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Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner

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Protein & Cell 2024年第1期15卷 36-51页

作者： Jinghui Lei Xiaoyu Jiang Daoyuan huang ying Jing Shanshan Yang Lingling Geng Yupeng Yan Fangshuo Zheng Fang Cheng Weiqi Zhang Juan Carlos Izpisua Belmonte Guang-hui Liu Si Wang Jing Qu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules CAs Center for Excellence in BiomacromoleculesInstitute of BiophysicsBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Aging Biomarker Consortium China Altos Labs San DiegoCA 92121United State

Hypoxia-inducible factor(HIF-1α),a core transcription factor responding to changes in cellular oxygen levels,is closely associated with a wide range of physiological and pathological ***,its differential impacts on vascular cell types and molecular programs modulating human vascular homeostasis and regeneration remain largely ***,we applied CRISPR/Cas9-mediated gene editing of human embryonic stem cells and directed differentiation to generate HIF-ia-deficient human vascular cells including vascular endothelial cells,vascular smooth muscle cells,and mesenchymal stem cells(MsCs),as a platform for discovering cell type-specific hypox-ia-induced response *** comparative molecular profiling across cell types under normoxic and hypoxic conditions,we provide insight into the indispensable role of HIF-1αin the promotion of ischemic vascular *** found human MSCs to be the vascular cell type most susceptible to HIF-1a deficiency,and that transcriptional inactivation of ANKZF1,an effector of HIF-1a,impaired pro-angiogenic ***,our findings deepen the understanding of HIF-ia in human angiogenesis and support further explorations of novel therapeutic strategies of vascular regeneration against ischemic damage.

关键词： HIF-1 human ESC vascular cell regeneration

Monomeric and self-assembled crystal phases of TNBT

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Rare Metals 2024年第10期43卷 5442-5448页

作者： Yun-hui Wu Hua-Bei You Wei-Kai Cui Zhi-Qian Cao Xiao Dong Zi-hui Meng Ming huang School of Chemistry and Chemical Engineering Beijing Institute of Technology Institute of Chemical Materials China Academy of Engineering Physics

（3,3′,5,5′-Tetranitro-4,4′-bi-1,2,4-Triazole） TNBT was designed and predicted more than three decades ago as a high energy *** with many other designed molecules,TNBT has not been successfully synthesized and has not been computationally studied in *** this work,theoretical calculations at density functional theory （DFT）level of theory were carried out for both the gas phase molecule and its possible bulk crystal *** （DFT） computations show that TNBT is comparable to CL-20 with high bulk density,

关键词： Density functional theory

Stable hydrogen-bonded organic frameworks and their photo-and electro-responses

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Nano Research 2024年第8期17卷 7675-7699页

作者： ying Hou Xin-Song huang Sheng-Hao Gong Chen Liu Yangyang Liu Tian-Fu Liu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry and Biochemistry California State UniversityLos AngelesCalifornia 90032USA College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China

Hydrogen-bonded organic frameworks(HOFs)are a recent class of porous materials that have garnered considerable research interest owing to their distinctive *** can be constructed through judicious selection of H-bonding motifs,which are further enforced by other weak intermolecular interactions such asπ–πstacking,van der Waals forces,and framework *** advantage of these interactions,we can expand the functional field of HOFs by introducing active ***,researchers have made substantial advancements in using HOFs for chemical sensing,catalysis,proton conduction,biological applications,and *** low bonding energy of H-bonds allows for precise control over the concentration of ligands in solvents,forming diverse HOF *** varied structures offer significant advantages for producing HOFs with photo-responsive and electro-responsive ***,the presence of H-bonds in HOFs results in their inherent lower stability compared to metal-organic frameworks(MOFs)and covalent-organic frameworks(COFs)formed via coordination and covalent bonds,*** a result,the pursuit of stable and innovative HOF materials with novel functional sites remains an ongoing *** review provides an overview of recent research progress in the development of new strategies for stable HOF synthesis and applications of HOFs with stimuli-responsive *** first classified all synthetic methods reported to date and discussed the stable HOFs synthesized,as well as their unique properties and *** addition,we summarized the applications of HOFs utilizing their synergistic responses to external stimuli,including photo,electrical,pressure,and chemical *** systematically reviewed stable HOF synthesis and applications,which may lead to a deeper understanding of the structure–activity relationship for these materials and guide future HOF design.

关键词： stable hydrogen-bonded organic frameworks(HOFs) photo-response electro-response photoelectric synergistic response

基质辅助激光解吸电离飞行时间质谱技术研究人血清转铁蛋白稳定性及裂解产物

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分析化学 2007年第6期35卷 791-796页

作者：卓慧钦金宏伟黄河清黄慧英蔡宗苇厦门大学生命科学学院细胞生物学与肿瘤细胞工程教育部重点实验室厦门大学生命科学学院附属中山医院临床检验中心香港浸会大学化学系

制备质谱纯人血清转铁蛋白(HTF),供分子结构分析。选用SDS-PAGE、胶外酶解、基质辅助激光解吸/电离质谱技术(MALDI-TOF)、数据库检索和比对技术鉴定铁饱和HTF、双铁HTF(HTF-2Fe3+)、单铁HTF(HTF-Fe3+)和脱铁HTF(apoHTF)的稳定性和裂解... 详细信息

制备质谱纯人血清转铁蛋白(HTF),供分子结构分析。选用SDS-PAGE、胶外酶解、基质辅助激光解吸/电离质谱技术(MALDI-TOF)、数据库检索和比对技术鉴定铁饱和HTF、双铁HTF(HTF-2Fe3+)、单铁HTF(HTF-Fe3+)和脱铁HTF(apoHTF)的稳定性和裂解产物。以乙腈溶液作为洗脱相,发现铁饱和HTF在RP-HPLC分离纯化过程中产生裂解现象。铁饱和HTF和HTF-2Fe3+经乙腈处理后均能产生不同分子量的短肽裂解产物,指出HTF结构稳定性与络合铁离子数量有关。铁组分改善了HTF分子结构的稳定性。采用比对法,研究在乙腈作用下HTF裂解成为各种各样短肽的规律,初步阐明其裂解机理。在乙腈作用下,HTF可能通过蛋白质去折叠途径,形成不同多聚态HTF或多肽裂解产物。推测目前用于临床诊断先天性糖基化紊乱(CDG)和慢性酒精滥用(CAA)疾病低准确率的起因可能是受HTF裂解产物或多聚体的干扰。

关键词：血清转铁蛋白基质辅助激光解吸电离飞行时间质谱胶内酶解反相高效液相色谱标志蛋白质

Microstructure Recrystallization and Mechanical Properties of a Cold-Rolled TiNbZrTaHf Refractory High-Entropy Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 633-647页

作者： Chuan Rong Jieren Yang Xiaoliang Zhao Ke huang ying Liu Xiaohong Wang Dongdong Zhu Ruirun Chen College of Materials Science and Engineering Sichuan UniversityChengdu610065China Key Laboratory of Air-Driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou324000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China

The equiatomic TiNbZrTaHf alloy was successfully rolled at room temperature with the reduction of ~ 85%. The microstructure and tensile properties were investigated after cold working and annealing. It was determined that the recrystallization temperature of the TiNbZrTaHf alloy between 850 and 900 ℃. Complete recrystallization and normal grain growth occurred, the high stability of single phase was maintained after annealing at 1000, 1200, and 1400 ℃. But the precipitated phase appeared after long term annealing, as seen after 500 h at 1000 ℃. After cold working, the tensile strength and the elongation of TiNbZrTaHf were 1137 MPa and 25.1%, respectively. The annealed alloy has a high tensile strength (σ_(b )= 863 MPa) and ductility (ε_(e )= 28.5%). Moreover, the oxidation of TiNbZrTaHf alloy at elevated temperatures has a significant impact on its mechanical properties. The poor oxidation resistance of TiNbZrTaHf can accelerate tensile failure by inducing fractures at grain boundaries.

关键词： Refractory high entropy alloy Cold rolling Recrystallization Oxidation resistance Mechanical properties

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异步电动机直接转矩控制系统的仿真研究

河南师范大学学报（自然科学版） 2011年第6期39卷 59-62页

作者：常晓颖黄会营洛阳理工学院电气工程与自动化系河南洛阳471023

针对异步电机交流调速的特点,利用闭环磁链观测器作为定子磁链观测装置,并应用MATLAB/Sim-ulink作为仿真工具,构建出异步电动机直接转矩控制系统的仿真模型.仿真结果证明了该方法的合理性、有效性.

关键词：直接转矩控制磁链观测器系统仿真

Application of three-dimensional speckle tracking technique in measuring left ventricular myocardial function in patients with diabetes

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World Journal of Diabetes 2024年第4期15卷 783-792页

作者： Zheng Li ying Qian Chun-Yun Fan Yong huang Department of Ultrasound The People’s Hospital of DanyangDanyang Hospital of Nantong UniversityDanyang 212300Jiangsu ProvinceChina Department of Endocrinology The People’s Hospital of DanyangDanyang Hospital of Nantong UniversityDanyang 212300Jiangsu ProvinceChina

BACKGROUND Diabetic cardiomyopathy is considered as a chronic complication of diabetes mellitus(DM).Therefore,early detection of left ventricular systolic function(LVSF)damage in DM is *** To explore the use of the three-dimensional speckle tracking technique(3D-STI)for measuring LVSF in DM patients via *** The electronic databases were retrieved from the initial accessible time to 29 April *** current study involved 9 studies,including 970 *** carried out this meta-analysis to estimate myocardial function in DM compared with controls according to myocardial strain attained by *** Night articles including 970 subjects were *** significant difference was detected in the left ventricular ejection fraction between the control and the diabetic group(P>0.05),while differences in global longitudinal strain,global circumferential strain,global radial strain,and global area strain were markedly different between the controls and DM patients(all P<0.05).CONCLUSION The 3D-STI could be applied to accurately measure early LVSF damage in patients with DM.

关键词： Diabetes mellitus Left ventricular systolic dysfunction Three-dimensional speckle tracking echocardiography Meta analysis

Astronomical influence of the development of Paleogene thin coal seam groups in offshore Lacustrine basins:A case study of the ZhuⅠDepression's Enping Formation located in the northern South China Sea

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Acta Oceanologica Sinica 2024年第4期43卷 136-150页

作者： Yan Liu Shengbing huang Dongdong Wang Nan Li Yuting Yin ying Chen Zengxue Li College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China CNOOC Research Institute Co. Ltd.Beijing 100028China School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTUK

The development of the Paleogene coal seams in China's offshore basin areas generally had the characteristics of coal measures with large thicknesses,large numbers of coal seams,thin single coal seams,poor stability,scattered vertical distribution,and a wide distribution *** study selected the Enping Formation of the ZhuⅠDepression in the northern section of the South China Sea as an example to determine the macro-control factors of the development of the Paleogene coal seam *** analysis was carried out on the influencing effects and patterns of the astronomical cycles related to the development of the thin coal seam groups in the region.A floating astronomical time scale of the Enping Formation was established,and the sedimentary time limit of the Enping Formation was determined to be approximately 6.15 Ma±.In addition,the cyclostratigraphy analysis results of the natural gamma-ray data of Well XJ in the Enping Formation of the Xijiang Sag revealed that the development of the thin coal seams had probably been affected by short eccentricity and precession *** formation process of coal seams was determined to have been affected by high seasonal contrast,precipitation,and *** the periods with high values of short eccentricity,the seasonal contrasts tended to be *** those periods,fluctuations in the precession controls resulted in periodic volume changes in precipitation and insolation of the region,resulting in the development of thin coal *** was also found that the periods with low precession were the most conducive to coal seam *** that basis,combined with such factors as sedimentary environmental conditions conducive to the development of thin coal seam groups,this study established a theoretical model of the comprehensive influences of short eccentricity and precession on the development and distribution of Paleogene thin coal seam groups in offshore lacustrine *** patterns of the Paleogene astrono

关键词： Paleogene Pearl(Zhujiang)River Mouth Basin coal seam development astronomical cycles

The Review of Land Use/Land Cover Mapping AI Methodology and Application in the Era of Remote Sensing Big Data

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Journal of Geodesy and Geoinformation Science 2024年第3期7卷 1-23页

作者： ZHANG Xinchang SHI Qian SUN ying huang Jianfeng HE Da College of Geography and Remote Sensing Sciences Xinjiang UniversityUrumqi 830017China School of Geography and Remote Sensing Guangzhou UniversityGuangzhou 510006China School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510006China School of Atmospheric Sciences Sun Yat-sen UniversityZhuhai 519082China

With the increasing number of remote sensing satellites,the diversification of observation modals,and the continuous advancement of artificial intelligence algorithms,historically opportunities have been brought to the applications of earth observation and information retrieval,including climate change monitoring,natural resource investigation,ecological environment protection,and territorial space *** the past decade,artificial intelligence technology represented by deep learning has made significant contributions to the field of Earth ***,this review will focus on the bottlenecks and development process of using deep learning methods for land use/land cover mapping of the Earth’s ***,it introduces the basic framework of semantic segmentation network models for land use/land cover ***,we summarize the development of semantic segmentation models in geographical field,focusing on spatial and semantic feature extraction,context relationship perception,multi-scale effects modelling,and the transferability of models under geographical ***,the application of semantic segmentation models in agricultural management,building boundary extraction,single tree segmentation and inter-species classification are ***,we discuss the future development prospects of deep learning technology in the context of remote sensing big data.

关键词： remote sensing big data deep learning semantic segmentation land use/land cover mapping