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Inulin Can Alleviate Metabolism Disorders in ob/ob Mice by Partially Restoring Leptinrelated Pathways Mediated by Gut Microbiota

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Genomics, Proteomics & Bioinformatics 2019年第1期17卷 64-75页

作者： Xiaofeng Song Liang Zhong Na Lyu Fei Liu Boxing Li Yanan hao Yong Xue Jing Li Yuqing Feng yue Ma Yongfei Hu Baoli Zhu CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Savaid Medical School University of Chinese Academy of Sciences Beijing Key Laboratory of Microbial Drug Resistance and Resistome College of Food Science and Nutritional Engineering China Agricultural University State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Department of Pathogenic Biology School of Basic Medical Sciences Southwest Medical University

Inulin has been used as a prebiotic to alleviate glucose and lipid metabolism disorders in mice and humans by modulating the gut microbiota. However, the mechanism underlying the alleviation of metabolic disorders by inulin through interactions between the gut microbiota and host cells is unclear. We use ob/ob mice as a model to study the effect of inulin on the cecal microbiota by16 S rRNA gene amplicon sequencing and its interaction with host cells by transcriptomics. The inulin-supplemented diet improved glucose and lipid metabolism disorder parameters in ob/ob mice,alleviating fat accumulation and glucose intolerance. The a diversity of gut microbial community of ob/ob mice was reduced after inulin treatment, while the b diversity tended to return to the level of wild type mice. Interestingly, Prevotellaceae UCG 001(family Prevotellaceae) was obviously enriched after inulin treatment. A comparative analysis of the gene expression profile showed that the cecal transcriptome was changed in leptin gene deficiency mice, whereas the inulin-supplemented diet partially reversed the changes in leptin gene-related signaling pathways, especially AMPK signaling pathway, where the levels of gene expression became comparable to those in wild type *** analysis indicated that Prevotellaceae UCG 001 was positively correlated with the AMPK signaling pathway, which was negatively correlated with markers of glycolipid metabolism disorders. Our results suggest that the inulin-supplemented diet alleviates glucose and lipid metabolism disorders by partially restoring leptin related pathways mediated by gut microbiota.

关键词： Prebiotics Gut microbiota Obesity Transcriptome Metabolic disorders

Deformation and failure of a high-steep slope induced by multi-layer coal mining

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Journal of Mountain Science 2020年第12期17卷 2942-2960页

作者： YU Jian-le Zhao Jian-jun YAN hao-yuan LAI Qi-yi huang Run-qiu LIU Xiu-wei LI Yang-chun State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China Guizhou Transportation Planning Survey&Design Academy Co. ltd.Guiyang 550081China Guizhou Geological Environment Monitoring Institute Guiyang 550001China

During underground mining,accurate revelation on the deformation and failure mechanisms of a high-steep slope under multi-layer mining conditions facilitates the prevention and control of geological disasters in *** simulation based on discrete element theory can be used to explore the characteristics and mechanism of action of deformation and failure of a slope under complex geological and multi-layer mining *** utilising PFC2 D(particle flow code) software,the deformation and failure characteristics of a high-steep slope in Faer Coal Mine in Guizhou Province,China were ***,the mechanism of influence of different numbers of mining layers on the deformation and failure of the high and steep slope was *** result showed that after the goaf passed by the slope toe,multi-layer mining aggravated the subsidence and deformation of the slope toe:the slope toppled forward as it *** toppling of the slope changed the slope structures:the strata in the front of the slope were transformed from anti-dip to down-dip *** by collapsedtoppled rock mass,the slope toe and the rock mass located in the lower part of the slope toe generally exhibited a locking effect on the ***-layer mining degraded the overall stability of the slope,in that the total displacement of the slope was much greater than the total mining thickness of the coal *** on the aforementioned research,ideas for preventing and controlling geological disasters during mining operations under a high-steep slope were proposed.

关键词： High steep slope Discrete element method Multilayer coal mining Mountain mine geological hazard Subsidence toppling deformation Mining schemes optimization

Fluorinated Colorless Polyimides with High Heat-resistance and Low Birefringence

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高分子科学:英文版 2023年第10期41卷 1599-1608页

作者： Bing-Yu Zou Lu-hao Qiu Huan-Yu Lei Jin-Ming Liu Wei-Feng Peng Hong-Qin Zhao Feng Bao Ming-Jun huang South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

The development of optical films with high transparency,high thermal resistance and low birefringence remains a challenge in the flexible display *** this work,we designed and synthesized a series of fluorinated colorless polyimides(CPIs)materials using 2,5-substituted m-phenylenediamine diamine monomers and 1,2,4,5-cyclohexanetetracarboxylic dianhydride(CHDA).We systematically studied the effects of fluorinated group substitutions on the thermal,mechanical,optical and dielectric properties of CPI *** introduction of alicyclic CHDA dianhydride affords high transparency and low yellowness,while the 2,5-substituted m-phenylenediamine diamines offer the CPIs with quite low birefringence as well as high glass transition temperatures.A particular CHDA/o3FBDA film with simple chemical structure stands out,exhibiting well-balanced overall properties.

关键词： Colorless polyimide Low birefringence Fluorinated Optical flm

PbrChiA:a key chitinase of pear in response to Botryosphaeria dothidea infection by interacting with PbrLYK1b2 and down-regulating ROS accumulation

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Horticulture Research 2023年第10期10卷 185-201页

作者： Qiming Chen Huizhen Dong Qionghou Li Xun Sun Xin Qiao hao Yin Zhihua Xie Kaijie Qi Xiaosan huang Shaoling Zhang State Key Laboratory of Crop Genetics and Germplasm Enhancement Centre of Pear Engineering Technology ResearchNanjing Agricultural UniversityNanjing 210095China

Pear ring rot,caused by the pathogenic fungi Botryosphaeria dothidea,seriously affects pear *** the infection-induced reactive oxygen species(ROS)burst of infected plants limits the proliferation of *** during the early infection stage,high ROS levels can also contribute to their growth during the later necrotrophic infection ***,it is important to understand how plants balance ROS levels and resistance to pathogenic *** during the later *** this study,we identified PbrChiA,a glycosyl hydrolases 18(GH18)chitinase-encoding gene with high infection-induced expression,through a comparative transcriptome *** substitution,stable overexpression,and virus induced gene silencing(VIGS)experiments demonstrated that PbrChiA can positively regulate pear resistance as a secreted chitinase to break down *** mycelium in vitro and that overexpression of PbrChiA suppressed infection-induced ROS *** analysis revealed that PbrChiA can bind to the ectodomain of PbrLYK1b2,and this interaction suppressed PbrLYK1b2-mediated chitin-induced ROS ***,we propose that the combination of higher antifungal activity from abundant PbrChiA and lower ROS levels during later necrotrophic infection stage confer resistance of pear against ***.

关键词： infection ChiA resistance

转录因子GhWRKY41促进水杨酸合成增强棉花对黄萎病菌的抗性

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作物学报 2024年第10期50卷 2447-2457页

作者：肖胜华董贤镘彭鑫李安子闭兆福廖铭静黄礼豪管倩倩胡琴朱龙付广西大学农学院/亚热带农业生物资源保护与利用国家重点实验室广西南宁530004 华中农业大学/作物遗传改良国家重点实验室湖北武汉430070 华中农业大学/湖北洪山实验室湖北武汉430070

棉花是我国最重要的经济作物之一,但其产量和品质受黄萎病菌危害而大幅度下降。挖掘棉花黄萎病抗性相关基因并解析其分子机制,对加快棉花抗黄萎病育种进程具有重要意义。前期研究鉴定到一个在多个抗病棉花品种中均受黄萎病菌诱导显著上... 详细信息

棉花是我国最重要的经济作物之一,但其产量和品质受黄萎病菌危害而大幅度下降。挖掘棉花黄萎病抗性相关基因并解析其分子机制,对加快棉花抗黄萎病育种进程具有重要意义。前期研究鉴定到一个在多个抗病棉花品种中均受黄萎病菌诱导显著上调表达的WRKY基因GhWRKY41,该基因通过激活苯丙烷代谢增强棉花对黄萎病菌的抗性。本研究进一步分析了GhWRKY41在不同激素处理下的诱导表达模式,利用病毒介导的基因沉默(VIGS)技术验证了GhWRKY41的抗病功能,并利用前期已创制的GhWRKY41转基因棉花株系‘Jin668’测定了其内源植物抗病激素含量。结果显示,GhWRKY41受水杨酸(SA)、Me-JA和H_(2)O_(2)诱导均显著上调表达;GhWRKY41被沉默后可削弱棉花对黄萎病菌的抗性;SA含量在GhWRKY41超表达棉花中显著增加,而在GhWRKY41干涉棉花中则明显减少。RT-qPCR分析显示,SA合成基因GhSID2及SA信号转导基因GhNPR1、GhPR1、GhPR5的表达水平在超表达植株中明显上调,而在干涉植株中则显著下降。ChIP-qPCR和双荧光素酶报告基因试验结果表明,GhWRKY41可结合并激活GhSID2、GhPR1和GhPR5的表达。此外,外施SA可明显提高棉花的黄萎病抗性。综上表明,GhWRKY41可通过促进棉花中内源植物激素SA的合成来增强植株的黄萎病抗性,这一结果完善了GhWRKY41在棉花抵御黄萎病菌过程中的生物学功能,为未来利用黄萎病抗性基因创制棉花抗病材料提供了理论基础。

关键词：棉花黄萎病菌 GhWRKY41 水杨酸

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家庭农场资本禀赋特征及对“趋粮化”的影响——基于云南省514个家庭农场数据分析

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现代农业 2024年第4期49卷 29-37页

作者：郭瑞婧谢彦明刘帅诗郝峻锋黄思思西南林业大学经济管理学院云南昆明650224

家庭农场代表中国农业经营方式的主流方向,是粮食生产的中坚力量。文章基于云南省514份家庭农场调查数据,建立家庭农场资本禀赋评价指标体系,在运用熵值法、单因素方差分析法分析家庭农场资本禀赋特征的基础上,进一步通过二元Logit模型... 详细信息

家庭农场代表中国农业经营方式的主流方向,是粮食生产的中坚力量。文章基于云南省514份家庭农场调查数据,建立家庭农场资本禀赋评价指标体系,在运用熵值法、单因素方差分析法分析家庭农场资本禀赋特征的基础上,进一步通过二元Logit模型、Tobit模型分别探究各类资本禀赋对异质性家庭农场“趋粮化”的影响。研究表明:(1)家庭农场“趋粮化”程度较低。56%的农场种粮,种粮面积占比39.30%;综合资本禀赋得分0.337,各类资本禀赋得分由高到低依次为人力资本禀赋、金融资本禀赋、自然资本禀赋、物质资本禀赋。(2)综合资本禀赋对家庭农场“趋粮化”具有显著负向影响。金融资本禀赋具有显著负向影响,自然资本禀赋具有显著正向影响。(3)不同资本禀赋对异质性家庭农场“趋粮化”的影响存在显著差异。据此,建议落实种粮补贴政策、完善土地流转和耕地用途监管体系,分类精准施策,促进家庭农场“趋粮化”生产经营,保障国家粮食安全。

关键词：资本禀赋家庭农场 “趋粮化” 云南省

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Border effects of the main and ratoon crops in the rice ratooning system

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Journal of Integrative Agriculture 2023年第1期22卷 80-91页

作者： ZHENG Chang WANG yue-chao XU Wen-ba YANG De-sheng YANG Guo-dong YANG Chen huang Jian-liang PENG Shao-bing National Key Laboratory of Crop Genetic Improvement/Hubei Hongshan Laboratory/MARA Key Laboratory of Crop Ecophysiology and Farming Systems in the Middle Reaches of the Yangtze River/College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070P.R.China

The border effect(BE)is widely observed in crop field experiments,and it has been extensively studied in many ***,only limited attention has been paid to the BE of ratoon *** conducted field experiments on ratoon rice in Qichun County,Hubei Province,Central China in 2018 and 2019 to compare the BE in the main and ratoon crops,and to quantify the contribution of BE in the main crop to that in the ratoon *** BE of two hybrid varieties was measured for the outermost,second outermost,and third outermost rows in each plot of both *** determine the contribution of BE between the two crops,portions of hills in the outermost and second outermost rows were uprooted during the harvest of the main crop so that the second and third outermost rows then became the outermost rows in the ratoon ***,the BE on grain yield was greater in the main crop than in the ratoon *** the main crop,the BE on grain yield was 98.3%in the outermost row,which was explained by the BE on panicles m^(–2),spikelets/panicle,spikelets m^(–2),and total dry *** the ratoon crop,the BE on grain yield was reduced to 60.9 and 27.6%with and without the contribution of the BE in the main crop,***,55.1%of the BE on grain yield in the ratoon crop was contributed from the main *** stubble dry weight and non-structural carbohydrate(NSC)accumulation at the harvest of the main crop were responsible for the contribution of BE in the main crop to that in the ratoon *** results suggest that increases in stubble dry weight and NSC accumulation at the harvest of the main crop could be important strategies for developing high-yielding cropping practices in the rice ratooning system.

关键词： border effect grain yield non-structural carbohydrate ratoon rice

Orbital and Millennial-Scale Climate Variability over the Past 76 ka in the Western Tarim Basin, Northwest China

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Journal of Earth Science 2023年第1期34卷 173-180页

作者： Rui Zhang Qiuzhen Yin Weihua Nai Zhixiang Wang hao Lu Chunju huang Yansheng Gu Lin Li Yusong Wang Linjing Liu College of Urban and Environmental Sciences Hubei Normal UniversityHuangshi435002China State Key Laboratory of Biogeology and Environmental Geology School of Earth SciencesChina University of GeosciencesWuhan430074China Georges Lemaître Centre for Earth and Climate Research Earth and Life InstituteUniversitéCatholique de LouvainLouvain-La-Neuve1348Belgium No.2 Hydrological and Engineering Geology Party of Xinjiang Bureau of Geology and Mineral Resources Exploration and Development Changji831100China Hubei Key Laboratory of Critical Zone Evolution School of Earth SciencesChina University of GeosciencesWuhan430074China Hubei Key Laboratory of Wetland Evolution&Eco-Restoration(WEER) China University of GeosciencesWuhan430074China School of Environmental Studies China University of GeosciencesWuhan430074China Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological Sciences(CAGS)Shijiazhuang050061China

Paleoclimate changes during the last glacial in the arid central Asia are not as well understood as the monsoon-dominated areas of Asia. Here we report a 75-m-long sediment core over past 120 kyr based on astronomical tuning combined with the optically stimulated luminescence(OSL) dating in the Kashi depression of the western Tarim Basin, Northwest China. Analysis of grain size and highresolution gamma ray(GR) logs from the KT11 borehole across the last glacial period yields a climate history for the Tarim Basin which reflects the variations of its temperature and the hydrological cycles. Comparison of these records with north hemisphere summer insolation, the Greenland ice core temperature, stalagmites and the loess from the nearby region indicates that the deposits in the fluvio-lacustrine system of the Kashi depression responded to climate change at the Younger Dryas(YD), six Heinrich cooling events and the Dansgaard-Oeschger cycles. Our work indicates that the alternations between warm-humid and cold-dry climates were prevalent in the western Tarim Basin during the last glacial period, showing an in-phase pattern with the climate variations of the East Asian Monsoon, controlled ultimately by precession and North Atlantic Ocean climate variability on orbital-millennial time scales.

关键词： abrupt climate changes glacial geology last glacial period KT11 borehole western Tarim Basin

Supplemental magnolol or honokiol attenuates adverse effects in broilers infected with Salmonella pullorum by modulating mucosal gene expression and the gut microbiota

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Journal of Animal Science and Biotechnology 2022年第1期13卷 288-302页

作者： Fang Chen hao Zhang Encun Du Qiwen Fan Na Zhao Feng Jin Wei Zhang Wanzheng Guo Shaowen huang Jintao Wei Institute of Animal Husbandry and Veterinary Hubei Academy of Agricultural SciencesWuhanChina Hubei Key Laboratory of Animal Embryo and Molecular Breeding WuhanChina Key Laboratory of Prevention and Control Agents for Animal Bacteriosis(Ministry of Agriculture and Rural Affairs) WuhanChina

Background:Salmonella pullorum is one of the most harmful pathogens to avian *** and honokiol,natural compounds extracted from Magnolia officinalis,exerts anti-inflammatory,anti-oxidant and antibacterial *** study was conducted to evaluate the effects of dietary supplemental magnolol and honokiol in broilers infected with ***.A total of 360 one-day-old broilers were selected and randomly divided into four groups with six replicates:the negative control group(CTL),***-infected group(SP),and the *** group supplemented with 300 mg/kg honokiol(SPH)or magnolol(SPM).Results:The results showed that challenging with *** impaired growth performance in broilers,as indicated by the observed decreases in body weight(Phao1,ACE,and PD whole tree)and β-diversity of the ileum bacteria(P<0.05).In addition,magnolol supplementation increased the abundance of Lactobacillus(P<0.01)and decreased unidentified Cyanobacteria(P<0.05)both at d 14 and d *** study confirmed that differentially expressed genes induced by magnolol and honokiol supplementation enriched in cytokine-cytokine receptor interactions,in the intestinal immune network for IgA production,and in the cell adhesion molecule ***:Supplemental magnolol and honokiol alleviated ***-induced impairments in growth performance,and the effect of magnolol was better than that of honokiol,which could be partially due to magnolol’s abi

关键词： Broiler Gut microbiota Honokiol Immune Magnolol Salmonella pullorum