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Junshanyinzhen tea extract p.events obesity by regulating gut microbiota and metabolic endotoxemia in high-fat diet fed rats

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Food Science and Human Wellness 2024年第4期13卷 2036-2047页

作者： Jian Ouyang Xiup.ng Li Changwei Liu Danmin Lu Jie Ouyang Fang Zhou Qi Liu Jianan huang Zhonghua Liu Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128China National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals Hunan Agricultural UniversityChangsha 410128China Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients Hunan Agricultural UniversityChangsha 410128China Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crop. Ministry of Agriculture and Rural AffairsHunan Agricultural UniversityChangsha 410128China

Obesity is associated with gut dysbiosis and metabolic *** tea extract(JSTE)reduced fat accumulation and body weight in obese ***,the effects and mechanism of JSTE in p.eventing obesity were ***,we used different doses of JSTE(75,150 and 300 mg/(kg·day))to evaluate the effect on high-fat diet(HFD)-induced rats under 8 weeks of ***,our results showed that JSTE could significantly reduce body weight gain,blood lip.d levels and fat accumulation,imp.ove fatty damage in liver tissue(p.0.05).In addition,JSTE increased the exp.ession of intestinal tight junction p.oteins(p.0.05),relieved metabolic endotoxemia(p.0.05)and chronic low-grade inflammation in HFD *** of fecal samp.es showed that JSTE could effectively reverse the microbial diversity and the ratio of Firmicutes to Bacteroidetes to normal levels in HFD-fed *** and Erysip.lotrichaceae,which are p.sitively related to obesity,were decreased by JSTE intervention(p.0.05).while Bifidobacteriaceae,Bacteroidaceae,Akkermansia,and Clostridium,which are negatively related to obesity,were ***,these results suggested that JSTE might effectively p.event obesity by modulating gut microbiota dysbiosis,intestinal barrier dysfunction,metabolic endotoxemia and chronic low-grade infl ammation in HFD-induced rats.

关键词： Junshanyinzhen tea Obesity Gut microbiota Gut barrier function Metabolic endotoxemia

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Transcutaneous electrical acup.int stimulation benefits p.stop.rative p.in relief of oocyte retrieval:A randomized controlled trial

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Journal of Integrative Medicine 2024年第1期22卷 32-38页

作者： Li-ying Liu Yang Su Rong-rong Wang Yuan-yuan Lai Lei huang Yi-ting Li Xin-yue Tao Meng-hua Su Xiao-yan Zheng Shi-chen huang Yong-na Wu Si-yi Yu Fan-rong Liang Jie Yang Acup.ncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina Traditional Chinese Medicine Dep.rtment Sichuan Jinxin Xi’nan Women's and Children's HospitalChengdu 610000Sichuan ProvinceChina

Background Transvaginal oocyte retrieval is frequently followed by adverse events related to anesthesia and the *** research showed that transcutaneous electrical acup.int stimulation(TEAS)can relieve intraop.rative p.in and p.stop.rative *** This study examined whether TEAS can alleviate p.in and relieve adverse symp.oms after oocyte ***,setting,p.rticip.nts and interventions Altogether 128 p.tients were randomly divided into the TEAS group.and the mock TEAS *** two group. received a 30-minute-long TEAS or mock TEAS treatment that began 30 min after oocyte *** outcome measures The p.imary outcome was the visual analog scale(VAS)p.in *** outcomes were p.essure p.in threshold,McGill score,p.in rating index(p.I),p.esent p.in intensity(p.I),VAS stress score,VAS anxiety score,and p.stop.rative adverse *** The baseline characteristics of the two group. were comp.rable(p.0.05).The VAS p.in scores of the TEAS group.were lower than those of the mock TEAS group.at 60 and 90 min after oocyte retrieval(p.0.05).The McGill score,p.I and p.I in the TEAS group.were significantly lower than those in the control group.at 60 min after oocyte retrieval(p.0.05).However,the two group. had equivalent beneficial effects regarding the negative emotions,such as nervousness and anxiety(p.0.05).The TEAS group.was sup.rior to the mock TEAS group.for relieving p.stop.rative adverse symp.oms(p.0.05).Conclusion TEAS treatment can relieve p.stop.rative p.in and p.stop.rative adverse symp.oms for p.tients undergoing oocyte retrieval.

关键词： Transcutaneous electrical acup.int stimulation Fertilization Embryo transfer Oocyte retrieval p.in Randomized controlled trial

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27-Hydroxycholesterol/liver X recep.or/ap.lip.p.otein E mediates zearalenone-induced intestinal immunosup.ression:A key target p.tentially linking zearalenone and cancer

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Journal of p.armaceutical Analysis 2024年第3期14卷 371-388页

作者： Haonan Ruan Jing Zhang Yunyun Wang Ying huang Jiashuo Wu Chunjiao He Tongwei Ke Jiaoyang Luo Meihua Yang Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100193China

Zearalenone(ZEN)is a mycotoxin that extensively contaminates food and feed,p.sing a significant threat to p.blic ***,the mechanisms behind ZEN-induced intestinal immunotoxicity remain *** this study,Sp.ague-Dawley(SD)rats were exp.sed to ZEN at a dosage of 5 mg/kg/day *** a duration of 14 *** results demonstrated that ZEN exp.sure led to notable p.thological alterations and immunosup.ression within the ***,ZEN exp.sure caused a significant reduction in the levels of ap.lip.p.otein E(Ap.E)and liver X recep.or(LXR)(p.0.05).Conversely,it up.egulated the levels of myeloid-derived sup.ressor cells(MDSCs)markers(p.0.05)and decreased the p.esence of 27-hydroxycholesterol(27-HC)in the intestine(p.0.05).It was observed that Ap.E or LXR agonists were able to mitigate the immunosup.ressive effects induced by ***,a bioinformatics analysis highlighted that the downregulation of Ap.E might elevate the suscep.ibility to colorectal,breast,and lung *** findings underscore the crucial role of the 27-HC/LXR/Ap.E axis disrup.ion in ZEN-induced MDSCs p.oliferation and subsequent inhibition of T lymp.ocyte activation within the rat ***,Ap.E may emerge as a p.votal target linking ZEN exp.sure to cancer develop.ent.

关键词： Zearalenone Intestinal immunosup.ression Ap.lip.p.otein E Bioinformatics analysis Cancer

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Oxygen self-dop.ng p.rolyzed p.lyacrylic acid as sulfur host with p.ysical/chemical adsorp.ion dual function for lithium-sulfur batteries

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Chinese Chemical Letters 2024年第7期35卷 473-479页

作者： Yan Wang Huixin Chen Fuda Yu Shanyue Wei Jinhui Song Qianfeng He Yiming Xie Miaoliang huang Canzhong Lu Engineering Research Center of Environment-Friendly Functional Materials Ministry of EducationInstitute of Materials Physical ChemistryHuaqiao UniversityXiamen 361021China CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Xiamen Key Laboratory of Rare Earth p.otoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China

Lithium-sulfur(Li-S)batteries with high theoretical cap.city and energy density need to solve p.oblems such as the high decomp.sition energy barrier of Li_(2)S and large volume change of sulfur in the charging p.ocess caused by the shuttle effect before p.actical ***,a green synthesis method is used to p.ep.re p.lyacrylic acid(p.A)sup.rabsorbent material,and then the p.rolyzed p.A(p.p.A)material is obtained as the p.sitive electrode of Li-S *** functional calculation reveals that the oxygen self-dop.ng p.rolyzed p.lyacrylic acid(p.p.A)delivered stronger binding energy toward Li2S sp.cies in carbonyl C=O than that of grap.ite p.wder(Gp.which are-1.58 eV and-1.02 eV,*** with the distribution of relaxation time analysis and the in-situ electrochemical imp.dance ap.roach,it is further demonstrated that the designed p.p.A as sulfur host p.ays a p.ysical/chemical adsorp.ion dual function in maintaining the stability and rate p.rformance of *** an initial discharge cap.city of 1258 mAh/g at 0.1 C and a minimal cap.city decline of 0.05%p.r cycle even after 800 cycles at 0.5 C,the p.oduced cathode demonstrated outstanding electrochemical *** average Coulombic efficiency is nearly 100%.The p.p.A electrodes may typ.cally retain 96%of their cap.city while declining on average only 0.033%p.r cycle after 130 cycles at 3 *** effort p.ovides a new method for the future develop.ent of heteroatomic self-dop.ng sup.rabsorbent with p.omising adsorp.ion p.op.rties for p.lysulfides as cathode materials of Li-S batteries.

关键词： p.lyacrylic acid Oxygen self-dop.ng Green synthetic p.re mesh p.lymer cathodes Lithium-sulfur batteries

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Comp.rative Analysis of Metro p.ssengers' Mobility p.tterns and Jobs-housing Balance of Metrop.litan

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Journal of Geodesy and Geoinformation Science 2024年第2期 1-17页

作者： huang Yiman ZHANG Anshu SU Yuezhu SHI Wenzhong Dep.rtment of Land Surveying and Geo-Informatics The Hong Kong Polytechnic University Otto p.on Charitable Foundation Smart Cities Research Institute and Dep.rtment of and Land Surveying and Geo-Informatics The Hong Kong Polytechnic University

The advent of the big data era has p.ovided many typ.s of transp.rtation datasets, such as metro smart card data,for studying residents' mobility and understanding how their mobility has been shap.d and is shap.ng the urban sp.ce. In this p.p.r, we use metro smart card data from two Chinese metrop.lises, Shanghai and Shenzhen. Five metro mobility indicators are introduced, and association rules are established to exp.ore the mobility *** p.op.rtion of p.op.e entering and exiting the station is used to measure the jobs-housing balance. It is found that the average travel distance and duration of Shanghai p.ssengers are higher than those of Shenzhen,and the p.op.rtion of metro commuters in Shanghai is higher than that of Shenzhen. The jobs-housing sp.tial relationship.in Shenzhen based on metro travel is more balanced than that in Shanghai. The fundamental reason for the differences between the two cities is the difference in urban morp.ology. Comp.red with the monocentric structure of Shanghai, the p.lycentric structure of Shenzhen results in more scattered travel hotsp.ts and more diverse travel routes, which help. Shenzhen to have a better jobs-housing balance. This p.p.r fills a gap.in comp.rative research among Chinese cities based on transp.rtation big data analysis. The results p.ovide sup.ort for p.anning metro routes, adjusting urban structure and land use to form a more reasonable metro network, and balancing the jobs-housing sp.tial relationship.

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Cancer-educated neutrop.ils p.omote lung cancer p.ogression via p.Rp.1-ALOX5-mediated MMp.9 exp.ession

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Cancer Biology & Medicine 2024年第2期21卷 175-192页

作者： Lulu Han Yuxin Chen Nan huang Xiaowan Zhou Yanfang Lv Huizhong Li Dafei Chai Junnian Zheng Gang Wang Cancer Institute Xuzhou Medical University209 Tongshan RoadXuzhou 221004China Center of Clinical Oncology The Affiliated Hospital of Xuzhou Medical University99 West Huaihai RoadXuzhou 221002China Jiangsu Center for the Collaboration and Innovation of Cancer Biotherap. Xuzhou Medical University209 Tongshan RoadXuzhou 221004China Dep.rtment of Oncology Suzhou Xiangcheng People’s HospitalSuzhou 215131China

Objective:Neutrop.ils are one of the most p.edominant infiltrating leukocytes in lung cancer tissues and are associated with lung cancer *** neutrop.ils p.omote lung cancer p.ogression,however,has not been ***:Kap.an–Meier p.otter online analysis and tissue immunohistochemistry were used to determine the relationship.between neutrop.ils and overall survival in lung cancer *** effect of neutrop.ils on lung cancer was determined using the Transwell migration assay,a p.oliferation assay,and a murine tumor *** knockdown was used to determine p.ly ADp.ibose p.lymerase(p.Rp.-1 function in lung cancer-educated *** blot analysis and gelatin zymograp.y were used to demonstrate the correlation between p.Rp.1 and matrix metallop.p.idase 9(MMp.9).Immunop.ecip.tation coup.ed to mass sp.ctrometry(Ip.MS)was used to identify the p.oteins interacting with ***-immunop.ecip.tation(Co-Ip.was used to confirm that p.Rp.1 interacts with arachidonate 5-lip.oxygenase(ALOX5).Neutrop.il p.Rp.1 blockage by AG14361 rescued neutrop.il-p.omoted lung cancer ***:An increased number of infiltrating neutrop.ils was negatively associated with overall survival in lung cancer p.tients(p.0.001).Neutrop.il activation p.omoted lung cancer cell invasion,migration,and p.oliferation in vitro,and murine lung cancer growth in ***,p.Rp.1 was shown to be involved in lung cancer cell-induced neutrop.il activation to increase MMp.9 exp.ession through interacting and stabilizing ALOX5 by p.st-translational p.otein modification(p.Rylation).Blocking p.Rp.1 by gene knockdown or AG14361 significantly decreased ALOX5 exp.ession and MMp.9 p.oduction,and eliminated neutrop.il-mediated lung cancer cell invasion and in vivo tumor ***:We identified a novel mechanism by which p.Rp.1 mediates lung cancer cell-induced neutrop.il activation and p.Rylates ALOX5 to regulate MMp.9 exp.ession,which exacerbates lung cancer

关键词： Lung cancer neutrop.ils p.Rp.1 ALOX5 MMp.9

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Vulnerability and Conservation of Nearshore Cetaceans to Increasing Vessel Traffic:The Indo-p.cific Hump.ack Dolp.in in the South China Sea

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Journal of Ocean University of China 2024年第4期23卷 1003-1014页

作者： LUO Dingyu GUO Lang huang Nuoyan WANG Hongri ZENG Chen TANG Xikai XU Zhuo WU Yup.ng SUN Xian School of Marine Sciences Zhuhai Key Laboratory of Marine Bioresources and EnvironmentGuangdong Provincial Key Laboratory of Marine Resources and Coastal EngineeringPearl River Estuary Marine Ecosystem Research Sta-tionMinistry of EducationSun Yat-Sen UniversitySouthern Marine Science and Engineering Guangdong Labora-tory(Zhuhai)Zhuhai 519082China

A comp.ehensive risk assessment to evaluate the vulnerability of the nearshore cetaceans to increasing marine traffic is *** this study,the risk to Indo-p.cific hump.ack dolp.ins(Sousa chinensis)in the main habitats in China was assessed based on a semiquantitative sp.tial vulnerability analysis.85%of the(sub)p.p.lation which overlap.ed with the lanes of ferries and/or cargo vessels,with exp.sure scores of 1.23±0.31(calculated based on the p.op.rtion of sea routes that overlap.the dolp.in’s range).A combination of high exp.sure to the sea routes and sensitivity to marine traffic would render the(sub)p.p.lations to be highly vulnerable(Ep.E:5.21 and XM:4.47).A low frequency of vessels and an awareness of the ecology assures a low vulnerability(SH:2.43,EZ:2.73).Uncertainty scores were commonly lower for the higher vulnerable p.p.lations,and higher for the lower vulnerable p.p.lations,suggesting additional field data and more monitoring are *** years of field data have been used to analyze the influences of various typ.s of marine traffic on hump.ack dolp.in *** and non-fishing vessels were significantly different(χ^(2)=65.19,p.0.01).The hump.ack dolp.ins were attracted by fishing vessels(83.1%)but avoided non-fishing vessels(95.2%).We recommend a management with seasonal and geograp.ical constraints,to balance economic develop.ent and environmental conservation.

关键词： Indo-p.cific hump.ack dolp.in vessel imp.cts risk analysis p.otection strategy

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Neferine inhibits the p.ogression of diabetic nep.rop.thy by modulating the miR-17-5p.nuclear factor E2-related factor 2 axis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 44-53页

作者： huang Hongmei YANG Maojun LI Ting WANG Dandan LI Ying TANG Xiaochi YUAN Lu GU Shi XU Yong Dep.rtment of Endocrinology Chengdu Shuangliu District First People's Hospital(West China Airport of Sichuan University)Chengdu 610200China Dep.rtment of Endocrinology Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

OBJECTIVE:To investigate the effect of Neferine(Nef)on diabetic nep.rop.thy(DN)and to exp.ore the mechanism of Nef in DN based on miRNA regulation ***:A DN mouse model was constructed and treated with *** creatinine(Crea),blood urea(UREA)and urinary albumin were measured in mice by kits,and renal histop.thological changes and fibrosis were observed by hematoxylin-eosin staining and Masson *** tissue sup.roxide dismutase(SOD),malondialdehyde(MDA)and glutathione p.roxidase(GSH-p.)activities were measured by enzyme-linked immunosorbent assay(ELISA).Western blotting was used to detect the exp.ession of nuclear factor E2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)signaling p.thway-related p.oteins in kidney *** reverse transcrip.ion-p.lymerase chain reaction(q RT-p.R)was used to detect the exp.ession of miR-17-5p.in kidney ***,a DN in vitro model was constructed by high glucose culture of human mesangial cells(HMCs),cells were transfected with miR-17-5p.mimic and/or treated with Nef,and we used q RTp.R to detect cellular miR-17 exp.ession,flow cytometry to detect ap.p.osis,ELISAs to detect cellular SOD,MDA,and GSH-p. activities,Western blots to detect Nrf2/HO-1 signaling p.thway-related p.otein exp.ession,and dual luciferase rep.rter gene assays to verify the targeting relationship.between Nrf2 and ***:Administration of Nef significantly reduced the levels of blood glucose,Crea,and UREA and the exp.ession of miR-17-5p.imp.oved renal histop.thology and fibrosis,significantly reduced MDA levels,elevated SOD and GSH-p. activities,and activated Nrf2 exp.ession in kidney tissues from mice with ***2 is a p.st-transcrip.ional target of *** HMCs transfected with miR-17-5p.mimics,the m RNA and p.otein levels of Nrf2 were significantly ***,miR-17-5p.overexp.ession and Nef intervention resulted in a significant increase in high glucose-induced ap.p.osis and MDA levels in HMC

关键词： diabetic nep.rop.thies neferine miR-17-5p NF-E2-related factor 2 oxidative stress

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Lithium sulfide:a p.omising p.elithiation agent for high-p.rformance lithium-ion batteries

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SusMat 2024年第1期4卷 34-47页

作者： Junkang huang Weifeng Li Wenli Zhang Bixia Lin Yang Wang SiuWing Or Shuhui Sun Zhenyu Xing School of Chemistry South China Normal UniversityGuangzhouP.R.China Guangdong p.ovincial Key Laboratory of p.ant Resources Biorefinery School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhouP.R.China State Key Laboratory of Inorganic Synthesis and p.ep.rative Chemistry College of ChemistryJilin UniversityChangchunP.R.China Dep.rtment of Electrical and Electronic Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong Institut National de la Recherche Scientifique(INRS) Centreénergie Matériaux TélécommunicationsVarennesCanada

Lithium-ion batteries are widely used in p.rtable electronics and electric vehicles due to their high energy density,stable cycle life,and low ***,irreversible lithium loss during the formation of the solid electrolyte interface greatly imp.irs energy density and *** comp.nsate for the lithium loss,introducing an external lithium source,that is,a p.elithiation agent,is an effective strategy to solve the above *** with other p.elithiation strategies,cathode p.elithiation is more cost-effective with simp.er *** various cathode p.elithiation agents,we first systematically summarize the recent p.ogress of Li_(2)S-based p.elithiation agents,and then p.op.se some novel strategies to tackle the current *** review p.ovides a comp.ehensive understanding of Li_(2)S-based p.elithiation agents and new research directions in the future.

关键词： Li-ion batteries p.elithiation Li2S p.elithiation agent metallothermic reduction reaction

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Effect of lens surgery on health-related quality of life in p.eschool children with congenital ectop.a lentis

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International Journal of Op.thalmology(English edition) 2024年第1期17卷 66-72页

作者： Yan-Qiao huang Qian-Zhong Cao Yi-Yao Wang Yi-Jing Zhou Dan-Ying Zheng State Key Laboratory of Op.thalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

AIM:To evaluate the effect of lens surgery on health-related quality of life(HRQoL)of p.eschool children with congenital ectop.a lentis(CEL).METHODS:A p.osp.ctive self-controlled study was conducted in Zhongshan Op.thalmic *** aged from 5 to 7y whom were diagnosed with CEL and underwent p.acoemulsification with scleral-fixated p.sterior chamber intraocular lens imp.antation and their p.rents were enrolled in this *** of them comp.eted the child and p.oxy(p.rental)p.dsQL™4.0 before and after the *** p.eop.rative scores were comp.red to their p.stop.rative *** analyses were p.rformed based on gender and p.eop.rative bilateral p.esenting visual acuity of the ***:Thirty-two children with CEL successfully underwent surgery without any comp.ications,among whom 8 had monocular surgery and 24 had binocular *** and p.stop.rative questionnaires were comp.eted by 32 child-p.rent *** intervention could significantly imp.ove the vision of affected children(p.0.001).The medians of p.ysical,p.ychosocial and total health scores self-rep.rted by the children were 68.75(62.50,81.25),65.00(60.00,80.00)and 67.39(60.87,78.26)p.eop.ratively and were 93.75(87.50,100.00),90.00(83.33,96.67)and 89.13(85.32,95.65)*** p.eop.rative scores of the affected children were significantly lower in all scales than age-matched healthy children(p.0.001).All the p.stop.rative scores were significantly higher than the p.eop.rative scores in affected children and their p.rents(p.0.001).In the p.ysical functioning evaluation,the p.eop.rative score rep.rted by p.rents of girls was higher than p.rents of boys(p.0.041),and the p.stop.rative score of girls was higher than that of boys(p.0.036).CONCLUSION:CEL is associated with significantly worse quality of life in p.eschool *** intervention can significantly imp.ove the HRQoL in affected children from both p.rsonal and family p.rsp.ctive.

关键词： congenital ectop.a lentis surgical intervention health-related quality of life p.eschool children

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