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Raman and UV-Vis Spectroscopy Applied to the Analysis of Liver Tissues from Rats with Myocardial Ischemia Induced by Isoproterenol

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Chemical Research in Chinese Universities 2011年第4期27卷 570-573页

作者： GAO Hai-cheng ZOU Ying-gang huang yu-xin GAO Hai-mei CHEN Lei PEI Jin School of Pharmaceutical Sciences Jilin University Changchun 130012 P. R. China Department of Obstetrics ＆ Gynecology the Second Hospital of Jilin University Changchun 130041 P. R. China Basic Science College Changchun University of Technology Changchun 130012 P. R. China Key Laboratory for Molecular Enzymology and Engineering Ministry of Education Jilin University Changchun 130012 P. R. China

The application of the laser Raman spectroscopic（LRS） technique for the analysis of liver tissues from rats with myocardial ischemia induced by isoproterenol（ISO） was *** model of myocardial ischemia was established for rats induced by *** were randomly divided into four groups as normal group and myocardial ischemia *** observed the successful myocardial ischemia model via serum enzymes levels and hematoxylin-eosin（HE） staining,and detected the liver tissue of the rats from normal group and liver tissue of the rats from myocardial ischemia groups via UV-Vis spectroscopy（UV-Vis） and LRS,and the changes of the absorbance spectra were compared in the above four different *** results show that ISO can induce rat myocardial ischemia *** spectrum of normal liver tissue supernatant exhibits a strong absorption band at 968 nm,but no absorption band appears in the spectra of liver tissue supernatant solutions from the rats with myocardial ischemia induction after 2,12 and 72 h presented at 968 *** results show that Raman intensities of the precipitates suffered from ISO-treatment after 2,12 and 72 h were obviously increased compared with that of the precipitate of the liver tissue of the normal rats suffered from 0.9 g/L normal saline（NS） *** results indicate that LRS and UV-Vis can be harmless,nondestructive,rapid and effective methods for analyzing different pathological specimens of liver tissue from myocardial ischemia rats.

关键词： Laser Raman spectroscopy UV-Vis spectroscopy Isoproterenol Myocardial ischemia Rat Liver tissue

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Antiangiogenic effect of celastrol on the growth of human glioma： an in vitro and in vivo study

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Chinese Medical Journal 2009年第14期122卷 1666-1673页

作者： ZHOU You-xin huang yu-lun Department of Neurosurgery the First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China

Background Celastrol is a major active component of Tripterygium wilfordii named ＂Thunder God Vine＂, which is widely used to treat rheumatoid arthritis in China. The present study aims to demonstrate that celastrol has potent anticancer activity against glioma in vitro and in vivo. Methods Proliferation, migration, and tube formation of ECV-304 cells were determined by MTT and matrigel assays. The antiangiogenesis effect of celastrol was assessed by the chick chorioallantoic membrane assay and the in vivo matrigel plug assay. Tumor microvessels （MVD） were determined immunohistochemically with anti-CD34 antibody. Vascular endothelial growth factor （VEGF） expression was defined as positive if distinct staining of the cytoplasm was observed in at least 10% of tumor cells at the deepest invasive site, central portion and superficial part of the tumor. MVD was estimated by averaging the counts of three times at a ×200 field in the most vascularized area of the deepest invasive site. Results Celastrol purified from T. wilfordiiinhibited the proliferation of vascular endothelial cells （ECV-304） with an IC50 value of 1.33 μg/ml. Celastrol, at the concentration of 0.2 μg/ml, significantly inhibited cell migration and tube formation. Celastrol inhibited angiogenesis in a dose-dependent manner both in vitro and in vivo. Subcutaneous administration of celastrol 5 days a week for 4 consecutive weeks significantly reduced tumor volume in a dose-dependent manner in the SHG-44 xenograff model. Celastrol at each different dose level lowered the density of MVD significantly in tumor bearing nude mice compared to the control group. Immunohistochemistry experiments further revealed that celastrol also decreased the level of VEGFR-1 and VEGFR-2 expression, but not the level of VEGF expression. Conclusions Celastrol elicits antiangiogenic effects in vitro and in vivo, and could be of potential use in the treatment of malignant cancers such as glioblastoma.

关键词： angiogenesis celastrol glioma vascular endothelial growth factor

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A case of occult insulinoma localized by pancreatic dynamic enhanced spiral CT

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World Journal of Gastroenterology 2010年第11期16卷 1418-1421页

作者： Bao, Zhao-Kang huang, xin-yu Zhao, Jun-Gong Zheng, Qi Wang, Xiao-Feng Wang, Hong-Cheng Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Gen Surg Shanghai 200233 Peoples R China Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Radiol Shanghai 200233 Peoples R China

Insulinomas are the most common category of pancreatic endocrine tumors,with an annual incidence of 1-4 cases per million *** are intrapancreatic,benign and ***,they have an excellent prognosis after surgical ***,the localization diagnosis of insulinomas still poses a challenge to surgeons and *** this case,the tumor was occult and could not be found by either abdominal enhanced spiral computed tomography(CT)or ***,we tried a new method of CT scanning and localized the tumor.

关键词： Insulinoma Computed tomography Localization diagnosis Dynamic enhanced scan Enhancement value

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A single nucleotide substitution in the MATE transporter gene regulates plastochron and the many noded dwarf phenotype in barley(Hordeum vulgare L.)

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Journal of Integrative Agriculture 2023年第8期22卷 2295-2305页

作者： GUO Bao-jian SUN Hong-wei QI Jiang huang xin-yu HONG Yi HOU Jian Lü Chao WANG yu-lin WANG Fei-fei ZHU Juan GUO Gang-gang XU Ru-gen Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Key Laboratory of Plant Functional Genomics Ministry of Education/Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Co-Innovation Center for Modern Production Technology of Grain CropsYangzhou UniversityYangzhou 225009P.R.China State Key Laboratory of Barley and Yak Germplasm Resources and Genetic Improvement/Tibet Academy of Agricultural and Animal Husbandry Sciences(TAAAS) Lhasa 850002P.R.China Key Laboratory of Crop Germplasm Resources and Utilization Ministry of Agriculture/National Key Facility for Crop Gene Resources and Genetic Improvement/Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081P.R.China

In higher plants,the shoot apical meristem produces lateral organs in a regular spacing(phyllotaxy)and timing(plastochron).The molecular analysis of mutants associated with phyllotaxy and plastochron would increase our understanding of the mechanism of shoot architecture *** this study,we identified mutant mnd8ynp5 that shows an increased rate of leaf emergence and a larger number of nodes in combination with a dwarfed growth habit from an EMS-treated population of the elite barley cultivar Yangnongpi *** a map-based cloning strategy,the mnd8 gene was narrowed down to a 6.7-kb genomic interval on the long arm of chromosome *** analysis revealed that a C to T single-nucleotide mutation occurred at the first exon(position 953)of HORVU5Hr1G118820,leading to an alanine(Ala)to valine(Val)substitution at the 318th amino acid ***,HORVU5Hr1G118820 was defined as the candidate gene of MND8 encoding 514 amino acids and containing two multidrug and toxic compound extrusion(MATE)*** is highly homologous to maize Bige1and has a conserved function in the regulation of plant development by controlling the leaf initiation *** of modern barely varieties showed that Hap-1 was the dominant haplotype and was selected in barley breeding around the ***,our results indicated that mnd8ynp5 is a novel allele of the HORVU5Hr1G118820 gene that is possibly responsible for the shortened plastochron and many noded dwarf phenotype in barley.

关键词： barley EMS plastochron many noded dwarf MATE transporter shoot architecture

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang yu-Wen Alvin huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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CO_2辅助超高压杀菌对复合调味料品质的影响

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高压物理学报 2015年第6期29卷 475-483页

作者：黄歆妤沈群中国农业大学食品科学与营养工程学院北京100083

超高压作为新兴的食品非热加工技术,使用方便、快捷,发展潜力巨大。选取3种具有代表性的复合调味料——复合黄豆酱、复合甜面酱及复合芝麻酱,研究CO_2辅助超高压(300、400和500MPa)处理对其细菌总数和黏度、颜色、风味等感官品质的影响... 详细信息

超高压作为新兴的食品非热加工技术,使用方便、快捷,发展潜力巨大。选取3种具有代表性的复合调味料——复合黄豆酱、复合甜面酱及复合芝麻酱,研究CO_2辅助超高压(300、400和500MPa)处理对其细菌总数和黏度、颜色、风味等感官品质的影响。结果表明,经CO_2辅助超高压处理后,3种复合酱料的细菌总数均减少,且压力越高,减少量越多,但均小于一个对数单位;黏度的变化无明显规律性;色泽方面,只有复合芝麻酱样品处理前、后出现较显著差异;风味物质的种类和含量方面,3种复合调味料均发生了不同程度的变化;感官评价结果显示,CO_2辅助超高压处理对于复合调味料的整体感官品质无显著影响。研究表明,常温下CO_2辅助500MPa高压处理5min的总体效果最好。研究结果可为超高压技术应用于调味料生产提供参考。

关键词：复合调味料 CO2辅助超高压感官品质细菌总数

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基于特征融合和自学习锚框的高分辨率图像小目标检测算法

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电子学报 2022年第7期50卷 1684-1695页

作者：李超黄新宇王凯湖北工业大学计算机学院湖北武汉430068

为了提高高分辨率图像中小目标的检测精度,解决高分辨率图像在下采样和局部裁切时由于细节和背景信息丢失造成的漏检和误检问题,本文提出了一种基于特征融合和自学习锚框的小目标检测算法.算法采用多路分支网络对高分辨率图像的全局语... 详细信息

为了提高高分辨率图像中小目标的检测精度,解决高分辨率图像在下采样和局部裁切时由于细节和背景信息丢失造成的漏检和误检问题,本文提出了一种基于特征融合和自学习锚框的小目标检测算法.算法采用多路分支网络对高分辨率图像的全局语义和细节特征平滑后逐层融合,以同时增强特征图上小目标的细节和背景特征.针对训练样本尺寸差异造成不同分支网络上特征表达不一致的问题,本文引入自学习锚框使融合后的特征图能够适应锚框的位置和形状.使用本文算法与目前先进的目标检测算法对下采样图像和切块检测,大量实验结果验证了本文算法对高分辨率图像小目标检测的准确性和有效性.

关键词：小目标检测特征融合自学习锚框高分辨率图像

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地方政府环保监管责任有效落实的路径分析

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政法论丛 2017年第3期 145-152页

作者：黄信瑜安徽财经大学法学院安徽蚌埠233030

实现生态环境的可持续发展是福国利民、代际公平的一项重要工作,是尊重民意的体现,也是当下民生的迫切需要,更是中国永续发展的根本保障。环保监管实践规律表明,政府作为环境保护的直接责任主体,其履行环境监管责任的优劣,是直接影响环... 详细信息

实现生态环境的可持续发展是福国利民、代际公平的一项重要工作,是尊重民意的体现,也是当下民生的迫切需要,更是中国永续发展的根本保障。环保监管实践规律表明,政府作为环境保护的直接责任主体,其履行环境监管责任的优劣,是直接影响环境质量好坏的关键所在。为此,实有必要在总结分析地方政府环保监管责任不足基础上,完善能充分反映环保绩效评价考核与激励机制的制度安排;以及通过公众参与和监督的外部机制,来协助与推进地方政府环保监管之责的有效落实。

关键词：环境利益环保监管考核机制公众参与

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Does China's digital economy contribute to low-carbon transition?

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Ecological Economy 2024年第2期20卷 102-122页

作者： LI Jun-jun huang xin-yu CHEN Mu ZHANG Meng-jiang ZHANG Zhen School of Economics Fujian Normal UniversityFuzhou 350007CHINA College of Mechanical and Electrical Engineering Wuyi UniversityNanping 354300CHINA

The digital economy,as a new emerging economic form,has become an important power for realizing Chinese-style modernization and promoting green development in *** paper measures the digital economy and low-carbon transition index based on the data of 30 provinces in China from 2013 to 2020 and analyzes the mechanism and path of the digital economy affecting low-carbon transition using the fixed effect panel data model and the threshold effect *** is found that,(1)The digital economy and low-carbon transition in China are various in different regions,with characteristics of being unbalanced and insufficient.(2)The digital economy significantly promotes low-carbon transition,with the greatest influence in the Central region,followed by the Eastern region and the Western *** different dimensions,the development of informatization and digital transactions promote low-carbon transition,but the development of the internet plays an inhibiting role.(3)The higher the degree of urbanization and environmental regulation,the greater the influence of the digital economy on low-carbon transition.

关键词： digital economy low-carbon transition threshold effect model instrumental variables quantile regression

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Experimental study on mechanism and protection of stress ulcer produced by explosive noise

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World Journal of Gastroenterology 1998年第6期4卷 64-68页

作者： LIU Guo Shi 1, huang yu xin 1, LI Shuan Wei 2, PAN Bo Rong 3, WANG xin 1, SUN Da Yong 1 and WANG Qing Li 1

AIM To establish an experimental model of stress ulcer produced by explosive noise, and to probe into its mechanism and protection. METHODS The country standard Wistar white rats were randomly divided into control group ( n =8), which were neither stimulated nor protected, and stimulating group (divided into subgroups A, B and C, including 8 rats each which were decapitated to draw blood for test immediately, 12 hours and 24 hours after stimulation) and prevention group (divided into subgroups A, B and C, having 8 rats each, subgroup A was given cimetidine, B anisodamine and C both drugs). Firing noises of submachine guns were used as inflicting factor. The rats were fasted for 24 hours and stimulated by firing noise for 12 hours. The change of ulcer index, gastric mucosal and related serum hormones were observed. RESULTS Stress ulcer was significant in the stimulating group, and its ulcer index (8 6±0 6) was remarkably higher than that in both the control group and prevention group (0 3±0 1, P <0 01). Its serum gastrin (Gas ng/L , 294±163 vs 63±40, P <0 01) and endothelin (ET ng/L , 181±57 vs 135±42, P <0 01) were apparently higher than those in the control group, and its serum nitric oxide (NO) level was conspicuously lower than that in the control group ( ng/L , 0 2±0 1 vs 0 8±0 5, P <0 05), while the serum gastrin level ( ng/L , 556±225) in prevention group was distinctly higher than that in both the control ( P <0 01) and stimulating group ( P <0 05). There were no significant differences in the changes of ET and NO between the control and the stimulating groups. CONCLUSION Stress ulcer model of rats can be successfully established by the stimulation of explosive noise. Gas, ET and NO are related to the formation of stress ulcer, and play an important role in its mechanism. Hepatic function affected by noise is observed in this experiment.

关键词： stomach ulcer/etiology stomach ulcer/prevention and control gastric mucosa/pathology noise/adverse effects stress ulcer

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