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Biomedical and Environmental Sciences 2024年第5期37卷 526-530页

作者： huang shi ting LI Shang Yuan LI Xin Yu ZHU Ying ZHU Lin ZHANG Jia Yan ZHAO Yan Sheng DAGLIA Maria XIAO Xiang BAI Juan School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina Department of Pharmacy University of Napoli FedericoⅡVia D.Montesano 4980131 NaplesItaly International Research Center for Food Nutrition and Safety Jiangsu UniversityZhenjiang 212013JiangsuChina

Bitter melon(Momordica Charania L.),a member of the Cucurbitaceae family,is widely distributed across tropical and subtropical ***,an important functional component of bitter melon,has been proven to exert hypoglycemic effects similarly to insulin,and also possesses lipid-lowering properties inhibiting preadipocyte differentiation and fat synthesis^([1]).

关键词： melon Momordica subtropical

超重肥胖与维生素D营养状况的交互作用对儿童肌肉减少症的影响

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现代预防医学 2024年第17期51卷 3123-3127页

作者：黄杰黄诗婷李艳艳李妍熊静帆姚平石河子大学医学院预防医学系深圳市慢性病防治中心儿童青少年慢性病防控科华中科技大学同济医学院公共卫生学院营养与食品卫生学系

目的探讨儿童青少年超重肥胖及维生素D不足与肌肉减少症的关系。方法 2021年采用多阶段分层整群随机抽样对深圳市中小学生进行调查，包括问卷调查、体格检查和实验室检查，并采用生物电阻抗法测定其身体成分。通过logistic回归分析模... 详细信息

目的探讨儿童青少年超重肥胖及维生素D不足与肌肉减少症的关系。方法 2021年采用多阶段分层整群随机抽样对深圳市中小学生进行调查，包括问卷调查、体格检查和实验室检查，并采用生物电阻抗法测定其身体成分。通过logistic回归分析模型分析超重肥胖与维生素D不足对儿童肌肉减少症的影响，并进一步分析其交互作用。结果 4 931名6～17岁儿童中肌肉减少症占10.3%，超重肥胖占23.0%，维生素D不足率为41.2%。多因素logistic回归分析模型调整混杂因素后超重肥胖合并维生素D不足的肌肉减少症的发病风险是无超重肥胖无维生素D不足儿童的118.107倍（95%CI:73.035～190.995）。超重肥胖与维生素D不足对其存在相乘交互作用（OR=2.436,95%CI:1.009～5.882）。相加交互结果也提示超重肥胖与维生素不足存在协同作用，交互作用指数（S）、交互作用相对超额危险度比（RERI）、交互作用归因比（AP）分别为1.684(95%CI:1.250～2.270)、47.591(95%CI:10.098～85.083)、40.280%(95%CI:22.650～57.910)。按年龄层交互作用分析也显示，超重肥胖与维生素D不足两者之间存在交互作用。结论在儿童青少年中超重肥胖与维生素D不足是肌肉减少症的危险因素且二者可能存在协同作用。

关键词：儿童青少年超重肥胖维生素D 肌肉减少症交互作用

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正畸上颌扩弓有限元分析研究进展

中国实用口腔科杂志 2024年第4期17卷 481-486页

作者：吴婉淇黄诗婷雷佳婕林捷钟萍萍福建医科大学口腔医学院·附属口腔医院正畸科福建福州350002 福建医科大学口腔医学院·附属口腔医院特诊科福建福州350002

上颌扩弓是治疗上颌横向发育不足、协调上下颌骨间关系的重要治疗方法之一。有限元分析是一种研究上颌扩弓实用且高效的数字化生物力学分析方法。如何在扩弓时获得最少的牙性效应和最多的骨性效应是正畸领域的研究热点。文章就正畸上颌... 详细信息

上颌扩弓是治疗上颌横向发育不足、协调上下颌骨间关系的重要治疗方法之一。有限元分析是一种研究上颌扩弓实用且高效的数字化生物力学分析方法。如何在扩弓时获得最少的牙性效应和最多的骨性效应是正畸领域的研究热点。文章就正畸上颌扩弓有限元分析的研究进展做一综述,探讨不同扩弓方式下上颌骨的应力变化和牙齿的移动趋势,为临床应用提供参考。

关键词：上颌扩弓有限元分析生物力学口腔正畸

Tuning the solubility of polysulfides for constructing practical lithium-sulfur battery

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Journal of Energy Chemistry 2024年第8期95卷 611-617,I0013页

作者： Jiapeng Li Jianlong Cong Haijin Ji ting shi Lixia Yuan Yunhui huang State Key Laboratory of Material Processing and Die&Mold Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina

Li-S batteries are regarded as one of the most promising candidates for next-generation battery systems with high energy density and low ***,the dissolution-precipitation reaction mechanism of the sulfur(S)cathode enhances the kinetics of the redox processes of the insulating sulfu r,which also arouses the notorious shuttle effect,leading to serious loss of S species and corrosion of Li *** get a balance between the shuttle restraining and the kinetic property,a combined strategy of electrolyte regulation and cathode modification is proposed via introducing 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoroprpyl ether(HFE)instead of 1,2-dimethoxyethane(DME),and SeS_(7)instead of S_*** introduction of HFE tunes the solvation structure of the LiTFSI and the dissolution of intermediate polysulfides with Se doping(LiPSSes),and optimize the interface stability of the Li anode *** minor Se substitution compensates the decrease in kinetic due to the decreased solubility of *** this way,the Li-SeS_(7)batteries deliver a reversible capacity of 1062 and 1037 mAh g^(-1)with 2.0 and 5.5 mg SeS_(7)cm^(-2)loading condition,***,an electrolyte-electrode loading model is established to explain the relationship between the optimal electrolyte and cathode *** makes more sense to guide the electrolyte design for practical Li-S batteries.

关键词： Li-S batteries Lithium polysulfides Solubility Shuttle effect Interface Se doping

[(H_(3)DIBA)_(2)Cl]·[HGeMo_(12)O_(40)]的合成、表征、光催化和电化学性质

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西北师范大学学报（自然科学版） 2024年第2期60卷 65-70,85页

作者：于晓洋黄仕霆吕艳欣耿嘉琦金华吉林化工学院化学与制药工程学院吉林吉林132022

利用水热法合成了一种新的基于Keggin型杂多酸的无机-有机杂化物[(H_(3)DIBA)_(2)Cl]·[HGeMo_(12)O_(40)],(HDIBA=3,5-二(1H--咪唑-1-基)苯甲酸).单晶X-射线衍射测试表明,该化合物为三斜晶系,P-1空间群,a=1.27831(4)nm,b=1.29723(4)nm,c=1.98978(5)nm;α=94.51°,β=102.61°,γ=117.99°,V=2.77968(14)nm 3,Z=2.结构研究表明,在该化合物中HDIBA被质子化,配体与游离的Cl-之间通过氢键相互作用形成了一维超分子链状结构,Keggin型[GeMo_(12)O_(40)]^(4-)多酸阴离子与[H_(3)DIBA]^(2+)之间通过氢键作用将相邻的一维超分子链连接形成三维超分子结构.该化合物可以光催化降解有机染料孔雀石绿,150 min内降解率达到99.99%;另外,该化合物具有电催化还原BrO_(3)^(-)和电催化氧化抗坏血酸(AA)的性质.总之,该化合物可以作为一种有效处理废水中污染物的异相光、电催化剂.

关键词： [GeMo_(12)O_(40)]^(4-) 超分子化合物水热法光催化电化学

A novel fused bi-macrocyclic host for sensitive detection of Cr_(2)O_(7)^(2-)based on enrichment effect

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Chinese Chemical Letters 2024年第7期35卷 291-295页

作者： ting-ting huang Jin-Fa Chen Juan Liu Tai-Bao Wei Hong Yao Bingbing shi Qi Lin Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission Gansu Provincial Biomass Function Composites Engineering Research CenterCollege of Chemical EngineeringNorthwest Minzu University(Northwest University for Nationalities)Lanzhou 730000China

Improving the highly selective and sensitive binding of chemosensor to target guest is always very *** order to solve this issue,herein,the enrichment effect was introduced into the design of chemosensor molecule.A novel bi-fused-macrocyclic host molecule BPN1 was synthesized by bridging a pillar[5]arene and a naphthalene diimide(NDI)group through hydrogen-bond-rich *** the BPN1,the naphthalimide side ring is outside the cavity of the pillar[5]*** addition,Cr(VI)greatly threat human health and the environment due to its severe toxicity,and it is very important to develop effective chemosensor for sensitive and selective detection of Cr_(2)O_(7)^(2-)or its ion *** this paper,the novel bi-fused-macrocyclic host molecule BPN1 can recognize Cr_(2)O_(7)^(2-)with high selectivity and *** mechanism of BPN1 recognition of Cr_(2)O_(7)^(2-)was studied through experiments and density functional theory(DFT),the results show that BPN1 could supply enrichment effect to bind Cr_(2)O_(7)^(2-)through multiple weak interactions such as hydrogen bonds and anion-π,and achieve highly sensitive and selective detection of Cr_(2)O_(7)^(2-).It is a significant and feasible strategy for improve high selectivity and sensitivity of host to specific objects by using the enrichment effect of fused bi-macrocyclic.

关键词： Pillararene Bi-macrocyclic Detection of Cr_(2)O_(7)^(2−) DFT The enrichment effect

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Recent progress in co-detection of single-cell transcripts and proteins

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Nano Research 2024年第1期17卷 132-150页

作者： Shanqing huang Qian Fan Yidi Wang Zhi huang Weixiong shi Yanli Gong ting Yang Jie Wang Lingling Wu Chaoyong Yang Discipline of Intelligent Instrument and Equipment College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of General Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361101China Research Center for Analytical Sciences Department of ChemistryCollege of SciencesNortheastern UniversityShenyang 110819China

Cellular heterogeneity is a universal property of living systems,and the interrogation of single cells facilitates in-depth understanding of distinct cellular states and functions in various biological ***-analysis of transcripts and proteins from the same single cells opens the way to decipher complex RNA regulatory frameworks and phenotypes,facilitating the understanding of cellular fate and function regulations,discovery of novel cell types,and construction of a high-resolution cell ***,we review the state-of-art advances in the development of methodologies for co-analysis of single-cell transcripts and ***,imaging-based methods are summarized with particular emphasis on optical and mass spectrometry ***,sequencing-based approaches for high-throughput and sensitive co-analysis of single-cell transcripts and proteins are described,including droplet-,microwell-,and split-pool-based ***,combined methods with more flexibility and universality are *** methods commonly employ different strategies or reactions to convert transcripts and proteins of single cells into distinct signals simultaneously,which can be detected by different instruments or ***,some perspectives on the future challenges and development trends in this field are presented.

关键词： single cell optical imaging mass spectrometry imaging single-cell RNA sequencing(scRNA-seq) co-detection

Statistical Process Monitoring Based on Ensemble Structure Analysis

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1889-1891页

作者： Likang shi Chudong Tong ting Lan Xuhua shi Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China

Dear Editor,This letter presents a novel process monitoring model based on ensemble structure analysis(ESA).The ESA model takes advantage of principal component analysis(PCA),locality preserving projections(LPP),and multi-manifold projections(MMP)models,and then combines the multiple solutions within an ensemble result through Bayesian *** the developed ESA model,different structure features of the given dataset are taken into account simultaneously,the suitability and reliability of the ESA-based monitoring model are then illustrated through ***:The requirement for ensuring safe operation and improving process efficiency has led to increased research activity in the field of process monitoring.

关键词： ensemble preserving letter

Neferine inhibits the progression of diabetic nephropathy by modulating the miR-17-5p/nuclear factor E2-related factor 2 axis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 44-53页

作者： huang Hongmei YANG Maojun LI ting WANG Dandan LI Ying TANG Xiaochi YUAN Lu GU shi XU Yong Department of Endocrinology Chengdu Shuangliu District First People's Hospital(West China Airport of Sichuan University)Chengdu 610200China Department of Endocrinology Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

OBJECTIVE:To investigate the effect of Neferine(Nef)on diabetic nephropathy(DN)and to explore the mechanism of Nef in DN based on miRNA regulation ***:A DN mouse model was constructed and treated with *** creatinine(Crea),blood urea(UREA)and urinary albumin were measured in mice by kits,and renal histopathological changes and fibrosis were observed by hematoxylin-eosin staining and Masson *** tissue superoxide dismutase(SOD),malondialdehyde(MDA)and glutathione peroxidase(GSH-Px)activities were measured by enzyme-linked immunosorbent assay(ELISA).Western blotting was used to detect the expression of nuclear factor E2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)signaling pathway-related proteins in kidney *** reverse transcription-polymerase chain reaction(q RT-PCR)was used to detect the expression of miR-17-5p in kidney ***,a DN in vitro model was constructed by high glucose culture of human mesangial cells(HMCs),cells were transfected with miR-17-5p mimic and/or treated with Nef,and we used q RTPCR to detect cellular miR-17 expression,flow cytometry to detect apoptosis,ELISAs to detect cellular SOD,MDA,and GSH-Px activities,Western blots to detect Nrf2/HO-1 signaling pathway-related protein expression,and dual luciferase reporter gene assays to verify the targeting relationship between Nrf2 and ***:Administration of Nef significantly reduced the levels of blood glucose,Crea,and UREA and the expression of miR-17-5p,improved renal histopathology and fibrosis,significantly reduced MDA levels,elevated SOD and GSH-Px activities,and activated Nrf2 expression in kidney tissues from mice with ***2 is a post-transcriptional target of *** HMCs transfected with miR-17-5p mimics,the m RNA and protein levels of Nrf2 were significantly ***,miR-17-5p overexpression and Nef intervention resulted in a significant increase in high glucose-induced apoptosis and MDA levels in HMC

关键词： diabetic nephropathies neferine miR-17-5p NF-E2-related factor 2 oxidative stress

Robust AUC maximization for classification with pairwise confidence comparisons

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Frontiers of Computer Science 2024年第4期18卷 73-83页

作者： Haochen shi Mingkun XIE Shengjun huang College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China MIIT Key Laboratory of Pattern Analysis and Machine Intelligence Nanjing 211106China

Supervised learning often requires a large number of labeled examples,which has become a critical bottleneck in the case that manual annotating the class labels is *** mitigate this issue,a new framework called pairwise comparison(Pcomp)classification is proposed to allow training examples only weakly annotated with pairwise comparison,i.e.,which one of two examples is more likely to be *** previous study solves Pcomp problems by minimizing the classification error,which may lead to less robust model due to its sensitivity to class *** this paper,we propose a robust learning framework for Pcomp data along with a pairwise surrogate loss called *** provides an unbiased estimator to equivalently maximize AUC without accessing the precise class ***,we prove the consistency with respect to AUC and further provide the estimation error bound for the proposed *** studies on multiple datasets validate the effectiveness of the proposed method.

关键词： method. pairwise weakly