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Shock-induced energy localization and reaction growth considering chemical-inclusions effects for crystalline explosives

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Defence Technology（防务技术） 2024年第3期33卷 278-294页

作者： Ruqin Liu Yanqing Wu Xinjie Wang Fenglei huang xiaona huang Yushi Wen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China School of Power and Mechanical Engineering Wuhan UniversityWuhan430072HubeiChina Institute of Chemical Materials China Academy of Engineering Physics(CAEP)Mianyang621999SichuanChina

Chemical inclusions significantly alter shock responses of crystalline explosives in macroscale gap experiments but their microscale dynamics origin remains *** shock-induced energy localization,overall physical responses,and reactions in a-1,3,5-trinitro-1,3,5-triazinane(a-RDX)crystal entrained various chemical inclusions were investigated by the multi-scale shock technique implemented in the reactive molecular dynamics *** indicated that energy localization and shock reaction were affected by the intrinsic factors within chemical inclusions,i.e.,phase states,chemical compositions,and *** atomic origin of chemical-inclusions effects on energy localization is dependent on the dynamics mechanism of interfacial molecules with free space volume,which includes homogeneous intermolecular compression,interfacial impact and shear,and void collapse and *** introducing various chemical inclusions,the initiation of those dynamics mechanisms triggers diverse decay rates of bulk RDX molecules and hereby impacts on growth speeds of final *** chemical inclusions can reduce the effectiveness of the void during the shock *** the shockwave velocity of 9 km/s,the parent RDX decay rate in RDX entrained amorphous carbon decreases the most and is about one fourth of that in RDX with a vacuum void,and solid HMX and TATB inclusions are more reactive than amorphous carbon but less reactive than dry air or acetone *** lessdense shocking system denotes the greater increases in local temperature and stress,the faster energy liberation,and the earlier final reaction into equilibrium,revealing more pronounced responses to the present intense *** quantitative models associated with the relative system density(RD_(sys))were proposed for indicating energy-localization mechanisms and evaluating initiation safety in the shocked crystalline ***_(sys)is defined by the density ratio of defective RDX to perfec

关键词： Shock responses Energy localization Crystalline explosives Chemical inclusions Reactive molecular dynamics

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Thermal and mechanical characterization of under-2-μm-thick AlCrNbSiTi high-entropy thin film

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Energy Storage and Saving 2024年第1期3卷 52-59页

作者： Yibo Wang xiaona huang Yan Liu Xiangyu Zhang Bing Yang Yanan Yue School of Power and Mechanical Engineering Wuhan UniversityWuhan430072China

High-entropy alloys(HEAs)exhibit extraordinary physical properties such as superior strength-to-weight ratios and enhanced corrosion and oxidation resistance,making them potentially useful in energy storage and gener-ation ***,thermal and mechanical properties of HEAs with various compositions vary ***,these properties have rarely been investigated simultaneously owing to material or instru-mentation ***,we synthesize an HEA(AlCrNbSiTi)coating with a thickness of less than 2μ*** customize a frequency-domain photothermal testing system to characterize the thermal and mechanical proper-ties of the proposed coating with high *** to the large mixing enthalpy of the Al-Ti,Nb-Si,and Ti-Si pairs in the coating,its hardness and elastic modulus are 15.2 and 254.7 GPa,respectively,which are higher than those of previously reported *** thermal conductivity of the AlCrNbSiTi coating is characterized to be 2.90 W·m^(−1)·K^(−1),within the expected range and well explained by the free-electron consistency diversity and phonon scattering from the amorphous ***,the coating exhibits adequate wear performance,with a wear rate of 5.4×10^(−8) mm^(3)·N^(−1)·m^(−1).This relatively low thermal conductivity,combined with extraordi-nary mechanical properties,makes the proposed material an excellent candidate as a protective coating material for nuclear reactor components which require high strength,irradiation resistance,and thermal protection.

关键词： High-entropy alloys Thin coating Thermal conductivity Mechanical properties Noncontact photothermal technique

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Weitiao No.3(微调3号方) enhances the efficacy of anti-programmed cell death protein-1 immunotherapy by modulating the intestinal microbiota in an orthotopic model of gastric cancer mice

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Journal of Traditional Chinese Medicine 2024年第5期44卷 906-915页

作者： huang xiaona LI Yuzhen ZHU Chenyang ZHU Hengzhou JIANG Chenyu ZHU Xiaodan ZHANG Chencen JIN Chunhui Department of Oncology Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine (Wuxi Hospital of Traditional Chinese Medicine)

OBJECTIVE: To explore the effects of Weitiao No. 3(微调3号方, WD-3) on anti-programmed cell death protein-1(PD-1) immunotherapy in gastric cancer(GC). METHODS: The intestinal microbiota was analyzed by 16S rDNA sequencing of fecal samples from three groups: healthy people(Health), GC patients(GC), and WD-3-treated GC patients(WD-3). Next, we established an orthotopic model of GC mice, which were treated with anti-PD-1, WD-3, or an inoculation of intestinal bacteria. Immune markers CD3, CD4, CD8, and forkhead box protein P3(FOXP3), and the cell proliferation marker Ki67, were evaluated by immunohistochemistry. Cell apoptosis in GC tumors was assessed by terminaldeoxynucleotidyl-transferase-mediated deoxyuridine triphosphate nick end labeling staining. Enzyme-linked immunosorbent assays(ELISAs) were performed to analyze the serum levels of the following cytokines in GC mice: tumor necrosis factor(TNF)-α, interleukin(IL)-2, IL-6, IL-10, interferon(IFN)-γ, and transforming growth factor(TGF)-β. RESULTS: Sequencing data showed that there were significant differences in the composition of the gut microbial community among the three human groups. The gut bacteria in the three groups mainly comprised the phyla Firmicutes, Proteobacteria, Bacteroidetes, and Actinobacteria. At the genus level, the relative abundances of Bifidobacterium and Coprococcus showed significant decreases in the GC group, and an obvious increase in the WD-3 group, compared with the Health group. Interestingly, the relative abundance of Saccharopolyspora was only detected in the WD-3 group. The results of in vivo experiments in GC mice showed that WD-3 or anti-PD-1 treatment increased the levels of CD3+, CD4+, and CD8+ T cells, but decreased the levels of FOXP3+ regulatory T cells. Furthermore, WD-3 or PD-1 antibody treatment inhibited proliferation and promoted apoptosis of GC tumor cells. ELISA analysis showed that WD-3 or PD-1 antibody treatment facilitated TNF-α, IL-2, and IFN-γ expression, while suppr

关键词： Weitiao No. 3 gastrointestinal microbiome immunotherapy programmed cell death 1 receptor stomach neoplasms

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近场作用下纳米针尖点接触界面传热研究

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工程热物理学报 2024年第10期45卷 3131-3136页

作者：徐屾邓书港黄小娜黄德钊岳亚楠武汉大学动力与机械学院武汉430072 上海工程技术大学机械与汽车工程学院上海201620

扫描探针光刻技术可实现10 nm以下的材料加工,为微纳加工技术带来新的发展方向。但在该技术中针尖与样品间热量传递是影响材料温升和加工效果的关键因素。本文设计了一种金纳米针尖阵列支撑的单层石墨烯结构,在真空条件下,针尖与石墨烯... 详细信息

扫描探针光刻技术可实现10 nm以下的材料加工,为微纳加工技术带来新的发展方向。但在该技术中针尖与样品间热量传递是影响材料温升和加工效果的关键因素。本文设计了一种金纳米针尖阵列支撑的单层石墨烯结构,在真空条件下,针尖与石墨烯间接触热阻是影响结构温升的主要因素。首先评估金纳米针尖阵列在532 nm激光作用下近场增强因子约为3.2,其次,结合实验和仿真,测定金纳米针尖阵列与石墨烯间接触热阻约为4.6×10^(-5)(m^(2)·K)/W。

关键词：界面接触热阻纳米针尖拉曼光谱近场增强扫描探针光刻技术

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1例产科抗磷脂综合征并发HELLP综合征患者的抗凝治疗分析与药学监护

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药物流行病学杂志 2024年第2期33卷 218-223页

作者：朱玥黄晓娜南京医科大学附属无锡人民医院药学部江苏无锡214023 南京医科大学药学院南京211166

1例37岁产科抗磷脂综合征(OAPS)孕妇因“血压控制不佳”入院,入院后血压波动大(152~161/100~112mmHg),血小板计数进行性下降(65×10^(9)·L^(-1)),乳酸脱氢酶367 U·L^(-1),丙氨酸氨基转移酶121.8 U·L^(-1),天冬氨酸氨基转移酶89 U·L^... 详细信息

1例37岁产科抗磷脂综合征(OAPS)孕妇因“血压控制不佳”入院,入院后血压波动大(152~161/100~112mmHg),血小板计数进行性下降(65×10^(9)·L^(-1)),乳酸脱氢酶367 U·L^(-1),丙氨酸氨基转移酶121.8 U·L^(-1),天冬氨酸氨基转移酶89 U·L^(-1),病情进展为HELLP综合征。临床药师参与其治疗过程,结合患者血栓及出血风险、血小板动态变化、抗凝药物药代动力学特征,协助临床医师制定其围产期个体化抗凝治疗方案,及时停用及启用抗凝药物,有效避免了患者血栓和产后出血并发症的发生。同时以循证药学为基础,分析了此类患者妊娠期和哺乳期的药学监护要点,羟氯喹、阿司匹林、泼尼松等OAPS常规用药在妊娠期规范化使用利大于弊,但需密切监护相应的不良反应,依诺肝素无乳汁蓄积,可在哺乳期安全使用,临床药师在保障妊娠与哺乳期患者用药安全有效中发挥重要作用。

关键词：产科抗磷脂综合征 HELLP综合征抗凝治疗妊娠期哺乳期药学监护

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胎膜早破患者B族链球菌感染预防药物临床路径的实践与评价

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药学与临床研究 2024年第4期32卷 359-363页

作者：黄晓娜刘月李静南京医科大学附属无锡人民医院药学部无锡214023

目的:评价产科胎膜早破(PROM)患者B族链球菌(GBS)感染预防药物临床路径(以下简称“临床药径”)的应用效果。方法:针对某院产科PROM患者GBS感染的抗菌药物预防性使用中存在的问题,制定了PROM患者GBS感染预防临床药径,分为足月PROM、≥34 ... 详细信息

目的:评价产科胎膜早破(PROM)患者B族链球菌(GBS)感染预防药物临床路径(以下简称“临床药径”)的应用效果。方法:针对某院产科PROM患者GBS感染的抗菌药物预防性使用中存在的问题,制定了PROM患者GBS感染预防临床药径,分为足月PROM、≥34 w未足月PROM(PPROM)、<34 w PPROM,“医药护”三师联动对PROM患者GBS感染预防进行管理。对比临床药径实施前后PROM患者GBS感染预防抗菌药物使用的合理性、抗菌药物使用强度、药物经济学(住院时间、抗菌药物费用)等指标。结果:临床药径实施后PROM患者GBS感染预防用药的药物选择、给药时机、疗程合理率均有显著升高(P<0.05)。足月PROM、≥34 w PPROM患者的用药疗程均较前显著缩短(P<0.05)。足月PROM平均住院时间缩短0.7 d,平均抗菌药物费用下降8.86元/人,与实施前比较,差异有统计学意义(P<0.05)。抗菌药物使用强度呈明显下降趋势,最低下降至9.78DDD。结论:建立产科PROM患者GBS感染预防临床药径切实可行,有效降低了医疗成本、住院天数及抗菌药物使用强度,在保障围产期PROM患者母婴安全中发挥积极作用。

关键词：胎膜早破 B族链球菌抗菌药物药物临床路径

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大黄素对脂多糖诱导的新生大鼠急性肺损伤的保护作用

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中国组织化学与细胞化学杂志 2024年第1期33卷 13-18,24页

作者：黄小娜许志有林坚海南省海口市第三人民医院儿内科海口571199

目的探索大黄素对脂多糖(lipopolysaccharide, LPS)诱导的新生大鼠急性肺损伤的保护作用。方法新生大鼠腹腔注射LPS制作建立急性肺损伤模型,每天腹腔注射不同剂量大黄素(emodin, EMD),连续治疗7 d,对照组腹腔注射等体积生理盐水。通... 详细信息

目的探索大黄素对脂多糖(lipopolysaccharide, LPS)诱导的新生大鼠急性肺损伤的保护作用。方法新生大鼠腹腔注射LPS制作建立急性肺损伤模型,每天腹腔注射不同剂量大黄素(emodin, EMD),连续治疗7 d,对照组腹腔注射等体积生理盐水。通过HE、Masson染色进行组织病理学检测,免疫组织化学检测肺组织平滑肌肌动蛋白(α-SMA)表达水平,原位末端标记法(TUNEL)检测肺组织细胞凋亡水平,Western Blot检测肺组织Ⅰ型胶原蛋白(Collagen Ⅰ)、Ⅲ型胶原蛋白(Collagen Ⅲ)、裂解的天冬氨酸特异性半胱氨酸蛋白酶3(cleaved Caspase 3)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)蛋白表达水平。结果脂多糖使大鼠肺损伤评分、肺纤维化程度、α-SMA平均光密度、TUNEL阳性率、Collagen I、Collagen Ⅲ、cleaved Caspase3、IL-1β、TNF-α蛋白表达水平较对照组显著增加,大黄素处理能剂量依赖性抑制脂多糖引起的上述变化。结论大黄素对LPS诱导的新生大鼠急性肺损伤具有保护作用。

关键词：脂多糖大黄素新生大鼠急性肺损伤

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Grain boundaries induce significant decrease in lattice thermal conductivity of CdTe

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能源与人工智能(英文) 2023年第1期11卷 43-50页

作者： xiaona huang Kun Luo Yidi Shen Yanan Yue Qi An School of Power and Mechanical Engineering Wuhan UniversityWuhanHubei 430072China Department of Chemical and Materials Engineering University of Nevada–RenoRenoNevada 89557United States Department of Materials Science and Engineering Iowa State UniversityAmesIA 50011United States

Semiconductors are promising in photoelectric and thermoelectric devices, for which the thermal transport properties are of particular interest. However, they have not been fully understood, especially when crystalline imperfections are present. Here, using cadmium telluride (CdTe) as an example, we illustrate how grain boundaries (GBs) affect the thermal transport properties of semiconductors. We develop a machine-learning force field from density functional theory calculations for predicting the lattice thermal conductivity (LTC) via equilibrium molecular dynamics simulations. The LTC of crystalline CdTe decreases with the relationship of κL~1/T in the simulation temperature range of 300 – 900 K, in which the isotropic LTC decreases from 3.34 to 0.23 W/ (m⋅K) due to the enhanced anharmonicity. More important, after introducing GBs, the LTC is suppressed in all directions, especially in the direction normal to the GB planes. More severe LTC suppression occurs in CdTe with Σ9 GB than that with Σ3 GB at 300 K, decreasing by 92.8% and 61.4% along the direction normal to the GB planes compared to the isotropic LTC of the crystalline CdTe, respectively. The decreased LTC is consistent with the weaker bonding near GB planes and lower shear modulus of the defective material. The analyses of the phonon dispersion curves, vibrational density of states, and phonon participation ratio indicate that the decreased LTC mainly arises from phonon scattering at GBs. Overall, our work highlights that GBs can greatly influence the LTC of semiconductors, thus providing a promising approach for thermal property design.

关键词： Lattice thermal conductivity Machine-learning force field Molecular dynamics CdTe Grain boundary

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In-situ formed NiS/Ni coupled interface for efficient oxygen evolution and hydrogen evolution

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Journal of Materials Science & Technology 2020年第7期42卷 10-16页

作者： Chaoyi Yan Jianwen huang Chunyang Wu Yaoyao Li Yuchuan Tan Luying Zhang Yinghui Sun xiaona huang Jie Xiong State Key Laboratory of Electronic Thin Film and Integrated Devices University of Electronic Science and Technology of ChinaChengdu610054China Chengdu Technological University Chengdu611730China Soochow Institute for Energy and Materials InnovationS&Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow UniversitySuzhou215006China

High-performance electrocatalysts for water splitting are desired due to the urgent requirement of clean and sustainable hydrogen *** reduce the energy barrier,herein,we adopt a facile in-situ surface modification strategy to develop a low-cost and efficient electrocatalyst for water *** synthesized mulberry-like NiS/Ni nanoparticles exhibit excellent catalytic performance for water *** overpotentials of 301 and 161 mV are needed to drive the current density of 10 mA cm^-2 accompanying with remarkably low Tafel slopes of 46 and 74 mV dec^-1 for oxygen evolution reaction(OER)and hydrogen evolution reaction(HER),***,a robust electrochemical stability is *** high-resolution X-ray photoelectron spectroscopy analyses reveal that the intrinsic HER activity improvement is attributed to the electron-enriched S on the strongly coupled NiS and Ni interface,which simultaneously facilitates the important electron transfer,consistent with the electrochemical impedance *** post characterizations demonstrate that surface reconstructed oxyhydroxide contributes to the OER activity and NiS/Ni is an OER *** structure construction with in-situ formation of active interface provides an effective way to design efficient electrocatalysts for energy conversion.

关键词： Water splitting Interface construction Electrocatalyst Bifunctional In-situ synthesis

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Analysis of Early Essential Newborn Care Capacities of Rural Health Facilities--Four Provinces in Western China, 2016

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China CDC weekly 2020年第1期2卷 8-12页

作者： Tao Xu Wen Qu Yan Wang Qing Yue xiaona huang Xiaobo Tian National Center for Women and Children’s Health Chinese Center for Disease Control and PreventionBeijingChina UNICEF China BeijingChina.

What is already known about this topic?The Early Essential Newborn Care(EENC)intervention package recommended by World Health Organization(WHO)is shown to prevent and treat the leading causes of newborn illness and *** has begun widespread implementation of the *** is added by this report?Among the 14 core interventions,including using antibiotics for mothers with premature rupture of membranes,immediate skin-to-skin contact of mother and baby,delayed umbilical cord clamping,kangaroo mother care for preterm newborn,and neonatal sepsis and pneumonia management,were not sufficiently implemented in health facilities in western *** are the implications for public health practice?There are gaps between the implementation situation and WHO recommendations in terms of EENC capacities in western *** interventions developed accordingly can ensure quality child health care and decrease newborn mortality in China.

关键词： mother Rural Health

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