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Prediction of biventricular repair by echocardiography in borderline ventricle

Chinese Medical Journal 2019年第17期132卷 2105-2108页

作者： Xiao-Jing Ma guo-ying huang Heart Center Children’s Hospital of Fudan University Shanghai 201102 China National Children’s Medical Center Shanghai 201102 China Shanghai Key Laboratory of Birth Defects Shanghai 201102 China

Objective: In recent years, attempting the biventricular pathway or biventricular conversions in patients with borderline ventricle has become a hot topic. However, inappropriate pursuit of biventricular repair in borderline candidates will lead to adverse clinical outcomes. Therefore, it is important to accurately assess the degree of ventricular development before operation and whether it can tolerate biventricular repair. This review evaluated ventricular development using echocardiography for a better prediction of biventricular repair in borderline ventricle. Data sources: Articles from January 1, 1990 to April 1, 2019 on biventricular repair in borderline ventricle were accessed from PubMed, using keywords including "borderline ventricle,""congenital heart disease,""CHD,""echocardiography," and "biventricular repair." Study selection: Original articles and critical reviews relevant to the review’s theme were selected. Results: Borderline left ventricle (LV):(1) Critical aortic stenosis: the Rhodes score, Congenital Heart Surgeons Society regression equation and another new scoring system was proposed to predict the feasibility of biventricular repair.(2) Aortic arch hypoplasia: the LV size and the diameter of aortic and mitral valve (MV) annulus should be taken into considerations for biventricular repair.(3) Right-dominant unbalanced atrioventricular septal defect (AVSD): atrioventricular valve index (AVVI), left ventricular inflow index (LVII), and right ventricle (RV)/LV inflow angle were the echocardiographic indices for biventricular repair. Borderline RV:(1) pulmonary atresia/intact ventricular septum (PA/IVS): the diameter z-score of tricuspid valve (TV) annulus, ratio of TV to MV diameter, RV inlet length z-score, RV area z-score, RV development index, and RV-TV index, etc. Less objective but more practical description is to classify the RV as tripartite, bipartite, and unipartite. The presence or absence of RV sinusoids, RV dependent coronary circulat

关键词： Borderline ventricle Congenital heart disease Echocardiography Biventricular repair

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Neonatal pulse oximetry screening improves detecting of critical congenital heart disease

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Chinese Medical Journal 2013年第14期126卷 2736-2740页

作者： MA Xiao-jing huang guo-ying Pediatric Heart Center Children's Hospital of Fudan University Shanghai 201102 China

Objective Life-threatening critical congenital heart disease （cCHD） is often not detected in the neonatal period. Unrecognized cCHD results in high morbidity and mortality rates. As a non-invasive, convenient, quick and accurate measuring method, pulse oximetry is considered to be a promising strategy to screen for cCHD in neonates. This article is a review on the neonatal pulse oximetry screening for cCHD. Data sources Articles on neonatal pulse oximetry screening for cCHD were accessed from PubMed, using keywords including congenital heart defects, neonatal screening and oximetry. Study selection Original articles and critical reviews selected were relevant to the review＇s theme. Results The factors in the course of implementation, including threshold for positive pulse-oximetry screening results, the pulse oximeters used, timing of the screening, and the measuring position, influence the accuracy of the screening. It is recommended that the screening is completed on the second day of life, before hospital discharge. Motion-tolerant pulse oximeters, which can also be applied to measure the saturation in Iow-perfusion conditions, should be used. The probe should be put on both the right hand and on one foot. Thresholds of 〈95% in either limb or a difference of 〉3% between the limbs as a positive result may be appropriate. It should be emphasized that pulse-oximetry screening cannot be used as the only way to detect cCHD, clinical examination is also important in this situation. Cost-benefit analysis in the United Kingdom revealed it was plausible to use pulse oximetry as an adjunct to clinical examination. However, it is still controversial as to whether pulse oximetry can be used as a routine screening method for cCHD in neonates. Conclusions Neonatal pulse oximetry screening improves detection of cCHD. Further studies should be carried out before it becomes one of the routine newborn screening programs.

关键词： congenital heart disease pulse oximetry screening newborn

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Folic Acid Supplementation in Chinese Periconceptional Population:Results from the SPCC Study

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Biomedical and Environmental Sciences 2020年第8期33卷 557-565页

作者： WANG Ding Mei ZHANG Yi JIANG Yuan YE ying huang Xiang Yuan LI Meng Ru JI Mi ZHAO Zheng Shan CHEN Xiao Tian SHENG Wei MA Xiao Jing ALLEN Stephen WANG Duo Lao YAN Wei Li huang guo ying 无 Children's Hospital of Fudan University Shanghai 201102China Shanghai Key Laboratory of Birth Defect Shanghai 201102China Department of Clinical Sciences Liverpool School of Tropical MedicineLiverpool L35QAUnited Kingdom the Shanghai PreConception Cohort Group

Objective To determine the prevalence and determinants of folic acid(FA)supplementation in Chinese couples planning for pregnancy and in women during early *** This was a cross-sectional study based on the Shanghai PreConception Cohort(SPCC)*** on FA supplementation and socio-demographic features were collected using *** visiting clinics for pre-pregnancy examination and pregnant women at<14 gestational weeks were recruited in Shanghai,China,between March 2016 and September *** Among the pregnancy planners,42.4%(4,710/11,099)women and 17.1%(1,377/8,045)men used FA supplements,while 93.4%(14,585/15,615)of the pregnant women used FA *** supplement use was higher in female pregnancy planners who were older(RR:1.13,95%CI:1.08–1.18),had higher education(RR:1.71,95%CI:1.53–1.92),and were residing in urban districts(RR:1.06,95%CI:1.01–1.11)of FA supplementation;female pregnancy planners with alcohol consumption(RR:0.95,95%CI:0.90–0.99)had lower odds of FA *** early pregnancy,women with higher educational level(RR:1.04,95%CI:1.03–1.06),who underwent pre-pregnancy examination(RR:1.02,95%CI:1.01–1.03)had higher odds of using an FA supplement;older aged(RR:0.99,95%CI:0.98–0.99),and multigravida(RR:0.97,95%CI:0.96–0.98)had lower odds of FA *** Although the majority of pregnant women took FA supplements,more than half of the women planning for pregnancy did *** strategies are needed to improve pre-conception FA supplementation.

关键词： Folic acid supplementation Peri-conception Birth defects China Pregnancy

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Micro-transesophageal Echocardiography Guided Mitral Valve Repair After Balloon Dilation for Aortic Valve Stenosis in a Small Infant

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Chinese Medical Journal 2015年第9期128卷 1277-1278页

作者： Xiao-Jing Ma guo-ying huang Jing Zhang Echo Lab Pediatric Cardiovascular Center Children@s Hospital of Fudan University Shanghai 201102 China Shanghai Key Laboratory of Birth Defects Shanghai 201102 China

To the Editor：Transoesophageal echocardiography （TEE） plays an important role in monitoring,guiding,and evaluating the surgical repair of congenital heart disease （CHD）.[1,2] However,the large size of the currently available TEE probes limits their application in pediatric cases,especially in small ***,a miniaturized micro-TEE probe compatible in neonates has been introduced for clinical ***,limited experiences with micro-TEE have been ***,we reported a special small infant case,whose mitral valve was damaged after balloon dilation for aortic valve stenosis （AS）,the infant went on to receive surgical repair under micro-TEE guidance.

关键词： Micro-transesophageal Echocardiography a Small Infant

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Research Progress on Bio‑inspired Flapping‑Wing Rotor Micro Aerial Vehicle Development

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Journal of Bionic Engineering 2024年第4期21卷 1621-1643页

作者： yingjun Pan Shijun guo Xun huang Centre for Aeronautics School of AerospaceTransport and ManufacturingCranfield UniversityBedford MK430ALUK

Flapping-wing rotor(FWR)is an innovative bio-inspired micro aerial vehicle capable of vertical take-off and *** unique design combines active flapping motion and passive wing rotation around a vertical central shaft to enhance aerodynamic *** research on FWR,though relatively new,has contributed to 6%of core journal publications in the micro aerial vehicle field over the past two *** paper presents the first comprehensive review of FWR,analysing the current state of the art,key advances,challenges,and future research *** review highlights FWR’s distinctive kinematics and aerodynamic superiority compared to traditional flapping wings,fixed wings,and rotary wings,discussing recent breakthroughs in efficient,passive wing pitching and asymmetric stroke amplitude for lift *** experiments and remote-controlled take-off and hovering tests of single and dual-motor FWR models have showcased their *** review compares FWR flight performance with well-developed insect-like flapping-wing micro aerial vehicles as the technology readiness level progresses from laboratory to outdoor flight testing,advancing from the initial flight of a 2.6 g prototype to the current free flight of a 60-gram *** review also presents ongoing research in bionic flexible wing structures,flight stability and control,and transitioning between hovering and cruise flight modes for an FWR,setting the stage for potential applications.

关键词： Flapping-wing rotor Micro aerial vehicle Bio-inspiration Flight

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Engineering self-catabolic DNAzyme nanospheres for synergistic anticancer therapy

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Science China Chemistry 2024年第7期67卷 2412-2422页

作者： Yu Chen Yu guo Jiaoli Wang Ruiting Liu Xiaohai Yang Kemin Wang ying Pu Hui Shi Jin huang Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringKey Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan ProvinceHunan UniversityChangsha 410082China National Clinical Research Center for Geriatric Disorders Department of GeriatricsXiangya HospitalCentral South UniversityChangsha 410008China

DNAzyme-based gene therapy faces some challenges including cell penetration,activity limitation,and co-delivery ***-assembled DNA nanomedicine has attracted widespread attention due to its many *** is urgent to develop a universal DNA degradation strategy for precise programmable drug ***,we reported a self-catabolic DNAzyme nanospheres(SCNS),which could simultaneously achieve cell penetration,activity enhancement,and co-delivery *** SCNS were assembled through Y-DNA stepwise hybridization with each other,which were then loaded with aptamer(Apt),doxorubicin(Dox),and zinc oxide nanoparticles(ZnO NPs).The acid-triggered dissociation of ZnO NPs leads to the generation of Zn^(2+)ions cofactors for immediately self-catabolic DNAzyme *** the disassembly of the SCNS,three types of anticancer treatments would be activated,which include Zn^(2+)involved reactive oxygen species(ROS),Dox-induced chemotherapy,and DNAzyme-based gene *** experimental results show that the nanoplatform(Apt-SCNS-Dox-ZnO)has a good tumor-killing effect and minimal side *** a smart self-driven drug delivery nanoplatform,it is anticipated to displace extraordinary potential in biomedicine and bioengineering.

关键词： DNAzyme nanosphere ZnO NPs ROS Dox anticancer therapy

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Research on light dark matter particle from evaporating primordial black hole in CDEX-10 experiment

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 168-169页

作者： Qing-guo huang School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

Dark matter is an essential component of the universe,accounting for approximately 85%of all ***,what the nature of dark matter actually is remains a huge *** far,all evidence for the existence of dark matter has come from gravitational *** gravitational interactions are universal,it is challenging to reveal the nature of dark matter through gravitational *** unravel the mystery of dark matter,it is essential to directly detect dark matter.

关键词： approximate particle gravitational

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Rational design of diamond through microstructure engineering:From synthesis to applications

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Carbon Energy 2024年第7期6卷 94-122页

作者： Yalun Ku Wentao huang Xing Li Li Wan Kuikui Zhang Longbin Yan ying guo Shaobo Cheng Chongxin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material PhysicsMinistry of EducationSchool of Physics and Laboratory of Zhongyuan LightZhengzhou UniversityZhengzhouChina Institute of Quantum Materials and Physics Henan Academy of SciencesZhengzhouChina

Diamond possesses excellent thermal conductivity and tunable ***,the high-pressure,high-temperature,and chemical vapor deposition methods are the most promising strategies for the commercial-scale production of synthetic *** diamond has been extensively employed in jewelry and cutting/grinding tasks,the realization of its high-end applications through microstructure engineering has long been ***,we discuss the microstructures encountered in diamond and further concentrate on cutting-edge investigations utilizing electron microscopy techniques to illuminate the transition mechanism between graphite and diamond during the synthesis and device *** impacts of distinct microstructures on the electrical applications of diamond,especially the photoelectrical,electrical,and thermal properties,are *** recently reported elastic and plastic deformations revealed through in situ microscopy techniques are also ***,the limitations,perspectives,and corresponding solutions are proposed.

关键词： diamond in situ microscopy microstructures phase transition structure-property relationship

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Discovery potential of the Glashow resonance in an air shower neutrino telescope

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Chinese Physics C 2024年第8期48卷 266-275页

作者： guo-Yuan huang School of Mathematics and Physics China University of GeosciencesWuhan 430074China Max-Planck-Institut für Kernphysik Saupfercheckweg 169117 HeidelbergGermany

The in-ice or in-water Cherenkov neutrino telescope,such as IceCube,has already proved its power in measuring the Glashow resonance by searching for the bump around E_(ν)=6.3PeV arising from the W-boson *** are many proposals for the next few decades for observations of cosmic tau neutrinos with extensive air showers,also known as tau neutrino *** air shower telescope is,in principle,sensitive to the Glashow resonance via the channel W→τν_(τ)followed by the tau decay in the air(e.g.,TAMBO,which has a geometric area of approximately 500km^(2)).Using a thorough numerical analysis,we find that the discovery significance can be up to 90%with a TAMBO-like setup if PeV neutrinos primarily originate from neutron decays,considering the flux parameters measured by IceCube as the *** presence of new physics affecting the neutrino flavor composition can also increase the ***,if ultrahigh-energy neutrinos are dominantly produced from meson decays,it will be statistically difficult for an advanced proposal such as TAMBO to discriminate the Glashow resonance induced byν¯e from the intrinsicντ/ν¯_(τ)*** have identified several limitations for such advanced telescopes,in comparison with the in-ice or in-water telescope,when measuring resonances:(i)a suppressed branching ratio of 11%for the decay W→τν_(τ);(ii)the smearing effect and reduced acceptance because the daughter neutrino takes away(y)∼75%of the energy from the W decay;and(iii)a large attenuation effect for Earth-skimming neutrinos with the resonance.

关键词： Ultrahigh-energy neutrinos Neutrino telescopes Glashow resonance

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Epidemiologic features of Kawasaki disease in Shanghai from 2003 through 2007

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Chinese Medical Journal 2010年第19期123卷 2629-2634页

作者： MA Xiao-jing YU Cen-yan huang Min CHEN Shu-bao huang Mei-rong huang guo-ying Children's Hospitai of Fudan University Shanghai 201102 China Children's Hospital of Shanghai Jiao Tong University Shanghai 200040 China Shanghai Children's-Medical Center Shanghai 200127 China Xinhua Hospital of Shanghai Jiao Tong University Shanghai 200092 China Institute of Biomedical Science Fudan University Shanghai 200032 China Pediatric Heart Center Children's Hospital of Fudan University 399 Wan Yuan Road Shanghai 201102 China

Background The epidemiologic pictures of Kawasaki disease （KD） in Shanghai from 1998 through 2002 were reported while the current status of KD in the following five years remains unknown. Methods A questionnaire form and diagnostic guidelines for KD were sent to 50 hospitals providing pediatric medical care in Shanghai, China. All patients with KD diagnosed during January 2003 through December 2007 were recruited. Results In total, 1187 cases of KD were enrolled. The incidence of KD was 36.78 to 53.28 （mean 46.32±6.51） per 100 000 children under the age of 5 years between 2003 and 2007, which was higher than the year from 1998 to 2002 of （27.32±7.11） per 100 000, （t=4.406, P=0.002）. Ages at onset ranged from 12 days to 13.6 years （median 1.8 years）. It occurred more frequently in summer and spring. Coronary arterial lesions （CAL）, defined as ectasia or aneurysm, accounted for 19.8% （232 cases）. Flattened or inverted T wave was the most frequent finding （194 cases, 20.5%） by electrocardiogram. Intravenous gamma-globulin was administrated to 1028 cases （86.6%）. The occurrence of CAL seemed less frequent in the patients received gamma-globulin from day 5 to day 9 after the onset with the regimen of 1000 mg/kg once or 1000 mg/kg twice. Conclusions The incidence of KD was increasing in Shanghai. Treatment with intravenous gamma-globulin from day 5 to day 9 after the onset with the regimen of 1000 mg/kg once or 1000 mg/kg twice resulted in less coronary seauelae.

关键词： Kawasaki disease mucocutaneous lymph node syndrome coronary arterial lesions epidemiology incidence

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