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大学生身体活动和睡眠质量与焦虑及抑郁情绪的关系

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中国学校卫生 2024年第5期45卷 684-688页

作者：陈保祥周玉兰黄赞浙江师范大学体育与健康科学学院金华321004

目的探讨大学生身体活动、睡眠质量与焦虑、抑郁情绪的关系,以期为大学生心理健康干预提供实证支持与理论指导。方法于2023年3—4月,采用方便抽样的方法选取中国6所不同省份高校的2099名大学生进行调查,采用国际体育活动问卷简表(IPAQ-... 详细信息

目的探讨大学生身体活动、睡眠质量与焦虑、抑郁情绪的关系,以期为大学生心理健康干预提供实证支持与理论指导。方法于2023年3—4月,采用方便抽样的方法选取中国6所不同省份高校的2099名大学生进行调查,采用国际体育活动问卷简表(IPAQ-SF)、匹兹堡睡眠质量指数(PSQI)、流调中心用抑郁量表(CES-D)和焦虑自评量表(SAS)评估参与者的身体活动量、睡眠质量、抑郁和焦虑情绪。采用描述性统计、Logistic回归模型对数据进行分析。结果高体力活动的大学生比例为30.3%,中等和低体力活动的大学生分别为45.3%和24.4%。62.3%的大学生睡眠质量较差,焦虑和抑郁情绪的检出率分别为21.6%和39.9%。与男生(42.8%)相比,女生参加高体力活动的比例较低(22.3%),而参加中等体力活动(48.1%)和低体力活动(29.5%)的比例则高于男生(40.8%,16.4%);女生(65.0%)睡眠质量差的比例高于男生(58.0%)(χ^(2)值分别为110.15,10.70,P值均<0.05)。女生有抑郁情绪的比例(43.8%)高于男生(33.9%)(χ^(2)=20.48,P<0.05)。Logistic回归分析结果显示,高体力活动与大学生焦虑和抑郁情绪均呈负相关(OR值分别为0.45,0.33),睡眠质量差与大学生焦虑和抑郁情绪呈正相关(OR值分别为3.89,3.94)(P值均<0.01);身体活动和睡眠质量与大学生的焦虑、抑郁情绪存在交互效应关系,即与低体力活动且睡眠质量差相比,高体力活动和睡眠质量好的共同作用与大学生焦虑和抑郁情绪的降低均相关(OR值分别为0.14,0.08,P值均<0.01)。结论身体活动和睡眠质量与大学生的焦虑、抑郁情绪存在相关性。提高身体活动量和睡眠质量有益于改善大学生抑郁和焦虑等心理健康问题。

关键词：运动活动睡眠焦虑抑郁精神卫生回归分析学生

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酰基辅酶A在疾病中的代谢调控

生物化工 2024年第3期10卷 158-163页

作者：郭萌皓丁俊黄赞武汉大学生命科学学院湖北武汉430072 中国科学院武汉植物园特色农业资源植物研究中心湖北武汉430074

酰基辅酶A是脂质代谢的中间体,参与脂肪酸合成和降解、转录因子活化、蛋白质翻译后修饰以及能量代谢等一系列代谢途径,在生物体的生命活动中发挥着重要作用。当酰基辅酶A发生紊乱时,会影响生物体的各种生理和病理过程,进而引起各种疾病... 详细信息

酰基辅酶A是脂质代谢的中间体,参与脂肪酸合成和降解、转录因子活化、蛋白质翻译后修饰以及能量代谢等一系列代谢途径,在生物体的生命活动中发挥着重要作用。当酰基辅酶A发生紊乱时,会影响生物体的各种生理和病理过程,进而引起各种疾病如肝细胞癌、糖尿病和心脏病等。因此,了解酰基辅酶A在这些疾病中的代谢功能对于临床靶向治疗有指导性意义。本文将从酰基辅酶A的结构和分类、参与代谢通路、酰基辅酶A在一些常见疾病中的代谢调控等方面进行综述,并对今后酰基辅酶A在疾病的临床靶向治疗方面的应用进行展望。

关键词：酰基辅酶A 脂肪酸代谢疾病代谢靶向治疗

STAT1 signaling is required for optimal Th1 cell differentiation in mice

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Chinese Science Bulletin 2010年第11期55卷 1032-1040页

作者： MA Da huang Hua huang zan The Key Laboratory of Developmental Genes and Human Disease of Education Ministry School of Basic Medical Science Southeast University Nanjing 210009 China Department of Cell Biology Neurology and Anatomy Stritch School of Medicine Loyola University Chicago Maywood IL 60153 USA

Although IFN-γ alone does not prime type I T helper cell (Th1) differentiation, the loss of IFN-γ signaling leads to impaired Th1 phenotype: IFN-γ receptor-deficient (Ifngr-/-) Th1 cells fail to permanently repress IL-4 expression. They can differentiate into IL-4-producing cells under Th2-inducing conditions. These observations suggest that IFN-γ signaling plays a critical role in si- lencing Il4 gene in Th1 cells and stabilizing Th1 phenotype. IFN-γ signaling has been further shown to inhibit IL-4 expression by inhibiting STAT6 phosphorylation. This work aims to study the mechanism by which STAT1, the downstream molecule that transduces IFN-γ signaling, may mediate suppression of IL-4 expression in Th1 cells. The results show that STAT1-deficient naive CD4+ T cells express a reduced level of IFN-γ as well as an elevated level of IL-4. These cells exhibit bias to differentiate into Th2 cells under unpolarized conditions. Under Th1-inducing conditions, STAT1-deficient naive CD4+ T cells show impaired Th1 differentiation: Stat1-/- Th1 cells express reduced levels of IFN-γ and T-bet. These cells also fail to repress the expression of IL-4 and GATA-3 and retain STAT6 signaling. More importantly, Stat1-/- Th1 cells can be effectively induced to differentiate into IL-4-producing cells under Th2-inducing conditions. Ectopic expression of T-bet in Stat1-/- Th1 cells dramatically represses their ability to do so and drastically restores IFN-γ expression, suggesting that STAT1 may inhibit IL-4 expression through T-bet. Finally, histone H3 acetylation (H3AC) and histone H3 K4 dimethylation (H3K4dim) were observed in two enhancer regions of Il4 gene locus in Stat1-/- Th1 cells, suggesting a permissive status of Il4 gene locus in these cells. Thus, this study reveals new mechanisms by which STAT1 signaling may mediate repression of Il4 gene in Th1 cells: upregulating T-bet that subsequently represses GATA3 and IL-4 expression, antagonizing STAT6 signaling, and inhibiting epigen

关键词： STAT1 Th1/Th2 房间 T 赌注 STAT6 信号 transduction

SH-2-containing protein tyro-sine phosphatase 1 is required for IL-4-induced IL-4R expression in spleen cells

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Chinese Science Bulletin 2005年第14期50卷 1456-1461页

作者： CAO Xin huang zan FAN Jingyi Department of Cell Biology and Medical Genetics Nanjing Medical University Nanjing 210029 China Molecular Biology Program Stritch School of Medicine Loyola University at Chicago Maywood IL 60153 USA Department of Organismal Biology and Anatomy University of Chicago Chicago IL 60637 USA

To investigate the role of SH-2-containing pro- tein tyrosine phosphatase 1, SHP-1, in IL-4-induced IL-4 receptor (IL-4R) expression, we examined IL-4 receptor α-chain (IL-4Rα) mRNA expression in Na3VO4-treated wild type (WT) spleen cells and measured IL-4R mRNA in IL-4-stimulated spleen cells of viable motheaten mice (mev/mev). It is found that IL-4-induced IL-4R mRNA ex- pression was impaired in Na3VO4-treated WT spleen cells and IL-4-stimulated mev/mev spleen cells. Here we show that the impaired IL-4-induced IL-4Rα mRNA expression was due to reduced expression of IL-4R that led to impaired STAT6 signaling. We further demonstrate that reduction of IL-4Rα protein expression in mev/mev spleen cells was due to alteration in cell compositions. In mev/mev spleen, the per- centages of CD4+, CD8+, and CD19+ cells expressing rela- tively high levels of IL-4R were reduced dramatically while the percentages of Mac-1+ and Gr-1+ cells with relative low levels of IL-4R increased greatly. Despite the profound effect of reduced expression of IL-4R protein, the IL-4Rα mRNA expression was comparable in spleen cells of littermate con- trol mice (+/?) and mev/mev mice and no differences were found in B cells, T cells, and macrophages, suggesting cell type-specific downregulation of IL-4R expression in macro- phages through a posttranscriptional mechanism. Our study suggests that SHP-1 is required for IL-4-meidated function and indirectly regulates IL-4-meidated function in spleen cells by affecting hematopoiesis.

关键词：蛋白质酪氨酸磷酸酶脾细胞

Further Investigation on the Rearrangement Mechanism of Reactions of 1,5-Benzothiazepines with Ethoxycarbonylcarbene

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Chemical Research in Chinese Universities 2006年第1期22卷 36-39页

作者： WU Chun-zan huang Jia-xing ZHANG Qi-han XU Jia-xi Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry and Molecular Engineering Peking University Beijing 100871 P. R. China

The reactions of 2,3-dihydro-1,5-benzothiazepines with ethoxyearbonylcarbene undergo complex rearrangements to produce rlng-opening and ring contraction products. Previously it was presumed that the different products were formed via different mechanisms depending on the kind of substituents at the 2-position of 1,5-benzothiazepines. However, on the basis of the further detailed investigation, it was found that all 1,5-benzothiazepines can undergo the same rearrangement to yield both ring-opening and ring contraction products.

关键词： 1,5-Benzothiazepine Ethoxycarbonylcarbene Rearrangement Ring-contraction Ring-opening

A Tumor Suppressor Gene fhit Prokaryotic Expression and Identification

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Wuhan University Journal of Natural Sciences 2000年第2期5卷 249-252页

作者： Sun Yan Li Wen-xin huang zan Jiang Da-he College of life sciences Wuhan University Wuhan 430072

The recombinant expression vector pGEMD-fhit which contains full encoding region offhit gene was constructed. The recombinant was introduced into the BL21 (DE3) strain ofE. coli and induced by 1 mmol/L IPTG to express a 29×103 polypeptide offhit fusion protein. And the 29×103 protein was sensitive and specific in reaction with anti-fhit antibody in Western blot.

关键词： fhit gene expression western blot

Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation

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Journal of Molecular Cell Biology 2019年第12期11卷 1069-1082页

作者： Yufang Wang Peiliang Shi Qin Chen zan huang Dayuan Zou Jingzi Zhang Xiang Gao Zhaoyu Lin State Key Laboratory of Pharmaceutical Biotechnology Department of Hepatopancreatobiliary SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolMOE Key Laboratory of Model Animals for Disease StudyModel Animal Research CenterNanjing UniversityNanjing 210061China Jiangsu Province Key Laboratory of Gastrointestinal Nutrition and Animal Health Nanjing Agriculture UniversityNanjing 210095China

Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activation and gasdermin-D (Gsdmd) cleavage, two central steps of the pyroptotic process. Here, we also found MMP collapse and ROS generation induced by Nlrp3 inflammasome activation as previous studies reported. The elimination of ROS alleviated the cleavage of Gsdmd, suggesting that Gsdmd cleavage occurs downstream of ROS release. Consistent with this result, hydrogen peroxide treatment augmented the cleavage of Gsdmd by caspase-1. Indeed, four amino acid residues of Gsdmd were oxidized under oxidative stress in macrophages. The efficiency of Gsdmd cleavage by inflammatory caspase-1 was dramatically reduced when oxidative modification was blocked by mutation of these amino acid residues. These results demonstrate that Gsdmd oxidation serves as a de novo mechanism by which mitochondrial ROS promote Nlrp3 inflammasome-dependent pyroptotic cell death.

关键词： ROS Nlrp3 gasdermin-D oxidation mitochondria

Counterion-Mediated Hydrogen Bonding Making Strong Polyelectrolytes pH-Responsive:Current Understanding and Perspectives

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Chinese Journal of Polymer Science 2024年第9期42卷 1270-1277,I0005页

作者： Yue huang Guang-Tao Mei zan Hua Guang-Ming Liu Hefei National Research Center for Physical Sciences at the Microscale Department of Chemical PhysicsKey Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education InstitutesUniversity of Science and Technology of ChinaHefei230026China The Key Laboratory of Functional Molecular Solids Ministry of Educationand Department of Materials ChemistrySchool of Chemistry and Materials ScienceAnhui Normal UniversityWuhu214002China

The counterion-mediated hydrogen bonding(CMHB)is related to the hydrogen bonding between bound counterions and polyelectrolyte chains in polyelectrolyte systems,where the counterions can both electrostatically bind to the charged groups of polyelectrolyte chains and act as hydrogen bond donors or acceptors to form hydrogen bonds with the hydrogen bond sites associated with polyelectrolyte chains simultaneously.A large number of literatures illustrate that strong polyelectrolytes(SPs)are insensitive to pH,which severely limmits the applications of SPs as smart ***,our studies have demonstrated that the CMHB makes SPs *** perspective discusses the mechanism of pH responsiveness of SPs and the pH-tunable properties of SPs,based on the pH-controlled CMHB *** future research directions on the pH responsiveness of SPs are also discussed *** is anticipated that the study of the pH responsiveness of SPs not only will provide a new understanding of the fundamental properties of SPs,but also will greatly expand the applications of SPs in the field of smart materials.

关键词： Counterion binding Hydrogen bond Polyelectrolyte brush Polyelectrolyte complexation

Urban Street Design from the Perspective of Complete Streets: A Case Study of Shashen Road in Shenzhen

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Journal of Landscape Research 2019年第4期11卷 19-24,28页

作者： huang zan School of Urban Planning and Design Peking University

The design concept of complete streets pays attention to the rights and interests of all road users, as well as the overall design of pedestrians, bicycles, public transportation, motor vehicles and other modes of transportation and transportation space, which is conducive to improving the misunderstanding of China’s urban street design aiming to serve motorized traffic. In this study, the development course, concept, objectives and design elements of complete streets were studied, and the conceptual framework of street integrity evaluation was established. Shashen Road in Shenzhen City was as a case to analyze the problems existing in traditional street design and explore the spatial design method of complete streets. It is pointed out that street design should adapt to local conditions and be optimized according to current situation. The improvement measures that can be implemented were proposed to enhance the vitality of streets.

关键词： Complete street Street design Street evaluation Space quality