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Occupational Radiation Exposure and Changes in Thyroid Hormones in a Cohort of Chinese Medical Radiation Workers

Biomedical and Environmental Sciences 2021年第4期34卷 282-289页

作者： GUO Qi Shan RUAN Ping huang Wei Xu huang dai zheng QIU Jia Chu School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510310GuangdongChina Guangdong Province Engineering&Technology Research Center for Medical 3D Printer and Personalized Medicine Guangzhou 510006GuangdongChina Department of Biomedical Engineering Guangdong Pharmaceutical UniversityGuangzhou 510006GuangdongChina Guangdong Prevention and Treatment Center for Occupational Disease Guangzhou 510300GuangdongChina Department of Biomedical Engineering Guangxi Medical UniversityNanning 530021GuangxiChina

Objective This study aimed to evaluate the association between occupational radiation exposure and changes in thyroid hormone levels among medical radiation *** This retrospective cohort study included 2,946 radiation workers from 20 Guangzhou *** on general characteristics,participant radiation dosimetry,and thyroid function test results[thyroid-stimulating hormone(TSH),triiodothyronine(T3),and thyroid hormone(T4)]were extracted from dosimetry and medical *** generalized estimating equation was used to evaluate the trend of changes in thyroid hormone levels over time and was adjusted for age,gender,and *** The average annual effective dose was very low and showed a general downward *** the follow-up period,changes in T3 and T4 levels among radiation workers were-0.015[95% confidence interval(CI)-0.018 to-0.012]nmol/L per year and-2.294(95%CI-2.426 to-2.162)nmol/L per year,*** hormone levels were significantly different between males and females.T3 levels in the group of upper quartile of dose were significantly higher than in the lower quartile group(P=0.006).No significant decreased trend in thyroid hormone levels was observed with increasing average effective *** Thyroid hormone secretion might be affected even in low-dose radiation exposure environments.

关键词： Occupational radiation Thyroid function Cohort

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The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： zheng Liu Chunhua Pan Hao huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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心肌梗死患者红细胞的光镊拉曼光谱

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发光学报 2011年第10期32卷 1088-1092页

作者：吴智辉黄代政陈朝旺莫华广西医科大学物理学教研室广西南宁530021

利用激光光镊拉曼光谱系统,测定了健康者红细胞和心肌梗死患者的红细胞拉曼光谱,研究其拉曼光谱之间存在的差异性,探讨其红细胞内容物的改变情况及其变化机理,为疾病的诊断提供一种新的、快速简便的光谱分析手段,为临床诊断提供有力的... 详细信息

利用激光光镊拉曼光谱系统,测定了健康者红细胞和心肌梗死患者的红细胞拉曼光谱,研究其拉曼光谱之间存在的差异性,探讨其红细胞内容物的改变情况及其变化机理,为疾病的诊断提供一种新的、快速简便的光谱分析手段,为临床诊断提供有力的实验依据。

关键词：心肌梗死光镊拉曼光谱红细胞

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迈克耳孙干涉仪分析的一种新方法

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贵州工业大学学报（自然科学版） 2008年第4期37卷 168-170页

作者：黄代政桂林医学院物理教研室广西桂林541004

从多谱勒频移的方法,利用伽里略变换,对迈克耳孙干涉仪进行了全新的分析,从频率变化的角度对迈克耳孙干涉仪进行了新的认识,为我们利用该干涉仪提供了更为广阔的思维空间。

关键词：迈克耳孙干涉仪多谱勒频移伽里略变换

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Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang Yang Jianfeng zheng Guoyu Wang Yifei Gao Yatao Yang Jia Li Xiaojin Han Yan Cui Zhanggen huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Photoelectrocatalysis Z-scheme C–C coupling Ethanol

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健康人血红蛋白紫外可见吸收光谱和FTIR光谱

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光谱学与光谱分析 2020年第5期40卷 1425-1430页

作者：丘家杵阮萍雍军光冯博华黄代政沈洪涛广东药科大学劳动卫生与环境卫生学系广东广州510310 广东药科大学生物医学工程系广东广州510006 广东药科大学附属门诊部广东广州510235 广东省医药3D打印机及个性化医疗工程技术研究中心广东广州510006 广西医科大学生物医学工程系广西南宁530021 广西师范大学物理科学与技术学院广西桂林541001

为了探究健康人固体血红蛋白(hemoglobin,Hb)的紫外可见吸收光谱和傅里叶变化红外光谱的谱学特征,将21~80岁健康人分成四个年龄阶段组,采用葡聚糖层析法高度纯化新鲜血液红细胞内的Hb,利用冷冻干燥法获得结构稳定的Hb固体,测定四组样本... 详细信息

为了探究健康人固体血红蛋白(hemoglobin,Hb)的紫外可见吸收光谱和傅里叶变化红外光谱的谱学特征,将21~80岁健康人分成四个年龄阶段组,采用葡聚糖层析法高度纯化新鲜血液红细胞内的Hb,利用冷冻干燥法获得结构稳定的Hb固体,测定四组样本的Hb紫外可见吸收光谱和FTIR光谱;利用OMNIC 8.0软件的QC比较分析功能、全光谱特征分析和二级结构分析首次归纳得出健康人Hb的紫外光谱及FTIR光谱。分析显示样本间,四组间Hb紫外可见吸收光谱和FTIR光谱高度相同,FTIR光谱间的匹配度高达95%;所有样本Hb的紫外光谱均有5个特征吸收峰,吸收峰所在位置的吸光度、波长相同;FTIR光谱均有13个特征吸收峰,吸收峰所在位置的吸光度、波数是相同的;Hb紫外吸收光谱显示健康人Hb拥有相同的三级结构,FTIR光谱的特征吸收带AmideⅠ带二阶导数谱匹配度高达99%,其二级结构均由11个子峰构成,组成则以α-螺旋为主。研究得出健康人Hb的紫外可见吸收光谱和FTIR光谱,并通过初步分析得到Hb的光谱学特征和结构特点,有助于研究相关疾病。

关键词：健康人血红蛋白紫外光谱 FTIR 参照光谱

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Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai Bo Sun Huijun Wang Yi zheng Siyu Zhou Huixin Li Yanyan huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(DBO)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with DBO show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original DBO,the R and RPD of models with the improved DBO increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

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Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke Jiang Zhi Chen Ji Yu Chen zheng Shan huang Ming Wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

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Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu huang Qiuyu Pang Lexin zheng Jiaxi Lin Hanxi Li Lingbo Wan Tao Wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan zheng Qingming Lin Yan You zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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