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Origin and nature of cold seep in northeastern Dongsha area,South China Sea:Evidence from chimney-like seep carbonates

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Chinese Science Bulletin 2013年第30期58卷 3689-3697页

作者： HAN XiQiu YANG KeHong huang yongyang Key Laboratory of Submarine Geosciences State Oceanic Administration Second Institute of Oceanography State Oceanic Administration Guangzhou Marine Geological Survey

The occurrence of seep carbonates is one of the characteristic features for cold seep sites at continental *** carbonates documented the venting history of methane-rich *** to the chemoherm carbonates and carbonate pavements which formed on the sediment-water interface,chimney-like seep carbonates precipitated around fluid conduits below the sediment-water interface therefore better recording information of the past fluid flow and *** the chimney-like seep carbonate samples from the northeastern Dongsha area of the South China Sea were studied to understand the origin and nature of the venting fluids and their potential relationship with gas hydrate deposits underneath the *** on the occurrence,morphology,petrology,mineralogy and C-and O-isotope compositions,combined with present and past bottom water temperatures and the timing of methane release events,the oxygen isotopic fractionation between calcite and water were used to estimate the equilibriumδ18O values of the precipitating ***δ13C values ranging from 56.33‰to 42.70‰V-PDB and thus clearly show that the studied chimneys were mainly derived from biogenic methane *** calculated equilibriumδ18O values of the precipitating fluids ranged from 1.9‰0.3‰to 0.6‰0.3‰V-SMOW,with an average of 1.4‰0.3‰V-SMOW which is heavier than those of seawater even at the last glacial *** is considered that the formation of chimney-like carbonates was closely related to methane hydrate dissociation in the *** methane hydrates contributed as much as45.7%of water to the venting *** is suggested that the climate and environmental changes(***-level lowering,down-cutting canyons and mass wasting)are the major mechanisms maybe responsible for the destabilization of methane hydrates in the study *** extensive occurrence of seep carbonates indicates that a large amount of the methane released from methane hydrate dissociation has been effectively captured

关键词：冷泉碳酸盐岩南海东北部群岛海域中国南海烟囱东沙性质甲烷水合物

齐墩果酸通过抑制自噬调节变应性鼻炎中的Treg/Th17细胞失衡

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中国免疫学杂志 2024年第7期40卷 1399-1404页

作者：王丽黄永阳张义綦彬万龙杜炎平陈才盛黄冈市中心医院耳鼻喉头颈外科黄冈438000

目的:探讨齐墩果酸对变应性鼻炎(AR)的作用及潜在作用机制。方法:密度梯度离心分离外周血单个核细胞(PBMCs)。实时定量PCR检测鼻黏膜中Foxp3、IL-17A、Beclin1、RORγt mRNA表达;流式细胞术检测PBMCs中Treg和Th17细胞比例;Western blot... 详细信息

目的:探讨齐墩果酸对变应性鼻炎(AR)的作用及潜在作用机制。方法:密度梯度离心分离外周血单个核细胞(PBMCs)。实时定量PCR检测鼻黏膜中Foxp3、IL-17A、Beclin1、RORγt mRNA表达;流式细胞术检测PBMCs中Treg和Th17细胞比例;Western blot检测鼻黏膜中RORγt、LC3-Ⅰ、LC3-Ⅱ、Beclin1、P62蛋白表达。将小鼠随机分为对照组、卵清蛋白(OVA)组、低剂量(L-)齐墩果酸组、高剂量(H-)齐墩果酸组、DSGC、3-MA和H-齐墩果酸+Rapa组。HE染色和高碘酸席夫(PAS)染色观察组织学变化。ELISA检测血清学变化、IL-17A、IL-10、嗜酸性阳离子蛋白(ECP)和抗OVA特异性抗体表达。结果:AR患者存在Th17/Treg失衡和自噬激活,而齐墩果酸在体外恢复Th17/Treg平衡并抑制自噬。体内实验表明,齐墩果酸可抑制OVA诱导的过敏性鼻部症状和自噬通路激活,与3-MA的调节作用相同,而Rapa可减弱高剂量齐墩果酸的作用。此外,齐墩果酸可减少鼻腔灌洗液中不同炎症细胞浸润,防止上皮细胞损伤,改善鼻黏膜厚度及黏液分泌。齐墩果酸可调节小鼠Th17/Treg相关细胞因子表达平衡。结论:齐墩果酸是治疗AR极具潜力的药物,通过抑制自噬调节Th17/Treg平衡发挥作用。

关键词：齐墩果酸变应性鼻炎自噬 Th17/Treg

Middle and Late Tertiary Palaeogeography and Palaeoenvironment on the Northern Continental Margin of the South China Sea

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Acta Geologica Sinica(English Edition) 1990年第2期64卷 211-222页

作者： Duan Weiwu huang yongyang Guangzhou Marine Geological Survey, Ministry of Geology and Mineral Resources, Guangzhou, Guangdong Chinese Academy of Geological Sciences Beijing

Based essentially on research results of calcareous nannofossils, combined with some other microfossil da-ta and several secondary depositional breaks, this paper discusses the criteria of division and comparison of themiddle and late Tertiary marine sediments, palaeogeographical and palaeoenvironmental evolution andpalaeoclimates on the northern continental margin of the South China Sea, comprising the Tainan basin, PearlRiver Mouth basin. Southeast Hainan basin and Beibu Gulf basin. Study shows that the upper Oligocene toPliocene strata in the whole area consist essentially of marine sediments except in the Beibu Gulf basin. Theyinclude littoral. neritic and deltaic sediments as well as carbonate rock-bioherm limestone. The sea advancedfrom southeast to northwest. During the transgression there appeared three culminations coinciding to thestages of deposition of nannofossil zones NN4-5, NN11 and 13-15.

关键词： Middle and Late Tertiary Palaeogeography and Palaeoenvironment on the Northern Continental Margin of the South China Sea

Tertiary Calcareous Nannofossil Biostratigraphy in the North Part of the South China Sea

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Acta Geologica Sinica(English Edition) 1991年第3期65卷 321-338,343-344页

作者： Duan Weiwu and huang yongyang Gangzhou Marine Geological Survey, Ministry of Geology and Mineral Resources, Guangzhou Chang Zhijun and Sun Sheping Guangzhou Marine Geological Survey Ministry of Geology and Mineral Resources Guangzhou

The marine Tertiary sequence in the north part of the South China Sea may be divided into 18 LateOligocene to Pliocene calcareous nannofossil zones and one unnamed Eocene assemblage based on an analysisof calcareous nannofossils from 40 offshore boreholes. The unnamed Eocene assemblage has been found onlyon the northeast margin of the Zhujiangkou basin. The 18 cakareous nannofossil zones of the Late Oligoceneto Pliocene were deposited in succession, but their development degrees are different. Among the 18 calcareousnannofossil zones, those corresponding to Martini's (1971) NN4- NN5 zones, NN11 zone and NN13-NN15zones are well developed, relatively persistent laterally and also widely distributed. They are the importantmarkers for the stratigraphical subdivision and correlation of the Upper Tertiary between the various basins inthe north part of the South China Sea. Based on the calcareous nannofossils and the sedimentsry features coup-led with the foraminifer zonation in certain basins, the present paper discusses the sedimentary characteristicsof the marine Tertiary and as well as the distribution and development of the sedimentary hiatus in the *** calcareous nannofossil markers for the Upper / Lower Tertiary and the Quaternary / Tertiary boundaries,and the characteristics and geological significance of the reworked calcareous nannofossils are also discussed inthe paper.

关键词： Tertiary Calcareous Nannofossil Biostratigraphy in the North Part of the South China Sea

Microbial diversity in cold seep sediments from the northern South China Sea

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Geoscience Frontiers 2012年第3期3卷 301-316页

作者： Yong Zhang Xin Su Fang Chen Yuanyuan Wang Lu Jiao Hailiang Dong yongyang huang Hongchen Jiang State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China School of Ocean Sciences China University of GeosciencesBeijing 100083China Guangzhou Marine Geology Survey Guangzhou 510075China Department of Geology Miami UniversityOxfordOH 45056USA Geomicrobiology Laboratory Science InstituteChina University of GeosciencesBeijing 100083China

South China Sea （SCS） is the largest Western Pacific marginal sea. However, microbial studies have never been performed in the cold seep sediments in the SCS. In 2004, ＂SONNE＂ 177 cruise found two cold seep areas with different water depth in the northern SCS. Haiyang 4 area, where the water depth is around 3000 m, has already been confirmed for active seeping on the seafloor, such as microbial mats, authigenic carbonate crusts and bivalves. We investigated microbial abundance and diver- sity in a 5.55-m sediment core collected from this cold seep area. An integrated approach was employed including geochemistry and 16S rRNA gene phylogenetic analyses. Here, we show that microbial abun- dance and diversity along with geochemistry profiles of the sediment core revealed a coupled reaction between sulphate reduction and methane oxidation. Acridine orange direct count results showed that microbial abundance ranges from 105 to 106 cells/g sediment （wet weight）. The depth-related variation of the abundance showed the same trend as the methane concentration profile. Phylogenetic analysis indicated the presence of sulphate-reducing bacteria and anaerobic methane-oxidizing archaea. The diver- sity was much higher at the surface, but decreased sharply with depth in response to changes in the geochemical conditions of the sediments, such as methane, sulphate concentration and total organic carbon. Marine Benthic Group B, Chloroflexi and JS1 were predominant phylotypes of the archaeal and bacterial libraries, respectively.

关键词： 16S rRNA Microbial diversity Cold seep Marine sediments Northern South China Sea

Wide-field ophthalmic space-division multiplexing optical coherence tomography

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Photonics Research 2020年第4期8卷 539-547页

作者： JASON JERWICK yongyang huang ZHAO DONG ADRIENNE SLAUDADES ALEXANDER J.BRUCKER CHAO ZHOU Department of Electrical and Computer Engineering Lehigh UniversityBethlehemPennsylvania 18015USA Department of Biomedical Engineering Washington University in St.LouisSt.LouisMissouri 63130USA Scheie Eye Institute Penn Presbyterian Medical CenterUniversity of PennsylvaniaPhiladelphiaPennsylvania 19104USA Department of Bioengineering Lehigh UniversityBethlehemPennsylvania 18015USA

High-speed ophthalmic optical coherence tomography(OCT)systems are of interest because they allow rapid,motion-free,and wide-field retinal ***-division multiplexing optical coherence tomography(SDMOCT)is a high-speed imaging technology that takes advantage of the long coherence length of micro electro mechanical vertical cavity surface emitting laser sources to multiplex multiple images along a single imaging *** demonstrate wide-field retinal OCT imaging,acquired at an effective A-scan rate of 800,000 A-scans/s with volumetric images covering up to 12.5 mm×7.4 mm on the retina and captured in less than 1 s.A clinical feasibility study was conducted to compare the ophthalmic SDM-OCT with commercial OCT systems,illustrating the high-speed capability of SDM-OCT in a clinical setting.

关键词： Wide-field ophthalmic space-division multiplexing optical coherence tomography

Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

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Oncology Research 2024年第7期32卷 1185-1195页

作者： XIAOBI huang CHUNYUAN CHEN yongyang CHEN HONGLIAN ZHOU YONGHUA CHEN ZHONG huang YULIU XIE BAIYANG LIU YUDONG GUO ZHIXIONG YANG GUANGHUA CHEN WENMEI SU Department of Pulmonary Oncology Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Thoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Orthopedics Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China

Background:Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as *** dysregulation has been closely associated with ***00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this ***,the mechanism underlying its function in cancer progression remains poorly ***:Here,the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines,clinical samples,and ***:We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients,whereas knockdown of LINC00265 inhibited proliferation of cancer cell lines and tumor growth in *** blot andﬂow cytometry analyses indicated that silencing of LINC00265 induced autophagy and ***,we showed that LINC00265 interacted with and stabilized the transcriptional co-repressor Switch-independent 3a(SIN3A),which is a scaffold protein functioning either as a tumor repressor or as an oncogene in a context-dependent *** of SIN3A also reduced proliferation of lung cancer cells,which was correlated with the induction of *** observations raise the possibility that LINC00265 functions to promote the oncogenic activity of SIN3A in lung ***:Ourﬁndings thus identify SIN3A as a LINC00265-associated protein and should help to understand the mechanism underlying LINC00265-mediated oncogenesis.

关键词： LINC00265 Autophagy Lung adenocarcinoma(LUAD) Cancer progression Switch-independent 3a(SIN3A)

基于ARM的振动传感器幅频特性测试系统研究

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传感技术学报 2011年第11期24卷 1564-1568页

作者：严家明黄永阳侯晓伟西北工业大学电子信息学院西安710129

设计了以ARM微处理器为核心的中央控制处理单元,以完成振动传感器幅频特性测试的系统。利用ARM上集成的数字模拟转换电路(D/A)的输出通道1产生频率可调的等幅正弦信号,输出通道2对可变增益运放电路进行控制,使得振动传感器输出信号幅度... 详细信息

设计了以ARM微处理器为核心的中央控制处理单元,以完成振动传感器幅频特性测试的系统。利用ARM上集成的数字模拟转换电路(D/A)的输出通道1产生频率可调的等幅正弦信号,输出通道2对可变增益运放电路进行控制,使得振动传感器输出信号幅度在系统工作范围内,采用模拟数字转换电路(A/D)将振动传感器输出的信号整周期采样,对信号的采样序列,运用Goertzel算法检测信号的幅度。实验结果证实了该测试系统软、硬件设计的正确性和有效性。

关键词： ARM 振动传感器幅频特性 Goertzel算法

NCAPH、AXL和YAP在喉癌中的表达及与预后的关系

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实用医学杂志 2019年第13期35卷 2078-2083页

作者：黄永阳张超周延辉河南科技大学临床医学院河南科技大学第一附属医院耳鼻喉科

目的观察非染色体结构维持蛋白凝缩蛋白复合体Ⅰ亚单位H(NCAPH)、受体酪氨酸激酶AXL和Hippo信号通路的转录共激活因子Yes结合蛋白(Y AP)在喉癌中的表达特征,探讨NCAPH、AXL和YAP的表达与喉癌临床病理因素和预后间的相关性。方法采用免... 详细信息

目的观察非染色体结构维持蛋白凝缩蛋白复合体Ⅰ亚单位H(NCAPH)、受体酪氨酸激酶AXL和Hippo信号通路的转录共激活因子Yes结合蛋白(Y AP)在喉癌中的表达特征,探讨NCAPH、AXL和YAP的表达与喉癌临床病理因素和预后间的相关性。方法采用免疫组化的方法分别检测NCAPH、AXL和YAP在40例喉癌组织和40例声带息肉组织中的表达情况并比较各组间的差异性,分析目标蛋白的表达与各临床病理参数及其预后的关系,并进行生存分析。结果 NCAPH、AXL和YAP在喉癌组织中的表达均明显高于声带息肉组织,差异有统计学意义(均P0.05);NCAPH和YAP在喉癌组织中的表达强度与患者的生存状况有关(均P<0.05)。结论 NCAPH、AXL和YAP在喉癌中的表达对于喉癌预后判断有重要指导意义,联合检测NCAPH、AXL和YAP有望作为一组有实用价值的喉癌预后判断的客观指标。

关键词：非染色体结构维持蛋白凝缩蛋白复合体Ⅰ亚单位H AXL Hippo信号通路的转录共激活因子Yes结合蛋白喉癌表达预后