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WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling

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International Journal of Oral Science 2024年第1期16卷 85-96页

作者： Qingling huang Yi Xiao Ting Lan Youguang Lu Li huang Dali Zheng Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFujian Medical UniversityFuzhouChina Fujian Key Laboratory of Oral Diseases School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Preventive Dentistry School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Dentistry The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina

Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry. Unexpectedly, overexpression of WNT7A did not activate the canonical Wnt-β-catenin pathway in HNSCC. Instead, our findings suggested that WNT7A potentially activated the FZD7/JAK1/STAT3 signaling pathway, leading to enhanced cell proliferation, self-renewal, and resistance to apoptosis. Furthermore, in a patient-derived xenograft (PDX) tumor model, high expression of WNT7A and phosphorylated STAT3 was observed, which positively correlated with tumor *** findings underscore the significance of WNT7A in HNSCC progression and propose the targeting of key molecules within the FZD7/JAK1/STAT3 pathway as a promising strategy for precise treatment of HNSCC.

关键词： WNT squamous tumorigenesis

Mechanism of acupuncture in attenuating cerebral ischaemia-reperfusion injury based on nuclear receptor coactivator 4 mediated ferritinophagy

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Journal of Traditional Chinese Medicine 2024年第2期44卷 345-352页

作者： ZHANG Xinchang huang Zheng huang Peiyan YANG Mengning ZHANG Zhihui NI Guangxia College of Acupuncture-Moxibustion and Tuina Nanjing University of Chinese MedicineNanjing 210023China Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE:To explore the effect of acupuncture treatment on cerebral ischaemia-reperfusion injury(CIRI)and reveal the underlying mechanism of the effect based on nuclear receptor coactivator 4(NCOA4)mediated ***:Sprague-Dawley male rats were divided into four groups:the sham group,model group,acupuncture group,and sham acupuncture *** 2 h of middle cerebral artery occlusion(MCAO),reperfusion was performed for 24 h to induce *** rats were treated with acupuncture at the Neiguan(PC6)and Shuigou(GV26)*** neurological function was evaluated by taking their Bederson scores at 2 h after ischaemia and 24 h after *** chloride staining was applied to assess the cerebral infarct volume at 24 h after *** malondialdehyde(MDA)and ferrous iron(Fe^(2+))levels were observed after 24 h of reperfusion using an assay *** blotting was performed to detect the expression of NCOA4 and ferritin heavy chain 1(FTH1)at 24 h after ***,the colocalization of ferritin with neurons,NCOA4 with microtubule-associated protein 1 light chain 3(LC3),and NCOA4 with ferritin was visualized using immunofluorescence ***:Acupuncture significantly improved neurological function and decreased cerebral infarct volume in the acupuncture *** CIRI,the expression of NCOA4,LC3 and FTH1 was increased,which enhanced ferritinophagy and induced an inappropriate accumulation of Fe^(2+)and MDA in the ischaemic ***,acupuncture dramatically downregulated the expression of NCOA4,LC3 and FTH1,inhibited the overactivation of ferritinophagy,and decreased the levels of MDA and Fe^(2+).CONCLUSIONS:Acupuncture can inhibit NCOA4-mediated ferritinophagy and protect neurons against CIRI in a rat model.

关键词： acupuncture ferritinophagy ferroptosis ferritin nuclear receptor coactivator 4 cerebral ischaemia-reperfusion injury

Triad-displaced ULAs configuration for non-circular sources with larger continuous virtual aperture and enhanced degrees of freedom

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Journal of Systems Engineering and Electronics 2024年第1期35卷 81-93页

作者： SHAIKH Abdul Hayee DANG Xiaoyu huang Daqing College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Non-uniform linear array(NULA)configurations are well renowned due to their structural ability for providing increased degrees of freedom(DOF)and wider array aperture than uniform linear arrays(ULAs).These characteristics play a significant role in improving the direction-of-arrival(DOA)estimation ***,most of the existing NULA geometries are primarily applicable to circular sources(CSs),while they limitedly improve the DOF and continuous virtual aperture for noncircular sources(NCSs).Toward this purpose,we present a triaddisplaced ULAs(Tdis-ULAs)configuration for *** TdisULAs structure generally consists of three ULAs,which are appropriately *** proposed antenna array approach fully exploits the non-circular characteristics of the *** the same number of elements,the Tdis-ULAs design achieves more DOF and larger hole-free co-array aperture than its sparse array ***,the number of uniform DOF,optimal distribution of elements among the ULAs,and precise element positions are uniquely determined by the closed-form ***,the proposed array also produces a filled resulting *** simulations are conducted to show the performance advantages of the proposed Tdis-ULAs configuration over its counterpart designs.

关键词： direction-of-arrival(DOA)estimation sparse array non-circular source(NCS) sum co-array difference co-array degrees of freedom(DOF)

Percarbonate activation catalyzed by nanoblocks of basic copper molybdate for antibiotics degradation: High performance, degradation pathways and mechanism

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Chinese Chemical Letters 2024年第10期35卷 375-378页

作者： Xiaotao Jin Yanlan Wang Yingping huang Di huang Xiang Liu Engineering Research Center of Eco-Environment in Three Gorges Reservoir Region of Ministry of Education College of Materials and Chemical EngineeringChina Three Gorges UniversityYichang 443002China Department of chemistry and chemical engineering Liaocheng UniversityLiaocheng 252059China

Sodium percarbonate(Na_(2)CO_(3)·1.5H_(2)O_(2),SPC)has been extensively employed as a solid substitute of H_(2)O_(2)for Fenton process in water treatment,because of its high stability during the production,transport,storage and *** addition,SPC can be applied in a wider range of work pH,it is also applied as a buffer in Fenton reaction for preventing a drop in ***,we have synthesized basic copper molybdate(BCM)nanoblocks with the molecular formula of Cu_(3)(MoO_(4))_(2)(OH)_(2)as an efficient and heterogeneous catalyst for antibiotics degradation via percarbonate ***,fully physical characterizations confirmed BCM nanocomposite exhibited a structure of *** also found that BCM/SPC system could work in a much wider pH range,compared with H_(2)O_(2).Then,BCM/SPC system presented a good anti-interference ability for natural organic matter in OTC *** results and Quenching tests confirmed that the co-presence of·CO_(3)-,·O_(2)-,1O_(2)and·OH in BCM/SPC system.

关键词： Sodium percarbonate Fenton process Water treatment Copper molybdate Nanoblocks

政府视野中青年形象的构建与变迁--基于1949—2020 年政府工作报告的定量分析

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当代青年研究 2020年第6期 12-18页

作者：雷开春黄清泉上海社会科学院社会学研究所华东理工大学信息科学与工程学院

政府工作报告是当年青年发展问题的集中呈现。通过对新中国成立后52份政府工作报告的定量分析发现,学生是政府视野中最典型的青年形象。然而,政府视野中的青年形象不是一成不变的,青年形象的构建既与青年自身发展的需要相关,更与社会发... 详细信息

政府工作报告是当年青年发展问题的集中呈现。通过对新中国成立后52份政府工作报告的定量分析发现,学生是政府视野中最典型的青年形象。然而,政府视野中的青年形象不是一成不变的,青年形象的构建既与青年自身发展的需要相关,更与社会发展的需求相关。教育既是提升青年成为人才精英的最重要阶梯,也是促使青年陨落为弱势群体的最重要因素。为此,如何正确看待教育尤其是高等教育,是青年和政府在未来都需要谨慎考虑的问题。

关键词：青年青年形象青年教育弱势群体

Risk Assessment of Deep-Water Horizontal X-Tree Installation

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China Ocean Engineering 2024年第2期38卷 210-220页

作者： MENG Wen-bo FU Guang-ming huang Yi LIU Shu-jie huang Liang GAOYong-hai CNOOC China Limited Zhanjiang BranchZhanjiang 524057China Key Laboratory of Unconventional Oil and Gas Development Ministry of Education(China University of Petroleum(East China))Qingdao 266580China

Due to the high potential risk and many influencing factors of subsea horizontal X-tree installation,to guarantee the successful completion of sea trials of domestic subsea horizontal X-trees,this paper established a modular risk evaluation model based on a fuzzy fault ***,through the analysis of the main process oftree down and combining the Offshore&Onshore Reliability Data(OREDA)failure statistics and the operation procedure and the data provided by the job,the fault tree model of risk analysis of the tree down installation was ***,by introducing the natural language of expert comprehensive evaluation and combining fuzzy principles,quantitative analysis was carried out,and the fuzzy number was used to calculate the failure probability of a basic event and the occurrence probability of a top ***,through a sensitivity analysis of basic events,the basic events of top events significantly affected were determined,and risk control and prevention measures for the corresponding high-risk factors were proposed for subsea horizontal X-tree down installation.

关键词： subsea horizontal X-tree risk assessment fuzzy fault tree modular risk evaluation model

Chimeric Monkey Born Alive with a High Contribution of Donor Cells

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Neuroscience Bulletin 2024年第6期40卷 849-851页

作者： Jia huang Jun Wu Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTX75390USA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTX75390USA Cecil H.and Ida Green Center for Reproductive Biology Sciences University of Texas Southwestern Medical CenterDallasTX75390USA

Chimeras,which consist of cells from different individuals or different species,represent an important tool in biological *** in the early twentieth century,studies on chimeras have been focusing on understanding fundamental genetic and cellular developmental *** the advances in genetic engineering and embryonic stem cell(ESC)technology,chimeras have become an important tool for the generation of transgenic animals.

关键词： mechanisms advances developmental

Automatic bug assignments without texts: a study

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Frontiers of Computer Science 2024年第4期18卷 211-213页

作者： Zexuan LI Kaixin huang Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

1 Introduction Automatic bug assignment has been well-studied in the past *** textual bug reports usually describe the buggy phenomena and potential causes,engineers highly depend on these reports to fix ***,researchers spend much effort on processing bug reports,aiming for obtaining key information and/or clues for reproducing bugs,analyzing their root causes,assigning them to developers/maintainers,and fixing these ***,our previous research[1]reveals that noises in texts bring adverse impacts to automatic bug assignments unexpectedly,mainly due to insufficiency of classical Natural Language Processing(NLP)techniques.

关键词： bug assignment maintain

SnapshotPrune: A Novel Bitcoin-Based Protocol Toward Efficient Pruning and Fast Node Bootstrapping

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Tsinghua Science and Technology 2024年第4期29卷 1037-1052页

作者： Pengfei huang Xiaojun Ren Teng huang Arthur Sandor Voundi Koe Duncan S Wong Hai Jiang Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou 510006China Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou 510006Chinaand also with Pazhou LabGuangzhou 510330China

Node synchronization is essential for the stability of the Bitcoin network. Critics have raised doubts about the ability of a new node to quickly and efficiently synchronize with the Bitcoin network and alleviate the storage pressure from existing full nodes to stockpile new data. Basic pruning and other techniques have been explored to address these concerns but have been insufficient to reduce node synchronization delay and effectively suppress the growth of synchronized data. In this study, we propose SnapshotPrune, a novel pruning and synchronization protocol that achieves fast node bootstrapping in the Bitcoin blockchain. Real Bitcoin historical data are leveraged to measure the synchronization time and monitor the network traffic during node bootstrapping. The protocol requires data downloads that are 99.70% less than Bitcoin Core, 81% less than CoinPrune, and 60% less than SnapshotSave, thereby saving 97.23% of download time. Findings show that the proposed design enhances the storage efficiency and reduces the node synchronization delay compared with existing techniques. We hypothesize that the efficiency of this protocol increases with the block height.

关键词： synchronization blockchain Unspent Transaction Output(UTXO)pruning snapshot fast bootstrapping