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Dek219 encodes the DICER-LIKE1 protein that affects chromatin accessibility and kernel development in maize

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Journal of Integrative Agriculture 2023年第10期22卷 2961-2980页

作者： XIE Si-di TIAN Ran ZHANG Jun-jie LIU Han-mei LI Yang-ping HU yu-feng yu Guo-wu huang yu-bi LIU Ying-hong State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130P.R.China College of Life Science Sichuan Agricultural UniversityYa’an 625014P.R.China College of Agronomy Sichuan Agricultural UniversityChengdu 611130P.R.China Maize Research Institute Sichuan Agricultural UniversityChengdu 611130P.R.China

Chromatin accessibility plays a vital role in gene transcriptional ***,the regulatory mechanism of chromatin accessibility,as well as its role in regulating crucial gene expression and kernel development in maize(Zea mays)are poorly *** this study,we isolated a maize kernel mutant designated as defective kernel219(dek219),which displays opaque endosperm and embryo ***219 encodes the DICER-LIKE1(DCL1)protein,an essential enzyme in mi RNA *** of function of Dek219 results in significant reductions in the expression levels of most mi RNAs and histone *** research showed that the Heat shock transcription factor17(Hsf17)-Zm00001d016571 module may be one of the factors affecting the expression of histone *** results for transposase-accessible chromatin sequencing(ATAC-seq)indicated that the chromatin accessibility of dek219 is altered compared with that of wild type(WT),which may regulate the expression of crucial genes in kernel *** analyzing differentially expressed genes(DEGs)and differentially accessible chromatin regions(ACRs)between WT and dek219,we identified 119 candidate genes that are regulated by chromatin accessibility,including some reported to be crucial genes for kernel *** together,these results suggest that Dek219 affects chromatin accessibility and the expression of crucial genes that are required for maize kernel development.

关键词： maize kernel development chromatin accessibility histone miRNA

Comparative Analysis of Genetic Diversity in Landraces of Waxy Maize from yunnan and Guizhou Using SSR Markers

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Agricultural Sciences in China 2005年第9期4卷 648-653页

作者： LIU Yong-jian huang yu-bi RONG Ting-zhao TIAN Meng-liang YANG Jun-pin College of Agriculture Sichuan Agricultural University Ya＇an 625014 P.R. China Maize Research Institute Sichuan Agrieultural University Ya＇an 625014 P.R.China Crop Research Institute Sichuan Academy of Agricultural Sciences Chengdu 610017 P.R.China

Waxy maize landraces are abundant inyunnan and Guizhou of China. Genetic diversity of waxy maize landraces from yunnan and Guizhou were analyzed using SSR markers. We screened 38 landraces with 50 primers that generated 3 to 6 polymorphic bands, with an average of 4.13 bands. Shannon＇s information indices for genetic diversity of the 14 waxy maize landraces from yunnan varied from 4.9571 to 42.1138 and averaged 26.5252; Shannon＇s information indices for genetic diversity of the 24 waxy maize landraces from Guizhou varied from 22.0066 to 40.6320 and averaged 32.3156. For the 14 waxy maize landraces from yunnan, the within-landrace genetic diversity accounted for 45.40% and the among-landrace genetic diversity accounted for 54.60% of the total genetic diversity observed. For the 24 waxy maize landraces from Guizhou, the within-landrace genetic diversity accounted for 50.76% and the among-landrace genetic diversity accounted for 49.24% of the total observed. Some individual landraces possessed as much as 96.86% of the total genetic diversity occurring among landraces within origins. Differentiation between geographic origins accounted for only 3.14% of the total genetic diversity. Both yunnan and Guizhou would be the diversity centers and the original centers of waxy maize.

关键词： Genetic diversity Simple sequence repeat Landrace Waxy maize

No-go guide for the Hubble tension:Late-time or local-scale new physics

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 73-85页

作者： Lu huang Shao-Jiang Wang Wang-Wei yu CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of Sciences(CAS)Beijing100190China Asia Pacific Center for Theoretical Physics(APCTP) Pohang37673Korea Max-Planck-Institut für Gravitationsphysik(Albert-Einstein-Institut) HannoverD-30167Germany Leibniz Universität Hannover Hannover30167Germany

The standard model of modern cosmology might be cracked by the recent persistent hot debate on the Hubble-constant(H_(0))tension,which manifests itself as the sound-horizon(r_(s))tension or absolute-magnitude(M_(B))tension if deeming the origin of the Hubble tension from modifying the early or late Universe,*** this study,we achieve a fully model-independent constraint(fitting a model-independent global parameterization to a model-independent inverse distant ladder with a modelindependent high-redshift calibration)on late-time models with strong evidence against homogeneous new physics over theΛ-cold-dark-matter(ΛCDM)*** using this model-independent constraint to calibrate sufficiently local supernovae with corresponding late-time models extrapolated below the homogeneity scale,we find surprisingly that,although both H_(0)tension and MB tension are absent in our local Universe,a combination of H_(0)and M_(B)as the intercept a B of the magnitude-redshift relation exhibits 3~7σtension even for theΛCDM *** aBtension seems to call for local-scale inhomogeneous new physics disguised as local observational systematics.

关键词： Hubble constant inverse distance ladder local Universe

Construction of a 12-metal Zn(Ⅱ)-Nd(Ⅲ) nanocluster for ratiometric fluorescence detection of inflammatory marker neopterin

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Journal of Rare Earths 2025年第2期43卷 270-275页

作者： Huanyin yu Xiaoping Yang Xiaoli Lv Xianfeng huang College of Chemistry and Materials Engineering Wenzhou UniversityZhejiang Key Laboratory of Carbon MaterialsKey Lab of Biohealth Materials and Chemistry of Wenzhou

A 12-metal Zn（Ⅱ）-Nd（Ⅲ） cluster 1（sizes:1.8 nm×2.0 nm×2.0 nm） was synthesized from a long-chain type Schiff base *** displays ratiometric fluorescence response to neopterin（Neo） with high selectivity and sensitivity,which can be expressed by the equation I545nm/I1060nm=A·[Neo]2+B·[Neo]+C.1 is used to quantitatively test Neo concentrations in fetal calf serum（FCS） and urine,and the recovery ranges are 98.57%-103.82% and 99.25%-103.50%,respectively,while the relative standard deviations（RSDs） are 7.89%-9.46% and 1.85%-4.16%,*** limits of detection of 1 to Neo in FCS and urine are 0.034 and 0.021 μmol/L,respectively.

关键词： Neopterin NIR luminescence Rare earths Ratiometric fluorescence detection Zn(II)-Nd(III) nanocluster

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蓄光纤维的开发与工艺讨论

合成纤维 2006年第8期35卷 32-33页

作者：黄碧玉连云港华鸿化纤有限责任公司江苏连云港222004

蓄光纤维是通过用碱土类硅酸盐荧光粉体或氧化铝加稀土元素组成的发光粉体,制成一定浓度母粒切片,用母粒来纺丝。粉体在纺丝时最易产生“团聚”现象。主要讨论粉体在切片中的均匀分布性以及运用两步法开发的蓄光涤纶长丝从原料、过滤材... 详细信息

蓄光纤维是通过用碱土类硅酸盐荧光粉体或氧化铝加稀土元素组成的发光粉体,制成一定浓度母粒切片,用母粒来纺丝。粉体在纺丝时最易产生“团聚”现象。主要讨论粉体在切片中的均匀分布性以及运用两步法开发的蓄光涤纶长丝从原料、过滤材料到工艺参数等关键点的选择。

关键词：蓄光纤维粉体开发

Prediction of intrusive gas pores caused by resin burning in sand core for iron castings

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China Foundry 2025年第1期22卷 23-32页

作者： Ji-wu Wang Xiao-long Wang yu-cheng Sun yu-hang huang Xiu-ming Chen Xiong-zhi Wu Na Li Jin-wu Kang Tao Jing Tian-you huang Hai-liang yu School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Weichai Power Co. Ltd.Weifang 261061ShandongChina School of Mechanical Engineering Central South UniversityChangsha 41000China School of Materials Science and Engineering Key Laboratory for Advanced Materials Processing TechnologyTsinghua UniversityBeijing 100084China

In the production of castings,intrusive gas pore represents a kind of common defects which can lead to leakage in high gas-tightness requirement castings,such as cylinder blocks and cylinder heads for *** occurs due to the intrusion of gases generated during the resin burning of the sand core into castings during the casting ***,a gas generation and flow constitution model was established,in which the gas generation rate is a function of temperature and time,and the flow of gas is controlled by the gas release,conservation,and Darcy's *** heat transfer and gas flow during casting process was numerically *** dangerous point of cores is firstly identified by a virtual heat transfer method based on the similarity between heat transfer and gas flow in the sand *** gas pores in castings are predicted by the gas pressure,the viscosity and state of the melt for these dangerous *** distinct sand core structures were designed and used for the production of iron castings,and the simulated gas pore results were validated by the obtained castings.

关键词： gas pore numerical simulation iron casting sand core resin

Advances in human umbilical cord mesenchymal stem cells-derived extracellular vesicles and biomaterial assemblies for endometrial injury treatment

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World Journal of Stem Cells 2025年第1期17卷 6-21页

作者： Wan-yu Zhang Han-bi Wang Cheng-Yan Deng Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Obstetrics and Gynecology Peking Union Medical College HospitalBeijing 100730China

Endometrial injury caused by repeated uterine procedures,infections,inflammation,or uterine artery dysfunction can deplete endometrial stem/progenitor cells and impair regeneration,thereby diminishing endometrial receptivity and evidently lowering the live birth,clinical pregnancy,and embryo implantation ***,safe and effective clinical treatment methods or gene-targeted therapies are unavailable,especially for severe endometrial *** cord mesenchymal stem cells and their extracellular vesicles are characterized by their simple collection,rapid proliferation,low immunogenicity,and tumorigenicity,along with their involvement in regulating angiogenesis,immune response,cell apoptosis and proliferation,inflammatory response,and fibrosis,Therefore,these cells and vesicles hold broad potential for application in endometrial *** article reviewed recent research on human umbilical cord mesenchymal stem cells as well as their extracellular vesicles in repairing endometrial injury.

关键词： Endometrial injury Umbilical cord mesenchymal stem cells Extracellular vesicles MicroRNA biomaterial assemblies Regenerative repair

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang yu-Wen Alvin huang John Marshall Department of Molecular biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Potassium-modified carbon nitride photocatalyzed-aminoacylation of N–sulfonyl ketimines

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Chinese Chemical Letters 2025年第02期36卷 406-411页

作者： Cailing Wu Shaojie Wu Qifei huang Kai Sun Xianqiang huang Jianji Wang bing yu Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and ReactionsMinistry of Education School of Chemistry and Chemical Engineering Henan Normal University College of Chemistry Zhengzhou University School of Chemistry & Chemical Engineering Liaocheng University

The development of innovative and sustainable catalytic strategies for organic synthesis is a pivotal aspect of advancing material science and chemical *** research presents a new catalytic method for the aminoacylation of N–sulfonyl ketimines by utilizing a potassium-doped graphite-like carbon nitride （g-C3N4） *** method not only enhances the catalytic efficiency and broadens the light absorption spectrum of g-C3N4but also significantly reduces the recombination rate of electronhole pairs,thereby increasing the reaction yield and ***,our approach facilitates the synthesis of aminoacylated N-heterocycles,expanding the applicability of potassium-modified g-C3N4in photocatalytic organic synthesis.A notable accomplishment of this study is the unprecedented generation of carbamoyl radicals via heterogeneous photocatalysis,which can be easily recycled after *** advancement highlights the capability of potassium-doped g-C3N4（namely K-CN） as an advanced heterogeneous photocatalyst for the formation of complex organic compounds.

关键词： Amides Aminoacylation K+-modified carbon nitride Oxamic acids Photocatalysis