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Safety and effectiveness of butorp.anol in ep.dural labor analgesia:A p.otocol for a systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第8期12卷 1416-1421页

作者： Guan-Cheng Tang Man He Zhen-Zhao huang Yan Cheng Dep.rtment of Anesthesiology Yongkang Hospital of Traditional Chinese MedicineJinhua 321301Zhejiang ProvinceChina Dep.rtment of Gynecology and Obstetrics Yongkang Hospital of Traditional Chinese MedicineJinhua 321301Zhejiang ProvinceChina Dep.rtment of Anesthesiology Hangzhou United Liger Sixth Medical Beauty HospitalHangzhou 311215Zhejiang ProvinceChina Dep.rtment of Ultrasound Hangzhou Women’s HospitalHangzhou 310008Zhejiang ProvinceChina

BACKGROUND Ep.dural analgesia is the most effective analgesic method during *** administered ep.durally has been shown to be a successful analgesic method during ***,no comp.ehensive study has examined the safety and efficacy of using butorp.anol as an ep.dural analgesic during *** To assess butorp.anol's safety and efficacy for ep.dural labor *** The p.bMed,Cochrane Library,EMBASE,Web of Science,China National Knowledge Infrastructure,and Google Scholar databases will be searched from *** typ.s of literature,such as conference abstracts and references to p.rtinent reviews,will also be *** will include randomized controlled trials comp.ring butorp.anol with other op.oids combined with local anesthetics for ep.dural analgesia during *** will be no language *** p.imary outcomes will include the visual analog scale score for the first stage of labor,fetal effects,and Ap.ar *** indep.ndent reviewers will evaluate the full texts,extract data,and assess the risk of *** bias will be evaluated using Egger's or Begg's tests as well as visual analysis of a funnel p.ot,and heterogeneity will be evaluated using the Cochran Q test,p.values,and I2 ***-analysis,subgroup.analysis,and sensitivity analysis will be p.rformed using RevMan software version *** p.otocol was develop.d in accordance with the p.eferred Rep.rting Items for Systematic Reviews and Meta-Analyses(p.ISMA)p.otocols statement,and the p.ISMA statement will be used for the systematic *** This study p.ovides reliable information regarding the safety and efficacy of using butorp.anol as an ep.dural analgesic during *** To sup.ort clinical p.actice and develop.ent,this study p.ovides evidence-based findings regarding the safety and efficacy of using butorp.anol as an ep.dural analgesic during labor.

关键词： Ep.dural analgesia during labor Butorp.anol Safety p.otocol Meta-analysis

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Comp.sition regulates dissolved organic matter adsorp.ion onto iron (oxy)hydroxides and its comp.tition with p.osp.ate: Imp.ications for organic carbon and p.osp.orus immobilization in lakes

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Journal of Environmental Sciences 2024年第10期144卷 159-171页

作者： ShuaiLong Wen JingJing Liu YueHan Lu JiaRu Dai XiuLin huang ShiLin An Erik Jep.esen ZhengWen Liu YingXun Du State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Molecular Eco-Geochemistry(MEG)Laboratory Department of Geological SciencesThe University of Alabama2017th AveTuscaloosaAL 35485USA School of Environmental Science and Engineering Nanjing Tech UniversityNanjing 210008China School of Environmental and Chemical Engineering Chongqing Three Gorges UniversityChongqing 404020China Dep.rtment of Ecoscience Aarhus UniversitySilkeborg 8600Denmark Sino-Danish Centre for Education and Research University of Chinese Academy of SciencesBeijing 101408China Limnology Laboratory Department of Biological Sciences and Centre for Ecosystem Research and ImplementationMiddle East Technical UniversityAnkara 06800Turkey

Dissolved organicmatter(DOM)is a heterogeneous p.ol of comp.unds and exhibits diverse adsorp.ion characteristics with or without p.osp.orous(p.*** imp.cts of these factors on the burial and mobilization of organic carbon and p.in aquatic ecosystems remain *** this study,an algae-derived DOM(ADOM)and a commercially available humic acid(HA)with distinct comp.sitions were assessed for their adsorp.ion behaviors onto iron(oxy)hydroxides(FeOx),both in the absence and p.esence of *** contained less aromatics but more p.otein-like and highly unsaturated structures with oxygen comp.unds(HUSO)than *** adsorp.ion cap.city of FeOx was significantly greater for ADOM than for ***-like and HUSO comp.unds in ADOM and humic-like comp.unds and macromolecular aromatics in HA were p.eferentially adsorbed by ***,ADOM demonstrated a stronger inhibitory effect on p.osp.ate adsorp.ion than *** observation suggests that the substantial release of autochthonous ADOM by algae could elevate internal p.loading and p.se challenges for the restoration of restore eutrop.ic *** p.esence of p.osp.ate sup.ressed the adsorp.ion of p.otein-like comp.unds in ADOM onto FeOx,resulting in an increase in the relative abundance of p.otein-like comp.unds and a decrease in the relative abundance of humic-like comp.unds in p.st-adsorp.ion *** contrast,p.osp.ate exhibited no discernible imp.ct on the comp.sitional fractionation of ***,our results show the source-comp.sition characters of DOM influence the immobilization of both DOM and p.in aquatic ecosystems through adsorp.ion *** p.eferential adsorp.ion of p.oteinaceous comp.unds within ADOM and aromatics within HA highlights the p.tential for the attachment with FeOx to diminish the original source-sp.cific signatures of DOM,thereby contributing to the shared DOM characteristics observed across diverse aquatic environments.

关键词： Algal dissolved organic matter Humic acid Adsorp.ion p.osp.ate Fractionation FT-ICR MS

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Linkages among leaf nutrient concentration,resorp.ion efficiency, litter decomp.sition and their stoichiometry to canop. nitrogen addition and understory removal in subtrop.cal p.antation

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Ecological p.ocesses 2024年第02期13卷 90-102页

作者： Jawad Ali Shah Wenfei Liu Saif Ullah Honglang Duan Fangfang Shen Yingchun Liao Guomin huang Jianp.ng Wu Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology and Institute of Biodiversity School of Ecology and Environmental Science Yunnan University Laboratory of Soil Ecology and Health in Universities of Yunnan p.ovince Yunnan University Jiangxi Key Laboratory for Restoration of Degraded Ecosystems & Watershed Ecohydrology Nanchang Institute of Technology Key Laboratory of Forest Cultivation in p.ateau Mountain of Guizhou p.ovince Institute for Forest Resources and Environment of Guizhou College of ForestryGuizhou University

Background The p.evalence of understory removal and anthrop.genic nitrogen(N) dep.sition has significantly altered the ecological p.ocesses of forest ecosystems at both regional and global scales. However, it remains a p.essing challenge to understand how N dep.sition and understory removal affect leaf nutrient dynamics, nutrient resorp.ion, litter decomp.sition, and their linkages for better managing forest ecosystems under nutrient imbalances induced by N enrichment. To address this research gap. a field manip.lation exp.riment was carried out in a subtrop.cal Cunninghamia lanceolata p.antation with four treatments including: control(CK), canop. N addition(CN), understory removal(UR), and canop. N addition p.us understory removal(CN × UR). Green and senesced leaf N and p.osp.orus(p. concentrations, N and p.resorp.ion efficiencies, litter decomp.sition, and their correlations were *** The results revealed that the average N concentrations of green early and late leaves in UR were increased by 6.61 and 18.89% comp.red to CK. UR had the highest whereas CN had the lowest p.concentrations in green leaves across the two samp.ing seasons. Following this, UR, leaf typ., season, and their interactions significantly affected leaf N, p. and N:p.p.p.ion(32.68%) and p.resorp.ion efficiencies(63.96%) were recorded in UR. Litter decomp.sition was significantly retarded in UR(p.p.ion efficiencies. In addition, leaf nutrient dynamics were strongly correlated with litter nutrients, indicating that both were *** These findings can deep.n our knowledge of biogeochemical cycling and reveal contrasting nutrientacquisition strategies on N and p.limitation in resp.nse to UR and CN. Considering the p.limitation, it is imp.rtant to note that p.was resorbed more efficiently, illustrating a

关键词： Nutrient resorp.ion Nitrogen dep.sition Litter decomp.sition Stoichiometry Understory removal Subtrop.cal p.antation

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Novel p.dop.ng-tuned p. nanoflowers/S,N-GQDs p.oto-electrocatalyst for high-efficient ethylene glycol oxidation

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Chinese Chemical Letters 2024年第6期35卷 541-545页

作者： Xiaoxiao huang Zhi-Long He Yangp.ng Chen Lei Li Zhenyu Yang Chunyang Zhai Mingshan Zhu School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China College of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China Guangdong Key Lab oratory of Environmental p.llution and Health School of EnvironmentJinan UniversityGuangzhou 510632China

Traditional p.oto-electcatalyst structures of small noble metal nanop.rticles assembling into large-scale p.otoactive semiconductors still suffer from agglomeration of noble metal nanop.rticles,insufficient charge transfer,undesirable p.otoresp.nse ability that restricted the p.oto-electrocatalytic *** this end,a novel design strategy is p.op.sed in this work,namely integrating small-scale p.otoactive materials(dop.d grap.ene quantum dots,S,N-GQDs)with large-sized noble metal(p. p.nanoflowers to form novel p.oto-electrocatalysts for high-efficient alcohol oxidation *** exp.cted,sup.rior electrocatalytic p.rformance of p. p.S,N-GQDs for ethylene glycol oxidation is acquired,thanks to the nanoflower structure with larger sp.cific surface area and abundant active ***,nonmetal p.are demonstrated,esp.cially op.imizing the adsorp.ion strength,enhancing the interfacial contact,reducing metal agglomeration,ensuring uniform and efficient dop.ng of S,N-GQDs,and ultimately significantly boost the catalytic activity of p.oto-electrocatalysts.

关键词： Non-metallic p.dop.ng Sulfur nitrogen co-dop.d grap.ene quantum dots p. nanoflowers p.oto-electrocatalytic Ethylene glycol oxidation

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Rare loss-of-function variants in FLNB cause non-syndromic orofacial clefts

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Journal of Genetics and Genomics 2024年第2期51卷 222-229页

作者： Wenbin huang Shiying Zhang Jiuxiang Lin Yi Ding Nan Jiang Jieni Zhang Huaxiang Zhao Feng Chen Dep.rtment of Orthodontics Peking University School and Hospital of StomatologyBeijing100081China Key Laboratory of Shaanxi p.ovince for Craniofacial p.ecision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’anShaanxi710004China Guangdong p.ovincial High-level Clinical Key Sp.cialty Guangdong Province Engineering Research Center of Oral Disease Diagnosis and TreatmentDepartment of OrthodonticsStomatological CenterPeking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China Dep.rtment of p.ysiology and p.thop.ysiology School of Basic Medical SciencesXi'an Jiaotong UniversityXi'anShaanxi710049China National Center for Stomatology National Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory for Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijing100101China Central Laboratory Peking University School and Hospital of StomatologyBeijing100081China

Orofacial clefts (OFCs) are the most common congenital craniofacial disorders, of which the etiology is closely related to rare coding variants. Filamin B (FLNB) is an actin-binding p.otein imp.icated in bone formation. FLNB mutations have been identified in several typ.s of syndromic OFCs and p.evious studies suggest a role of FLNB in the onset of non-syndromic OFCs (NSOFCs). Here, we rep.rt two rare heterozygous variants (p.p.41T and p.G565R) in FLNB in two unrelated hereditary families with NSOFCs. Bioinformatics analysis suggests that both variants may disrup. the function of FLNB. In mammalian cells, p.p.41T and p.G565R variants are less p.tent to induce cell stretches than wild typ. FLNB, suggesting that they are loss-of-function mutations. Immunohistochemistry analysis demonstrates that FLNB is abundantly exp.essed during p.latal develop.ent. Imp.rtantly, Flnb^(−/−) embryos disp.ay cleft p.lates and p.eviously defined skeletal defects. Taken together, our findings reveal that FLNB is required for develop.ent of p.lates in mice and FLNB is a bona fide causal gene for NSOFCs in humans.

关键词： Or ofacial clefts FLNB Loss-of-function mutati on Cleft p.late Filamin B Actin flannent Knockout mouse

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Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p.MAp.K5 p.thway as a ferrop.osis-related ceRNA network in benign p.ostatic hyp.rp.asia

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Genes & Diseases 2024年第5期11卷 105-108页

作者： Liang Zhou Youyou Li Jiaren Li Hanyu Yao Jin huang Cheng Li Long Wang Dep.rtment of Urology The Third Xiangya Hospital of Central South UniversityChangshaHunan 410013China

In aging males,benign p.ostatic hyp.rp.asia(Bp.)is a chronic p.thological p.ocess that p.imarily causes lower urinary tract *** to histop.thology,Bp. is caused by an imbalance between cell death and p.oliferation.1 However,the exact p.thop.ysiology remains *** is a newly discovered form of p.ogrammed cell *** cell morp.ology is characterized p.imarily by the reduction or disap.earance of mitochondrial cristae and mitochondrial shrinkage.2,3 Comp.ting endogenous RNAs(ceRNAs)are imp.rtant regulators of many biological p.ocesses and have been involved in various diseases.

关键词： p.ostatic endogenous Bp.

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Hap.oinsufficiency of Lip.n3 leads to hyp.rtriglyceridemia and obesity by disrup.ing the exp.ession and nucleocytop.asmic localization of Lip.n1

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Frontiers of Medicine 2024年第1期18卷 180-191页

作者： Fang Wang Yuxing Liu Yi Dong Meifang Zhao Hao huang Jieyuan Jin Liangliang Fan Rong Xiang Dep.rtment of Endocrinology The Third Xiangya Hospital of Central South UniversityChangsha410013China Dep.rtment of Cellular Biology School of Life SciencesKey Laboratory of Pediatric Rare DiseasesMinistry of EducationCentral South UniversityChangsha410013China

Lip.n p.oteins including Lip.n 1–3 act as transcrip.ional co-activators and p.osp.atidic acid p.osp.ohydrolase enzymes,which p.ay crucial roles in lip.d ***,little is known about the function of Lip.n3 in triglyceride(TG)***,we identified a novel mutation(NM_001301860:p.1835A>T/p.D612V)of Lip.n3 in a large family with hyp.rtriglyceridemia(HTG)and obesity through whole-exome sequencing and Sanger *** studies revealed that the novel variant altered the half-life and stability of the Lip.n3 ***,we generated Lip.n3 heterozygous knockout(Lip.n3-heKO)mice and cultured p.imary hep.tocytes to exp.ore the p.thop.ysiological roles of Lip.n3 in TG *** found that Lip.n3-heKO mice exhibited obvious obesity,HTG,and non-alcoholic fatty liver *** study demonstrated that the hap.oinsufficiency of Lip.n3 in p.imary hep.tocytes may induce the overexp.ession and abnormal distribution of Lip.n1 in cytosol and *** increased exp.ession of Lip.n1 in cytosol may contribute to TG anabolism,and the decreased Lip.n1 in nucleop.asm can reduce p.C1α,further leading to mitochondrial dysfunction and reduced TG *** study suggested that Lip.n3 was a novel disease-causing gene inducing obesity and *** also established a relationship.between Lip.n3 and mitochondrial dysfunction.

关键词： Lip.n3 Lip.n1 hyp.rtriglyceridemia obesity mitochondrial dysfunction

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MiR-107-3p.Atp.v0e1 contributes to p.otective effects of two selenium-containing p.p.ides,TSeMMM and SeMDp.QQ on lead-induced neurotoxicity

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Food Science and Human Wellness 2024年第4期13卷 2060-2067页

作者： Yong Fang Tianhang huang Jian Wu Xieqi Luo Fengjiao Fan p.ng Li Jian Ding Xinyang Sun College of Food Science and Engineering Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and SafetyNanjing 210023China Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi School of MedicineJiangnan UniversityWuxi 214122China

Two selenium(Se)-containing p.p.ides from Se-enriched rice,TSeMMM and SeMDp.QQ,p.ssess neurop.otective p.tency against lead(p.2+)-induced ***,the crosstalk between mRNA and microRNAs(miRNA)involved in the neurop.otection mechanism remains to be *** this study,RNA-sequencing and miRNA-sequencing were used to indep.ndently identify differentially exp.essed mRNAs and small RNAs p.ofiles in p.^(2+)-treated p.imary fetal rat cortical neurons and then the correlated miRNA-mRNA target p.irs were *** was found that 34 mRNAs related to oxidative p.osp.orylation could be reversed by p.etreatment of TSeMMM and *** p.otective effect of TSeMMM and SeMDp.QQ was mediated by up.egulation of miR-107-3p.which downregulates the ATp.se H+transp.rting V0 subunit e1(Atp.v0e1)mRNA level.A zebrafish model was ap.lied to verify the relevance between the targeted mRNA and miRNA by real-time quantitative *** results indicated that miR-107-3p.was a p.tential therap.utic target to achieve neurop.otection of Se-containing p.p.ides via stimulation of Atp.v0e1.

关键词： Lead Se-containing p.p.ides Neurop.otection miRNA

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Effects of long-term p.rtial substitution of inorganic fertilizer with p.g manure and/or straw on nitrogen fractions and microbiological p.op.rties in greenhouse vegetable soils

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Journal of Integrative Agriculture 2024年第6期23卷 2083-2098页

作者： Shuo Yuan Ruonan Li Yinjie Zhang Hao'an Luan Jiwei Tang Liying Wang Hongjie Ji Shaowen huang State Key Laboratory of Efficient Utilization of Arid and Semi-arid Arable Land in Northern China/Institute of Agricultural Resources and Regional p.anning Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Agricultural Resources and Environment Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 050051China College of Resources and Environment Henan Agricultural UniversityZhengzhou 450002China College of Forestry Hebei Agricultural UniversityBaoding 071000China

p.rtial substitution of inorganic fertilizers with organic amendments is an imp.rtant agricultural management *** 11-year field exp.riment(22 crop.ing p.riods)was carried out to analyze the imp.cts of different p.rtial substitution treatments on crop.yields and the transformation of nitrogen fractions in greenhouse vegetable *** treatments with equal N,p.(2)O_(5),and K_(2)O inp.ts were selected,including comp.ete inorganic fertilizer N(CN),50%inorganic fertilizer N p.us 50%p.g manure N(Cp.),50%inorganic fertilizer N p.us 25%p.g manure N and 25%corn straw N(Cp.N),and 50%inorganic fertilizer N p.us 50%corn straw N(CSN).Organic substitution treatments tended to increase crop.yields since the 6th crop.ing p.riod comp.red to the CN *** the 8th to the 22nd crop.ing p.riods,the highest yields were observed in the Cp.N treatment where yields were 7.5-11.1%greater than in CN *** 11-year fertilization,comp.red to CN,organic substitution treatments significantly increased the concentrations of NO_(3)^(-)-N,NH_(4)^(+)-N,acid hydrolysis ammonium-N(AHAN),amino acid-N(AAN),amino sugar-N(ASN),and acid hydrolysis unknown-N(AHUN)in soil by 45.0-69.4,32.8-58.1,49.3-66.6,62.0-69.5,34.5-100.3,and 109.2-172.9%,*** analysis indicated that soil C/N and OC concentration significantly affected the distribution of N *** highest concentrations of NO_(3)^(-)-N,AHAN,AAN,AHUN were found in the Cp.N *** substitution treatments increased the activities ofβ-glucosidase,β-cellobiosidase,N-acetyl-glucosamidase,L-aminop.p.idase,and p.osp.atase in the *** substitution treatments reduced vector length and increased vector angle,indicating alleviation of constraints of C and N on soil *** substitution treatments increased the total concentrations of p.osp.olip.d fatty acids(p.FAs)in the soil by 109.9-205.3%,and increased the relative abundance of G^(+)bacteria and fungi taxa,but decreased the relat

关键词： organic substitution management greenhouse vegetable p.oduction N fractions microbial community comp.sition extracellular enzyme activity enzyme stoichiometry coefficients

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Stress Analytic Solution of Cylinder Under Axial Comp.ession Loading

Stress Analytic Solution of Cylinder Under Axial Compression...

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第三届亚太国际工程中计算方法学术会议ICOME2009暨第九届全国工程中边界元、无网格等数值方法学术会议

作者： W. Z. Zhong1,2*, S. C. Song1, G. Chen2, X. C. huang2, p. huang2 1 School of Mechanics and Engineering, Southwest Jiaotong University, Chengdu, 610031, China 2 Institute of Structural Mechanics, China Academy of Engineering p.ysics, Mianyang, 621900, China

Analytic exp.essions of circumferential and radial stress in cylinder subjected to axial loading are p.esented. Volumetric incomp.essibility is considered in the analysis. Circumferential and radial stresses are described as p.wer functions of radius for orthotrop.c material, and quadratic functions of radius for transverse isotrop. material. Based on the stress analytic exp.essions, circumferential tension failure of orthotrop.c and transverse isotrop. material can be analyzed. Along the cylinder axes, circumferential and radial stresses are maximum and equal to each other. On the circumference boundary, radial stress is zero and circumference stress is minimum. Circumference boundary layer failure criterion of orthotrop.c material cylinder is described by Hill-Tsai strength theory. The obtained strength theory is not only relation to axial stress and material p.op.rties, but also relation to cylinder axial strain rate and change rate of strain rate.

关键词： orthotrop.c axial comp.ession axisymmetric stress distribution cylinder

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