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Microstructure and Mechanical Properties of NANOBAIN Steel

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Journal of Iron and Steel Research International 2016年第3期23卷 253-260页

作者： yao huang Xue-li zhang wei-ning LIU Xu-min WANG Jun-ke HAN China Electric Power Research Institute Beijing 100192China Beijing Electric Power Design Institute Beijing 100055China AC Construction Branch State Grid Corporation of ChinaBeijing 100031China

The microstructure and mechanical properties of NANOBAIN steel treated at different isothermal temperatures were investigated by scanning electron microscopy（SEM）,transmission electron microscopy（TEM）,uniaxial tensile tests and X-ray diffraction（XRD）.It was found that bainitic ferrite（BF）plate was made of basic shear transformation units arranged in the same direction of *** existence of defects,such as nanoscale twinning and dislocation,suggested that the growth of transformation units was controlled by the surrounding defect plane with dislocation,which was consistent with the moving direction of BF/austenite interface parallel to the twinning *** behavior of work hardening indicated that mechanical stability of microstructures obtained at 250 ℃ and 300 ℃ was much more stable than that obtained at 210℃.The evolution of carbon partitioning in retained austenite and bainitic ferrite also indicated that austenite was enriched in carbon at the initial stage step by step;after the formation of BF,the austenite did not seem to be greatly enriched in carbon and the carbon content showed a little decrease instead;subsequently,aphenomenon of little decarburization of supersaturated bainitic ferrite has also been found.

关键词： NANOBAIN steel shear transformation unit work hardening behavior carbon partitioning

A scalable fish-school inspired self-assembled particle system for solar-powered water-solute separation

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National Science Review 2021年第10期8卷 50-59页

作者： ning Xu Haoran zhang Zhenhui lin Jinlei Li Guoliang Liu Xiuqiang Li wei Zhao Xinzhe Min Pengcheng yao lin Zhou yan Song Bin Zhu Shining Zhu Jia Zhu National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced MicrostructuresCollege of Engineering and Applied SciencesKey Laboratory of Intelligent Optical Sensing and ManipulationMinistry of EducationJiangsu Key Laboratory of Artificial Functional MaterialsNanjing University

Complete separation of water and solute is the ultimate goal of water treatment, for maximized resource recycling. However, commercialized approaches such as evaporative crystallizers consume a large amount of electricity with a significant carbon footprint, leading to calls for alternative energy-efficient and eco-friendly strategies. Here, inspired by schooling fish, we demonstrate a collective system self-assembled by expanded polystyrene（EPS）-core/graphene oxide（GO）-shell particles, which enables autonomous,efficient and complete water-solute separation powered by sunlight. By taking advantage of surface tension,these tailored particles school together naturally and are bonded as a system to function collectively and coordinatively, to nucleate, grow and output salt crystals continuously and automatically out of even saturated brine, to complete water-solute separation. Solar-vapor conversion efficiency over 90% and salt production rate as high as 0.39 kg m-2h-1are achieved under 1-sun illumination for this system. It reduces the carbon footprint of ～50 kg for treating 1-ton saturated brine compared with the commercialized approaches.

关键词： solar-vapor conversion self-assemble collective system water-solute separation

Abnormal characterization of dynamic functional connectivity in Alzheimer’s disease

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Neural Regeneration Research 2022年第9期17卷 2014-2021页

作者： Cui Zhao wei-Jie huang Feng Feng Bo Zhou Hong-Xiang yao yan-E Guo Pan Wang Lu-ning Wang Ni Shu Xi zhang Department of Neurology Second Medical CenterNational Clinical Research Center for Geriatric DiseaseChinese PLA General HospitalBeijingChina Department of Geriatrics Affiliated Hospital of Chengde Medical UniversityChengdeHebei ProvinceChina State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijingChina Center for Collaboration and Innovation in Brain and Learning Sciences Beijing Normal UniversityBeijingChina Beijing Key Laboratory of Brain Imaging and Connectomics Beijing Normal UniversityBeijingChina Department of Neurology First Medical CenterChinese PLA General HospitalBeijingChina Department of Neurology PLA Rocket Force Characteristic Medical CenterBeijingChina Department of Radiology Second Medical CenterChinese PLA General HospitalBeijingChina Department of Neurology Tianjin Huanhu HospitalTianjinChina

Numerous studies have shown abnormal brain functional connectivity in individuals with Alzheimer’s disease(AD)or amnestic mild cognitive impairment(aMCI).However,most studies examined traditional resting state functional connections,ignoring the instantaneous connection mode of the whole *** this case-control study,we used a new method called dynamic functional connectivity(DFC)to look for abnormalities in patients with AD and *** calculated dynamic functional connectivity strength from functional magnetic resonance imaging data for each participant,and then used a support vector machine to classify AD patients and normal ***,we highlighted brain regions and brain networks that made the largest contributions to the *** found differences in dynamic function connectivity strength in the left precuneus,default mode network,and dorsal attention network among normal controls,aMCI patients,and AD *** abnormalities are potential imaging markers for the early diagnosis of AD.

关键词： Alzheimer’s disease amnestic mild cognitive impairment blood oxygen level-dependent default mode network dynamic functional connectivity frontoparietal network resting-state functional magnetic resonance imaging support vector machine

Annexin A2 silencing inhibits invasion, migration, and tumorigenic potential of hepatoma cells

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World Journal of Gastroenterology 2013年第24期19卷 3792-3801页

作者： Hai-Jian zhang Deng-Fu yao Min yao Hua huang Li Wang Mei-Juan yan Xiao-Di yan Xing Gu wei Wu Shao-lin Lu Research Centre of Clinical Medicine Affiliated Hospital of Nantong University Department of Pathology Affiliated Hospital of Nantong University Department of Clinical Oncology Affili-ated Hospital of Nantong University

AIM: To investigate the effects of Annexin A2 (ANXA2) silencing on invasion, migration, and tumorigenic potential of hepatoma cells. METHODS: Human hepatoma cell lines [HepG2, SMMC-7721, SMMC-7402, and MHCC97-H, a novel human hepatocellular carcinoma (HCC) cell line with high metastasis potential] and a normal hepatocyte cell line(LO2) were used in this study. The protein and mRNA expression levels of ANXA2 were analysed by western blotting and real-time polymerase chain reaction, re-spectively. The intracellular distribution profile of ANXA2 expression was determined by immunofluorescence and immunohistochemistry. Short hairpin RNA target-ing ANXA2 was designed and stably transfected into MHCC97-H cells. Cells were cultured for in vitro analy-ses or subcutaneously injected as xenografts in mice for in vivo analyses. Effects of ANXA2 silencing on cell growth were assessed by cell counting kit-8 (CCK-8) as-say (in vitro ) and tumour-growth assay (in vivo ), on cell cycling was assessed by flow cytometry and propidium iodide staining (in vitro ), and on invasion and migration potential were assessed by transwell assay and wound-healing assay, respectively (both in vitro ). RESULTS: The MHCC97-H cells, which are known to have high metastasis potential, showed the highest lev-el of ANXA2 expression among the four HCC cell types examined; compared to the LO2 cells, the MHCC97-H expression level was 8-times higher. The ANXA2 expres-sion was effectively inhibited (about 80%) by ANXA2-specific small hairpin RNA (shRNA). ANXA2 expression in the MHCC97-H cells was mainly localized to the cel-lular membrane and cytoplasm, and some localization was detected in the nucleus. Moreover, the proliferation of MHCC97-H cells was obviously suppressed by shR-NA-mediated ANXA2 silencing in vitro , and the tumour growth inhibition rate was 38.24% in vivo . The per-centage of MHCC97-H cells in S phase dramatically de-creased (to 27.76%) under ANXA2-silenced conditions. Furthermore, ANXA2-s

关键词： Annexin A2 Small hairpin RNA Hepatocel-lular carcinoma Invasion Migration Tumorigenic po-tential

Nuclear magnetic resonance-based metabolomics and metabolic pathway networks from patient-matched esophageal carcinoma,adjacent noncancerous tissues and urine

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World Journal of Gastroenterology 2019年第25期25卷 3218-3230页

作者： Jia-Hao Liang yan lin Ting Ouyang Wan Tang yao huang wei Ye Jia-Yun Zhao Zhe-ning Wang Chang-Chun Ma Department of Radiology Second Affiliated HospitalShantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of Radiation Oncology Affiliated Tumor HospitalShantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND Several studies have demonstrated a correlation between esophageal cancer(EC)and perturbed urinary metabolomic profiles,but none has described the correlation between urine metabolite profiles and those of the tumor and adjacent esophageal mucosa in the same *** To investigate how urinary metabolic phenotypes were linked to the changes in the biochemical landscape of esophageal *** Nuclear magnetic resonance-based metabolomics were applied to esophageal tumor tissues and adjacent normal mucosal tissues alongside patient-matched urine *** Analysis revealed that specific metabolite changes overlapped across both metrics,including glucose,glutamate,citrate,glycine,creatinine and taurine,indicating that the networks for metabolic pathway perturbations in EC,potentially involved in but not limited to disruption of fatty acid metabolism,glucose and glycolytic metabolism,tricarboxylic acid cycle and ***,changes in most urinary biomarkers correlated with changes in biomarker candidates in EC tissues,implying enhanced energy production for rapid cell *** Overall,these associations provide evidence for distinct metabolic signatures and pathway disturbances between the tumor tissues and urine of EC patients,and changes in urinary metabolic signature could reflect reprogramming of the aforementioned metabolic pathways in EC *** investigation is needed to validate these initial findings using larger samples and to establish the underlying mechanism of EC progression.

关键词： Esophageal cancer Metabolites Metabolic pathways Nuclear magnetic resonance-based metabolomics Tumor tissue Urine

Zinc-based metal-organic frameworks as efficient carriers for anticancer drug to reduce toxicity and increase efficacy

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Rare Metals 2024年第10期43卷 5152-5163页

作者： Dong-wei Ma Jing-Sheng Lu Xiang-Xin Cao yan-wei Cheng Gang Wang Zi-Qian zhang Bo-Cheng Chen ning lin Qing Chen College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese MedicineNanning 530200China Guangxi Zhuang yao Medicine Center of Engineering and Technology Nanning 530200China

The rational design of a specific co-drug delivery platform that can address the unavoidable resistance,toxic side effects and low targeting efficiency of traditional cancer treatments is of great ***,Zn-based MOF-zeolitic imidazole framework-90(ZIF-90)was selected as the drug delivery carrier,with the cancer therapeutic drug mercaptopurine(6-MP)and glucose oxidase(GOD)as the drug models,hyaluronic acid(HA)was used for protection and targeted delivery,which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA).This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment ***,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity,which provides new possibilities for the development of more precise and effective treatment strategies.

关键词： Metal-organic framework Cancer treatment Combination therapy Drug delivery Reduced toxicity

Designing of spin filter devices based on zigzag zinc oxide nanoribbon modified by edge defect

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Chinese Physics B 2019年第10期28卷 585-589页

作者： Bao-Rui huang Fu-Chun zhang yan-ning yang Zhi-Yong zhang wei-Guo Wang School of Information Science Technology Northwest UniversityXi’an 710127China School of Physics and Electronic Information Yan’an UniversityYan’an 716000China

The spin-dependent electronic transport properties of a zigzag zinc oxide(ZnO) nanoribbon are studied by using density functional theory with non-equilibrium Green's functions. We calculate the spin-polarized band structure, projected density of states, Bloch states, and transmission spectrum of the ZnO nanoribbon. It is determined that all Bloch states are located at the edge of the ZnO nanoribbon. The spin-up transmission eigenchannels are contributed from Zn 4s orbital,whereas the spin-down transmission eigenchannels are contributed from Zn 4s and O 2p orbitals. By analyzing the current-voltage curves for the opposite spins of the ZnO nanoribbon device, negative differential resistance(NDR) and spin filter effect are observed. Moreover, by constructing the ZnO nanoribbon modified by the Zn-edge defect, the spin-up current is severely suppressed because of the destruction of the spin-up transmission eigenchannels. However, the spin-down current is preserved, thus resulting in the perfect spin filter effect. Our results indicate that the ZnO nanoribbon modulated by the edge defect is a practical design for a spin filter.

关键词： ZnO nanoribbon spin-dependent transport nonequilibrium Green's functions transmission eigenchannels spin filtering efficiency

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ZnO薄膜的电沉积制备及其荧光特性研究

功能材料 2006年第10期37卷 1603-1605页

作者：黄延伟姚宁张兵临郑州大学材料物理教育部重点实验室河南郑州450052

以Zn(NO3)2水溶液为电解液,用阴极电沉积法分别在透明导电玻璃ITO和FTO衬底上制备了ZnO薄膜。X射线衍射(XRD)和扫描电子显微镜(SEM)分析结果表明ZnO薄膜属六角纤锌矿结构,ZnO颗粒均匀,大小约1μm;在室温光致发光谱(PL)中(激发波长为385... 详细信息

以Zn(NO3)2水溶液为电解液,用阴极电沉积法分别在透明导电玻璃ITO和FTO衬底上制备了ZnO薄膜。X射线衍射(XRD)和扫描电子显微镜(SEM)分析结果表明ZnO薄膜属六角纤锌矿结构,ZnO颗粒均匀,大小约1μm;在室温光致发光谱(PL)中(激发波长为385和390nm)分别观察到了波长位于439和442nm处的较强的蓝光发射峰。本文讨论了样品蓝光峰的发光机理,并指出蓝光峰与样品中由锌填隙引起的潜施主能级上的电子到价带的跃迁有关。

关键词：电沉积 ZnO薄膜光致发光锌填隙蓝色荧光谱

Two-stage extraction by partial grinding of impacted mandibular third molar in close proximity to the inferior alveolar nerve

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World Journal of Clinical Cases 2024年第10期12卷 1728-1732页

作者： Guang-Ming Luo zhang-Shun yao wei-Xiang huang Lei-yan Zou yan yang Kunbaida Outpatient Department Kunming Medical University School and Hospital of StomatologyKunming 650106Yunnan ProvinceChina Yunnan Key Laboratory of Stomatology Kunming 650106Yunnan ProvinceChina

BACKGROUND Extraction of impacted third molars often leads to severe complications caused by damage to the inferior alveolar nerve(IAN).AIM To proposes a method for the partial grinding of an impacted mandibular third molar(IMM3)near the IAN to prevent IAN injury during IMM3 *** Between January 1996 and March 2022,25 patients with IMM3 roots near the IAN were *** first stage of the operation consisted of grinding a major part of the IMM3 crown with a high-speed turbine dental drill to achieve sufficient space between the mandibular second molar and *** 6 months,when the root tips were observed to be away from the IAN on X-ray examination,the remaining part of the IMM3 was completely *** All IMM3s were extracted easily without symptoms of IAN injury after *** Partial IMM3 grinding may be a good alternative treatment option to avoid IAN injury in high-risk cases.

关键词： Partial grinding Impacted mandibular third molar Inferior alveolar nerve Cone-beam computed tomography