为0.946。多因素logistic回归分析结果显示,RSBI>53.489次·min^(-1)·L^(-1)、D-RSBI>1.42.次·min^(-1)·mm^(-1)、LUS>32.683分是脱机失败的独立危险因素。D-RSBI与RSBI呈正相关(r=0.335,P=0.002.,LUS与RSBI无相关性(r=0.184,P=0.671)。结论D-RSBI联合LUS可用于预测ICU患者机械通气后脱机不良结局。D-RSBI>1.42.次·min^(-1)·mm^(-1)、LUS>32.683分是脱机失败的独立危险因素。

关键词：呼吸,人工重症监护病房膈肌浅快呼吸指数肺部超声评分脱机

维布妥昔单抗联合化疗治疗儿童难治及复发霍奇金淋巴瘤10例分析

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中华儿科杂志 2024年第8期62卷 775-779页

作者：李楠李英周春菊黄爽金玲杨菁邵苗苗孙豪王晓玲段彦龙国家儿童医学中心、首都医科大学附属北京儿童医院儿童肿瘤中心肿瘤内科、北京市儿童血液肿瘤重点实验室、儿科重大疾病研究教育部重点实验室北京100045 首都医科大学附属北京儿童医院药学部北京100045 首都医科大学附属北京儿童医院病理科北京100045 大连市妇女儿童医疗中心(集团)药学部大连116012

目的评估CD30抗体-药物偶联物(ADC)维布妥昔单抗(BV)联合化疗治疗儿童难治或复发经典性霍奇金淋巴瘤(R/R cHL)的有效性和安全性。方法回顾性分析2.2.年10月至2.2.年8月在首都医科大学附属北京儿童医院诊治的10例R/R cHL患儿的临床资料(... 详细信息

目的评估CD30抗体-药物偶联物(ADC)维布妥昔单抗(BV)联合化疗治疗儿童难治或复发经典性霍奇金淋巴瘤(R/R cHL)的有效性和安全性。方法回顾性分析2.2.年10月至2.2.年8月在首都医科大学附属北京儿童医院诊治的10例R/R cHL患儿的临床资料(包括年龄、性别、B症状、临床分期、既往治疗情况等),10例患儿均接受至少2.期BV联合化疗,根据化疗药物强度的不同决定与其同疗程应用的BV剂量,每3周1次应用BV者剂量为1.8 mg/kg,每2.1次应用BV者剂量为1.2.mg/kg。每2.周期评估患儿缓解情况,随访至2.2.年5月31日。记录用药期间有无输注反应及用药后的不良反应。结果10例患儿中男7例,女3例;年龄5.3~16.9岁;难治6例,复发4例;结节硬化型6例,混合细胞型2.,富于淋巴细胞型1例,淋巴细胞消减型1例。临床分期Ⅳ期5例,Ⅲ期5例。既往接受治疗以化疗为主,4例患儿曾接受放疗,1例患儿曾接受程序性死亡受体1(PD-1)抗体治疗。随访时间为9~2.个月,共计43周期单独应用BV或BV联合不同方案化疗,疗程数为2.10个,10例患儿均无事件生存,9例患儿持续完全缓解。BV均顺利完成输注,共记录到2.例次患儿发生3级以上的不良事件,以骨髓抑制为主,均与化疗相关,均未影响序贯治疗。结论BV治疗儿童难治及复发CD30阳性霍奇金淋巴瘤的早期显效,安全性可耐受。

关键词：儿童霍奇金病药物评价维布妥昔单抗

On the ratio of expectation crossings of random-excited dielectric elastomer balloon

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Theoretical & Applied mechanics Letters 2017年第2期7卷 100-104页

作者： xiaoling jin Yong Wang {2. {2. department of Engineering mechanics Zhejiang University Hangzhou 310027 China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Hangzhou 310027 China

The ratio of expectation crossings of dielectric elastomer balloon excited by random pressure is analytically evaluated in this letter. The Mooney-Rivlin model is adopted to describe the constitutive relation while the random pressure is described by Gaussian white noise. Through a specific transformation, the stochastic differential equations for the total energy and phase are derived. With the application of the stochastic averaging, the system total energy is then approximated by a one-dimensional diffusion pro-cess. Solving the associated Fokker-Planck-Kolmogorov （FPK） equation yields the stationary probability density of the system total energy. The ratio of expectation crossings is then derived based on the joint stationary probability density of stretch ratio and its ratio of change. The efficacy and accuracy of the proposed procedure are verified by comparing with the results from Monte Carlo simulation （MCS）.

关键词： Dielectric elastomer balloon Ratio of expectation crossings Random pressure Stochastic averaging

A method to determine Young's modulus of soft gels for cell adhesion

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Acta Mechanica Sinica 2009年第4期25卷 565-570页

作者： xiaoling Peng Jianyong huang Lei Qin Chunyang Xiong {2.g Fang Laboratory of Cell mechanics Department of Biomedical Engineering Peking University 100871 Beijing China

A convenient technique is reported in this note for measuring elastic modulus of extremely soft material for cellular adhesion. Specimens of bending cylinder under gravity are used to avoid contact problem between testing device and sample, and a beam model is presented for evaluating the curvatures of gel beams with large elastic deformation. A self-adaptive algorithm is also proposed to search for the best estimation of gels＇ elastic moduli by comparing the experimental bending curvatures with those computed from the beam model with preestimated moduli. Application to the measurement of the property of polyacrylamide gels indi- cates that the material compliance varies with the concentrations of bis-acrylamide, and the gels become softer after being immersed in a culture medium for a period of time, no matter to what extent they are polymerized.

关键词： Young's modulus Bending measurement Cell adhesion Polyacrylamide gel