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Chinese Journal of Structural Chemistry 2020年第6期39卷 1157-1166页

作者： SHI Jian-Cheng huang Xiao-Qian LUO Min huang chu-sheng College of Chemistry and Material Nanning Normal UniversiyNanning 530001China

The three-dimensional quantitative structure-activity relationships(3D-QSAR)for 37 curcumin derivatives were constructed by CoMFA and CoMSIA methods,*** results showed that the cross validated coefficient(q^2)and non-cross-validated coefficient(R^2)were 0.711,0.962 in CoMFA model and 0.774,0.856 in CoMSIA model,respectively,which suggests that two models are robust and have good exterior predictive *** on these two models and the binding mode with tubulin,nine novel curcuminoids inhibitors which could exhibit much higher anticancer potency and efficiently occupy the colchicine binding site of tubulin,were *** expect that the results in this paper have the potential to facilitate the process of design and to develop new potent curcumin derivatives with stronger anticancer activities.

关键词： anticancer activity tubulin curcumin derivatives 3D-QSAR molecular docking molecular design

Facile Syntheses of 3-Isopentenyl Flavone and 3-Geranyl Flavone

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Chemical Research in Chinese Universities 2012年第6期28卷 994-998页

作者： huang chu-sheng SHI Jian-cheng LIU Hong-xing CHEN Qian DUAN Hong-xia College of Chemistry and Life Sciences Guangxi Teachers Education University Nanning 530001 1~ R. China" Department of Applied Chemistry College of Science China Agricultural University Beijing 100193 P. R. China

Although there was a strong steric effect,isopentenyl and geranyl moieties were successfully introduced into C3 position in flavone skeleton so as to synthesize the 3-isopentenyl flavone and 3-geranyl flavone under two cyclization conditions（AcOH/HCl and concentrated H 2 SO 4 /MeOH） in this *** was found that the optimum cyclization conditions for 3-isopentenyl flavone and 3-geranyl flavone were,respectively,AcOH/HCl and H 2 SO 4 /***,the donating electron ability is in the sequence 3-geranyl flavone3-isopentenyl flavone according to the density functional theory（DFT） calculations,suggesting the longer alkyl chain at 3-position would be more favorable for enhancing the donating electron *** present synthetic routes might reveal potential applicability in our continued studies on the total syntheses of other natural 3-alkyl flavonoids.

关键词： 3-Isopentenyl flavone 3-Geranyl flavone 3-Alkyl flavonoid

Trophic relationships in the Changjiang River estuarine salt marshes: preliminary investigation from δ^(13)C and δ^(15)N analysis

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Acta Oceanologica Sinica 2009年第3期28卷 50-58页

作者： QUAN Weimin huang Danqing chu Tianjiang sheng Qiang FU Cuizhang CHEN Jiakuan WU Jihua Coastal Ecosystems Research Station of Yangtze River Estuary Ministry of EducationKey Laboratory for Biodiversity Science and Ecological Engineering Fudan UniversityShanghai 200433 China

To obtain information on food web structure in salt marshes of the Changjiang （Yangtze） River Estuary, the （ δ3C and δ15N values of primary producers and consumers were determined. The mean δ13C values of 31 dominant consumers ranged from -23.13‰ to -14.37‰. Except for several species （ Eriocheir sinensis, Sinonovacula constricta and Potamocorbula ustulata）, consumers had interme- diate δ13C values between those of benthic microalgae and Spartina alterniflora. The mean δ15N values of 31 dominant consumers varied between 6.87‰ and 13.33‰, which indicate three trophic levels in salt marshes of the Changjiang River Estuary. A total of 18 macroinvertebrates species and four fish species represented primary consumers with trophic levels ranging from 2.0 to 2.7. Secondary consumers included two maeroinvertebrates and seven fishes with trophic levels varying between 3.0 and 3.9. The consumers were divided into three trophic guilds, i.e., detritivorous/algae feeders, omnivores and carnivores. The detrital food chain was the main energy flow pathway in the salt marsh food web of the Changjiang River Estuary, and the marsh vascular plants were at least as equally important as microphytobenthos for secondary production. The important trophic function of the salt marsh habitats in the estuary is revealed.

关键词： energy base food web salt marshes stable isotope trophic level Changjiang River Estuary

Demixing microwave signals using system-on-chip photonic processor

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Light(Science & Applications) 2024年第3期13卷 399-401页

作者： sheng Gao chu Wu Xing Lin Department of Electronic Engineering Tsinghua University100084 BeijingChina Beijing National Research Center for Information Science and Technology Tsinghua University100084 BeijingChina

The integrated photonic processor,co-packaged with electronic peripherals,is proposed for blind source separation of microwave signals,which separates signal-of-interest from dynamic interference with real-time adapta... 详细信息

关键词： processor microwave mixing

Aberrant protamination in sperm correlates to anomalous nuclear and cytoplasmic architectures in infertile males with sperm dysmorphology

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Asian Journal of Andrology 2024年第2期26卷 183-188页

作者： Huan Jiang chu-Jie huang Department of Reproductive Endocrinology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)Shenzhen 518172China Institute of Reproductive Immunology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China

Aberrant sperm protamination is linked to sperm dysmorphology and nuclear chromatin ***,its effects on sperm cytoplasmic maturation remain largely *** relationships of protamines,sperm morphology,DNA damage,and cytoplasmic remodeling were illustrated in this study to provide fresh perspectives on the mechanisms of male infertility.A total of 205 infertile males were allocated into 5 groups according to the percentage of spermatozoa exhibiting abnormal morphology within their *** concentration,motility,abnormal sperm morphology,cytoplasmic droplets(CDs),and excess residual cytoplasm(ERC)were analyzed according to the World Health Organization manual(2010).Sperm nuclear vacuoles(NVs)were determined by propidium iodide(PI)*** protamine expressions(P1 and P2)were detected by western *** damage was measured by acridine orange test(AOT)to calculate the proportion of sperm with single-strand DNA breaks(SSBs).Our data showed that sperm concentration and motility in infertile males significantly decreased with the severity of abnormal sperm morphology(both P<0.01).P1 level,P1/P2 ratio,and SSB rate increased with the severity of sperm dysmorphology,whilst the P2 level decreased(all P

关键词： abnormal sperm morphology excess residual cytoplasm male infertility protamines sperm DNA damage sperm nuclear vacuoles

Navigating Epstein–Barr virus autoimmunity:role of NK cells and T cells in multiple sclerosis

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Signal Transduction and Targeted Therapy 2024年第3期9卷 833-835页

作者： chu Xie Cong Sun Mu-sheng Zeng State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouP.R.China

In a recent study published in Cell,Vietzen and colleagues discovered the novel role of natural killer(NK)cells and EBVspecific CD8+T cell response in controlling EBV-inducing autoimmune response and collectively def... 详细信息

关键词： Epstein sclerosis killer

A Facile Total Synthesis of 2-Geranyl-2',3,4',4-tetrahydroxydihydrochalcone with Highly 5-Lipoxygenase Inhibiting Activity

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Chemical Research in Chinese Universities 1998年第4期14卷 80-81页

作者： huang chu sheng and LI Yu lin (National Laboratory of Applied Organic Chemistry and Organic Chemical Institute, Lanzhou University, Lanzhou, 730000)

２－Ｇｅｒａｎｙｌ－２，３，４，４－ｔｅｔｒａｈｙｄｒｏｘｙｄｉｈｙｄｒｏｃｈａｌｃｏｎｅ（１，ＡＣ－５－１），ｏｎｅｏｆａｆｅｗｎａｔｕｒａｌｏｃｕｒｉｎｇＣ－ｇｅｒａｎｙｌａｔｅｄｃｈａｌｃｏｎｅｓｉｎｎａｔ... 详细信息

２－Ｇｅｒａｎｙｌ－２，３，４，４－ｔｅｔｒａｈｙｄｒｏｘｙｄｉｈｙｄｒｏｃｈａｌｃｏｎｅ（１，ＡＣ－５－１），ｏｎｅｏｆａｆｅｗｎａｔｕｒａｌｏｃｕｒｉｎｇＣ－ｇｅｒａｎｙｌａｔｅｄｃｈａｌｃｏｎｅｓｉｎｎａｔｕｒｅ［１］，ｗａｓｉｓｏｌａｔｅ...

关键词： Geranyl 2 ,3,4 ,4 tetrahydroxdihydrochalcone 5 Lipoxygenase C geranylated chalcone

再论赛艇动力学——对FISA《赛艇教练员培训教程》动力学理论的商榷

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武汉体育学院学报 2005年第12期39卷 69-71,78页

作者：黄胜初武汉体育学院科研处湖北武汉430079

对黄胜初于2000年建立的双动力赛艇动力学方程进行矢量推导,结果显示,在操桨过程中人体质心的移动产生无击水动力。据此,认为国际赛艇联合会(FISA)赛艇教练员培训手册(2002年版)中,单动力赛艇动力模型衍生出的三点错误之处。研究认为,... 详细信息

对黄胜初于2000年建立的双动力赛艇动力学方程进行矢量推导,结果显示,在操桨过程中人体质心的移动产生无击水动力。据此,认为国际赛艇联合会(FISA)赛艇教练员培训手册(2002年版)中,单动力赛艇动力模型衍生出的三点错误之处。研究认为,国内生物力学界和赛艇界对赛艇动力学及其在训练中的应用存在认识上的误区。应注重回桨技术的研究和训练,降低1桨中拉推桨时间比,提高1桨的划桨效率。

关键词：赛艇动力学 FISA 培训教程质疑

A Deep Model for Partial Multi-label Image Classification with Curriculum-based Disambiguation

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Machine Intelligence Research 2024年第4期21卷 801-814页

作者： Feng Sun Ming-Kun Xie sheng-Jun huang MIIT Key Laboratory of Pattern Analysis and Machine Intelligence College of Computer Science and TechnologyNanjing University of AeronauticsandAstronauticsNanjing211106China

In this paper,we study the partial multi-label(PML)image classification problem,where each image is annotated with a candidate label set consisting of multiple relevant labels and other noisy *** PML methods typically design a disambiguation strategy to filter out noisy labels by utilizing prior knowledge with extra assumptions,which unfortunately is unavailable in many real ***,because the objective function for disambiguation is usually elaborately designed on the whole training set,it can hardly be optimized in a deep model with stochastic gradient descent(SGD)on *** this paper,for the first time,we propose a deep model for PML to enhance the representation and discrimination *** the one hand,we propose a novel curriculum-based disambiguation strategy to progressively identify ground-truth labels by incorporating the varied difficulties of different *** the other hand,consistency regularization is introduced for model training to balance fitting identified easy labels and exploiting potential relevant *** experimental results on the commonly used benchmark datasets show that the proposed method significantlyoutperforms the SOTA methods.

关键词： Partial multi-label image classification curriculum-based disambiguation consistency regularization label difficulty candidatelabel set.

Radical involved reactive wetting and retarding mechanism of alumina refractory ceramic by molten slags under weak static magnetic field

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Journal of Iron and Steel Research International 2024年第6期31卷 1355-1366页

作者： sheng-hao Li Ao huang Fan-bo Zeng Hui Peng Hao-ran Wei Xue-chun huang sheng-qiang Song Hua-zhi Gu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

High alumina slag will cause severe corrosion at the interface of alumina refractory,and the wetting behavior of slag is a key factor influencing the corrosion resistance of refractory *** static magnetic field is a promising solution for improvement in the slag resistance of *** wetting of alumina refractory ceramics with different basicities of high alumina slags under a weak static magnetic field was analyzed,given that a weak static magnetic field can affect the corrosion behavior of refractory *** slag S_(3) as an example,when there was an external static magnetic field of 1.0 mT at 1600 ℃,the thickness of calcium aluminate reaction layer at the interface decreased by 36.7%,the denting depth of interface decreased by 35.6%,and the apparent wetting angle increased by 20%.The living radicals and their formation path in oxide melts were verified by first-principles calculation combined with electron paramagnetic resonance spectroscopy *** influence of the flux density of a weak static magnetic field on the wetting behavior of slags was also *** contact angle of the slags increased owing to the inhibitory effect of magnetic field on the radicalinvolved reaction at the interface of the slag and the alumina refractory *** relationships between the magnetic flux density,diffusion coefficient,slag microstructure(hyperfine coupling constant),and contact angle were *** provides a theoretical basis for the field control of radical involved reactive wetting between inorganic oxide slags and solid oxide ceramics.

关键词： Alumina refractory ceramic Molten slag Weak magnetic field effect Reactive wetting Free radical