检索结果-南通市图书馆

Effects of preoperative ketamine on the endocrine-metabolic and inflammatory response to laparoscopic surgery

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2011年第22期124卷 3721-3725页

作者： DU jin huang yu-guang yu Xue-rong ZHAO Na Department of Anaesthesiology Subei People＇s Hospital Yangzhou University Yangzhou Jiangsu 225001 China

Background Ketamine is hypothesized to reduce perioperative endocrine-metabolic and inflammatory responses in cardiac surgery patients. This randomized, placebo-controlled, double-blind study was performed to determine whether perioperative endocrine-metabolic and inflammatory responses are attenuated by preoperative administration of ketamine to healthy females receiving elective laparoscopic surgery. Methods Forty female patients with American Society of Anesthesiologist classification Ⅰ or Ⅱwho elected to receive gynecological laparoscopic surgery were randomly assigned to the ketamine-treated （group K; n = 20） or control （group C n = 20） group. At 2 minutes prior to induction patients in group K received ketamine （0.25 mg/kg） whereas those in group C received normal saline. All patients received standardized general anesthesia. Serum glucose and cortisol values were measured before ketamine administration （TO）, 2 minutes after tracheal intubation （T1）, 30 minutes after skin incision （T2）, 2 minutes after tracheal extubation （T3） and 1 hour postoperatively （T4）. Serum interleukin-6 and tumor necrosis factor-α values were determined at TO and T4. Postoperative analgesic efficacy, side effects of administered drugs, and time to discharge were recorded. Results Compared with subjects in group C, those in group K had lower serum glucose values at T1, T2, T3 and T4 and lower serum cortisol values at T4 （P 〈0.05）. Postoperative interleukin-6 and tumor necrosis factor-α concentrations for group K were lower than those for group C （P 〈0.05）. Postoperative visual analog scale scores at rest, cumulative fentanyl consumption, and time to discharge were lower in group K as compared to group C （P 〈0.05）. No significant differences in drug side effects were observed postoperatively between the two groups. Conclusion Endocrine-metabolic and inflammatory responses to laparoscopic surgery are attenuated in part by Dre-incisienal administration of ketamine.

关键词： endocrine-metabolic response inflammatory response ketamine laparoscopic surgery preemptive analgesia

Shexiang Tongxin Dropping Pill(麝香通心滴丸)Reduces Coronary Microembolization in Rats via Regulation of Mitochondrial Permeability Transition Pore Opening and AKT-GSK3βPhosphorylation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2021年第7期27卷 527-533页

作者： DING yu ZHU Hou-yong ZHANG Li-zong GAO Bei-bei ZHOU Liang huang jin-yu Central Laboratory Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou310006China Department of Cardiology Hangzhou Chinese Medical HospitalHangzhou310007China Experimental Animal Research Center Zhejiang Chinese Medical UniversityHangzhou310053China Department of Cardiology Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou310006China

Objective To investigate the protective effects of Shexiang Tongxin Dropping Pill(麝香通心滴丸,STDP)following sodium laurate-induced coronary microembolization(CME)in *** Forty rats were divided into 4 groups:the control(sham)group,CME group,low-dose STDP pretreatment group(20 mg·kg^(−1)·d^(−1)),and high-dose STDP pretreatment group(40 mg·kg^(−1)·d^(−1)).The rats were intragastric administrated with STDP 2 weeks before ***,the histopathological alterations were observed using optical microscopy and transmission electron *** biomarkers were analyzed by enzyme-linked immunosorbent *** functions including the mitochondrial permeability transition pore(mPTP)mtDNA copy number were determined and proteins of AKT/GSK3βwere analyzed by Western *** The rats in the CME group showed a significant increase in the fibrinogen-like protein 2 expression level and mitochondrial dysfunction and a decrease in the expression level of antioxidant biomarkers(superoxide dismutase and catalase,P<0.01 for all).In contrast,the rats in the low-and high-dose STDP pretreatment groups showed a significant decrease in coronary microthrombi(P<0.05);moreover,STDP restored the antioxidant-related protein activities and mitochondrial function,inhibited mPTP opening,decreased AKT-Ser473 phosphorylation,and increased GSK3β-Ser9 phosphorylation(P<0.05 or P<0.01).Conclusion STDP may be useful for treatment of CME,possibly via regulation of mPTP opening and AKT/GSK3βphosphorylation.

关键词： Shexiang Tongxin Dropping Pill Chinese medicine coronary microembolization mitochondrial permeability transition pore AKT GSK3β

Palladium complex catalyzed rearrangement of allylic sulfinates

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1984年第2期 185-187页

作者： LU Xi-Yan huang yu-jin Shanghai Institute of Organic Chemistry,Academia Sinica

In a systematic study of the reactions between allylic esters of hetero-atom acids andlow valent transition metal complexes,we found that allylic sulfinates can easily rearrangeto the corresponding sulfones by the catalysis of Pd(PPh3)*** reaction can be carriedout at lower temperature,in shorter time and with a higher yield than that of the correspondingthermal reaction.

关键词： Ph Palladium complex catalyzed rearrangement of allylic sulfinates

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

白附子的研究进展

中草药 2015年第18期46卷 2816-2822页

作者：黄金钰戴忠马双成中国药科大学江苏南京211198 中国食品药品检定研究院北京100050

白附子为天南星科犁头尖属植物独角莲Typhonium giganteum的干燥块茎,临床上多用于治疗肿瘤、中风、三叉神经痛、面瘫等,但其具体的药效、毒性成分及药理机制尚不明确。通过对国内外文献研究与分析,对白附子的本草考证及药典沿革、化学... 详细信息

白附子为天南星科犁头尖属植物独角莲Typhonium giganteum的干燥块茎,临床上多用于治疗肿瘤、中风、三叉神经痛、面瘫等,但其具体的药效、毒性成分及药理机制尚不明确。通过对国内外文献研究与分析,对白附子的本草考证及药典沿革、化学成分、药理毒理作用、炮制工艺、质量控制等方面进行了较全面的综述,为合理开发白附子药用价值提供参考。

关键词：白附子本草考证苷类化合物抗肿瘤炮制质量控制

在线全文

学校读者我要写书评

暂无评论

高校学科带头人的类型、特征及成长路径

教育理论与实践 2016年第21期36卷 3-5页

作者：郑友训黄金煜江南大学教育系

高校学科带头人肩负着学科建设与发展、培养创新人才等重任。依据不同分类标准,其类型也有所不同。但他们都拥有较高的学术影响力、杰出的团队领导力、独特的人格魅力和培养创新人才的能力。根据组织生命周期理论,高校学科带头人大致会... 详细信息

高校学科带头人肩负着学科建设与发展、培养创新人才等重任。依据不同分类标准,其类型也有所不同。但他们都拥有较高的学术影响力、杰出的团队领导力、独特的人格魅力和培养创新人才的能力。根据组织生命周期理论,高校学科带头人大致会经历初任、成长、胜任、更迭阶段。初任阶段的学科带头人应扎根学术,拓展国际视野;成长阶段的学科带头人应整合各种资源,提高自身领导力;胜任阶段的学科带头人应注重建设创新团队,形成学科文化;更迭阶段的学科带头人则应总结经验,着力培养下一代学科带头人。

关键词：高校学科带头人初任阶段成长阶段胜任阶段更迭阶段成长路径

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang yu-Wen Alvin huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi huang Mingwei Zhao Shuling Liao Quanhong Yang Nianjun Yang Siyu yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Flexible supercapacitors High-temperature tolerance Gel polymer electrolytes Electrode materials

金砖国家合作机制对全球经济治理体系与机制创新的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

亚太经济 2015年第3期 3-8页

作者：王厚双关昊黄金宇辽宁大学经济学院辽宁大学国际关系学院

2008年全球金融危机的爆发要求对全球经济失衡进行深度治理,而要对全球经济失衡进行深度治理就必须对传统的全球经济治理体系与机制进行改革与创新。金砖国家合作机制的构建,对倒逼传统的全球经济治理体系与机制的改革与创新正在发挥越... 详细信息

2008年全球金融危机的爆发要求对全球经济失衡进行深度治理,而要对全球经济失衡进行深度治理就必须对传统的全球经济治理体系与机制进行改革与创新。金砖国家合作机制的构建,对倒逼传统的全球经济治理体系与机制的改革与创新正在发挥越来越重要的积极作用。虽然仍存在着不少影响金砖国家合作机制运行及其对全球经济治理体系与机制改革与创新的不确定因素,但随着金砖国家合作机制的进一步深化,金砖国家合作机制将在更大范围上对全球经济治理体系与机制改革与创新产生重要影响。

关键词：金砖国家合作机制全球经济治理体系与机制影响

在线全文

学校读者我要写书评

暂无评论

一种分布式计费管理系统的设计及实现

小型微型计算机系统 2005年第4期26卷 589-592页

作者：黄瑾瑜熊焰华蓓中国科学技术大学计算机系安徽合肥230026

Internet网络通信费由使用者承担的政策使得网络计费成为使用网络的一个前提,而随着网络规模的扩大,传统的集中式计费管理暴露出了许多缺点.本文提出了一种基于移动代理(mobileagent)分布式计费管理的体系结构;详细介绍了采用移动代理... 详细信息

Internet网络通信费由使用者承担的政策使得网络计费成为使用网络的一个前提,而随着网络规模的扩大,传统的集中式计费管理暴露出了许多缺点.本文提出了一种基于移动代理(mobileagent)分布式计费管理的体系结构;详细介绍了采用移动代理技术对计费管理中数据收集和数据统计进行分布式处理的设计与实现;给出了分布式计费管理系统在我校校园网上的实验结果.

关键词：分布式计费 SNMP协议移动代理