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比较视角下广东省生物医药产业集群竞争力分析和发展模式探索

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中国药物经济学 2024年第3期19卷 31-36,45页

作者：李伊玲黄慧莹黄满东张秋广东药科大学医药化工学院广州510006 广东药科大学医药商学院广州510006

目的探究广东省生物医药产业集群竞争力和未来发展模式。方法基于熵值法构建由规模、经营、绿色技术创新、成长竞争力组成的生物医药产业集群竞争力综合评价指标体系,分析2010—2020年广东省生物医药产业集群竞争力发展现状,并与浙江省... 详细信息

目的探究广东省生物医药产业集群竞争力和未来发展模式。方法基于熵值法构建由规模、经营、绿色技术创新、成长竞争力组成的生物医药产业集群竞争力综合评价指标体系,分析2010—2020年广东省生物医药产业集群竞争力发展现状,并与浙江省进行比较。结果现阶段广东省生物医药产业集群竞争力发展趋势与浙江省相似,但各项竞争力指标均低于浙江省,其中绿色技术创新竞争力与浙江省差距最大。结论广东省生物医药产业集群未来发展模式应以“链式”为导向,稳固政策、服务、金融链的优势基础,强化人才链的中坚作用,以绿色技术创新为核心的创新链驱动产业链高质量发展。

关键词：生物医药产业集群竞争力广东省模式

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乡村旅游对农户增收的影响

河北农业科学 2024年第4期28卷 11-15页

作者：王珺董孝斌黄惠英北京悦途出行科技(集团)股份有限公司北京100102 北京师范大学地理科学学部/北京师范大学地表过程与资源生态国家重点实验室北京100875 防灾科技学院经济管理学院河北廊坊065200

乡村旅游是我国乡村振兴战略实施的重要举措,是促进我国农村地区高质量发展的新模式。基于张家口崇礼区514份实地调研数据,采用双重差分模型、固态效应模型分别分析了乡村旅游对农户增收的影响、乡村旅游开发前后农户收入变化的影响因... 详细信息

乡村旅游是我国乡村振兴战略实施的重要举措,是促进我国农村地区高质量发展的新模式。基于张家口崇礼区514份实地调研数据,采用双重差分模型、固态效应模型分别分析了乡村旅游对农户增收的影响、乡村旅游开发前后农户收入变化的影响因素。结果表明:(1)乡村旅游项目开发后,参与组(参与旅游项目)和对照组(未参与旅游项目)农户的收入均有不同程度的提高,其中参与组农户的各项收入较对照组增长更多;转移性收入对参与组农户的总收入影响最大,工资性收入对对照组农户的总收入影响最大。乡村旅游项目分别在0.01、0.01、0.05水平上显著正向影响农户总收入(Y)、农户工资性收入(Y1)、农户财产性收入(Y3)。(2)年龄、文化水平、耕地面积、从事乡村旅游年限分别在0.1、0.1、0.01、0.01水平上显著正向影响农户总收入(Y);文化水平、从事乡村旅游年限分别在0.1、0.01水平上显著正向农户工资性收入(Y1);文化水平、耕地面积分别在0.1、0.01水平上显著正向影响农户财产性收入(Y3)。提出鼓励农户积极参与乡村旅游项目、营造宽松的就业环境、延伸乡村旅游产业链的对策建议。

关键词：乡村旅游农户增收

Translocation and recovery of 15N-labeled N derived from the foliar uptake of 15NH3 by the greenhouse tomato（Lycopersicon esculentum Mill.）

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Journal of Integrative Agriculture 2020年第3期19卷 859-865页

作者： huang hui-ying LI Huan XIANG Dan LIU Qing LI Fei LIANG Bin College of Resources and Environmental Sciences Qingdao Agricultural University

In order to completely evaluate ammonia emission from greenhouse vegetable fields,crop canopy absorption should not be *** foliar uptake of NH3 applied at two growth stages and the subsequent 15N-labeled N translocation to other plant components were investigated under greenhouse conditions using chambers covered with the soil of a tomato *** comprised three NH3-N application rates(70,140,and 210 mg/plot) using 15N-labeled ammonium *** were harvested immediately after exposure for 24 h,and the total N concentrations and 15N/14 N ratios were *** increased NH3 concentration,total 15NH3-N absorption increased considerably,whereas the applied 15NH3-N uptake decreased *** tomato plants absorbed 33-38% and 24-31% of the 15NH3-N generated at the anthesis and fruit growth stages,respectively.A total of 71-80% of the recovered NH3 was observed in the leaves and 20-30% of the recovered NH3 was remobilized to other *** them,an average of 10% of the absorbed 15NH3-N was transferred into the tomato *** these results indicated the potential of the tested tomatoes for the foliar uptake of atmospheric 15NH3 and the distribution of 15N-labeled vegetative N among different plant *** results are of great importance for the complete evaluation of nitrogen use efficiency in the greenhouse tomato fields.

关键词： greenhouse tomato 15N foliar ammonia absorption NH3 canopy

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淮河文化教育课程线上传播成效研究

蚌埠学院学报 2024年第2期13卷 118-123页

作者：曹建磊黄迎辉吕部朱洪浩姜雪蚌埠学院计算机与信息工程学院安徽蚌埠233030 蚌埠学院科研处安徽蚌埠233030 蚌埠学院经济与管理学院安徽蚌埠233030

以学习满意度为视角,经过实验过程和数据分析,证实年级、教学交互、学习兴趣、教学课程和教学环境五项因素与大学生学习满意度呈正向显著性关系,相关性越高,对学习满意度影响的程度越大,这些正向因素为淮河文化教育课程的线上传播效果... 详细信息

以学习满意度为视角,经过实验过程和数据分析,证实年级、教学交互、学习兴趣、教学课程和教学环境五项因素与大学生学习满意度呈正向显著性关系,相关性越高,对学习满意度影响的程度越大,这些正向因素为淮河文化教育课程的线上传播效果提供了积极作用。

关键词：淮河文化教育传播成效大学生学习满意度网络课程

Metallothionein 1E Alleviates Cadmium-induced Renal Cytotoxicity through Promoting Mitochondrial Functional Recovery

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Biomedical and Environmental Sciences 2024年第1期37卷 117-121页

作者： WEN Si hui LI Lu Bei huang hui Dan XIE ying LUO Lei Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha 410081HunanChina Department of Occupational Health Changsha Centre for Disease Control and PreventionChangsha 410004HunanChina The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province Hunan Normal University School of MedicineChangsha 410013HunanChina

The pervasive utilization of industrial substances has escalated human exposure to cadmium(Cd),a metal associated with long-term negative health outcomes such as renal dysfunction,neurological disorders,and various cancers^([1]).Once ingested by humans,Cd interacts with cysteine-rich metallothioneins(MTs)which have metal-binding and antioxidant properties and is subsequently transported to the kidney^([2]).

关键词： Renal kidney cadmium

Pien Tze huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： CAO Liu-jing LIU Li-ya CHEN You-qin HAN Yu-ying WEI Li-hui YAO Meng-ying FANG Yi WU Mei-zhu CHENG ying Thomas J.Sferra LIU hui-xin LI Li PENG Jun SHEN A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRNA levels of PNO1, TP53, and CDKN1A. Western blotting was performed to determine protein levels of PNO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PNO1. Colony formation assay was used to detect cell survival in PNO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PNO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. Xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PNO1 or sh-Ctrl lentivirus were evaluated. Western blot assay was performed to detect PNO1, p53, p21 and PCNA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUNEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PNO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (P<0.05). PNO1 overexpression attenuated the effects of PZH treatment, including the expression of p53 and p21, cell growth, cell viability, cell cycle arrest and cell apoptosis in vitro (P<0.05). PNO1 knockdown eliminated the effects of PZH treatment on tumor growth, inhibiting cell proliferation inhibition and apoptosis induction in vivo (P<0.05). Similarly, PNO1 knockdown attenuated the effects of PZH treatment on the down-regulation of PNO1 and up-regulation of p53 and p21 in vivo (P<0.05).ConclusionThe mechanism by which PZH induces its CRC anti-proliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze huang Chinese medicine partner of NOB1 proliferation p53/p21 pathway

Long-term results of prophylactic cranial irradiation for limited-stage small-cell lung cancer in complete remission

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Chinese Medical Journal 2005年第15期118卷 1258-1262页

作者： CAO Ka-jia huang hui-ying TU Ming-chi PAN Guo—ying Department of Radiation Oncology Cancer Centre Sun Yat-sen University Guangzhou 510060 China

Background Brain metastasis is one of the most important causes of treatment failure in patients with small cell lung cancer （SCLC）. This study was conducted to evaluate the effects of prophylactic cranial irradiation （PCI） on survival and brain metastases for patients with limited stage small cell lung cancer in complete remission. Methods Fifty one patients with limited stage SCLC in complete remission after chemoradiotherapy were randomly divided into PCI group （n = 26） and control group （n = 25 ）. Patients in the PCI group received PCI at a dose of 25.2 to 30. 6 Gy in 1.8 to 2.0 Gy per fraction. The Kaplan-Meier method and Log rank test were used to analyse and compare survival rates, and X^2 test was used to compare the incidences of cranial metastases in two groups. Results There was no significant difference in clinical characteristics of patients such as age, sex, effect of treatment before PCI between the two groups. The incidence of brain metastases was 3.8% in the PCI group in contrast to 32. 0% in the control group （X^2 =5.15, P =0. 02）. The 1, 3, 5-year survival rates were 84. 6%, 42. 3%, 34. 6% respectively in the PCI group and 72.0%, 32. 0%, 24. 0% respectively in the control group, with no difference between the two groups （X^2 = 2. 25, P = 0. 13 ）. No serious sequelae were observed in patients receiving PCI. Conclusion For patients with limited stage SCLC responding completely to chemotherapy plus radiotherapy, PCI can decrease the incidence of brain metastases and improve survival rate.

关键词： small cell lung carcinoma cranial irradiation· chemotherapy

Endowing low fatigue for elastocaloric effect by refined hierarchical microcomposite in additive manufactured NiTiCuCo alloy

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International Journal of Extreme Manufacturing 2024年第4期6卷 307-322页

作者： Bo Feng Helong Liu ying Yang hui Shen Yang Ren Yinong Liu Lishan Cui Bingmin huang Shijie Hao College of New Energy and Materials China University of PetroleumBeijing 102249People's Republic of China College of Chemical Engineering and Environment China University of PetroleumBeijing 102249People's Republic of China Department of Physics City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong Special Administrative Region of ChinaPeople's Republic of China Department of Mechanical Engineering The University of Western AustraliaPerthWA 6009Australia Jiangsu Smart Advanced Material Tech Co. LtdXuzhou 221000People's Republic of China

NiTiCu-based shape memory alloys have been considered as ideal materials for solid-state refrigeration due to their superb cycling stability for elastocaloric ***,the embrittlement and deterioration caused by secondary phase and coarse grains restrict their applications,and it is still challenging since the geometric components are ***,bulk NiTiCuCo parts with excellent forming quality were fabricated by laser powder bed fusion(LPBF)*** as-fabricated alloy exhibits refined three-phases hierarchical microcomposite formed based on the rapid cooling mode of LPBF,composed of intricate dendritic Ti2Ni–NiTi composite and nano Ti2Cu embedded inside the *** configuration endows far superior elastocaloric stability compared to the as-cast *** low fatigue stems from the strong elastic coupling between the interphases with reversible martensite transformation,revealed by in-situ synchrotron high-energy x-ray *** fabrication of NiTiCuCo alloy via LPBF fills the bill of complex geometric structures for elastocaloric NiTiCu *** understanding of interphase micro-coupling could provide the guide for designing LPBF fabricated shape memory-based composites,enabling their applications for special demands on other functionalities.

关键词： NiTiCuCo shape memoryalloy microcomposite high-energyx-raydiffraction laser powderbedfusion

Scientific and technological innovations of wastewater treatment in China

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 43-48页

作者： hui huang Rui Ma Hongqiang Ren State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China

The“dual-carbon”strategy promotes the development of the wastewater treatment sector and is an important tool for leading science and technology *** on the global climate change and the new policies introduced by China,this paper described the new needs for the development of wastewater treatment science and *** offered a retrospective analysis of the historical trajectory of scientific and technological advancements in this *** bibliometrics,it delineated the research hotspots within wastewater treatment,notably highlighting materials genomics,artificial intelligence,and synthetic ***,it posited that,in the future,the field of wastewater treatment should follow the paths of technological innovations with multi-dimensional needs,such as carbon reduction,pollution reduction,health,standardisation,and *** purpose of this paper was to provide references and suggestions for scientific and technological innovations in the field of wastewater treatment,and to contribute to the common endeavor of moving toward a Pollution-Free Planet.

关键词： Wastewater treatment Dual-carbon strategy Technological innovation Carbon reduction