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Robust containment control for a class of heterogeneous uncertain nonlinear multi-agent systems in lower triangular form

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Journal of Control and Decision 2021年第3期8卷 269-279页

作者： Jing Zhao shibin Shen fei Xie Yanfei Sun Fengyu xu College of Automation&College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjingPeople’s Republic of China School of Electrical and Automation Engineering Nanjing Normal UniversityNanjingPeople’s Republic of China Jiangsu Engineering Laboratory for Internet of Things and Intelligent Robotics Nanjing University of Post and TelecommunicationsNanjingPeople’s Republic of China Nanjing Institute of Intelligent High-End Equipment Industry Limited Company NanjingPeople’s Republic of China

This paper studies the robust containment control problem for a class of nonlinear multi-agent systems in lower triangular form with parameter *** agents are heterogenous with the particularity that the dynamics of the leaders are totally different from those of the *** interconnection topology is described by a general directed *** on the distributed internal model,the robust containment control problem is first converted into the stabilisation problem for an augmented network.A distributed state feedback control is then proposed to solve the stabilisation problem of the subsequent augmented network by the block backstepping *** the proposed control,all the followers’outputs will converge to the convex hull spanned by the leaders.

关键词： Containment nonlinearmultiagentsystems heterogeneous uncertainparameter internal model

基于数值模拟的大口径高精度射电望远镜台址风障优化设计研究

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天文学报 2024年第2期65卷 15-27页

作者：何飞龙许谦王娜李琳黄释怡中国科学院新疆天文台乌鲁木齐830011 中国科学院大学北京100049 中国科学院射电天文重点实验室乌鲁木齐830011 新疆射电天体物理重点实验室乌鲁木齐830011 新疆大学物理科学与技术学院乌鲁木齐830046 西华师范大学物理与天文学院南充637002

随着射电望远镜口径增大、观测频率提高,对其指向精度的要求也越来越高.然而,望远镜服役于野外台站,台址风扰对天线指向精度的影响在高频段观测时已不能忽略.由于风扰的时变性,现有的抗风方法无法保障大口径高指向精度望远镜在高频段的... 详细信息

随着射电望远镜口径增大、观测频率提高,对其指向精度的要求也越来越高.然而,望远镜服役于野外台站,台址风扰对天线指向精度的影响在高频段观测时已不能忽略.由于风扰的时变性,现有的抗风方法无法保障大口径高指向精度望远镜在高频段的有效观测时长.因此,提出了一种基于风障精确布置改善台址风环境的方法.通过数值模拟构建了风障仿真模型,并将仿真结果与风洞实测数据比较,两种孔隙率风障的平均误差分别为3.7%和6.1%,保证了风障模型的可靠性.以新疆奇台射电望远镜(QiTai radio Telescope,QTT)台址为例,基于QTT台址斜坡地形构建了计算域模型,开展单风障不同高度、不同孔隙率的系列风场仿真试验,得到了风障参量与下游挡风效果的关系.基于单风障合理高度和最优孔隙率设置南北风障,仿真结果表明在确定高度下最优孔隙率可以组合,孔隙率0.1-0.1组合的风障挡风效果最优,南方向来风在天线区域可以有效降低75%以上的风速.

关键词：望远镜方法:数值台址风障风场调控

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流感病毒感染人扁桃体类器官的免疫效应

陆军军医大学学报 2024年第9期46卷 978-987页

作者：李思琪徐赟李红费蕾黄小勇陈永文陆军军医大学(第三军医大学)全军免疫学研究所重庆400038 重庆仁品耳鼻喉医院咽喉科重庆400042

目的建立人扁桃体免疫类器官模型并探讨流感病毒感染后产生的免疫学效应。方法经扁桃体腺样体肥大手术摘除后的人扁桃体组织在经过单个核细胞梯度离心后,利用2.5D-Transwell进行体外培养并添加IL-2及Baff等成细胞因子促扁桃体类器官(t... 详细信息

目的建立人扁桃体免疫类器官模型并探讨流感病毒感染后产生的免疫学效应。方法经扁桃体腺样体肥大手术摘除后的人扁桃体组织在经过单个核细胞梯度离心后,利用2.5D-Transwell进行体外培养并添加IL-2及Baff等成细胞因子促扁桃体类器官(tonsil organoids, TO)的形成。通过单细胞转录组测序(single cell RNA sequencing, scRNA-seq)技术,分析流感病毒细胞受体在类器官各细胞亚群的分布;体外感染流感病毒,使用免疫荧光法(IF)和流式细胞术(FCM)检测扁桃体类器官感染病毒后的免疫学效应。结果于体外成功诱导扁桃体类器官;scRNA-seq分析结果显示流感病毒细胞受体广泛表达于所有的细胞类型中。流感病毒感染48 h后,刺激扁桃体类器官产生大量可分泌特异性IgG抗体的浆细胞和记忆性B细胞。病毒直接感染还促进CD8^(+)T细胞分泌细胞因子TNF-α与IL-2及CD4^(+)T细胞分泌细胞因子TNF-α、IFN-γ和IL-2。结论人扁桃体类器官在体外可以被成功诱导且在培养第6天左右达到成熟;流感病毒受体广泛分布于人扁桃体类器官的各细胞亚型;流感病毒可通过受体直接感染T细胞,刺激T细胞活化并分泌细胞因子;同时流感病毒直接感染也可促B细胞分化为浆细胞分泌IgG抗体,并在后期诱导记忆性B细胞的形成。

关键词：扁桃体类器官流感病毒免疫记忆炎症因子浆细胞

Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice

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Protein & Cell 2024年第4期15卷 261-284页

作者： He-Zhou huang Wen-Qing Ai Na Wei Ling-Shuang Zhu Zhi-Qiang Liu Chao-Wen Zhou Man-fei Deng Wen-Tao Zhang Jia-Chen Zhang Chun-Qing Yang Ya-Zhuo Hu Zhi-Tao Han Hong-Hong Zhang Jian-Jun Jia Jing Wang Fang-Fang Liu Ke Li Qi xu Mei Yuan Hengye Man Ziyuan Guo Youming Lu Kai Shu Ling-Qiang Zhu Dan Liu Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Medical Genetics School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450002China Department of Pathology School of Basic MedicineZhengzhou UniversityZhengzhou 450002China The Second Affiliated Hospital Department of NeurologyHengyang Medical SchoolUniversity of South ChinaHengyang 421001China Beijing Key Laboratory of Aging and Geriatrics National Clinical Research Center for Geriatric DiseaseInstitute of GeriatricsChinese PLA General Hospital and Chinese PLA Medical AcademyBeijing 100853China Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurology Union HospitalHuazhong University of Science and TechnologyWuhan 430022China Department of Biology Boston UniversityBostonMA 02215USA Center for Stem Cell and Organoid Medicine(CuSTOM) Division of Developmental BiologyCincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA

Sporadic or late-onset Alzheimer’s disease(LOAD)accounts for more than 95%of Alzheimer’s disease(AD)cases without any family *** genome-wide association studies have identified associated risk genes and loci for LOAD,numerous studies suggest that many adverse environmental factors,such as social isolation,are associated with an increased risk of ***,the underlying mechanisms of social isolation in AD progression remain *** the current study,we found that 7 days of social isolation could trigger pattern separation impairments and presynaptic abnormalities of the mossy fibre-CA3 circuit in AD *** also revealed that social isolation disrupted histone acetylation and resulted in the downregulation of 2 dentate gyrus(DG)-enriched miRNAs,which simultaneously target reticulon 3(RTN3),an endoplasmic reticulum protein that aggregates in presynaptic regions to disturb the formation of functional mossy fibre boutons(MFBs)by recruiting multiple mitochondrial and vesicle-related ***,the aggregation of RTN3 also recruits the PP2A B subunits to suppress PP2A activity and induce tau hyperphosphorylation,which,in turn,further elevates RTN3 and forms a vicious ***,using an artificial intelligence-assisted molecular docking approach,we determined that senktide,a selective agonist of neurokinin3 receptors(NK3R),could reduce the binding of RTN3 with its ***,application of senktide in vivo effectively restored DG circuit disorders in socially isolated AD *** together,our findings not only demonstrate the epigenetic regulatory mechanism underlying mossy fibre synaptic disorders orchestrated by social isolation and tau pathology but also reveal a novel potential therapeutic strategy for AD.

关键词： Alzheimer’s disease memory impairment synaptic disorder tau pathology

凹凸形周期结构遮障面的雷达及红外隐身性能分析

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激光与红外 2024年第4期54卷 593-598页

作者：李浩许卫东肖菲菲俞宙吴昌峰黄伟陆军工程大学江苏南京210000

为了提高遮障面的雷达及红外隐身效果,采用外形隐身技术,设计了一种具有凸起和凹陷的周期结构遮障面。首先建立4种不同形状的模型,进行电磁仿真计算并与实验测量结果进行对比,结果显示仿真与实验数据相关系数在09以上,仿真结果准确可用... 详细信息

为了提高遮障面的雷达及红外隐身效果,采用外形隐身技术,设计了一种具有凸起和凹陷的周期结构遮障面。首先建立4种不同形状的模型,进行电磁仿真计算并与实验测量结果进行对比,结果显示仿真与实验数据相关系数在09以上,仿真结果准确可用。其次分析各模型的电磁散射机理,为遮障面外形设计提供理论基础。然后设计具有起伏特征的遮障面,经过仿真计算,发现凸起和凹陷程度半径r达到24mm时,遮障面反射系数小于-10dB,r达到28mm时反射系数小于-17dB。最后,在遮障面的凸起部分填充隔热材料,仿真其覆盖在运行温度为80℃的装(设)备上,发现具有隔热材料的遮障面温度降低35℃,具有一定的红外伪装效果。

关键词：遮障起伏隐身雷达技术红外技术

甘草酸靶向干预高迁移率族蛋白1抑制炎症相关疾病的研究进展

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中国新药杂志 2024年第4期33卷 345-350页

作者：黄健徐佳范婧婧苏惠飞张清云叶敏北京大学药学院天然药物及仿生药物全国重点实验室北京100191

高迁移率族蛋白1(high mobility group box1,HMGB1)是一种高度保守的非组蛋白染色体结合蛋白。在生理条件下,HMGB1参与核内DNA的转录、复制、修复、重组和核小体形成。在病理条件下,大量释放到细胞外的HMGB1作为重要的炎症介质启动和维... 详细信息

高迁移率族蛋白1(high mobility group box1,HMGB1)是一种高度保守的非组蛋白染色体结合蛋白。在生理条件下,HMGB1参与核内DNA的转录、复制、修复、重组和核小体形成。在病理条件下,大量释放到细胞外的HMGB1作为重要的炎症介质启动和维持炎症反应。HMGB1已被证实与脓毒症、创伤性损伤、自身免疫性疾病以及缺血/再灌注损伤等多种疾病的发病机制密切相关。甘草酸(glycyrrhizic acid)是大量存在于甘草的根和根茎中的一种天然三萜皂苷,具有多种药理功能。研究发现甘草酸作为天然的HMGB1抑制剂,通过与HMGB1结合进而阻断HMGB1与其受体的相互作用从而发挥抗炎活性。本文综述近年来甘草酸及其衍生物治疗HMGB1相关炎症性疾病的药理作用研究,为甘草酸及其衍生物的进一步临床应用提供实验基础。

关键词：高迁移率族蛋白1 甘草酸炎症性疾病药理作用

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等规聚丙烯拉伸取向片晶结构的温度关联性

高分子通报 2024年第3期37卷 358-367页

作者：林浩严飞国江黄想姜胜宝许梦伊中国电力科学研究院武汉430074

为了探究加工温度对热拉伸聚丙烯取向晶体结构的影响规律,将等规聚丙烯(iPP)铸片在不同温度下拉伸到相同应变,并通过二维广角/小角X射线散射、差示扫描量热仪、动态力学分析等手段,对拉伸取向iPP的微观结构特性进行了系统研究。结果表明... 详细信息

为了探究加工温度对热拉伸聚丙烯取向晶体结构的影响规律,将等规聚丙烯(iPP)铸片在不同温度下拉伸到相同应变,并通过二维广角/小角X射线散射、差示扫描量热仪、动态力学分析等手段,对拉伸取向iPP的微观结构特性进行了系统研究。结果表明:经过热拉伸后,由球晶形貌演变成纤维晶形貌,纤维晶体由高度取向片晶和无定形层交替堆叠排列构成;升高温度引起结晶性能增强,结晶度和片晶平均厚度随温度连续递增;提高温度造成结晶相与无定形相之间的物性差异变大,两相链段运动松弛温度的变化趋势相反;热拉伸过程中新形成了不同厚度(熔点)的片晶,高熔点片晶是通过熔融-再结晶机理形成,而低熔点片晶由应变诱导结晶方式获得。本研究初步阐明了拉伸温度对聚丙烯取向片晶结构的影响规律和作用机制,对于开展结晶聚合物拉伸加工过程中多层次结构调控与性能优化具有参考价值。

关键词：等规聚丙烯拉伸温度片晶结晶度熔点

Space advanced technology demonstration satellite

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Science China(Technological Sciences) 2024年第1期67卷 240-258页

作者： ZHANG XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE JunWang BI XingZi ZHANG YongHe SHI Qi LI fei LIU Rui FENG ZhengGong LIU Liu LI JinSong WU HaiChen xu DongXiao LI TaiJie huang JiangJiang LIU Shuo LI TianTong YU XianSheng GAO Yang ZHOU Heng BAN HanYu ZHANG YanLi ZHANG YueTing YANG YingQuan HE Tao DUAN xuLiang CHEN Xin WANG YaMin SUN AnTai ZHANG KuoXiang SUN Ying WANG YaoBin FAN ChengCheng XIONG ShaoLin LI XinQiao WEN XiangYang LING ZhiXing SUN XiaoJin ZHANG Chen BAI XianYong WANG ZhanShan DENG YuanYong TIAN Hui YANG JianFeng xuE HongBo SANG Peng LIU JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui xu LuXiang xu ShuYan CHEN WenWu LIU ZhenDong WANG ZhaoLi MAO XiangLong GAO Rong LI Zongxuan DING GuoPeng WANG XinYu DOU RunJiang WENG LuBin LUO Hao WANG YaPing LIANG XianFeng FANG ZiRuo Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of China Beijing 100101China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China Institute of Precision Optical Engineering School of Physics Science and EngineeringTongji UniversityShanghai 200092China School of Earth and Space Sciences Peking UniversityBeijing 100871China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China National Space Science Center Chinese Academy of SciencesBeijing 100190China Shenyang Institute of Automation Chinese Academy of SciencesShenyang 110016China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghai 200032China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China Nanyang Technological University Singapore 569830Singapore Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100049China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Institute of Automation Chinese Academy of SciencesBeijing 100190China School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310058China

The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch *** as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,*** paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance.

关键词： SATech-01 spacecraft design scientific instruments on-orbit performance

适用于多种一次调频技术及工况变化的抽汽凝汽式汽轮机数学模型

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中国电机工程学报 2024年第15期44卷 6065-6077,I0019页

作者：黄怡涵郝玲陈磊徐飞徐达睿孙国辉姜楠程仁静新型电力系统运行与控制全国重点实验室(清华大学电机工程与应用电子技术系) 北京市海淀区100084 华能伊敏电厂内蒙古自治区呼伦贝尔市021134

火电机组是目前电力系统中重要的调频资源,其一次调频能力与汽轮机动态密切相关,但现有汽轮机动态数学模型无法准确反映火电机组在多种一次调频技术以及工况变化情况下的一次调频能力。为准确描述火电机组真实的一次调频动态,该文对汽... 详细信息

火电机组是目前电力系统中重要的调频资源,其一次调频能力与汽轮机动态密切相关,但现有汽轮机动态数学模型无法准确反映火电机组在多种一次调频技术以及工况变化情况下的一次调频能力。为准确描述火电机组真实的一次调频动态,该文对汽轮机本体、回热抽汽管道及回热加热器的动态耦合特性进行机理分析,建立适用于主汽阀调节、凝结水节流和高加给水旁路调频技术的汽轮机动态模型;基于机组结构数据及分布式控制系统实测数据,提出跟随工况变化的模型参数在线确定方法;最后,以实际600MW机组为例进行模型验证与仿真分析。结果表明,汽轮机输出功率会受到汽轮机本体和回热系统动态耦合特性的重要影响,且不同工况下机组一次调频能力存在明显差异。该文模型能更准确地描述不同一次调频技术方案及不同运行工况下汽轮机的动态响应特性。

关键词：汽轮机动态模型一次调频回热系统凝结水节流高加给水旁路

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