检索结果-南通市图书馆

Combination of methylthio-chemistry with living crystallization-driven self-assembly toward uniformπ-conjugated nanostructures with antibacterial activity,surface tailorability,tunable morphology and dimension

引用

Science China Chemistry 2024年第7期67卷 2341-2352页

作者： Chuyu Duan Binbin Xu Ruru Li xiaoyu huang Shaoliang Lin Chun Feng Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Living crystallization-driven self-assembly(CDSA)provides robust access to uniformπ-conjugated nanostructures(CNSs)from block copolymers(BCPs)containing a crystallineπ-conjugated segment with controlled dimension,morphology and composition,which show appealing applications in biomedicine,photocatalysis and *** further expand the application spectrum of these CNSs,the development of facile strategies toward diverse CNSs with varying structures/functionalities is highly ***,BCPs consisting of oligo(p-phenylene ethynylene)-b-poly(polypropyl-3-methanethiol acrylate)(OPE_(9)-bPMTPA35and OPE_(9)-b-PMTPA_(58);the subscript represents the number of repeat unit of each block)consisting of a crystallineπ-conjugated core-forming OPE_(9)segment and a corona-forming PMTPA block are *** efficient“click-type”alkylation of methylthio groups,OPE_(9)-b-PMTPA with varying contents of sulfonium unit is *** ribbon-like micelles with different widths and lengths can then be generated in a controlled manner via the self-seeding approach of living ***,negatively charged polymeric and Ag nanoparticles can be immobilized on sulfonium/methylthio-containing shells by taking advantage of electrostatic attraction and coordination interaction,***,the ribbon-like micelles with positively charged shells exhibit antibacterial activity against *** the ease of modification of PMTPA-based shell and attractive opto-electronic/photocatalytic properties ofπ-conjugated units,the combination of methylthio-chemistry and living CDSA opens a new avenue to generate multi-functional CNSs for widespread applications from biomedicine to photocatalysis.

关键词： crystallization-driven self-assembly block copolymer π-conjugated nanostructure methylthio-chemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Single‑cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes

引用

Journal of Animal Science and Biotechnology 2024年第2期15卷 614-631页

作者： Ting Ge Yifan Wen Bo Li xiaoyu huang Shaohua Jiang Enping Zhang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China

Background In the modern sheep production systems,the reproductive performance of ewes determines the economic profitability of *** the genetic mechanisms underlying differences in the litter size is important for the selection and breeding of highly prolific *** sheep,a high-quality Chinese sheep breed,is known for its high fecundity and is often used as a model to study prolificacy *** the current study,animals were divided into two groups according to their delivery rates in three consecutive lambing seasons(namely,the high and low reproductive groups with≥3 lambs and one lamb per season,n=3,respectively).The ewes were slaughtered within 12 h of estrus,and unilateral ovarian tissues were collected and analyzed by 10×Genomics single-cell RNA *** A total of 5 types of somatic cells were identified and corresponding expression profiles were mapped in the ovaries of each ***,the differences in the ovary somatic cell expression profiles between the high and low reproductive groups were mainly clustered in the granulosa ***,four granulosa cell subtypes were *** analysis revealed that the abundance of JPH1 expression and the reduction of LOC101112291 expression could lead to different evolutionary directions of the granulosa ***,the expression levels of FTH1 and FTL in mural granulosa cells of the highly reproductive group were significantly *** genes inhibit necroptosis and ferroptosis of mural granulosa cells,which helps prevent follicular *** This study provides insights into the molecular mechanisms underlying the high fecundity of Hu *** differences in gene expression profiles,particularly in the granulosa cells,suggest that these cells play a critical role in female *** findings also highlight the importance of genes such as JPH1,LOC101112291,FTH1,and FTL in regulating granulosa cell function and follicular development.

关键词： Granulosa cells Hu sheep Lambing number Ovarian somatic cells Single-cell RNA sequencing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dielectric Resonator Magnetoelectric Dipole Arrays with Low Cross Polarization,Backward Radiation,and Mutual Coupling for MIMO Base Station Applications

引用

China Communications 2024年第6期21卷 290-304页

作者： Song Simin Da Yiran Qian Bingyi huang xiaoyu Chen Xiaoming Li Yingsong Ahmed A.Kishk School of Information and Communications Engineering Xi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Intelligent Computing and Signal Processing Ministry of Education Anhui UniversityHefei 230039China Department of Electrical and Computer Engineering Concordia UniversityMontrealQC H3G 1M8Canada

Dielectric resonator magnetoelectric dipole(DRMED)arrays with enhanced isolation,reduced cross-polarization,and backward radiation are proposed for base station(BS)*** proposed antenna comprises an elevated dielectric resonator antenna(DRA)on a small metal plate above a sizeable common ground *** DRA is designed in its T Eδ11 mode,acting like a magnetic *** surface current excited by the differential probes flowing on the small ground plane is equivalent to an electric *** these two equivalent dipoles are orthogonal,they have the magnetoelectric dipole characteristics with reduced backward ***,the small ground planes can be treated as decoupling structures to provide a neutralization path to cancel the original coupling path.A linearly-polarized 4-element prototype array was verified experimentally in previous ***,a dual-polarized DRMED antenna is presented to construct a 2-element and 4×4 array for BS *** investigate its MIMO performance,sophisticated multi-cell scenario simulations are carried *** using the proposed dualpolarized DRMED array,the cellular system capacityis improved by 118.6%compared to a conventional DRA *** significant MIMO system improvement is mainly due to the reduced backward radiation and,therefore,reduced inter-cell *** align well with the simulations.

关键词： backward radiation dielectric resonator antennas(DRAs) isolation magnetoelectric-dipole(ME-dipole)antennas

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeted anti-cancer therapy: Co-delivery of VEGF siRNA and Phenethyl isothiocyanate (PEITC) via cRGD-modified lipid nanoparticles for enhanced anti-angiogenic efficacy

引用

Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 170-187页

作者： Bao Li Haoran Niu xiaoyun Zhao xiaoyu huang Yu Ding Ke Dang Tianzhi Yang Yongfeng Chen Jizhuang Ma Xiaohong Liu Keda Zhang Huichao Xie Pingtian Ding School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical University Shenyang 110016 China Department of Basic Pharmaceutical Sciences School of Pharmacy Husson University Bangor ME 04401USA College of Pharmacy Shenzhen Technology UniversityShenzhen 518118China

Anti-tumor angiogenesis therapy, targeting the suppression of blood vessel growth in tumors, presents a potent approach in the battle against cancer. Traditional therapies have primarily concentrated on single-target techniques, with a specific emphasis on targeting the vascular endothelial growth factor, but have not reached ideal therapeutic efficacy. In response to this issue, our study introduced a novel nanoparticle system known as CS-siRNA/PEITC&L-cRGD NPs. These chitosan-based nanoparticles have been recognized for their excellent biocompatibility and ability to deliver genes. To enhance their targeted delivery capability, they were combined with a cyclic RGD peptide (cRGD). Targeted co-delivery of gene and chemotherapeutic agents was achieved through the use of a negatively charged lipid shell and cRGD, which possesses high affinity for integrin αvβ3 overexpressed in tumor cells and neovasculature. In this multifaceted approach, co-delivery of VEGF siRNA and phenethyl isothiocyanate (PEITC) was employed to target both tumor vascular endothelial cells and tumor cells simultaneously. The co-delivery of VEGF siRNA and PEITC could achieve precise silencing of VEGF, inhibit the accumulation of HIF-1α under hypoxic conditions, and induce apoptosis in tumor cells. In summary, we have successfully developed a nanoparticle delivery platform that utilizes a dual mechanism of action of anti-tumor angiogenesis and pro-tumor apoptosis, which provides a robust and potent strategy for the delivery of anti-cancer therapeutics.

关键词： Anti-angiogenesis Tumor apoptosis Nanoparticles VEGF siRNA Hypoxia inducible factor(HIF)-1 protein Phenethyl isothi ocyanate(PEITC)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evolutionary analysis of green credit and automobile enterprises under the mechanism of dynamic reward and punishment based on government regulation

引用

中国科学技术大学学报 2024年第5期54卷 49-62,I0007页

作者： Yu Dong xiaoyu huang Hongan Gan Xuyang Liu School of Economics and Management Anhui University of Science and TechnologyHuainan 232001China School of Management University of Science and Technology of ChinaHefei 230026China

To explore the green development of automobile enterprises and promote the achievement of the“dual carbon”target,based on the bounded rationality assumptions,this study constructed a tripartite evolutionary game model of gov-ernment,commercial banks,and automobile enterprises;introduced a dynamic reward and punishment mechanism;and analyzed the development process of the three parties’strategic behavior under the static and dynamic reward and punish-ment *** PLE was used for numerical simulation *** results indicate that the system could not reach a stable state under the static reward and punishment mechanism.A dynamic reward and punishment mechanism can effectively improve the system stability and better fit real *** the dynamic reward and punishment mechan-ism,an increase in the initial probabilities of the three parties can promote the system stability,and the government can im-plement effective supervision by adjusting the upper limit of the reward and punishment ***,the implementa-tion of green credit by commercial banks plays a significant role in promoting the green development of automobile enter-prises.

关键词： automobile enterprises green credit system dynamics reward and punishment mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

辨思风险机遇寻求专业定力--2024档案年会主题折射国内外档案工作的最新特点和趋势

引用

档案学研究 2024年第5期 36-44页

作者：黄霄羽张一中国人民大学信息资源管理学院北京100872

国内外档案年会主题能够客观反映档案学界与实践部门的关注焦点,每年的年会主题各有侧重。本文基于对2024年国内外档案年会主题的归纳与分析,概括出当前国内外档案工作的特点为重视风险与机遇的辩证统一,并普遍呈现出寻求专业发展定力... 详细信息

国内外档案年会主题能够客观反映档案学界与实践部门的关注焦点,每年的年会主题各有侧重。本文基于对2024年国内外档案年会主题的归纳与分析,概括出当前国内外档案工作的特点为重视风险与机遇的辩证统一,并普遍呈现出寻求专业发展定力的整体趋势。两者均说明当前国际档案界对专业发展的判断更加趋于客观与理性。

关键词：国内国外档案年会档案工作发展趋势

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国人内脏脂肪指数与中老年心血管疾病发病风险的关联性研究

引用

临床心血管病杂志 2024年第1期40卷 40-45页

作者：杨静芬黄晓渝广东医科大学第一临床医学院广东湛江524000 广东医科大学附属阳江市人民医院心血管内科

目的:探究中国人内脏脂肪指数(Chinese visceral adiposity index, CVAI)与中老年心血管疾病发病风险的关联。方法:以2011年中国健康与养老追踪调查(China Health and Retirement Longitudinal Study, CHARLS)的45岁及以上的中老年人信息作为基线数据,并随访至2018年。采用Cox比例风险模型分析不同CVAI水平与心血管疾病发病的关联。结果:研究纳入6 484例基线时无心血管疾病的研究对象,平均年龄为(57.8±9.0)岁。在长达7年的随访期间,心血管疾病的发生率为7.0%。Cox比例风险模型结果表明,在调整潜在的混杂因素后,CVAI每增加1个标准差水平,心血管疾病发病风险增加15%(HR=1.15,95%CI:1.04~1.30),二者存在非线性正相关。亚组分析结果显示,在年龄>65岁、男性、合并高血压、血脂异常、糖尿病和卒中的人群中,CVAI与心血管疾病发病风险关联不显著。结论:CVAI与中老年心血管疾病发病相关联,在相对年轻的中老年人群的心血管病一级预防中具有应用潜力。

关键词：内脏脂肪指数一级预防危险因素心血管疾病

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

艺术接受视域下的国产动画电影民俗角色研究

引用

四川戏剧 2024年第6期 77-81页

作者：黄晓瑜程心福州大学厦门工艺美术学院

民俗文化是国产动画电影的重要素材,民俗角色作为国产动画电影鉴赏的基本层面,承载着推动故事发展、引发情感共鸣、展现主题的重要作用。近年来,以中国民俗文化为题材的国产动画电影佳作频出,但其民俗角色的呈现却在国内颇受争议,因此,... 详细信息

民俗文化是国产动画电影的重要素材,民俗角色作为国产动画电影鉴赏的基本层面,承载着推动故事发展、引发情感共鸣、展现主题的重要作用。近年来,以中国民俗文化为题材的国产动画电影佳作频出,但其民俗角色的呈现却在国内颇受争议,因此,国产动画电影的民俗角色形象既要在视觉上满足观众美好的审美期待,又要在心理上达到兼具陌生感的接受效果。本文着眼于讨论国产动画电影民俗角色审美接受的过程,即观众对民俗角色造型的期待视野、对民俗角色表演的动态感知以及对民俗角色意蕴的理解共鸣,进而探讨国产动画电影民俗角色审美接受的一般规律,为国产动画电影民俗角色的塑造提供视角和启示。

关键词：国产动画电影艺术接受民俗文化民俗角色

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

档案部门赋能生态文明建设的角色定位与实现路径

引用

北京档案 2024年第2期 6-12页

作者：黄霄羽吴彦洁中国人民大学信息资源管理学院

2012年以来,“大力推进生态文明建设”正式成为中国特色社会主义事业的重要战略决策。本文借助文献、案例和网络调查,认为档案部门具备赋能生态文明建设的条件和能力,并从自身建设完善与生态档案对外开发两方面总结档案部门赋能生态文... 详细信息

2012年以来,“大力推进生态文明建设”正式成为中国特色社会主义事业的重要战略决策。本文借助文献、案例和网络调查,认为档案部门具备赋能生态文明建设的条件和能力,并从自身建设完善与生态档案对外开发两方面总结档案部门赋能生态文明建设的角色定位,以此为基础从对内建设和对外赋能两方面提出赋能实现路径。

关键词：档案部门生态文明建设赋能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

巴西国家档案馆档案展映的特色及启示

引用

北京档案 2024年第3期 56-62页

作者：黄霄羽白路浩中国人民大学信息资源管理学院

巴西国家档案馆通过开展档案展映,践行保护和传播音像档案的理念,在长期实践中不断克服困难,形成较为固定的品牌活动,在国内外产生了较强的影响力。论文基于文献、案例和网站调研,将档案展映的主要特点概括为主题聚焦,借助档案观照社会... 详细信息

巴西国家档案馆通过开展档案展映,践行保护和传播音像档案的理念,在长期实践中不断克服困难,形成较为固定的品牌活动,在国内外产生了较强的影响力。论文基于文献、案例和网站调研,将档案展映的主要特点概括为主题聚焦,借助档案观照社会;机构合作,相投理念汇聚资源;场景融合,多元渠道丰富参与;职能延伸,助力教学提供动力。此外,论文结合我国实际总结启示如下:搭建平台,并行推动馆藏保护与传播;拓展合作,协力实现资源整合与共享;赋能教学,积极助力故事创作与融通。

关键词：巴西国家档案馆档案展映电影节音像档案

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：