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电力建设工程施工现场安全管控模式研究

小水电 2024年第3期 44-47页

作者：黄宜勤福建华电福瑞能源发展有限公司池潭水力发电厂福建三明354400

近年来,我国电力行业获得了迅速发展,电力工程的建设数量也不断增加;但是由于电力工程施工的特殊性,在工程项目建设中还存在比较多的安全隐患,如果没有做好施工现场安全管控工作,还可能诱发重大安全事故发生,对施工人员的生命健康与安... 详细信息

近年来,我国电力行业获得了迅速发展,电力工程的建设数量也不断增加;但是由于电力工程施工的特殊性,在工程项目建设中还存在比较多的安全隐患,如果没有做好施工现场安全管控工作,还可能诱发重大安全事故发生,对施工人员的生命健康与安全造成严重威胁。因此,在电力建设工程施工期间,施工单位要做好施工现场的安全管控工作,从源头上规避安全施工风险问题,做到防患于未然,推动电力工程建设工作的稳步发展。图2幅。

关键词：电力工程施工现场安全管控措施

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双重预防体系在水电站安全隐患排查中的应用

小水电 2024年第4期 57-60页

作者：黄宜勤福建华电福瑞能源发展有限公司池潭水力发电厂福建三明354400

水电站要强化安全生产意识,在生产运营中应把握好危险源、风险、隐患、事故之间的关系,落实好安全隐患排查、隐患治理和风险防范控制工作。围绕水电站安全隐患排查工作实施现状和问题简要分析,讨论如何推进有关工作中双重预防体系的构建... 详细信息

水电站要强化安全生产意识,在生产运营中应把握好危险源、风险、隐患、事故之间的关系,落实好安全隐患排查、隐患治理和风险防范控制工作。围绕水电站安全隐患排查工作实施现状和问题简要分析,讨论如何推进有关工作中双重预防体系的构建,并提出建议,希望对水电站安全生产运营和防范事故风险有所参考。图1幅。

关键词：水电站安全隐患排查双重预防体系应用

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区域配送中心供应链物流管理的优化思考

物流科技 2024年第12期47卷 127-130页

作者：黄艺琴开封大学国际教育学院河南开封475000

区域配送中心在全球供应链网络日益复杂多变的环境下已经成为确保供应链效率和响应速度的关键环节,而面对日益激烈的市场竞争和客户需求的变化,传统的物流管理模式在库存管理、运输与配送效率以及信息系统应用方面已经难以满足现代供应... 详细信息

区域配送中心在全球供应链网络日益复杂多变的环境下已经成为确保供应链效率和响应速度的关键环节,而面对日益激烈的市场竞争和客户需求的变化,传统的物流管理模式在库存管理、运输与配送效率以及信息系统应用方面已经难以满足现代供应链的高效率和低成本要求,直接阻碍了区域配送中心的运营效能和整体供应链竞争力的提升。文章对区域配送中心在供应链物流管理中的优化进行深入探讨,旨在优化库存控制、加强运输与配送流程,并提高信息系统的综合应用效率,以期帮助区域配送中心在动态市场环境中保持竞争优势,同时提高整个供应链网络的协调性和适应性。

关键词：区域配送中心供应链管理物流管理

A genome scan for quantitative trait loci affecting grain yield and its components of maize both in single-and two-locus levels

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Chinese Science Bulletin 2006年第12期51卷 1452-1461页

作者： YAN Jianbing TANG Hua huang yiqin ZHENG Yonglian SUBHASH Chander LI Jiansheng National Maize Improvement Center of China China Agricultural University Beijing 100094 China National Key Lab of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China

By adding thirty-one markers in the pre- vious linkage map, a new genetic linkage map con- taining 205 markers was constructed, spanning a total of 2305.4 cM with an average interval of 11.2 cM. The genotypic errors in the whole genome were de- tected by the statistical method and removed manu- ally. The precision of the linkage map was improved significantly. Main and epistatic QTL were detected by R/qtl, and main QTL were confirmed and refined by multiple interval mapping (MIM). Finally, MIM de- tected seven QTL for rows number, and five QTL for each grain yield, kernels per row and 100-kernel weight. The contribution to genetic variations of QTL varied from 35.3% for grain yield to 61.5% for rows number. Only kernels per row exhibited significant epistatic interactions between QTL. Twenty-four epistatic QTL were detected which distributed on almost all the ten chromosomes. About two-third epistatic QTL were observed between main QTL and another locus, which had no significant effects. These results indicate rather clearly that there are a number of QTL affecting trait expressions, not directly but indirectly through interactions with other loci. Thus, epistatic QTL effects may play a crucial role, if not more important than main QTL effects, in the genetic variation for the measured traits in present study.

关键词：基因扫描分子标记上位QTL 谷物玉米

GPR120基因通过调控NLRP3炎症小体激活保护脓毒症肺损伤的机制研究

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老年医学与保健 2024年第3期30卷 711-720页

作者：张凯黄一沁余纳宓林张自妍复旦大学附属华东医院全科医疗科上海200040 复旦大学附属华东医院病理科上海200040

目的通过脂多糖(Lipopolysaccharide,LPS)诱导的脓毒症模型验证G蛋白偶联受体120(G-protein coupled receptor120,GPR120)基因对NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor thermal protein domain associated protein 3,NLRP3)炎症小体及肺损伤的影响,并探索其调控分子机制。方法通过C57BL/6小鼠构建体内脓毒症模型,通过GPR120基因激动剂TUG891进行干预,验证GPR120基因对脓毒症小鼠肺损伤的保护作用;然后进行转录组测序,筛选差异信号通路,并在动物模型中验证NLRP3炎症小体及调控蛋白的差异表达。通过慢病毒转染构建GPR120基因过表达/低表达的Raw264.7单核巨噬细胞株,观察GPR120基因对NLRP3炎症小体的调控作用。结果与脓毒症组相比,LPS+TUG891组小鼠肺组织中包括cAMP通路基因在内的77个基因表达显著上调,37个基因表达下降。LPS组的GPR120水平较正常对照组显著降低,同时cAMP/PKA信号通路关键蛋白CREB及PKA表达减少,NLRP3、Caspase-1及IL-1β等炎症小体激活相关蛋白水平升高(P<0.01),予以TUG891处理后,组织内GPR120表达回升,cAMP/PKA信号通路重新被激活(P<0.01),NLRP3炎症小体蛋白活化程度下降(P<0.05)。体外实验中,LPS诱导的脓毒症可引起细胞增殖活性下降,GPR120基因在脓毒症巨噬细胞中表达减低(P<0.001),通过干预GPR120基因表达,证实GPR120基因可负性调控NLRP3炎症小体的活化程度及细胞炎症反应(P<0.01)。结论脓毒症中GPR120基因的激活可通过抑制NLRP3炎症小体的活化,减轻脓毒症的炎症反应及肺损伤。

关键词：脓毒症肺损伤 GPR120基因 NOD样受体热蛋白结构域相关蛋白3

基于脏腑功能与结构论中医学脾藏与解剖学脾脏不同

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中医药学报 2024年第3期52卷 1-6页

作者：黄一钦尹秀平高艳王义国周宇航张启明陕西中医药大学第一临床医学院陕西咸阳712046 中国中医科学院医学实验中心北京100700 滨州医学院中西医结合学院山东烟台264003

关于中、西医学同名脏器“脾”的认识,历来学者们争议不断,难以形成统一的认识。本文以中医脾藏的功能为基础,以功能异常引发的症状作为中医学和西医学的连接点,以期阐明两者之间的关系。研究发现,中医学脾藏与解剖学脾脏的内涵完全不同... 详细信息

关于中、西医学同名脏器“脾”的认识,历来学者们争议不断,难以形成统一的认识。本文以中医脾藏的功能为基础,以功能异常引发的症状作为中医学和西医学的连接点,以期阐明两者之间的关系。研究发现,中医学脾藏与解剖学脾脏的内涵完全不同,①中医学脾藏运化功能定位于消化系统功能,中医学脾藏统血功能定位于凝血、抗凝血系统功能,中医脾藏主肌肉功能定位于躯体运动系统功能;②解剖学脾脏的储血、调节血量功能可归属于中医肝藏的功能范畴,解剖学脾脏的造血功能可归属于中医肾藏的功能范畴,解剖学脾脏的免疫功能可归属于中医肾藏的功能范畴。基于以上研究结果,在今后的研究中可将脏腑功能、异常症状作为探讨中、西医学同名脏器两者之间的关系以及中医五藏客观化研究的落脚点。

关键词：脾藏脾脏功能定位功能性五藏

Dynamic Variation and Correlation of Pericarp Tenderness and Component Contents of Super Sweet Corn(sh_(2))in Kernel Development

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Agricultural Biotechnology 2022年第4期11卷 26-31,35页

作者： Shilong ZHANG Xiaoqin LI Zhenghua HE yiqin huang Institute of Food Crops Hubei Academy of Agriculture SciencesWuhan 430064China Hubei Key Laboratory of Germplasm Innovation and Genetic Improvement of Grain Crops Wuhan 430000China State Key Laboratory for Conservation and Utilization of Subtropical Agrobioresources/South China Agricultural University Guangzhou 510000China Hubei Collaborative Innovation Center for Grain Industry Yangtze UniversityJingzhou 434000China

Data on the mechanism of how pericarp components in fresh sweet corn affect pericarp tenderness are *** study explored variation and correlation of pericarp tenderness and components over time in three inbred lines of sweet corn that were selected for their differences in pericarp *** three lines presented a curvilinear increase in pericarp tenderness(puncture reading)from 12 to 24 d after pollination(DAP)across two environments,with the means at each time point always in the same order:S33205>T105>*** tenderness difference at each same time point in two environments over time varied similarly in each of the three inbred lines:increasing first,then dropping after peak,and insignificant at the *** the main pericarp components,mean contents were in the order:hemicellulose>cellulose>lignin in both environments at each time point for the three inbred *** the pericarp developed,hemicellulose content increased gradually,lignin content varied along a single-peak curve,cellulose content fluctuated around 24%,and pectin and ash contents changed slightly and *** pericarp of PE10,with the most tender pericarp,accumulated hemicellulose faster than other two *** and lignin contents were significantly correlated with pericarp tenderness,and the main components affected pericarp tenderness.

关键词： Super sweet corn Pericarp tenderness Main ingredients Growth curve Interrelation

服务“一带一路”视域下推进高职教育国际化的探索

维普期刊数据库评论

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职业技术教育 2019年第5期40卷 16-18页

作者：黄益琴浙江商业职业技术学院杭州310053

"一带一路"给高职教育国际化带来了前所未有的发展机遇,高职院校必须从实际出发,发挥自身优质教育资源的优势,加强高职教育"供给侧"结构改革,提升顶层设计、培养模式、专业建设和师资建设等的国际化水平,切实为"一带一路"沿线国家的经... 详细信息

"一带一路"给高职教育国际化带来了前所未有的发展机遇,高职院校必须从实际出发,发挥自身优质教育资源的优势,加强高职教育"供给侧"结构改革,提升顶层设计、培养模式、专业建设和师资建设等的国际化水平,切实为"一带一路"沿线国家的经济建设提供高素质技术技能人才支持。与此同时,政府、学校、企业应密切协作,协同发力,建立机制,为职业教育资源输出提供保障。

关键词：一带一路高职院校教育资源输出国际化

Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF-1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3591-3604页

作者： Juan Rong Chenxia Han Yan huang yiqin Wang Qi Qiu Manjiangcuo Wang Shisheng Wang Rui Wang Juqin Yang Xia Li Chenggong Hu Zhiyao Chen Lihui Deng Wei huang Qing Xi Dan Du West China Center of Excellence for Pancreatitis Institute of Integrated Traditional Chinese and Western MedicineWest China Hospital/West China Medical SchoolSichuan UniversityChengdu 610041China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Advanced Mass Spectrometry Center Research Core FacilityFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610213China Proteomics-Metabolomics Platform Research Core FacilityInstitutes for Systems GeneticsWest China HospitalSichuan UniversityChengdu 610093China Biobank West China HospitalSichuan UniversityChengdu 610093China West China School of Nursing Sichuan UniversityChengdu 610041China Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China

Acute pancreatitis(AP)is a potentially fatal condition with no targeted treatment *** inhibiting xanthine oxidase(XO)in the treatment of AP has been studied in several experimental models and clinical trials,whether XO is a target of AP and what its the main mechanism of action is remains ***,we aimed to re-evaluate whether XO is a target aggravating AP other than merely generating reactive oxygen species that trigger *** first revealed that XO expression and enzyme activity were significantly elevated in the serum and pancreas of necrotizing AP *** also found that allopurinol and febuxostat,as purine-like and non-purine XO inhibitors,respectively,exhibited protective effects against pancreatic acinar cell death in vitro and pancreatic damage in vivo at different doses and treatment time ***,we observed that conditional Xdh overexpression aggravated pancreatic necrosis and *** mechanism analysis showed that XO inhibition restored the hypoxia-inducible factor 1-alpha(HIF-1α)-regulated lactate dehydrogenase A(LDHA)and NOD-like receptor family pyrin domain containing 3(NLRP3)signaling pathways and reduced the enrichment of^(13)C_(6)-glucose to^(13)C_(3)-***,we observed that clinical circulatory XO activity was significantly elevated in severe cases and correlated with C-reactive protein levels,while pancreatic XO and urate were also increased in severe AP *** results together indicated that proper inhibition of XO might be a promising therapeutic strategy for alleviating pancreatic necrosis and preventing progression of severe AP by downregulating HIF-1α-mediated LDHA and NLRP3 signaling pathways.

关键词： Xanthine oxidase inhibitor Multi-omics HIF-1a Necrotizing acute pancreatitis Lactate Therapeutic target NLRP3 Metabolic flux