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BRIGHT:the three-dimensional X-ray crystal Bragg diffraction code

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Nuclear Science and Techniques 2019年第3期30卷 28-36页

作者： Nan-shun huang Kai Li Hai-Xiao Deng Shanghai Institute of Applied Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Physics The University of Chicago

In pursuit of a fully coherent X-ray free-electron laser(FEL), highly reflective Bragg crystals are used and will be used as a highly selective spectral filter in hard X-ray self-seeding FELs and X-ray FEL oscillators(XFELO), respectively. However, currently, when simulating self-seeding and XFELO, the three-dimensional effect of Bragg diffraction is not fully considered. In this paper, we derive a comprehensive solution for the response function of the crystal in Bragg diffraction. A three-dimensional X-ray crystal Bragg diffraction code, named BRIGHT, is introduced, which can be combined with other FEL-related codes, e.g., GENESIS and OPC. Performance and feasibility are assessed using two numerical examples,namely a self-seeding experiment for the linac coherent light source and XFELO options for Shanghai high repetition rate XFEL. The results indicate that BRIGHT provides a new and useful tool for three-dimensional modeling of FEL.

关键词： X-ray Bragg diffraction Self-seeding XFELO

Augmenter of Liver Regeneration Monoclonal Antibody Promotes Apoptosis of Hepatocellular Carcinoma Cells

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 605-613页

作者： Li-Li huang Fei-Yang Luo Wen-Qi huang Hui Guo Qi Liu Ling Zhang Ai-shun jin Hang Sun Department of Nephrology The Second Affiliated HospitalChongqing Medical UniversityChongqingChina Department of Immunology College of Basic MedicineChongqing Medical UniversityChongqingChina Key Laboratory of Molecular Biology for Infectious Diseases Ministry of EducationInstitute for Viral HepatitisThe Second Affiliated Hospital of Chong-qing Medical UniversityChongqingChina

Background and Aims: Hepatocellular carcinoma (HCC) is one of the most common types of cancer, often resulting in death. Augmenter of liver regeneration (ALR), a widely expressed multifunctional protein, has roles in liver dis-ease. In our previous study, we reported that ALR knock-down inhibited cell proliferation and promoted cell death. However, there is no study on the roles of ALR in HCC. Methods: We used in vitro and in vivo models to inves-tigate the effects of ALR in HCC as well as its mechanism of action. We produced and characterized a human ALR-specific monoclonal antibody (mAb) and investigated the effects of the mAb in HCC cells. Results: The purified ALR-specific mAb matched the predicted molecular weight of IgG heavy and light chains. Thereafter, we used the ALR-specific mAb as a therapeutic strategy to suppress tumor growth in nude mice. Additionally, we assessed the prolif-eration and viability of three HCC cell lines, Hep G2, Huh-7, and MHC97-H, treated with the ALR-specific mAb. Com-pared with controls, tumor growth was inhibited in mice treated with the ALR-specific mAb at 5 mg/kg, as shown by hematoxylin and eosin staining and terminal deoxynu-cleotidyl transferase dUTP nick end labeling. Simultaneous treatment with the ALR-specific mAb and adriamycin pro-moted apoptosis, whereas treatment with the ALR-specific mAb alone inhibited cell proliferation. Conclusions: The ALR-specific mAb might be a novel therapy for HCC by blocking extracellular ALR.

关键词： Hepatocellular carcinoma Augmenter of liver regeneration Mono-clonal antibody Apoptosis

Factors influencing postoperative anxiety and depression following Iodine-131 treatment in patients with differentiated thyroid cancer:A cross-sectional study

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World Journal of Psychiatry 2023年第7期13卷 486-494页

作者： Ying-Rui Su Xiao-Peng Yu Li-Qun huang Long Xie jin-shun Zha Department of Nuclear Medicine The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND Differentiated thyroid cancer(DTC)often seriously impacts patients’*** Iodine-131(131I)is widely used in treating patients with ***,most patients know little about radionuclide therapy,and the treatment needs to be performed in a special isolation ward,which can cause anxiety and *** To explore anxiety and depression status and their influencing factors after 131I treatment in patients with *** A questionnaire survey was conducted among postoperative patients with DTC who received 131I treatment at our hospital from June 2020 to December *** patient data were collected using a self-administered demographic characteristics *** self-rating depression scale and self-rating anxiety scale were used to determine whether patients were worried about their symptoms and the degree of anxiety and *** patients were categorized into anxiety,non-anxiety,depression,and non-depression *** and multiple-variable analyses were used to determine the risk factors for anxiety and depression in patients with thyroid cancer after *** A total of 144 patients were included in this *** baseline mean score of self-rating anxiety and depression scales were 50.06±16.10 and 50.96±16.55,***,48.62%(70/144)had anxiety and 47.22%(68/144)of the patients had ***,age,education level,marital status,household income,underlying diseases,and medication compliance significantly differed among groups(P<0.05).Furthermore,multivariate logistic regression analysis showed that education level,per capita monthly household income,and medication compliance level affected anxiety(P=0.015,0.001,and 0.001 respectively).Patient’s sex,marital status,and underlying diseases affected depression(P=0.007,0.001,and 0.009,respectively).CONCLUSION Nursing interventions aiming at reducing the risk of anxiety and depression should target unmarried female patients with low education

关键词： Iodine-131 Thyroid gland Neoplasms Anxiety Depression Prognosis

Tetrahydrofuran Ring-opening with Acyloxyphosphonium Bromide Catalyzed by Zinc Bromide: An Effective Method for the Preparation of 4-Bromobutyl Esters

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Chinese Chemical Letters 2002年第7期13卷 589-592页

作者： Hua Yue WU jin Chang DING shun WANG Department of Chemistry Wenzhou Normal CollegeWenzhou 325027

Catalyzed by zinc bromide, tetrahydrofuran ring can be opened with acyloxyphos- phonium bromide generated in situ to afford 4-bromobutyl esters under mild conditions in good to excellent yields.

关键词： Zinc bromide tetrahydrofuran ring acyloxyphosphonium bromide 4-bromobutyl esters.

Even and Odd Coherent States for Time-Dependent Harmonic Oscillator

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Communications in Theoretical Physics 2002年第7期38卷 25-30页

作者： WEI Lian-Fu YANG Qing-Yi WANG shun-jin Department of Physics Shanghai Jiao Tong University Shanghai 200030 China Department of Physics Guangxi University Nanning 530003 China Institute of Physics Southwest Jiao Tong University Chengdu 610031 China Department of Modern Physics Lanzhou University Lanzhou 730000 China

The dynamical invariant for a general time-dependent harmonic oscillator is constructed by making use of two linearly independent solutions to the classical equation of motion. In terms of this dynamical invariant we define the time-dependent creation and annihilation operators and relevantly introduce even and odd coherent states for time dependent harmonic oscillator. The mathematical and quantum statistical properties of these states are discussed in detail. The harmonic oscillator with periodically varying frequency is treated as a demonstration of our general approach.

关键词： even and odd coherent states, time-dependent harmonic oscillator, dynamical invariant

Role of Ru on the Microstructural Evolution During Long-Term Aging of Ni-Based Single Crystal Superalloys

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Acta Metallurgica Sinica(English Letters) 2020年第12期33卷 1689-1698页

作者： Wei Song Xin-Guang Wang jin-Guo Li Ye-shun huang Jie Meng Yan-Hong Yang jin-Lai Liu Ji-De Liu Yi-Zhou Zhou Xiao-Feng Sun Superalloys Division Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Two experimental alloys containing diff erent contents of Ru were investigated to study the eff ect of Ru on the microstructural evolution during long-term thermal *** increase in Ru promoted the formation of cubical,tiny,and evenγ′phase after full heat ***,the samples after full heat treatment were exposed at 1100℃ for diff erent *** on the classical model by Lifshitz,Slyozov,and Wagner,the coarsening ofγ′phase of the alloy containing 2.5 and3.5 wt.%Ru during the long-term aging was controlled by the interface reaction and diff usion,***γ/γ′lattice misfi t was more negative with the increment of Ru addition,which induced the formation of stable raftedγ′phase in the alloy containing 3.5 wt.%Ru at the initiation of long-term ***,the increase in Ru reduced the diff usion coeffi cient,which could restrain theγ′phase *** lowerγ/γ′lattice misfi t of the alloy containing 2.5 wt.%Ru promoted the interface reaction,which induced the rapid coarsening ofγ′***,the increase in Ru improved the microstructural stability of the *** the other hand,the raise of Ru induced"reverse partitioning"behavior,which was eff ective in suppressing the emergence of the topologically close-packed phase(TCP phase).The TCP phase occasionally occurred in the alloy containing 2.5 wt.%Ru,which was attributed to the high temperature and the supersaturation of theγ***,the TCP phase was determined asμphase,which had a high concentration of Co,Re,Mo,and W.A sketch map describing the evolution of the TCP phase was also constructed.

关键词： Ni-based superalloys Ruthenium Coarsening TCP phase

Quantum phase transition of the Jaynes-Cummings model

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 1-9页

作者： Cheng Liu jin-Feng huang Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Key Laboratory for Matter Microstructure and Function of Hunan ProvinceDepartment of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsInstitute of Interdisciplinary StudiesHunan Normal UniversityChangsha 410081China

Herein,we propose an experimentally feasible scheme to show the quantum phase transition of the Jaynes-Cummings(JC)model by modulating the transition frequency of a two-level system in a quantum Rabi model with strong *** tuning the modulation frequency and amplitude,the ratio of the effective coupling strength of the rotating terms to the effective cavity(atomic transition)frequency can enter the deep-strong coupling regime,while the counter-rotating terms can be ***,a deep-strong JC model is *** ratio of the coupling strength to resonance frequencies in the deep-strong JC model is two orders of magnitude larger than the corresponding ratio in the original quantum Rabi *** scheme can be employed in atom-cavity resonance and off-resonance cases,and it is valid over a broad *** nonzero average cavity photons of the ground state indicate the emergence of a quantum phase ***,we demonstrate the dependence of the phase diagram on the atom-cavity detuning and modulation *** the parameters used in our scheme are within the reach of current experimental *** scheme provides a new mechanism for investigating the critical phenomena of finite-sized systems without requiring classical field limits,thereby opening a door for studying fundamental quantum phenomena occurring in the ultrastrong and even deep-strong coupling regimes.

关键词： Jaynes-Cummings model quantum phase transition frequency modulation

Antitumor and antimicrobial activities of endophytic fungi from medicinal parts of Aquilaria sinensis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第5期12卷 385-392页

作者： jin-long CUI shun-xing GUO Pei-gen XIAO Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193 China

The purpose of this study was to isolate and characterize endophytic fungi from the stem tissue which can produce fragrant ingredients in Aquilaria sinensis(also called agarwood) to determine their antitumor and antimicrobial ***-eight fungal endophytes were isolated from agarwood by strict sterile sample preparation and were classified into 14 genera and 4 taxonomic classes(Sordariomycetes,Dothideomycetes,Saccharomycetes,and Zy-gomycetes) based on molecular *** the 28 isolates,13(46.4%) showed antimicrobial activity against at least one of the test strains by the agar well diffusion method,and 23 isolates(82.1%) displayed antitumor activity against at least one of five cancer cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) *** diameters of inhibition zones of YNAS07,YNAS14,HNAS04,HNAS05,HNAS08,and HNAS11 were equal to or higher than 14.0 mm against Staphylococcus aureus,Escherichia coli,Bacillus subtilis,***,Aspergillus fumigatus,and ***,*** inhibition rates of YNAS06,YNAS08,and HNAS06 were not less than 60% to 293-T,293-T,and SKVO3 cells,*** results suggest that the endophytic fungi associated with agarwood will provide us with not only useful micro-ecological information,but also potential antimicrobial and anti-tumor agents.

关键词： Agar diffusion method Agarwood Antimicrobial bioactivity Antitumor bioactivity Endophytic fungi

Light Flavor Vector and Pseudo Vector Mesons from a Light-Cone QCD Inspired Effective Hamiltonian Model with SU（3） Flavor Mixing Interactions

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Chinese Physics Letters 2010年第6期27卷 37-39页

作者： GUO Xiao-Bo TAO Jun LI Lei WANG shun-jin Center of Theoretical Physics School of Physics and Technology Sichuan University Chengdu 610064 School of Science Southwest University of Science and Technology Mianyang 621010 Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator Lanzhou 730000

Based on the light-cone effective Hamiltonian with confining potential and SU （3） flavor mixing interactions, the flavor mixing mesons on the u, d, and s quark sectors are investigated. The mass eigen equations of the flavor mixing vector and pseudo vector mesons are solved. The calculated masses are in good agreement with the experimental data.

关键词： PARTICLES (Nuclear physics) -- Flavor VECTOR mesons LIGHT cones QUANTUM chromodynamics HAMILTONIAN systems SUPERSYMMETRY (Physics)