检索结果-南通市图书馆

Diagnosis of pulmonary tuberculosis among asymptomatic HIV＋ patients in Guangxi, China

Chinese Medical Journal 2010年第23期123卷 3400-3405页

作者： ZHANG Yao YU Lan TANG Zhi-rong huang shao-biao ZHENG Yuan-jia MENG Zhi-hao SUN Kai WANG Li-ming Ray Y.CHEN ZHANG Fu-jie Division of Treatment and Care National Center for AIDS/STD Control and Prevention Chinese Center for Diseases Control and Prevention Beijing 100050 China Beijing Ditan Hospital Beijing 100015 China Provincial Center of Diseases Control and Prevention NaningGuangxi 53000 China Nanning 4th People's Hospital Nanning Guangxi 530000 China Center for Diseases Control and Prevention of Liuzhou City Liuzhou Guangxi 545000 China Liuzhou Longtan Hospital Liuzhou Guangxi 545000 China University of North Carolina Chapel Hill USA Washington University in St. Louis School of Medicine St. LouisUSA Global AIDS Program U.S. Centers for Disease Control andPrevention Beijing 100600 China The Office of Global Research National Institute of Allergy andInfectious Diseases US National Institutes of Health Beijing100600 Chin

Background Pulmonary tuberculosis （PTB） among asymptomatic Chinese patients with HIV infection has not been investigated despite high tuberculosis burden in China. This study was aimed to evaluate the prevalence, risk factors and clinical outcomes of PTB among asymptomatic patients with HIV/AIDS in Guangxi to facilitate the development of diagnostic and treatment *** All asymptomatic adult HIV-infected patients with CD4 ＜350 cells/μl who attended four HIV clinics in Guangxi between August 2006 and March 2008 were evaluated for active PTB with physical examination, chest X-ray （CXR）,sputum smear and/or sputum liquid culture. Data were described using median （interquartile range, IQR） and *** and multivariate Logistic regression analyses were performed to identify risk factors associated with *** Among 340 asymptomatic subjects, 15 （4%） were diagnosed with PTB, with 4 （27%） sputum smear positive and 8 （53%） sputum culture positive. CXR has higher diagnostic sensitivity （87%） than sputum smear （25%） and sputum culture （67%）, but lower specificity （56%） compared with sputum smear （99%） and culture （100%）. In univariate analysis,injection drug user, body mass index （BMI）＜18 kg/m2, CD4 ＜50 cells/μl and presence of peripheral lymphadenopathy were associated with an increased risk of asymptomatic PTB, while in multivariate analysis only peripheral lymphadenopathy maintained statistical significance （OR=7.6, 95% CI 1.4-40）. Patients with negative smear and minor or no abnormalities on CXR had longer interval between screening and TB *** PTB was relatively common in this group of HIV＋ asymptomatic Chinese patients. Diagnosis is challenging especially where sputum culture is unavailable. These findings suggest that an enhanced evaluation for PTB needs to be integrated with HIV care in China and transmission prevention in China to control at both households and health care facilities, especially for patients with fact

关键词： tuberculosis human immunodeficiency virus diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

HAART阻断HIV母婴传播效果观察

引用

广西医学 2009年第9期31卷 1254-1255页

作者：庞俊黄绍标广西南宁市第四人民医院产科南宁市530023 广西南宁市第四人民医院艾滋病科南宁市530023

目的观察三联高效抗逆转录病毒药物治疗（HAART）阻断艾滋病病毒（HIV）母婴传播的效果。方法39例HIV感染的孕妇，在孕13～38周前给予HAART，如CD4^＋T淋巴细胞〈200／mm^3的孕妇在孕早期也尽早用药，孕前已经开始抗病毒治疗的孕妇．孕... 详细信息

目的观察三联高效抗逆转录病毒药物治疗（HAART）阻断艾滋病病毒（HIV）母婴传播的效果。方法39例HIV感染的孕妇，在孕13～38周前给予HAART，如CD4^＋T淋巴细胞〈200／mm^3的孕妇在孕早期也尽早用药，孕前已经开始抗病毒治疗的孕妇．孕期则继续正在使用的方案，结合安全分娩和人工喂养，婴儿出生后给予联合抗病毒药物预防。婴儿出生后4—6周和4月龄分别进行HIV-1 DNA检测，12～18月龄进行HIV抗体检测，判断婴儿的HIV感染情况。结果随访至2009年6月，39例婴儿年满12～18月龄，HIV抗体检测结果全部阴性（其中13例婴儿12月龄检测HIV抗体结果阴性，26例婴儿18月龄检测HIV抗体结果阴性）；有24例（61．54％）婴儿进行HIV-1 DNA检测，其中有22例检测结果二次阴性，有2例检测结果一次阴性一次阳性，18月龄进行HIV抗体检测结果均阴性。现阶段HIV母婴传播率为0。结论HIV感染的孕妇孕期应用HAART是安全可行的。结合安全分娩和人工喂养可明显降低HIV母婴传播率。

关键词： HIV感染孕产妇高效抗逆转录药物治疗(HAART) 母婴传播阻断效果

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

HIV/AIDS患者长期高效抗逆转录病毒治疗后眼底动脉硬化发生及影响因素分析

引用

中国热带医学 2023年第4期23卷 327-332页

作者：陈万邹俊黄绍标李健玲广西医科大学广西南宁530021 广西医科大学附属传染病医院(南宁市第四人民医院) 广西南宁530023 广西医科大学第一附属医院广西南宁530021

目的探讨HIV/AIDS患者长期高效抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)后眼底动脉硬化情况及影响因素。方法收集2020年1月—2022年6月南宁市第四人民医院收治的203例HIV/AIDS患者HAART前后临床基本资料和眼底检... 详细信息

目的探讨HIV/AIDS患者长期高效抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)后眼底动脉硬化情况及影响因素。方法收集2020年1月—2022年6月南宁市第四人民医院收治的203例HIV/AIDS患者HAART前后临床基本资料和眼底检查资料,评估患者眼底动脉硬化发生情况,并对其影响因素进行分析。结果203例HIV/AIDS患者出现眼底动脉硬化159例,发生率为78.33%,其中Ⅰ级33例(20.75%)、Ⅱ级87例(54.72%)、Ⅲ级28例(17.61%)、Ⅳ级11例(6.92%);HAART前,眼底动脉硬化组及正常组患者CD4^(+)T淋巴细胞计数、CD8^(+)T淋巴细胞计数、病毒载量、白细胞计数、血小板计数、血红蛋白、血肌酐、血尿素氮、三酰甘油、总胆固醇、空腹血糖、谷丙转氨酶、谷草转氨酶及血清总胆红素两组间比较差异无统计学意义(P>0.05);在HAART 6个月后,动脉硬化组CD8^(+)T淋巴细胞计数、甘油三酯、空腹血糖值显著高于正常组,两者比较差异有统计学意义(P4年HIV病程、合并机会性感染、HAART 6个月后较低的CD4^(+)T淋巴细胞计数,较高的CD8^(+)T淋巴细胞计数和三酰甘油值是患者发生眼底动脉硬化的独立危险因素。应对此类人群在HAART前后均需进行眼底筛查,针对心血管疾病风险,制定HAART方案,并在治疗过程中加强心血管疾病风险管理改善患者结局。

关键词：人类免疫缺陷病毒获得性免疫缺陷综合征眼底动脉硬化心血管

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy and Safety of Tenofovir and Lamivudine in Combination with Efavirenz in Patients Co-infected with Human Immunodeficiency Virus and Hepatitis B Virus in China

引用

Chinese Medical Journal 2016年第3期129卷 304-308页

作者： Ya-Song Wu Wei-Wei Zhang Xue-Mei Ling Lian Yang shao-biao huang Xi-Cheng Wang Hao Wu Wei-Ping Cai Min Wang Hui Wang Yan-Fen Liu Hao-Lan He Fei-Li Wei Zun-You Wu Fu-Jie Zhang National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Department of Infectious Diseases The Third People's Hospital of Hengyang City Hengyang Hunan 421005 China Department of Infectious Diseases The Fourth People's Hospital of Nanning City Nanning Guangxi 530023 China Department of Infectious Diseases Yunnan Provincial Infectious Disease Hospital Kunming Yunnan 650301 China Center for Infectious Diseases Beijing You'an Hospital Capital Medical University Beijing 100069 China Department of Infectious Diseases Guangzhou No. 8 People's Hospital Guangzhou Guangdong 510060 China The Institute of HIV/AIDS The First Hospital of Changsha Changsha Hunan 410005 China Department of Infectious Diseases Shenzhen Third People's Hospital Shenzhen Guangdong 518112 China Department of Infectious Diseases Beijing Ditan Hospital Capital Medical University Beijing 100015 China

Background： The prevalence of hepatitis B virus （HBV） infection is high among individuals infected with human immunodeficiency virus （HIV） in *** HIV and HBV can be treated with tenofovir disoproxil fumarate （TDF） and lamivudine （3TC）, so we evaluated the safety and efficacy of combination antiretroviral therapy （ART） that included TDF, 3TC, and efavirenz （EFV） among ART-naive individuals who were co-infected with HIV and ***： One hundred HIV/HBV co-infected ARV-naive individuals were started on the regimen ofTDF, 3TC, and EFV, and the levels of plasma HBV DNA, HIV RNA, and biochemical evaluation related to the function of liver and kidney were ***： Concerning efficacy, this study found that by week 48, the vast majority co-infected participants receiving this ART regimen had undetectable HBV DNA levels （71%） and/or HIV RNA levels （90%）.Concerning safety, this study found that the median estimated glomerular filtration rate of participants decreased from baseline （109 ml＆#183;min-1＆#183; 1.73 m-2） to week 12 （104 ml＆#183;min-1＆#183; 1.73 m-2） but was almost back to baseline at week 48 （1 1 1 ml＆#183;min-1＆#183; 1.73 m-2）.Conclusion： This combination ART regimen is safe and effective for patients with HIV/HBV *** Registration： ***, NCT01751555;https：//***/ct2/show/NCT01751555.

关键词： Antiretroviral Therapy Co-infection Hepatitis B Virus Human lmmunodeficiency Virus Tenofovir Disoproxil Fumarate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

HIV核苷类反转录酶抑制剂线粒体毒性的研究现状

引用

广西医学 2011年第10期33卷 1357-1361页

作者：吴念宁黄绍标广西南宁市第四人民医院感染科南宁市530023

自从开展高效抗反转录病毒治疗（ highly active antiretroviral therapy, HAART）之后，人类免疫缺陷病毒（humen immunodeficiency virus, HIV）感染者或艾滋病（ acquired immunodeficiency syndrome, AIDS）患者的预期寿命大为改观。

关键词：人类免疫缺陷病毒核苷类反转录酶抑制剂线粒体毒性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

两种干预模式对替诺福韦-拉米夫定、依非韦伦方案抗病毒治疗疗效影响的评价

引用

世界复合医学 2016年第1期2卷 8-11页

作者：刘燕芬黄绍标南宁市第四人民医院广西艾滋病临床治疗中心广西南宁530023

目的比较常规干预模式和加强模式对艾滋病病毒(HIV)/艾滋病(AIDS)病人(简称HIV/AIDS病人)使用替诺福韦-拉米夫定、依非韦伦方案抗病毒治疗疗效影响,探讨基于首选方案下资源有限地区适宜的干预模式。方法选取2013年1月—2014年6月抗反转... 详细信息

目的比较常规干预模式和加强模式对艾滋病病毒(HIV)/艾滋病(AIDS)病人(简称HIV/AIDS病人)使用替诺福韦-拉米夫定、依非韦伦方案抗病毒治疗疗效影响,探讨基于首选方案下资源有限地区适宜的干预模式。方法选取2013年1月—2014年6月抗反转录病毒治疗(ART)1年的185例HIV/AIDS病人随机分成常规干预模式组86例和加强干预模式组99例,比较两组患者治疗后CD4+T淋巴细胞(简称CD4细胞)及病毒载量抑制率的差异情况。结果在不同的基线CD4细胞计数水平情况下加强组与常规组在治疗后不同时期的CD4细胞计数相互比较差异无统计学意义(P>0.05)。两组患者在治疗后6个月、12个月的病毒载量抑制率相互比较差异无统计学意义(P>0.05)。结论初治使用TDF+3TC+EFV首选方案的HIV/AIDS病人比较常规的干预模式和加强干预模式对抗病毒的疗效影响上无明显差异。采用常规模式达到理想的抗病毒治疗疗效,适宜艾滋病治疗医护资源有限地区的推广运用。

关键词：依从性干预艾滋病病毒感染者/艾滋病病人抗病毒治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nitrogen addition promotes soil carbon accumulation globally

引用

Science China Life Sciences 2025年第1期 284-293页

作者： Xuemei Yang Suhui Ma Erhan huang Danhua Zhang Guoping Chen Jiangling Zhu Chengjun Ji biao Zhu Lingli Liu Jingyun Fang Institute of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking University Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China School of Ecology and Environmental ScienceYunnan University State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences

Soil is the largest carbon(C) reservoir in terrestrial ecosystems and plays a crucial role in regulating the global C cycle and climate *** nitrogen(N) deposition has been widely considered as a critical factor affecting soil organic carbon(SOC) storage, but its effect on SOC components with different stability remains unclear. Here, we analyzed extensive empirical data from 304 sites worldwide to investigate how SOC and its components respond to N addition. Our analysis showed that N addition led to a significant increase in bulk SOC(6.7%), with greater increases in croplands(10.6%) and forests(6.0%) compared to grasslands(2.1%). Regarding SOC components, N addition promoted the accumulation of plant-derived C(9.7%–28.5%) over microbial-derived C(0.2%), as well as labile(5.7%) over recalcitrant components(–1.2%), resulting in a shift towards increased accumulation of plant-derived labile C. Consistently, N addition led to a greater increase in particulate organic C(11.9%) than mineral-associated organic C(3.6%), suggesting that N addition promotes C accumulation across all pools, with more increase in unstable than stable pools. The responses of SOC and its components were best predicted by the N addition rate and net primary productivity. Overall, our findings suggest that N enrichment could promote the accumulation of plant-derived and non-mineral associated C and a subsequent decrease in the overall stability of soil C pool, which underscores the importance of considering the effects of N enrichment on SOC components for a better understanding of C dynamics in soils.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Information extraction and dynamic evaluation of soil salinization with a remote sensing method in a typical county on the huang-Huai-Hai Plain of China

引用

Pedosphere 2020年第4期30卷 496-507页

作者： Xiaoguang ZHANG biao huang Feng LIU State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008(China) Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008(China) College of Resource and Environment Qingdao Agricultural UniversityQingdao 266109(China)

Monitoring the dynamics of soil salinization is of great importance for agricultural *** study selected Yucheng County,a typical county on the huang-Huai-Hai Plain(HHHP)of China,as the study area and evaluated the spatial and temporal variation of soil *** methods,consisting of principal component analysis(PCA)transformation,tasseled cap(TC)transformation,and optimal band combination(OBC),were used to extract information from an early Landsat multispectral scanner(MSS)image from 1984,and their advantages were *** addition,OBC was used on a thematic mapper(TM)image from *** iteratively self-organizing data analysis algorithm was used together with prior knowledge of likely classifications to interpret the MSS and TM images for data ***,a transfer matrix method was used to assess the spatial and temporal variability of soil salinization and analyze the driving factors of soil *** to PCA transformation and OBC,TC transformation was a more effective method for extracting soil salinization information from the MSS *** results indicate that a soil area of approximately 298 km^2was affected by salinity in 1984 in Yucheng County,of which 5.40%,11.96%,and 12.75%were classified as being subject to slight,moderate,and severe salinization,*** 2009,the saline area was reduced to only 146 km^2,of which 10.70%and 3.75%were characterized by slight to moderate salinization and no severe salinization,*** saline land decreased at an average rate of 6 km^2per *** decrease was probably a result of lower groundwater depth,increased organic fertilizer or crop straw in soil,changed land use type,and increased vegetation coverage.

关键词： Landsat multispectral scanner optimal band combination principal component analysis soil salinity tasseled cap thematic mapper

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Local-contrastive-learning machine with both generalization and adversarial robustness: A statistical physics analysis

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 109-123页

作者： Mingshan Xie Yuchen Wang Haiping huang PMI Lab School of Physics Sun Yat-sen University Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices Sun Yat-sen University

Distinct from human cognitive processing, deep neural networks trained by backpropagation can be easily fooled by adversarial examples. To design a semantically meaningful representation learning, we discard backpropagation, and instead, propose a local contrastive learning, where the representations for the inputs bearing the same label shrink(akin to boson) in hidden layers,while those of different labels repel(akin to fermion). This layer-wise learning is local in nature, being biologically plausible.A statistical mechanics analysis shows that the target fermion-pair-distance is a key parameter. Moreover, the application of this local contrastive learning to MNIST benchmark dataset demonstrates that the adversarial vulnerability of standard perceptron can be greatly mitigated by tuning the target distance, i.e., controlling the geometric separation of prototype manifolds.

关键词： machine learning statistical mechanics adversarial robustness neural networks

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：