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血清SOX6、VCAN表达对胃癌诊断及病情评估的价值分析

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局解手术学杂志 2024年第2期33卷 149-152页

作者：黄小平李轶李萍西安市第九医院消化内科陕西西安710054 西安市第九医院血管介入科陕西西安710054

目的探讨胃癌患者血清中性别决定区Y框蛋白6(SOX6)、多功能蛋白聚糖(VCAN)的表达情况,并分析其对胃癌患者诊断及病情评估的价值。方法选取2019年1月至2021年10月本院收治的胃癌患者105例为胃癌组,依据病理分期将患者分为Ⅰ、Ⅱ期组(37例... 详细信息

目的探讨胃癌患者血清中性别决定区Y框蛋白6(SOX6)、多功能蛋白聚糖(VCAN)的表达情况,并分析其对胃癌患者诊断及病情评估的价值。方法选取2019年1月至2021年10月本院收治的胃癌患者105例为胃癌组,依据病理分期将患者分为Ⅰ、Ⅱ期组(37例)和Ⅲ、Ⅳ期组(68例);另选取本院收治的胃良性病变患者85例为良性组;同时选取85例健康体检者为对照组。采用实时qRT-PCR法对血清中SOX6、VCAN mRNA表达水平进行检测,采用Spearman法分析SOX6、VCAN表达与病理分期的相关性;受试者工作特征(ROC)曲线评价血清SOX6、VCAN表达对胃癌的诊断价值。结果胃癌组患者血清中SOX6表达水平低于对照组和良性组,VCAN表达水平高于对照组和良性组,差异均有统计学意义(P<0.05)。胃癌Ⅲ、Ⅳ期组患者血清中VCAN表达水平高于Ⅰ、Ⅱ期组患者,SOX6表达水平低于Ⅰ、Ⅱ期组患者,差异均有统计学意义(P<0.05)。相关性分析结果显示,胃癌患者血清中SOX6表达与病理分期呈负相关(r=-0.485,P<0.05),VCAN表达与病理分期呈正相关(r=0.518,P<0.05)。ROC曲线结果显示,SOX6、VCAN预测胃癌患者的曲线下面积(AUC)分别为0.921(95%CI:0.873~0.955)、0.915(95%CI:0.865~0.950),敏感度分别为92.38%、79.05%,特异度分别为83.53%、95.29%;二者联合诊断胃癌患者的AUC为0.969(95%CI:0.934~0.989),敏感度为94.29%,特异度为90.59%。结论胃癌患者血清中SOX6表达水平降低,VCAN表达水平升高,二者联合检测可作为胃癌诊断的血清标志物,同时可间接预测胃癌病情程度。

关键词：胃癌性别决定区Y框蛋白6 多功能蛋白聚糖相关性

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An Improved Spectral Analysis Method for Fatigue Damage Assessment of Details in Liquid Cargo Tanks

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China Ocean Engineering 2018年第1期32卷 62-73页

作者： ZHAO Peng-yuan huang xiao-ping Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration Shanghai Jiao Tong University

Errors will be caused in calculating the fatigue damages of details in liquid cargo tanks by using the traditional spectral analysis method which is based on linear system, for the nonlinear relationship between the dynamic stress and the ship acceleration. An improved spectral analysis method for the assessment of the fatigue damage in detail of a liquid cargo tank is proposed in this paper. Based on assumptions that the wave process can be simulated by summing the sinusoidal waves in different frequencies and the stress process can be simulated by summing the stress processes induced by these sinusoidal waves, the stress power spectral density(PSD) is calculated by expanding the stress processes induced by the sinusoidal waves into Fourier series and adding the amplitudes of each harmonic component with the same frequency. This analysis method can take the nonlinear relationship into consideration and the fatigue damage is then calculated based on the PSD of stress. Take an independent tank in an LNG carrier for example, the accuracy of the improved spectral analysis method is proved much better than that of the traditional spectral analysis method by comparing the calculated damage results with the results calculated by the time domain method. The proposed spectral analysis method is more accurate in calculating the fatigue damages in detail of ship liquid cargo tanks.

关键词： liquid cargo tank nonlinear system fatigue damage spectral analysis method dynamic pressure

基于LPWAN和AQI指数预测的空气质量监测系统

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科学技术与工程 2024年第15期24卷 6558-6566页

作者：张天娇海涛王钧黄孝平招兴业广西大学电气工程学院南宁530004 华蓝设计(集团)有限公司南宁530011 南宁学院电气工程学院南宁530200

针对传统空气质量监测系统耗电量大、抗干扰能力差、稳定性不高以及空气质量指数(air quality index,AQI)预测精度不足等问题,设计了一种集低功耗广域物联网LPWAN、One-NET云平台和循环神经网络(gated recurrent unit,GRU)于一体的空气... 详细信息

针对传统空气质量监测系统耗电量大、抗干扰能力差、稳定性不高以及空气质量指数(air quality index,AQI)预测精度不足等问题,设计了一种集低功耗广域物联网LPWAN、One-NET云平台和循环神经网络(gated recurrent unit,GRU)于一体的空气质量监测系统。系统采用光伏为主、市电为辅的混合模式供电;利用远距离无线电LoRa技术采集环境参数,集合云平台技术、麻雀搜索算法-变分模态分解-循环神经网络(sparrow search algorithm-variational mode decomposition-GRU,SSA-VMD-GRU)耦合模型实现远程监控和预测AQI指数。通过通信测试,结果表明通信距离1000 m内,通信率在96%以上,丢包率不超过4%。将采集到的特征参数用传统的GRU模型、VMD-GRU模型和本文提出的SSA-VMD-GRU模型进行训练、测试仿真和对比,结果表明SSA-VMD-GRU模型相较于传统的GRU模型和VMD-GRU模型对AQI指数有更好的预测效果,均方根误差分别减小了22.434、0.833,平均绝对误差分别减小了16.849、0.623,预测误差率在3%以内。该系统能够实现对空气质量的实时监控和AQI指数的精准预测,为准确发布空气质量预警提供借鉴。

关键词：低功耗广域物联网 AQI指数预测 SSA-VMD-GRU模型监测系统光伏供电

多系统朗格汉斯细胞组织细胞增生症并发淋巴瘤1例超声表现并文献复习

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中国临床医学影像杂志 2024年第8期35卷 599-600页

作者：徐迪雅段若男农华斌黄小平东莞松山湖东华医院广东东莞523000

病例男,13岁,因“右膝部疼痛3周,加重1周”入院,既往患者因反复间断皮疹多次就诊于我院,入院后查体:右膝部稍肿胀,局部压痛,皮温稍高,右膝关节活动可,右腹股沟区、右腘窝触及肿大淋巴结。血常规:白细胞计数6.52×10^(9)L^(-1)、血红蛋白... 详细信息

病例男,13岁,因“右膝部疼痛3周,加重1周”入院,既往患者因反复间断皮疹多次就诊于我院,入院后查体:右膝部稍肿胀,局部压痛,皮温稍高,右膝关节活动可,右腹股沟区、右腘窝触及肿大淋巴结。血常规:白细胞计数6.52×10^(9)L^(-1)、血红蛋白112 g/L、血小板计数276×10^(9)L^(-1)。右膝关节X线检查(图1):右胫骨上端干骺端,考虑感染性病变可能。右膝关节CT平扫+增强检查(图2):右胫骨上端干骺端病变,考虑感染性病变,肿瘤病变待排;右侧腘窝结节,考虑增大淋巴结。右膝关节MR平扫+增强检查:右股骨内侧髁、右胫骨上端及周围软组织病变,考虑感染性病变,结核可能性大,其它病变待排。

关键词：组织细胞增多症,郎格尔汉斯细胞淋巴瘤超声检查

miR-519e-5p靶向ANXA5对脊索瘤U-CH1细胞生物学行为的影响

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局解手术学杂志 2024年第10期33卷 892-897页

作者：李轶黄小平王玮西安市第九医院血管介入科陕西西安710054 西安市第九医院消化内科陕西西安710054 西安市第九医院肿瘤血液科陕西西安710054

目的探讨miR-519e-5p靶向膜联蛋白A5(ANXA5)对脊索瘤U-CH1细胞生物学行为的影响。方法以qRT-PCR测定人脊索瘤组织和癌旁组织中miR-519e-5p和ANXA5的表达。体外培养U-CH1细胞,并分为miR-519e-5p mimics组、miR-519e-5p mimics阴性对照+空载组、miR-519e-5p mimics+ANXA5过表达组、对照组。平板集落形成实验、MTT实验检测各组U-CH1细胞增殖;流式细胞术检测各组U-CH1细胞凋亡;划痕实验、Transwell实验分别检测各组U-CH1细胞迁移与侵袭;Western blot检测各组U-CH1细胞ANXA5蛋白、凋亡相关蛋白(Bcl-2、Bax)及迁移上皮-间充质转化相关蛋白(Claudin-1、Vimentin、E-cadherin)表达;qRT-PCR法检测各组U-CH1细胞miR-519e-5p及ANXA5 mRNA表达;双荧光素酶报告基因实验检验miR-519e-5p与ANXA5在U-CH1细胞中的相互作用。结果与癌旁组织相比,脊索瘤组织miR-519e-5p表达降低(P<0.05),ANXA5 mRNA表达升高(P<0.05)。与对照组相比,miR-519e-5p mimics组细胞增殖率、集落生成率、迁移率、侵袭数、ANXA5 mRNA及ANXA5、Bcl-2、Claudin-1、Vimentin蛋白表达降低(P<0.05),miR-519e-5p mRNA表达、凋亡率及Bax、E-cadherin蛋白表达增高(P<0.05)。与miR-519e-5p mimics组相比,miR-519e-5p mimics+ANXA5过表达组细胞集落生成率、增殖率、侵袭数、迁移率、ANXA5 mRNA及ANXA5、Bcl-2、Vimentin、Claudin-1蛋白表达升高(P<0.05),凋亡率及Bax、E-cadherin蛋白表达下降(P<0.05)。miR-519e-5p可靶向下调U-CH1细胞中ANXA5表达。结论miR-519e-5p通过靶向抑制ANXA5表达降低脊索瘤U-CH1细胞迁移、增殖和侵袭活力,促进其凋亡。

关键词： miR-519e-5p ANXA5 脊索瘤 U-CH1细胞生物学行为

Cyclic Pulsating Pressure Enhanced Segregating Structuration of Ultra-High Molecular Weight Polyethylene/Graphene Composites as High-performance Light-Weight EMI Shields

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Chinese Journal of Polymer Science 2024年第7期42卷 958-967,I0008页

作者： Yun-Zhi huang xiao-xiao Liu Lan-Wei Li Guang-Ming huang Zhao-Xia huang Jin-ping Qu National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing EngineeringMinistry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China School of Advanced Manufacturing Technology Guangdong Mechanical&Electrical PolytechnicGuangzhou 510550China

Currently,the enhancement in electromagnetic interference(EMI)performance of polymeric composite generally relies on either improving electrical conductivity(σ)for stronger electromagnetic(EM)reflections or tailoring structure for higher EM ***,we proposed a novel technique called cyclic pulsating pressure enhanced segregating structuration(CPP-SS),which can reinforce these two factors *** structural information was supplied by optical microscopy(OM)and scanning electron microscopy(SEM),both of which confirmed the formation and evolution of segregate structured ultra-high molecular weight polyethylene(UHMWPE)/graphene ***,the result showed that CPP-SS can significantly improve theσof ***,advanced specific EMI shielding efficiency of 31.1 d B/mm was achieved for UHMWPE/graphene composite at 1-mm thickness and a low graphene loading of 5 wt%.Meanwhile,it also confirmed that the intrinsic disadvantage of poor mechanical properties of conventional segregated structure composites can be *** work is believed to provide a fundamental understanding of the structural and performance evolutions of segregated structured composites prepared under CPPSS,and to bring us a simple and efficient approach for fabricating high-performance,strong and light-weight polymeric EMI shields.

关键词： Cyclic pulsating pressure Segregated structure Ultra-high molecular weight polyethylene Graphene Electromagnetic interface

Scattering Law Analysis Based on Hapke and Lommel-Seeliger Models for Asteroidal Taxonomy

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Research in Astronomy and Astrophysics 2017年第10期17卷 83-90页

作者： Xiang-Jie huang xiao-ping Lu Jian-Yang Li Bao Mei Chih-Hao Hsia Hai-Bin Zhao Macao University of Science and Technology Lunar and Planetary Science Laboratory Macao University of Science and Technology - Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration Chinese Academy of Sciences Key Laboratory of Planetary Sciences Chinese Academy of Sciences Planetary Science Institute Purple Mountain Observatory Chinese Academy of Sciences

In deriving the physical properties of asteroids from their photometric data, the scattering law plays an important role, although the shape variations of asteroids result in the main variations in lightcurves. By following the physical behaviors of light reflections, Hapke et al. deduced complex functions to represent the scattering process, however, it is very hard to accurately simulate the surface scattering law in reality. For simplicity, other numerical scattering models are presented for efficiently calculating the physical properties of asteroids, such as the Lommel-Seeliger （LS） model. In this article, these two models are compared numerically. It is found that in some numerical applications the LS model in simple form with four parameters can be exploited to replace the Hapke model in complex form with five parameters. Furthermore, the generated synthetic lightcurves by the Cellinoid shape model also show that the LS model can perform as well as the Hapke model in the inversion process. Finally, by applying the Principal Component Analysis （PCA） technique to the parameters of the LS model, we present an efficient method to classify C and S type asteroids, instead of the conventional method using the parameters of the Hapke model.

关键词： scattering -- techniques: photometric -- minor planets -- asteroids: general

Feature Matching via Topology-Aware Graph Interaction Model

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 113-130页

作者： Yifan Lu Jiayi Ma xiaoguang Mei Jun huang xiao-ping Zhang the Electronic Information School Wuhan UniversityWuhan 430072China IEEE Tsinghua Berkeley Shenzhen Institute Shenzhen 518071China the Department of Electrical Computer and Biomedical EngineeringToronto Metropolitan UniversityToronto ON M5B 2K3Canada

Feature matching plays a key role in computer vision. However, due to the limitations of the descriptors, the putative matches are inevitably contaminated by massive *** paper attempts to tackle the outlier filtering problem from two aspects. First, a robust and efficient graph interaction model,is proposed, with the assumption that matches are correlated with each other rather than independently distributed. To this end, we construct a graph based on the local relationships of matches and formulate the outlier filtering task as a binary labeling energy minimization problem, where the pairwise term encodes the interaction between matches. We further show that this formulation can be solved globally by graph cut algorithm. Our new formulation always improves the performance of previous localitybased method without noticeable deterioration in processing time,adding a few milliseconds. Second, to construct a better graph structure, a robust and geometrically meaningful topology-aware relationship is developed to capture the topology relationship between matches. The two components in sum lead to topology interaction matching(TIM), an effective and efficient method for outlier filtering. Extensive experiments on several large and diverse datasets for multiple vision tasks including general feature matching, as well as relative pose estimation, homography and fundamental matrix estimation, loop-closure detection, and multi-modal image matching, demonstrate that our TIM is more competitive than current state-of-the-art methods, in terms of generality, efficiency, and effectiveness. The source code is publicly available at http://***/YifanLu2000/TIM.

关键词： Feature matching graph cut outlier filtering topology preserving

Coupling effect of cement-stabilization and biopolymer-modification on the mechanical behavior of dredged sediment

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3284-3298页

作者： Lei Lang Jiangshan Li xiao huang ping Wang Wei Zhang State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Hubei Provincial Key Laboratory of Contaminated Sludge and Soil Science and Engineering Wuhan430071China University of Chinese Academy of Sciences Beijing100049China

Nowadays,biopolymer stabilization as a promising eco-friendly approach in soft ground improvement has attracted wide ***,the feasibility of using biopolymer as a green additive of cementstabilized dredged sediment(CDS)with high water content is still *** this study,guar gum(GG)and xanthan gum(XG)were adopted as typical biopolymers,and a series of unconfined compressive strength(UCS),splitting tensile strength(STS)and scanning electron microscopy(SEM)tests were performed to evaluate the mechanical and microstructural properties of XG-and GG-modified CDSs considering several factors including biopolymer modification,binderesoil ratio and wateresolid ***,the micro-mechanisms revealing the evolutions of mechanical properties of biopolymermodified CDS were *** results indicate that the addition of XG can effectively improve the strength of CDS,while the GG has a side *** XG content of 9%was recommended,which can improve the 7 d-and 28 d-UCSs by 196%and 51.8%,together with the 7 d-and 28 d-STSs by 118.3%and 42.2%,*** the binderesoil ratio or decreasing the wateresolid ratio significantly improved the strength gaining but aggravated the brittleness characteristics of *** XG to CDS contributed to the formation of microstructure with more compactness and higher cementation degrees of ordinary Portland cement(OPC)-XG-stabilized DS(CXDS).The micro-mechanism models revealing the interactions of multiple media including OPC cementation,biopolymer film bonding and bridging effects inside CXDS were *** key findings confirm the feasibility of XG modification as a green and high-efficiency mean for improving the mechanical properties of CDS.

关键词： Dredged sediment(DS) Stabilization Biopolymer modification Mechanical properties Micro-mechanism