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Chinese Journal of Structural Chemistry 2020年第6期39卷 1157-1166页

作者： SHI Jian-Cheng huang Xiao-Qian LUO Min huang chu-sheng College of Chemistry and Material Nanning Normal UniversiyNanning 530001China

The three-dimensional quantitative structure-activity relationships(3D-QSAR)for 37 curcumin derivatives were constructed by CoMFA and CoMSIA methods,*** results showed that the cross validated coefficient(q^2)and non-cross-validated coefficient(R^2)were 0.711,0.962 in CoMFA model and 0.774,0.856 in CoMSIA model,respectively,which suggests that two models are robust and have good exterior predictive *** on these two models and the binding mode with tubulin,nine novel curcuminoids inhibitors which could exhibit much higher anticancer potency and efficiently occupy the colchicine binding site of tubulin,were *** expect that the results in this paper have the potential to facilitate the process of design and to develop new potent curcumin derivatives with stronger anticancer activities.

关键词： anticancer activity tubulin curcumin derivatives 3D-QSAR molecular docking molecular design

Facile Syntheses of 3-Isopentenyl Flavone and 3-Geranyl Flavone

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Chemical Research in Chinese Universities 2012年第6期28卷 994-998页

作者： huang chu-sheng SHI Jian-cheng LIU Hong-xing CHEN Qian DUAN Hong-xia College of Chemistry and Life Sciences Guangxi Teachers Education University Nanning 530001 1~ R. China" Department of Applied Chemistry College of Science China Agricultural University Beijing 100193 P. R. China

Although there was a strong steric effect,isopentenyl and geranyl moieties were successfully introduced into C3 position in flavone skeleton so as to synthesize the 3-isopentenyl flavone and 3-geranyl flavone under two cyclization conditions（AcOH/HCl and concentrated H 2 SO 4 /MeOH） in this *** was found that the optimum cyclization conditions for 3-isopentenyl flavone and 3-geranyl flavone were,respectively,AcOH/HCl and H 2 SO 4 /***,the donating electron ability is in the sequence 3-geranyl flavone3-isopentenyl flavone according to the density functional theory（DFT） calculations,suggesting the longer alkyl chain at 3-position would be more favorable for enhancing the donating electron *** present synthetic routes might reveal potential applicability in our continued studies on the total syntheses of other natural 3-alkyl flavonoids.

关键词： 3-Isopentenyl flavone 3-Geranyl flavone 3-Alkyl flavonoid

Trophic relationships in the Changjiang River estuarine salt marshes: preliminary investigation from δ^(13)C and δ^(15)N analysis

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Acta Oceanologica Sinica 2009年第3期28卷 50-58页

作者： QUAN Weimin huang Danqing chu Tianjiang sheng Qiang FU Cuizhang CHEN Jiakuan WU Jihua Coastal Ecosystems Research Station of Yangtze River Estuary Ministry of EducationKey Laboratory for Biodiversity Science and Ecological Engineering Fudan UniversityShanghai 200433 China

To obtain information on food web structure in salt marshes of the Changjiang （Yangtze） River Estuary, the （ δ3C and δ15N values of primary producers and consumers were determined. The mean δ13C values of 31 dominant consumers ranged from -23.13‰ to -14.37‰. Except for several species （ Eriocheir sinensis, Sinonovacula constricta and Potamocorbula ustulata）, consumers had interme- diate δ13C values between those of benthic microalgae and Spartina alterniflora. The mean δ15N values of 31 dominant consumers varied between 6.87‰ and 13.33‰, which indicate three trophic levels in salt marshes of the Changjiang River Estuary. A total of 18 macroinvertebrates species and four fish species represented primary consumers with trophic levels ranging from 2.0 to 2.7. Secondary consumers included two maeroinvertebrates and seven fishes with trophic levels varying between 3.0 and 3.9. The consumers were divided into three trophic guilds, i.e., detritivorous/algae feeders, omnivores and carnivores. The detrital food chain was the main energy flow pathway in the salt marsh food web of the Changjiang River Estuary, and the marsh vascular plants were at least as equally important as microphytobenthos for secondary production. The important trophic function of the salt marsh habitats in the estuary is revealed.

关键词： energy base food web salt marshes stable isotope trophic level Changjiang River Estuary

再论赛艇动力学——对FISA《赛艇教练员培训教程》动力学理论的商榷

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武汉体育学院学报 2005年第12期39卷 69-71,78页

作者：黄胜初武汉体育学院科研处湖北武汉430079

对黄胜初于2000年建立的双动力赛艇动力学方程进行矢量推导,结果显示,在操桨过程中人体质心的移动产生无击水动力。据此,认为国际赛艇联合会(FISA)赛艇教练员培训手册(2002年版)中,单动力赛艇动力模型衍生出的三点错误之处。研究认为,... 详细信息

对黄胜初于2000年建立的双动力赛艇动力学方程进行矢量推导,结果显示,在操桨过程中人体质心的移动产生无击水动力。据此,认为国际赛艇联合会(FISA)赛艇教练员培训手册(2002年版)中,单动力赛艇动力模型衍生出的三点错误之处。研究认为,国内生物力学界和赛艇界对赛艇动力学及其在训练中的应用存在认识上的误区。应注重回桨技术的研究和训练,降低1桨中拉推桨时间比,提高1桨的划桨效率。

关键词：赛艇动力学 FISA 培训教程质疑

A Facile Total Synthesis of 2-Geranyl-2',3,4',4-tetrahydroxydihydrochalcone with Highly 5-Lipoxygenase Inhibiting Activity

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Chemical Research in Chinese Universities 1998年第4期14卷 80-81页

作者： huang chu sheng and LI Yu lin (National Laboratory of Applied Organic Chemistry and Organic Chemical Institute, Lanzhou University, Lanzhou, 730000)

２－Ｇｅｒａｎｙｌ－２，３，４，４－ｔｅｔｒａｈｙｄｒｏｘｙｄｉｈｙｄｒｏｃｈａｌｃｏｎｅ（１，ＡＣ－５－１），ｏｎｅｏｆａｆｅｗｎａｔｕｒａｌｏｃｕｒｉｎｇＣ－ｇｅｒａｎｙｌａｔｅｄｃｈａｌｃｏｎｅｓｉｎｎａｔ... 详细信息

２－Ｇｅｒａｎｙｌ－２，３，４，４－ｔｅｔｒａｈｙｄｒｏｘｙｄｉｈｙｄｒｏｃｈａｌｃｏｎｅ（１，ＡＣ－５－１），ｏｎｅｏｆａｆｅｗｎａｔｕｒａｌｏｃｕｒｉｎｇＣ－ｇｅｒａｎｙｌａｔｅｄｃｈａｌｃｏｎｅｓｉｎｎａｔｕｒｅ［１］，ｗａｓｉｓｏｌａｔｅ...

关键词： Geranyl 2 ,3,4 ,4 tetrahydroxdihydrochalcone 5 Lipoxygenase C geranylated chalcone

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安全生产与经济社会发展多元回归分析

煤炭学报 2005年第5期30卷 580-584页

作者：黄盛初周心权张斌川中国矿业大学(北京)资源与安全工程学院北京100083 安全生产信息研究院北京100029

对世界40个国家的统计分析表明,10万人死亡率与人均GDP呈现较强的相关性.为了研究安全生产与经济社会发展的关系,选择了其中27个样本国家的10万人死亡率和14个经济社会发展指标,运用多元回归分析方法,建立了10万人死亡率指标与经济社会... 详细信息

对世界40个国家的统计分析表明,10万人死亡率与人均GDP呈现较强的相关性.为了研究安全生产与经济社会发展的关系,选择了其中27个样本国家的10万人死亡率和14个经济社会发展指标,运用多元回归分析方法,建立了10万人死亡率指标与经济社会指标之间的多元回归模型,分析影响安全生产状况的经济社会因素.根据回归模型分析,预测我国安全事故10万人死亡率呈缓冲上升趋势,建议通过对主要经济社会因素进行宏观调控,包括改变经济增长方式,提高综合经济实力,增加科技投入和教育培训投入,加强安全监管,实现安全状况的稳定好转.

关键词：安全生产经济社会发展多元回归分析

First Synthesis of 3'- Geranyl-2', 3,4,4'-tetrahydroxychalcone with 5 α- Reductase Inhibitory Properties

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有机化学 2003年第Z1期23卷 76-76页

作者： LIU Hong-Xing huang chu-sheng CHEN Xi-Hui ZHU Yan-Yun Applied Chemical lnstitute of Guangxi Teachers'' College Nanning 530001 Applied Chemical lnstitute of Guangxi Teachers'' College Nanning 530001 College of Chemistry and Chemical Engineering Guangxi University Nanging 530004 College of Chemistry and Chemical Engineering Guangxi University Nanging 530004

　　The geranylated chalcone 1,3′-geranyl-2′, 3,4,4′-tetvahydroxychalcone with high 5α-reductase inhibitory prop erties, was isolated from Artocarpus incisus by Shimizu in 2000. [1] Herein, we describe the first synthesis of the natural product 1 by four steps starting from compounds 2 and 7. The synthetic route was shown in Scheme 1:……

关键词： natural product

PSO算法结合BP神经网络在传感器静态非线性校正中的应用

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计量学报 2009年第6期30卷 -页

作者：张媛媛徐科军许耀华黄胜初 Yuan-yuan Ke-jun Yao-hua sheng-chu 安徽大学电子科学与技术学院安徽合肥230039 合肥工业大学仪器科学与光电工程学院安徽合肥230009 合肥工业大学电气与自动化工程学院安徽合肥230009 工业自动化安徽省工程技术研究中心安徽合肥230009

将粒子群优化(PSO)算法与BP神经网络相结合,应用在传感器静态非线性特性的校正中.用PSO算法所得到的全局最优值作为BP神经网络的初始权值,训练BP神经网络,训练结束后的神经网络作为传感器的静态特性校正器.应用结果表明,该方法可以提高B... 详细信息

将粒子群优化(PSO)算法与BP神经网络相结合,应用在传感器静态非线性特性的校正中.用PSO算法所得到的全局最优值作为BP神经网络的初始权值,训练BP神经网络,训练结束后的神经网络作为传感器的静态特性校正器.应用结果表明,该方法可以提高BP神经网络的精度,并且该神经网络具有良好的泛化能力.Abstract：A static nonlinear errors method for correcting the sensors based on BP neural network using particle swarm optimization (PSO) is described. The global best values of particle swarm are used as initial weights of BP neural network to train BP neural network. Then the trained neural network is regarded as the sensor's corrector. The application results show that this method can improve the precision of the BP neural network, and the generalization capability of the neural network is good.

关键词： PSO算法神经网络传感器非线性校正 BP Neural Network BP neural network particle swarm optimization generalization capability application results 全局最优值粒子群优化非线性特性应用结果训练静态特性泛化能力初始权值 initial improve 校正器

硫化氢对肺动脉高压大鼠肺血管重塑及其抑制因子的影响

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解剖学报 2020年第1期51卷 109-113页

作者：黄初生覃家锦谭夏娴黄宏剑冼磊广西医科大学第二附属医院胸心血管外科南宁530007 广西医科大学第一附属医院心胸外科南宁530021 广西医科大学研究生院南宁530021

目的探讨硫化氢(H2S)对肺动脉高压(PH)大鼠肺血管重塑及其抑制因子的影响。方法 30只雄性SD大鼠,通过随机数字表方式分为对照组10只、模型组10只及H2S干预组10只,其中模型组通过野百合碱诱导建立PH模型,H2S干预组在模型组基础上,对大鼠... 详细信息

目的探讨硫化氢(H2S)对肺动脉高压(PH)大鼠肺血管重塑及其抑制因子的影响。方法 30只雄性SD大鼠,通过随机数字表方式分为对照组10只、模型组10只及H2S干预组10只,其中模型组通过野百合碱诱导建立PH模型,H2S干预组在模型组基础上,对大鼠腹腔注射Na HS(56μmol/kg),对照组注射等剂量的生理盐水。制作模型4周后,测定各组大鼠血流动力学指标,计算右心室肥厚指数(RVHI),通过HE染色检测肺血管病理形态学变化,应用Western blotting及Real-time PCR检测丝裂原激活蛋白激酶(MAPK)家族中p38、c-Jun氨基末端激酶(JNK)蛋白的表达及表达含量。结果各组血流动力学、RVHI、管壁厚度占血管直径百分比(WT%)、肺血管壁面积占血管截面积百分比(WA%)、p38 mRNA和JNK mRNA差异比较,具有统计学意义(P<0. 05)。其中模型组及H2S干预组平均体循环动脉压(MSAP)、平均肺动脉压(MPAP)、RVHI、WT%、WA%、p38mRNA和JNK mRNA表达水平均显著高于对照组(P<0. 05),而H2S干预组MSAP、MPAP、RVHI、WT%、WA%、p38mRNA和JNK mRNA水平均显著低于模型组(P<0. 05)。肺动脉形态图显示,与对照组相比,模型组及H2S干预组的血管管壁厚度均增加,管腔变狭窄,但H2S干预组管厚度及管腔狭窄度均较模型组明显减轻;Western blotting显示,模型组及H2S干预组p38、JNK蛋白表达量均高于对照组,而H2S干预组p38、JNK蛋白表达量均低于模型组。结论 H2S可改善PH大鼠血流动力学、右心室肥厚指数;减轻肺动脉血管管壁增厚及管腔狭窄,抑制大鼠肺血管重构,其作用机制可能与H2S下调MAPK信号通路上JNK及p38蛋白的表达有关。

关键词：硫化氢肺动脉高压肺血管重塑抑制因子免疫印迹法大鼠

B环3',4'-二甲氧基多甲氧基黄酮的研究进展

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天然产物研究与开发 2015年第3期27卷 547-551,528页

作者：杨进华黄初升刘红星广西师范学院化学与材料科学学院南宁530001

多甲氧基黄酮(PMFs)由于具有抗炎、抗氧化、抗癌、抗动脉粥样硬化等生理活性而备受青睐。到目前为止,国内外报道的多甲氧基黄酮(PMFs)近80种其广泛分布于芸香科、茜草科等科属植物中。本文对分离提取比较多的B环3',4'-二甲氧基多甲氧基... 详细信息

多甲氧基黄酮(PMFs)由于具有抗炎、抗氧化、抗癌、抗动脉粥样硬化等生理活性而备受青睐。到目前为止,国内外报道的多甲氧基黄酮(PMFs)近80种其广泛分布于芸香科、茜草科等科属植物中。本文对分离提取比较多的B环3',4'-二甲氧基多甲氧基黄酮的结构特征、生物活性、A环或C环不同甲氧基,羟基取代对B环上H化学位移变化进行了初步总结,为开发多甲氧基黄酮(PMFs)资源的开发利用提供初步的参考。

关键词：多甲氧基黄酮生物活性核磁