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Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： chun Qin Gan-Rong huang Ai-Xing Guan Wen-Ting Zhou Hao Chen Pei-Pei Luo Xian-Ke Luo Yan-Qiang huang Zan-Song huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BACKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(CagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PCR and Western *** was used to analyze CagA,CagM,CagE,Cag1,Cag3,and CagT.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** CagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as CagA,CagM,CagE,Cag1,Cag3,and *** these factors,CagM and CagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,CagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and Cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

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黄铜矿半导体DMS的第一原理计算

厦门大学学报（自然科学版） 2005年第2期44卷 172-175页

作者：曾永志黄美纯厦门大学物理学系福建厦门361005

为了寻找新的高Tc的稀磁半导体(DMS),利用自旋局域密度泛函的第一性原理对 3d过渡金属(TM= V、Cr、Mn、Fe、Co或Ni)掺杂的II IV V2(CdGeP2 和ZnGeP2)以及I III VI2(CuGaS2 和CuGaSe2)黄铜矿半导体的电磁性质进行系统计算.结果发现:V或Cr... 详细信息

为了寻找新的高Tc的稀磁半导体(DMS),利用自旋局域密度泛函的第一性原理对 3d过渡金属(TM= V、Cr、Mn、Fe、Co或Ni)掺杂的II IV V2(CdGeP2 和ZnGeP2)以及I III VI2(CuGaS2 和CuGaSe2)黄铜矿半导体的电磁性质进行系统计算.结果发现:V或Cr 掺杂的 II IV V2 将出现铁磁(FM)状态,而 Mn、Fe或者 Co掺杂的 II IV V2 将出现反铁磁(AFM)状态,Ni掺杂时,DMS的磁性非常不稳定;在TM掺杂的 I III VI2 的DMS中,Cr、Mn掺杂的 CuGaS2 和 CuGaSe2将表现为FM状态,而当V、Fe、Co或Ni掺杂时,Cu(Ga,TM)S2 和Cu(Ga,TM)Se2 则表现了AFM性质.Cr掺杂的I IV V 以及 I III VI 黄铜矿半导体将可能出现较高的居里温度(Tc).

关键词：稀磁半导体过渡金属双交换作用黄铜矿计算方法磁性稳定性

Norwegian scabies presenting as erythroderma:A case report

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World Journal of Clinical Cases 2024年第21期12卷 4802-4806页

作者： Hai-Ju Chen chun-Ying Lu Guo-mei huang Lu-Lu Tang Department of Dermatology and Venereology The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007Guangxi Zhuang Autonomous RegionChina

BACKGROUND Norwegian scabies(NS)is a serious parasitic skin *** NS is one of the causes of erythroderma,it is frequently ***,it is essential to raise awareness regarding NS presenting as *** SUMMARY We present a case of NS that persisted for more than 3 *** following nonstandard treatment,the patient’s rash worsened and gradually progressed into ***,NS was diagnosed by skin microscopy and *** When patients with pruritic dermatosis have high-risk factors such as prolonged bed rest and immunodeficiency,clinicians need to enhance their awareness of NS and ensure prompt diagnosis and treatment.

关键词： Norwegian scabies Crusted scabies Erythroderma Diagnosis Case report

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社会资本的经济学界定、构成与属性

当代财经 2007年第3期 17-20页

作者：李晓红黄春梅西南财经大学经济学院四川成都610074 江西经济管理干部学院江西南昌330020

从经济学的视角看,社会资本是嵌入到关系网络中的历史传统、价值理念、行为规范、认知模式和行为范式以及网络成员获得资源的能力的综合。社会资本由两个维度构成:关系维度和认知维度。相应地,社会资本包括两种类型:关系型社会资本和认... 详细信息

从经济学的视角看,社会资本是嵌入到关系网络中的历史传统、价值理念、行为规范、认知模式和行为范式以及网络成员获得资源的能力的综合。社会资本由两个维度构成:关系维度和认知维度。相应地,社会资本包括两种类型:关系型社会资本和认知型社会资本。制度属性和资本属性是社会资本的两种属性。社会资本的关系维度决定了认知维度,但是认知维度会反作用于关系维度;同样,制度属性决定了资本属性,而资本属性会反作用于制度属性。关系维度对应着资本属性,认知维度对应着制度属性。通过关系网络获得资源的能力是关系型社会资本,对应着社会资本的资本属性;因为认知的同质性而获得的增加产出的可能,是认知型社会资本,对应着社会资本的制度属性。

关键词：社会资本关系型社会资本认知型社会资本关系维度认知维度

Current knowledge for the risk factors of early permanent pacemaker implantation following transcatheter aortic valve replacement and what is next for the primary prevention?

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World Journal of Cardiology 2024年第2期16卷 54-57页

作者： Gen-Min Lin Wei-chun huang Chih-Lu Han Department of Medicine Hualien Armed Forces General HospitalHualien 970Taiwan Cardiovascular Center Kaohsiung Veterans General HospitalKaohsiung 81346Taiwan Department of Medicine Taipei Veterans General HospitalTaipei 112Taiwan

In this editorial,we comprehensively summarized the preoperative risk factors of early permanent pacemaker implantation after transcatheter aortic valve replacement(TAVR)among patients with severe aortic stenosis from several renowned clinical studies and focused on the primary prevention of managing the modifiable factors,e.g.,paroxysmal atrial fibrillation before the TAVR.

关键词： Permanent pacemaker implantation Transcatheter aortic valve replacement Interventricular conduction delay Diabetes Supraventricular arrhythmia

Enzymatically controlled DNA tetrahedron nanoprobes for specific imaging of ATP in tumor

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Chinese Chemical Letters 2024年第8期35卷 221-224页

作者： Xiaohong Wen mei Yang Lie Li Mingmin huang Wei Cui Suping Li Haiyan Chen Chen Li Qiuping Guo College of Biology State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringKey Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan ProvinceHunan UniversityChangsha 410082China

Intracellular ATP is an emerging biomarker for cancer early diagnosis because it is a key messenger for regulating the proliferation and migration of cancer ***,the conventional ATP biosensing strat-egy is often limited by the undesired on-target off-tumor ***,we reported a novel strategy to design enzymatically controlled DNA tetrahedron nanoprobes(En-DT)for biosensing and imaging ATP in tumor *** En-DT was designed via rational engineering of structure-switching aptamers with the incorporation of an enzyme-activatable site and further conjugation on the DNA *** En-DT could be catalytically activated by apurinic/apyrimidinic endonuclease 1(APE1)in cancer cells,but they did not respond to ATP in normal cells,thereby enabling cancer-specific ATP biosensing and imaging in vitro and in vivo with improved tumor *** strategy would facilitate the precise detection of a broad range of biomarker in tumors and may promote the development of smart probes for cancer diagnosis.

关键词： Enzyme-controlled APE1 DNA tetrahedron Cancer-specific ATP biosensing

Prevalence and Genomic Characterization of Multidrug-Resistant Salmonella enterica Serovar Kentucky Sequence Type 198 Circulating — Beijing Municipality, China, 2016–2023

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China CDC weekly 2024年第33期6卷 825-833页

作者： mei Qu Ying huang Bing Lyu Xin Zhang Yi Tian Zhaomin Feng Zhiyong Gao Daitao Zhang Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing Center for Disease Prevention and ControlBeijingChina

Introduction Highly fluoroquinolone-resistant Salmonella enterica serovar Kentucky(***)of sequence type(ST)198 has emerged as a global multidrug-resistant(MDR)clone,posing a threat to public *** Whole genome sequencing and antibiotic susceptibility testing was used to characterize the population structure and evolutionary history of 54 *** isolates recovered from food and human clinical cases in Beijing from 2016 to *** All 54 *** ST198 isolates exhibited resistance to quinolones,carrying point mutations in the quinolone resistance-determining regions(gyrA_S83F and parC_S80I).Resistance to other antibiotics(folate pathway inhibitors,cephems,aminoglycosides,phenicols,rifamycin,fosfomycin,macrolides,and tetracyclines),mediated by the sul1,sul2,dfrA14,blaCTX-M,blaTEM-1B,aac(3)-Id,aadA2,aadA7,aph(3')-I,aph(3'')-Ib,rmtB,floR,arr-2,fosA,mph(A),and tet(A)genes,was also observed in different *** Beijing *** ST198 evolutionary tree was divided into clades 198.2-1 and 198.2-2,which were further differentiated into three subclades:198.2-2A,198.2-2B,and *** with the extended-spectrumβ-lactamase-encoding gene blaCTX-M-14b in 198.2-1,the co-existence of blaCTX-M-55 and blaTEM-1B,as well as chromosomally located qnrS1,was detected in most 198.2-2 isolates,which showed more complex MDR *** ST198 outbreak isolates derived from two predominant clonal sources:198.2-1 with cgST236434 and 198.2-2A with *** The *** population in Beijing is genetically diverse,consisting of multiple co-circulating lineages that have persisted since *** surveillance of food and humans will aid in implementing measures to prevent and control the spread of AMR.

关键词： Kentucky predominant Whole

Comprehensive analysis of the protein phosphatase 2A regulatory subunit B56ε in pan-cancer and its role and mechanism in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 475-492页

作者： Hong-mei Wu Yuan-Yuan huang Yu-Qiu Xu Wei-Lai Xiang Chang Yang Ru-Yuan Liu Di Li Xue-Feng Guo Zheng-Bao Zhang chun-Hua Bei Sheng-Kui Tan Xiao-Nian Zhu Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health Guilin Medical UniversityGuilin 541199Guangxi Zhuang Autonomous RegionChina

BACKGROUND B56εis a regulatory subunit of the serine/threonine protein phosphatase 2A,which is abnormally expressed in tumors and regulates various tumor cell *** present,the application of B56εin pan-cancer lacks a comprehensive analysis,and its role and mechanism in hepatocellular carcinoma(HCC)are still *** Cancer Genome Atlas,Genotype-Tissue Expression,Gene Expression Profiling Interactive Analysis,and Tumor Immune Estimation Resource databases were used to analyze B56εexpression,prognostic mutations,somatic copy number alterations,and tumor immune characteristics in 33 *** relationships between B56εexpression levels and drug sensitivity,immuno-therapy,immune checkpoints,and human leukocyte antigen(HLA)-related genes were further *** Set Enrichment Analysis(GSEA)was performed to reveal the role of B56εin *** Cell Counting Kit-8,plate cloning,wound healing,and transwell assays were conducted to assess the effects of B56εinterference on the malignant behavior of HCC *** In most tumors,B56εexpression was upregulated,and high B56εexpression was a risk factor for adrenocortical cancer,HCC,pancreatic adenocarcinoma,and pheochromocytoma and paraganglioma(all P<0.05).B56εexpression levels were correlated with a variety of immune cells,such as T helper 17 cells,B cells,and *** was a positive correlation between B56εexpression levels with immune checkpoint genes and HLA-related genes(all P<0.05).The expression of B56εwas negatively correlated with the sensitivity of most chemotherapy drugs,but a small number showed a positive correlation(all P<0.05).GSEA analysis showed that B56εexpression was related to the cancer pathway,p53 downstream pathway,and interleukin-mediated signaling in *** of B56εexpression in HCC cells inhibited the proliferation,migration,and invasion capacity of tumor *** Tip:The expression of protein phosphatase 2A(PP2A)subunit B56εis up-regulated in most tumors,and its high

关键词： B56ε Prognosis Tumor microenvironment Immune infiltration Immunotherapy Hepatocellular carcinoma

Z-scheme Bi_(4)O_(5)Br_(2)/NH_(2)-MIL-125(Ti)heterojunctions enable exceptional visible photocatalytic degradation of organic pollutant

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Rare Metals 2024年第7期43卷 3161-3172页

作者： Feng huang Muhammad Humayun Gang Li Ting-Ting Fan Wen-Lin Wang Yu-Lin Cao Anton Nikiforov chun-Dong Wang Jing Wang Key Laboratory of Analytical Science and Technology of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationState Key Laboratory of New Pharmaceutical Preparations and ExcipientsCollege of Chemistry and Materials ScienceHebei UniversityBaoding071002China Energy Water and Environment LabCollege of Humanities and SciencesPrince Sultan University11586 RiyadhSaudi Arabia Baoding Green Yijia Environmental Protection Technology Ltd Baoding 071051China Physics Laboratory Industrial Training CenterShenzhen Polytechnic UniversityShenzhen 518055China Department of Applied Physics Ghent University9000 GhentBelgium School of Integrated Circuits Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China

One key strategy to enhance photocatalytic performance is to improve the transfer and separation efficiency of photogenerated carriers by building optimized ***,novel Bi_(4)O_5Br_(2)/NH_(2)-MIL-125(Ti)Z-scheme heterojunctions are fabricated and used as photocatalysts for organic pollutant *** NH_(2)-MIL-125(Ti)nanosheets are exfoliated via a self-developed alkali solution stripping approach and then uniformly decorated on Bi_(4)O_(5)Br_(2).The as-prepared Bi_(4)O_(5)Br_(2)/NH_(2)-MIL-125(Ti)presents more than 90%degradation of various pollutants,outperforming the counterpart individual *** various characterization results suggest that the enhanced degradation rate is due to the more intimate face-to-face interfacial contact of the lamellar Z-scheme heterojunction materials,in which the migration path of carriers from the material's interior to the surface can be reduced,in turn enhancing migration efficiency and separation capability significantly.A possible photocatalytic reaction mechanism is proposed based on the photoelectric behaviors,radical trapping experiments and liquid chromatography mass spectrometry *** work promotes the development of new photocatalytic materials for heterojunctions with face-to-face interfacial contacts,as well as the effective purification of wastewater in environmental remediation.

关键词： Z-scheme heterojunctions Photocatalysis Alkaline solution stripping Bi_(4)O_(5)Br_(2) NH_(2)-MIL-125(Ti)