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黄河流域水稀缺风险评价

中国环境科学 2024年第6期44卷 3455-3465页

作者：陆中桂康哲李巍黄明辉北京师范大学环境学院水环境模拟国家重点实验室北京100875 鄂尔多斯市环保投资有限公司内蒙古鄂尔多斯017010

基于黄河流域水稀缺特点及其成因,提出了综合考虑水量､水质和生态需水因素的流域水稀缺风险(WSR)评估框架,以此评估了2017年黄河流域90个地级市42个部门的直接水稀缺风险损失(DWSR),并通过构建城市尺度环境拓展多区域投入产出模型(MRIO)... 详细信息

基于黄河流域水稀缺特点及其成因,提出了综合考虑水量､水质和生态需水因素的流域水稀缺风险(WSR)评估框架,以此评估了2017年黄河流域90个地级市42个部门的直接水稀缺风险损失(DWSR),并通过构建城市尺度环境拓展多区域投入产出模型(MRIO),评估了城市间贸易驱动的间接水稀缺风险损失(IWSR).结果表明:流域DWSR和IWSR分别约为28941.49亿元和34464.08亿元,贸易导致的间接经济损失大于直接经济损失;各城市DWSR和IWSR整体上呈现一定的空间差异性,但高风险城市具有明显的空间集聚性和重合性,主要集中在流域中下游的山东､河南两省,如潍坊､淄博､郑州等;IWSR转移主要由各省内的城市间贸易产生,省际间的风险转移没有形成明显的热点区域;农林牧渔业､化学工业､石油加工､炼焦和核燃料加工业等部门的DWSR较高,同时也是主要的IWSR出口部门.建议结合识别出的重点城市､关键部门等全面加强WSR管理,协同推进黄河流域节水控水､水质改善和生态用水保障,促进流域水资源节约集约高效利用.

关键词：黄河流域水稀缺风险转移路径综合评估多区域投入产出模型

瓦尼桑黄固体发酵产物的化学成分及其生物活性研究

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天然产物研究与开发 2024年第4期36卷 607-615页

作者：吴椰高鹤萍毛燕妍黄明慧徐帮邹坤刘呈雄汪蕾三峡大学生物与制药学院天然产物研究与利用湖北省重点实验室(中国轻工业功能酵母重点实验室) 三峡大学第一临床医学院宜昌443002

对瓦尼桑黄(Sanghuangporus vaninii)固体发酵产物的化学成分及生物活性进行研究。采用超声提取、柱层析以及半制备高效液相色谱等方法分离纯化,通过波谱数据鉴定了化合物的结构,并对所得单体化合物进行体外抗氧化活性、α-葡萄糖苷酶... 详细信息

对瓦尼桑黄(Sanghuangporus vaninii)固体发酵产物的化学成分及生物活性进行研究。采用超声提取、柱层析以及半制备高效液相色谱等方法分离纯化,通过波谱数据鉴定了化合物的结构,并对所得单体化合物进行体外抗氧化活性、α-葡萄糖苷酶和黄嘌呤氧化酶抑制活性筛选。从瓦尼桑黄固体发酵产物中分离得到17个化合物,分别为(2Z,4E)-γ-ionylideneacetic acid(1)、phellinulin E(2)、phellinulin F(3)、phellinulin G(4)、phellinulin J(5)、phellinulin L(6)、phellinulin M(7)、phellinulin N(8)、elgonenes D(9)、咖啡酸(10)、hispidin(11)、3-hydroxyhispidin(12)、原儿茶酸(13)、4-(3-ethoxy-4-hydroxyphenyl)but-3-en-2-one(14)、丁子香酚(15)、亚油酸甲酯(16)、硬脂酸(17),其中化合物1~9为首次从瓦尼桑黄中分离得到。活性测试结果显示化合物10~13表现出良好的抗氧化活性,对DPPH自由基的半数抑制浓度(IC_(50))分别为16.45、37.52、82.71、50.46μg/mL,对ABTS自由基的IC_(50)值分别为1.43、2.26、34.55、21.60μg/mL,对羟基自由基的IC_(50)值分别为38.43、49.46、86.74、69.16μg/mL。化合物10、11还对黄嘌呤氧化酶表现出良好的抑制作用,IC_(50)值分别为28.73和44.80μg/mL。化合物17具有一定的α-葡萄糖苷酶抑制活性,其IC_(50)值2.31μg/mL。

关键词：瓦尼桑黄化学成分体外抗氧化活性 α-葡萄糖苷酶黄嘌呤氧化酶

A novel LS-SVM control for unknown nonlinear systems with application to complex forging process

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Journal of Central South University 2017年第11期24卷 2524-2531页

作者： FAN Bin LU Xin-jiang huang ming-hui School of Mechanical and Electrical Engineering Central South University College of Mechanical and Electrical Engineering Hunan City University

A novel LS-SVM control method is proposed for general unknown nonlinear systems. A linear kernel LS-SVM model is firstly developed for input/output(I/O) approximation. The LS-SVM control law is then derived directly from this developed model without any approximation and assumption. It further proves that the control error is fully equal to the LS-SVM modeling error. This means that a desirable control performance can be achieved because the LS-SVM has been proven to have an outstanding modeling ability in the previous studies. Case studies finally demonstrate the effectiveness of the proposed LS-SVM control approach.

关键词： unknown system inverse control input/output approximation LS-SVM control linear kernel

施用聚磷酸铵的紫色土壤对磷的吸附-解吸特征

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西南农业学报 2024年第8期37卷 1780-1788页

作者：黄明慧李洋许德华严正娟王辛龙四川大学化学工程学院成都610065

【目的】探讨施用不同聚合度分布的聚磷酸铵(APP)土壤对磷的吸附-解吸特征及其与施用传统正磷酸盐磷酸一铵(MAP)和磷酸二铵(DAP)土壤的差异,为APP的高效利用提供理论依据。【方法】分别以3种APP(18-58-APP、16-60-APP和11-37-APP,N-P2O5... 详细信息

【目的】探讨施用不同聚合度分布的聚磷酸铵(APP)土壤对磷的吸附-解吸特征及其与施用传统正磷酸盐磷酸一铵(MAP)和磷酸二铵(DAP)土壤的差异,为APP的高效利用提供理论依据。【方法】分别以3种APP(18-58-APP、16-60-APP和11-37-APP,N-P2O5-K2O分别为18-58-0、16-60-0和11-37-0,聚合度分布分别为1-2、1-4和1-7)、MAP和DAP为供试肥料,在石灰性和酸性紫色土壤进行56 d培养,测定各处理土壤磷的吸附-解吸特征和土壤理化性质。【结果】Langmuir和Freundlich方程均能很好地拟合两种紫色土壤对磷的吸附特征(R2=0.825~0.997)。在石灰性紫色土壤中,与施用MAP和DAP土壤相比,施用APP土壤对磷的吸附率降低15.1%~20.7%,解吸率提高4.5%~164.9%;施用APP土壤的Langmuir KL值、吸附自由能(|ΔG|)和Freundlich KF值分别降低20.4%~54.0%、3.3%~10.6%和23.8%~43.8%,土壤对磷的吸附结合力减弱,其中施用11-37-APP土壤相应值的变幅最大(KL、|ΔG|和KF值分别降低40.8%~54.0%、7.2%~10.6%和43.6%~43.8%)。在酸性紫色土壤中,施用不同磷肥对土壤磷的吸附-解吸特征影响不显著,但施用APP土壤较施用MAP和DAP土壤表现出降低磷吸附和促进磷解吸的趋势。相关分析表明,土壤pH、铁铝氧化物和土壤有效磷(Olsen-P)含量与石灰性紫色土壤磷素吸附参数显著相关;土壤Olsen-P与酸性紫色土壤磷素吸附参数显著相关。施用APP石灰性紫色土壤中络合态铁铝氧化物降低,游离态铁铝氧化物增加,对磷的吸附降低且解吸增加。与石灰性土壤相比,酸性紫色土壤的有效磷含量更低,对磷的吸附能力更强,使得其吸附-解吸特征在短期内受不同磷肥影响差异不明显。【结论】施用APP紫色土壤磷的吸附-解吸特征受土壤性质和自身聚和度分布的影响,在石灰性紫色土壤中变化显著,且以聚合度分布更广泛的11-37-APP对土壤磷素吸附-解吸特征的影响更显著。

关键词：聚磷酸铵紫色土壤吸附解吸

Mechanistic Drifting Forecast Model for A Small Semi-Submersible Drifter Under Tide–Wind–Wave Conditions

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China Ocean Engineering 2018年第1期32卷 99-109页

作者： ZHANG Wei-na huang hui-ming WANG Yi-gang CHEN Da-ke ZHANG lin Key Laboratory of Coastal Disaster and Defence Ministry of Education Hohai University College of Harbour Coastal and offshore Engineering Hohai University

Understanding the drifting motion of a small semi-submersible drifter is of vital importance regarding monitoring surface currents and the floating pollutants in coastal regions. This work addresses this issue by establishing a mechanistic drifting forecast model based on kinetic analysis. Taking tide–wind–wave into consideration, the forecast model is validated against in situ drifting experiment in the Radial Sand Ridges. Model results show good performance with respect to the measured drifting features, characterized by migrating back and forth twice a day with daily downwind displacements. Trajectory models are used to evaluate the influence of the individual hydrodynamic forcing. The tidal current is the fundamental dynamic condition in the Radial Sand Ridges and has the greatest impact on the drifting distance. However, it loses its leading position in the field of the daily displacement of the used drifter. The simulations reveal that different hydrodynamic forces dominate the daily displacement of the used drifter at different wind scales. The wave-induced mass transport has the greatest influence on the daily displacement at Beaufort wind scale 5–6; while wind drag contributes mostly at wind scale 2–4.

关键词： in situ drifting experiment mechanistic drifting forecast model tide–wind–wave coupled conditions small semi-submersible drifter daily displacement

一种新型查耳酮衍生物C13通过ErbB4/PI3K/AKT信号通路抑制人胃癌细胞的生长

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药学学报 2024年第4期59卷 957-964页

作者：谭鹏张云封王龙燕黄惠铭王飞魏雪娇王柱国李军胡仲冬北京中医药大学北京中医药研究院中药现代研究中心北京100029

3ʹ-羟基-4ʹ-甲氧基-2-羟基-5-溴查耳酮(以下简称C13)是本课题组对龙血竭抗肿瘤活性化合物DHMMF进行结构修饰过程中获得的一个新型查耳酮衍生物。本研究探讨了C13对人胃癌HGC-27、AGS细胞增殖、凋亡的影响及其潜在的作用机制。首先采用... 详细信息

3ʹ-羟基-4ʹ-甲氧基-2-羟基-5-溴查耳酮(以下简称C13)是本课题组对龙血竭抗肿瘤活性化合物DHMMF进行结构修饰过程中获得的一个新型查耳酮衍生物。本研究探讨了C13对人胃癌HGC-27、AGS细胞增殖、凋亡的影响及其潜在的作用机制。首先采用噻唑蓝(methyl thiazolyl tetrazolium,MTT)、集落形成实验、5-乙炔基-2′-脱氧尿苷(5-ethynyl-2ʹ-deoxyuridine,EdU)染色法发现C13能显著抑制人胃癌HGC-27、AGS细胞的增殖能力。采用流式细胞术和免疫印迹法检测发现C13能诱导人胃癌HGC-27、AGS细胞发生凋亡,并上调剪切的聚腺苷酸二磷酸核糖转移酶(cleaved-poly ADP-ribose polymerase,cleaved-PARP)的蛋白水平。转录组测序分析结果显示C13可能通过调控人表皮生长因子受体4/磷脂酰肌醇3-激酶/蛋白激酶B(Erb-B2 receptor tyrosine kinase 4/phosphoinositide 3-kinase/AKT,ErbB4/PI3K/AKT)信号通路发挥抗胃癌作用。最后免疫印迹实验结果表明,C13处理后能下调人胃癌细胞中ErbB4总蛋白及磷酸化水平,并能够抑制其下游PI3K及AKT蛋白磷酸化水平,进一步验证了转录组测序结果。综上所述,新型查耳酮衍生物C13能够显著抑制人胃癌HGC-27、AGS细胞增殖并诱导其发生凋亡,其机制可能与下调ErbB4/PI3K/AKT信号通路有关。本研究能够为胃癌治疗提供一个候选研究药物。

关键词：查耳酮衍生物C13 人胃癌细胞增殖凋亡 ErbB4/PI3K/AKT信号通路

A Review of Type 1 and Type 2 Intraductal Papillary Neoplasms of the Bile Duct

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Current Medical Science 2024年第3期44卷 485-493页

作者： Xia-hui huang Tian-xiang CHEN Hong-liang LIU ming-wen huang Department of General Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang330006China

Intraductal papillary neoplasm of the bile duct(IPNB)is a heterogeneous disease similar to intraductal papillary mucinous neoplasm of the *** lesions have been recognized as one of the three major precancerous lesions in the biliary tract since *** 2018,Japanese and Korean pathologists reached a consensus,classifying IPNBs into type l and type 2 *** are more prevalent in male patients in East Asia and are closely related to diseases such as cholelithiasis and *** a molecular genetic perspective,IPNBs exhibit early genetic variations,and different molecular pathways may be involved in the tumorigenesis of type 1 and type 2 *** histological subtypes of IPNBs include gastric,intestinal,pancreaticobiliary,or oncocytic subtypes,but type 1 IPNBs typically exhibit more regular and well-organized histological features than type 2 IPNBs and are more commonly found in the intrahepatic bile ducts with abundant *** to the rarity of these lesions and the absence of specific clinical and laboratory features,imaging is crucial for the preoperative diagnosis of IPNB,with local bile duct dilation and growth along the bile ducts being the main imaging *** resection remains the optimal treatment for IPNBs,but negative bile duct margins and the removal of lymph nodes in the hepatic hilum significantly improve the postoperative survival rates for patients with IPNBs.

关键词： intraductal papillary neoplasm of the bile duct subclassification neoplasms precancerous tissue prognosis

A review of ultra-high temperature heat-resistant energetic materials

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Defence Technology（防务技术） 2024年第8期38卷 33-57页

作者： Rongzheng Zhang Yuangang Xu Feng Yang Pengcheng Wang Qiuhan Lin hui huang ming Lu School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China

Heat-resistant energetic materials refer to a type of energetic materials that possess a high melting point,high stability and operational safety. By studying the structures of these energetic materials has showed that the thermal stability can be enhanced by introducing amino groups to form intra/inter-molecular hydrogen bonds, constructing conjugate systems and designing symmetrical structures. This article aims to review the physical and chemical properties of ultra-high temperature heat-resistant energetic compounds and provide valuable theoretical insights for the preparation of ultra-high temperature heatresistant energetic materials. We also analyze the selected 20 heat-resistant energetic materials with decomposition temperatures higher than 350℃, serving as templates for the synthesis of various highperformance heat-resistant energetic materials.

关键词： Heat-resistant energetic materials Organic synthesis Conjugated Hydrogen bond Symmetrical structure Stabilization

Scientific and technological innovations of wastewater treatment in China

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 43-48页

作者： hui huang Rui Ma Hongqiang Ren State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China

The“dual-carbon”strategy promotes the development of the wastewater treatment sector and is an important tool for leading science and technology *** on the global climate change and the new policies introduced by China,this paper described the new needs for the development of wastewater treatment science and *** offered a retrospective analysis of the historical trajectory of scientific and technological advancements in this *** bibliometrics,it delineated the research hotspots within wastewater treatment,notably highlighting materials genomics,artificial intelligence,and synthetic ***,it posited that,in the future,the field of wastewater treatment should follow the paths of technological innovations with multi-dimensional needs,such as carbon reduction,pollution reduction,health,standardisation,and *** purpose of this paper was to provide references and suggestions for scientific and technological innovations in the field of wastewater treatment,and to contribute to the common endeavor of moving toward a Pollution-Free Planet.

关键词： Wastewater treatment Dual-carbon strategy Technological innovation Carbon reduction